Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献

A protective effect of Ivermectin on vasculitis rat model: Histopathological study. 伊维菌素对大鼠血管炎模型的保护作用：组织病理学研究。

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2025-10-30 DOI: 10.32947/ajps.v25i4.1220

Teeba Sarem Sadeq, Nadia Hameed Mohammed, Inam Sameh Arif, Sayed Mahmood Alqallaf

{"title":"A protective effect of Ivermectin on vasculitis rat model: Histopathological study.","authors":"Teeba Sarem Sadeq, Nadia Hameed Mohammed, Inam Sameh Arif, Sayed Mahmood Alqallaf","doi":"10.32947/ajps.v25i4.1220","DOIUrl":"https://doi.org/10.32947/ajps.v25i4.1220","url":null,"abstract":"Vasculitis is an inflammation in the blood vessel wall, with variation in severity and the system affected. Vasculitis pathogenesis is caused by three possible mechanisms, including autoantibodies anti-neutrophil cytoplasmic antibodies, activation of T lymphocyte cells, and immune complexes.Various pathogens stimulate innate and adaptive immune systems, modulating the expression of pro-inflammatory cells, cytokines, and the complement system, that have a role in vasculitis progression. Ivermectin is an anti-parasitic drug, effective in treating parasitic infections. Thirty-three male albino rats were used for the experiment and divided into five groups. The disease was induced in all groups except group A (control), rats received the vehicles used in dissolving drug and chemicals. Group B (induction group) received Ovalbumin and Lipopolysaccharide. Group C, group D, and group E (Ivermectin groups) received 0.5mg/kg, 1 mg/kg and 1.5 mg/kg of Ivermectin, respectively, for seven days. All doses were injected by intraperitoneal route. Results of histopathological evaluation of lung sections of Ivermectin groups show a decrease in the inflammation severity, alveolar destruction, and vascular congestion and dilatation, with the absence of: hemorrhage, thrombi, and fibrinoid wall necrosis in comparison to the disease group. Therefore, the Ivermectin drug might have a protective effect against vasculitis.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"25 4","pages":"515-524"},"PeriodicalIF":0.0,"publicationDate":"2025-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/download/1220/839","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrospinning Fibres Mucoadhesive Buccal Tablet using Atorvastatin Calcium Trihydrate as modeling drug: Preparation and Characterization 以阿托伐他汀三水合钙为模拟药物的静电纺丝纤维黏附含片的制备与表征

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2025-08-31 DOI: 10.32947/ajps.v25i3.1167

Zainab Farhan Muaiz, Masar Basim Mohsin Mohamed, Lina A. Dahabiyeh

{"title":"Electrospinning Fibres Mucoadhesive Buccal Tablet using Atorvastatin Calcium Trihydrate as modeling drug: Preparation and Characterization","authors":"Zainab Farhan Muaiz, Masar Basim Mohsin Mohamed, Lina A. Dahabiyeh","doi":"10.32947/ajps.v25i3.1167","DOIUrl":"https://doi.org/10.32947/ajps.v25i3.1167","url":null,"abstract":"الخلاصة هذا البحث يهدف إلى تطوير أقراص لاصقة مخاطية تحتوي على الأتورفاستاتين كألياف عبر تقنية الغزل الكهربائي للتطبيق في الفم، بهدف تقليل التهيج المعدي، والأيض في المرور الأول، وتعزيز الامتصاص الحيوي. تم تحضير ثلاثة تركيبات من الألياف بكميات ثابتة من الأتورفاستاتين ، بوليفينيل بيروليدين، ونسب مختلفة من سولوبلس (1:4:1، 1:4:2، 1:4:3) وخضعت لاختبارات توصيف مختلفة مثل الطيف الأشعة تحت الحمراء بالتحويل الفوري، والكالوريمترية التفاضلية للمسح الحراري، وتصوير المجهر البصري. وتمت متابعة تركيبة الالياف F1 بشكل اعمق وصنعت بشكل اقراص مخاطية لاصقة. خضعت هذه الاقراص الى لاختبارات متنوعة ،واظهرت نتائج مرضية. تم مزامنة الدراسات الطيفية للأشعة تحت الحمراء بالتحويل الفوري والكالوريمترية من خلال الكشف عن التغيير الذي أكد على أن الروابط الهيدروجينية على الأرجح بين الاتورفستاتين والبوليمرات التي ضمنت الشكل البلوري للألياف من خلال الكالوريمترية التفاضلية للمسح الحراري. حققت الالياف F1 من اطلاق 90% من الدواء، بينما حققت F2 و F3 37.9% و 23.07% على التوالي، كما تم فحص الألياف تحت المجهر البصري، و المجهر الإلكتروني الماسح ولوحظ نجاح تكوين الألياف والألياف ذات سطح املس دون وجود أي حبيبات أو بلورات دوائية عليه على التوالي. الاقراص (B2,B1 )التي تحتوي على ألياف ما يعادل 10 ملغ من الاتورفاستاتين باستخدام مضخة تدفق متحكمة أظهرت إطلاقًا بطيئًا بنسبة 14% و 21.9% على التوالي ، بينما وصل إطلاق الذوبان بالطريقة التقليدية لاقراص B2الى 56.4% خلال 4 ساعات.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"25 3","pages":"400-418"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/download/1167/815","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147334209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the effect of EX-527 as a selective SIRT1 inhibitor against MCF-7 breast cell line by modulating POLD1 activity 探讨EX-527作为选择性SIRT1抑制剂通过调节POLD1活性对MCF-7乳腺细胞系的作用

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2025-08-31 DOI: 10.32947/ajps.v25i3.1204

Areege Ibrahim Salih, Bahir Abdul Razzaq Mshimesh, Basma Talib Al-Sudani

{"title":"Exploring the effect of EX-527 as a selective SIRT1 inhibitor against MCF-7 breast cell line by modulating POLD1 activity","authors":"Areege Ibrahim Salih, Bahir Abdul Razzaq Mshimesh, Basma Talib Al-Sudani","doi":"10.32947/ajps.v25i3.1204","DOIUrl":"https://doi.org/10.32947/ajps.v25i3.1204","url":null,"abstract":"سرطان الثدي هو الورم الأكثر انتشارا بين النساء وثالث أكبر سبب للوفاة في جميع انحاء العالم. وبالتالي، فان تحسين تشخيص وفعالية علاج سرطان الثدي يتطلب المزيد من الدراسات لفهم الاليات الجزيئية الكامنة وراء التسبب في المرض. السيرتوين 1 هو عبارة عن انزيم هيستون ديسيتيلاز من الدرجة الثالثة المعتمد على النيكوتينامايد داي نيوكليوتايد والذي يشارك في انتشار الأورام الخبيثة وموت الخلايا المبرمج وتطور الورم ومسارات التسرطن الأخرى. الوظيفة الدقيقة للسيرتوين 1 فيما يتعلق بسرطان الثدي غير معروفة حتى الان ولا يزال تأثيرها محل جدل. كان الغرض من هذا البحث هو دراسة تأثير تقليل تنظيم السيرتوين 1 على مستوى تعبير بروتين P53 وعلى بوليميريز الحمض النووي دلتا 1 POLD1 وهو الجين الذي يشفر الوحدة الفرعية الحفزية p125 وتصحيح التجارب المطبعية من الحمض النووي δ من اجل تحديد الوظيفة الهامة للسيرتوين 1 في سرطان الثدي. تم تحديد مستوى التعبير عن البروتينات بواسطة اختبار الويسترن بلوت. كشفت نتائج الدراسة الحالية ان تقليل تنظيم السيرتوين 1 أدى الى زيادة التعبير عن p53 وانخفاض التعبير عن POLD1 .","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"25 3","pages":"291-301"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/download/1204/804","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors 新型细胞周期蛋白依赖性激酶2抑制剂1,3,4-恶二唑衍生物的设计、分子对接、合成、表征和初步评价

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2025-01-14 DOI: 10.32947/ajps.v25i1.1132

Yousef Sabah Ali, Monther Faisal Mahdi, Basma M. Abd Razik, Talal Aburjaı

{"title":"Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors","authors":"Yousef Sabah Ali, Monther Faisal Mahdi, Basma M. Abd Razik, Talal Aburjaı","doi":"10.32947/ajps.v25i1.1132","DOIUrl":"https://doi.org/10.32947/ajps.v25i1.1132","url":null,"abstract":"تم تصميم وتخليق وتوصيف مشتقات جديدة لحلقة 1،3،4-أوكساديازول الجديدة واختبارها داخل المختبر للتأكد من نشاطها السام للخلايا. في دراسة الارساء الجزيئي، تم ربط هذه المواد الكيميائية بالبنية البلورية لبروتين CDK-2 (PDB-2R3J) لتقييم درجة الارتباط. باستخدام الخصائص الفيزيائية والكيميائية، طيف الاشعة تحت الحمراء الدقيق، طيف الرنين النووي المغناطيسي للبروتون، وطيف الرنين النووي المغناطيسي للكاربون، تم توصيف وتشخيص المركبات المصنعة. اشارت نتائج تحليل الارساء الجزيئي إلى أن مشتقات 1،3،4-أوكساديازول اظهرت ارتباطا قويًا داخل موقع الارتباط النشط لبروتين CDK-2. من بين الجزيئات التي تم اختبارها، أظهرت المركبات 5a و 5d أعلى درجة ارتباط 10.654 -و 10.169- Kcal/mol على التوالي، بينما اظهرت الجزيئة المرجعية درجة ارتباط 9.919- Kcal/mol. أظهرت المركبات 5a و 5d نشاطًا بارزا ومشجعًا مضادًا لسرطان القولون في خط خلايا Caco-2، أظهرت هذه المركبات قيم IC50 تبلغ 43.16 و60.8 ميكرومولار عند 24 ساعة، على التوالي، مقارنة بقيمة IC50 لعقار فلافوبيريدول (59.2 ميكرومولار عند 24 ساعة). كانت نتائج تجارب السمية الخلوية التي أجريت على المركبات النهائية متوافقة مع نتائج بحث الارساء الجزيئي مما يشير إلى أهمية اجراء دراسة دوائية شاملة لفهم الآليات المضادة للسرطان لهذه المشتقات بشكل كامل.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"25 1","pages":"94-109"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/download/1132/781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Evaluating Serum Calprotectin and Serum Oncostatin M Levels as Diagnostic Markers in Crohn's Disease and Ulcerative Colitis Iraqi Patients. Research 评估作为伊拉克克罗恩病和溃疡性结肠炎患者诊断标志物的血清钙黏蛋白和血清 Oncostatin M 水平。研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1067

Yahya G. Karwi, Inam S. Arif, S. A. Abdulameer

{"title":"Evaluating Serum Calprotectin and Serum Oncostatin M Levels as Diagnostic Markers in Crohn's Disease and Ulcerative Colitis Iraqi Patients. Research","authors":"Yahya G. Karwi, Inam S. Arif, S. A. Abdulameer","doi":"10.32947/ajps.v24i2.1067","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1067","url":null,"abstract":"Abstract \u0000Introduction: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), presents as chronic gastrointestinal inflammation. Timely diagnosis and effective monitoring are crucial for better outcomes. This study aims to explore serum calprotectin and oncostatin M as potential biomarkers for diagnosing and monitoring CD and UC. Calprotectin, released during inflammation, and oncostatin M, an immune-response cytokine, have shown promise, but their precise role in IBD remains unclear. \u0000Methodology: Using a cross-sectional observational design, the study included 93 IBD patients on biological treatment (50 CD, 43 UC) at Baghdad Teaching Hospital. Demographic data and disease characteristics were collected via interviews, and blood samples were analyzed using specific ELISA kits for calprotectin and oncostatin M levels. \u0000Results: The results demonstrated significantly elevated serum levels of both biomarkers in IBD patients, increasing with disease activity. Significant distinctions were observed among different disease statuses in UC and CD patients. \u0000Conclusion: These findings suggest that serum calprotectin and oncostatin M have potential as practical and non-invasive biomarkers for diagnosing and monitoring IBD. However, further research is required to validate their clinical utility and optimize IBD management.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"32 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration 用于局部用药的姜黄素 12-羟基硬脂酸三醋酸有机凝胶的制备与表征

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1011

Duaa Razaq, Masar Basim Mohsin Mohamed, Lina A. Dahabiyeh

{"title":"Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration","authors":"Duaa Razaq, Masar Basim Mohsin Mohamed, Lina A. Dahabiyeh","doi":"10.32947/ajps.v24i2.1011","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1011","url":null,"abstract":"Background: Curcumin (CUR) and its derivatives have shown a wide variety of biological activities, such as anti-oxidant, anti-inflammatory, anti-tumor, antimicrobial and antiparasitic effects as well as for the treatment of skin diseases. Due to its physico-chemical limitations such as low aqueous solubility and low bioavailability,\u0000we developed curcumin organogel as a topical delivery system to overcome those limitations. The12-hydroxystearic acid (12-HSA) is well known as a low-molecular-weight organogelators (LMOGs) capable of gelling an organic liquid phase. Different concentrations of (12-HSA) in triacetin with 50 mg CUR were gelled and applied for various examinations: tabletop rheology, oil binding capacity, pH measurement, spreadability, in vitro drug release, antibacterial activity and oscillatory rheology studies. The results revealed that the organogels transition temperatures from solid to liquid were greater than the normal body temperature, this helped the organogels keep their shape; they had good spreadability,and the organogels pH levels were within the safe range for the skin . In vitro release data showed that 4% 12HSA+5%CUR +TA (4TA) gave us 100% release after 6 hours. The selected 4TA illustrated good viscoelastic properties in the amplitude sweep test and a frequency-independent as seen in the frequency sweep test. CUR has good antibacterial action against Staphylococcus aureus; Streptococcus pyrogen, Proteus mirabilis, and Escherichia coli, which prevail at the site of wound injury as this pointed out that 4TA organogel can be used for topical wound healing.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"173 S394","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Favipiravir Adverse Drug Reactions during COVID-19 Pandemic: A Retrospective Study Based on Iraqi Pharmacovigilance Center Database COVID-19 大流行期间法维拉韦药物不良反应分析：基于伊拉克药物警戒中心数据库的回顾性研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1069

Yasir A. Noori, Inam S. Arif, M. M. Younus, Mohammed M. Mohammed, Abdullah M. Alrawi, Salim Hamadi

{"title":"Analysis of Favipiravir Adverse Drug Reactions during COVID-19 Pandemic: A Retrospective Study Based on Iraqi Pharmacovigilance Center Database","authors":"Yasir A. Noori, Inam S. Arif, M. M. Younus, Mohammed M. Mohammed, Abdullah M. Alrawi, Salim Hamadi","doi":"10.32947/ajps.v24i2.1069","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1069","url":null,"abstract":"The “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)” was the reason behind the recent pandemic “COVID-19” that started from Wuhan, china, and rapidly spread to many regions of the world. Research in Drug repurposing processes to treat this novel coronavirus involved many medications,\u0000one of the most discussed is Favipiravir. The objective of the current work was aimed towards Examining the cause, severity, preventability, predictability, and outcome of favipiravir-associated adverse events that had been reported in Iraq. In terms of adverse drug responses, \"Gastrointestinal disorders\" accounted for the majority (57.4%), followed by \"Cardiac disorders\" (35.2%), and \"Investigations\" (abnormal lab test results) (13%). The causality of these reactions Is majorly “Possible” (62%). Severity level 1 (40.9%) and 2 (41.8%). Ninety-nine percent of the ADRs are expected. The majority of the ADRs are non-Preventable (76.3%). The main outcome is Recovered / Resolved (44.5%). About (50%) of the ADRs were serious.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"36 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid 组蛋白去乙酰化酶 8 抑制活性的硅学分析：与羟肟酸交联的新型二肽化合物的计算分析

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1059

Omer mohammed Ammash, S. Alwan, A. R. Albakaa, İsmail Alshrif, Ibrheam ben Sulaiman

{"title":"In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid","authors":"Omer mohammed Ammash, S. Alwan, A. R. Albakaa, İsmail Alshrif, Ibrheam ben Sulaiman","doi":"10.32947/ajps.v24i2.1059","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1059","url":null,"abstract":"This study involved the development of innovative compounds consisting of dipeptide cross-links combined with hydroxamic acid. Our objective was to assess their binding affinities with histone deacetylase 8 (HDAC8) by conducting a docking study, comparing the results with the reference ligand, suberoylanilide hydroxamic acid (SAHA).\u0000Docking scores were measured in terms of ΔG (Kcal/mol), and the recorded scores for compounds 2A-D were found to be higher than that of SAHA, with values of 87.36, 80.46, 79.42, and 74.14, respectively. Notably, compound 2A, a dipeptide consisting of L-tryptophyl-L-tyrosine linked to a hydroxamic acid moiety, exhibited the highest docking score of 87.36. This finding suggests that compound 2A may possess the most potent HDAC8 inhibitory activity among the other designed compounds. Furthermore, we utilized the SwissADME server to predict the physicochemical properties and additional ADME parameters for the designed compounds. The analysis revealed that all investigated compounds exhibited a high potential for passive oral absorption and demonstrated no penetration into the blood-brain barrier. Compound 2A, 2B, and 2D exhibited one Lipinski's rule violation each, whereas Compound 2C demonstrated no such violations in all parameters. Additionally, compounds 2A and 2C exhibited potential as P-glycoprotein (P-gp) substrates. SAHA did not exhibit inhibition of any of the cytochrome P450 (CYP) enzymes used in this study, whereas compounds 2B, 2C and 2D displayed possible inhibitory activities. These compelling findings provide encouraging prospects for the future synthesis of the designed compounds and warrant further evaluation through in vitro and in vivo biological studies.\u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"274 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking, Synthesis, Characterization and Antimicrobial Evaluation of 5-methylthiazolidine-4-ones 5- 甲基噻唑烷-4-酮的分子对接、合成、表征和抗菌评估

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1033

Sarmad Saadi Hussein, K. Ali, Fouad A. A. Al-saady, Atheer Atiroğlu

引用次数: 0

The incidence of coxiella infection in Iraqi women with early pregnancy loss 伊拉克早孕流产妇女的柯西氏菌感染率

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1032

Noor Hasan, Baydaa Hameed, Abdulkarreem Abbas, Mamdouh Mohamed Elbahnasawy

{"title":"The incidence of coxiella infection in Iraqi women with early pregnancy loss","authors":"Noor Hasan, Baydaa Hameed, Abdulkarreem Abbas, Mamdouh Mohamed Elbahnasawy","doi":"10.32947/ajps.v24i2.1032","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1032","url":null,"abstract":"Query fever is a bacterial disease resulting from Coxiella burnetii (CB) infection in animals. It is well known that small ruminants who get Q fever lose their babies. People think pregnant women may also have lousy gestation results if they get the infection or the infection comes back to life during pregnancy.\u0000This study looks at how serologic results of Q fever and early pregnancy loss (EPL) are linked. In Baghdad, including Madinat Al-Imamain Al-Kadhmain Teaching Hospital and Abu Ghraib Hospital, multicenter case-control research was conducted from September to December 2022. A total of 90 women were enrolled in this investigation. Sixty clinically suffered from early pregnancy loss by having a nonviable intrauterine pregnancy. The other 30 women were subjects of comparable age, the week of pregnancy, and the healthy subjects as controls. Using a commercial enzyme-linked immunosorbent assay (ELISA), serum samples were screened for antibodies against CB. Three (5%) cases tested positive for CB by ELISA. The study reveals no association between adverse gestation outcomes and positive Q fever serology. Age and abortion history were not significantly correlated with C. burnetii seropositivity, according to the findings of CB cases that tested positive results.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"193 S550","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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