Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献

Evaluating Serum Calprotectin and Serum Oncostatin M Levels as Diagnostic Markers in Crohn's Disease and Ulcerative Colitis Iraqi Patients. Research 评估作为伊拉克克罗恩病和溃疡性结肠炎患者诊断标志物的血清钙黏蛋白和血清 Oncostatin M 水平。研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1067

Yahya G. Karwi, Inam S. Arif, S. A. Abdulameer

{"title":"Evaluating Serum Calprotectin and Serum Oncostatin M Levels as Diagnostic Markers in Crohn's Disease and Ulcerative Colitis Iraqi Patients. Research","authors":"Yahya G. Karwi, Inam S. Arif, S. A. Abdulameer","doi":"10.32947/ajps.v24i2.1067","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1067","url":null,"abstract":"Abstract \u0000Introduction: Inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), presents as chronic gastrointestinal inflammation. Timely diagnosis and effective monitoring are crucial for better outcomes. This study aims to explore serum calprotectin and oncostatin M as potential biomarkers for diagnosing and monitoring CD and UC. Calprotectin, released during inflammation, and oncostatin M, an immune-response cytokine, have shown promise, but their precise role in IBD remains unclear. \u0000Methodology: Using a cross-sectional observational design, the study included 93 IBD patients on biological treatment (50 CD, 43 UC) at Baghdad Teaching Hospital. Demographic data and disease characteristics were collected via interviews, and blood samples were analyzed using specific ELISA kits for calprotectin and oncostatin M levels. \u0000Results: The results demonstrated significantly elevated serum levels of both biomarkers in IBD patients, increasing with disease activity. Significant distinctions were observed among different disease statuses in UC and CD patients. \u0000Conclusion: These findings suggest that serum calprotectin and oncostatin M have potential as practical and non-invasive biomarkers for diagnosing and monitoring IBD. However, further research is required to validate their clinical utility and optimize IBD management.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"32 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration 用于局部用药的姜黄素 12-羟基硬脂酸三醋酸有机凝胶的制备与表征

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1011

Duaa Razaq, Masar Basim Mohsin Mohamed, Lina A. Dahabiyeh

{"title":"Formulation and Characterization of Curcumin 12-Hydroxystearic Acid in Triacetin Organogel for Topical Administration","authors":"Duaa Razaq, Masar Basim Mohsin Mohamed, Lina A. Dahabiyeh","doi":"10.32947/ajps.v24i2.1011","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1011","url":null,"abstract":"Background: Curcumin (CUR) and its derivatives have shown a wide variety of biological activities, such as anti-oxidant, anti-inflammatory, anti-tumor, antimicrobial and antiparasitic effects as well as for the treatment of skin diseases. Due to its physico-chemical limitations such as low aqueous solubility and low bioavailability,\u0000we developed curcumin organogel as a topical delivery system to overcome those limitations. The12-hydroxystearic acid (12-HSA) is well known as a low-molecular-weight organogelators (LMOGs) capable of gelling an organic liquid phase. Different concentrations of (12-HSA) in triacetin with 50 mg CUR were gelled and applied for various examinations: tabletop rheology, oil binding capacity, pH measurement, spreadability, in vitro drug release, antibacterial activity and oscillatory rheology studies. The results revealed that the organogels transition temperatures from solid to liquid were greater than the normal body temperature, this helped the organogels keep their shape; they had good spreadability,and the organogels pH levels were within the safe range for the skin . In vitro release data showed that 4% 12HSA+5%CUR +TA (4TA) gave us 100% release after 6 hours. The selected 4TA illustrated good viscoelastic properties in the amplitude sweep test and a frequency-independent as seen in the frequency sweep test. CUR has good antibacterial action against Staphylococcus aureus; Streptococcus pyrogen, Proteus mirabilis, and Escherichia coli, which prevail at the site of wound injury as this pointed out that 4TA organogel can be used for topical wound healing.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"173 S394","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Favipiravir Adverse Drug Reactions during COVID-19 Pandemic: A Retrospective Study Based on Iraqi Pharmacovigilance Center Database COVID-19 大流行期间法维拉韦药物不良反应分析：基于伊拉克药物警戒中心数据库的回顾性研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1069

Yasir A. Noori, Inam S. Arif, M. M. Younus, Mohammed M. Mohammed, Abdullah M. Alrawi, Salim Hamadi

{"title":"Analysis of Favipiravir Adverse Drug Reactions during COVID-19 Pandemic: A Retrospective Study Based on Iraqi Pharmacovigilance Center Database","authors":"Yasir A. Noori, Inam S. Arif, M. M. Younus, Mohammed M. Mohammed, Abdullah M. Alrawi, Salim Hamadi","doi":"10.32947/ajps.v24i2.1069","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1069","url":null,"abstract":"The “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)” was the reason behind the recent pandemic “COVID-19” that started from Wuhan, china, and rapidly spread to many regions of the world. Research in Drug repurposing processes to treat this novel coronavirus involved many medications,\u0000one of the most discussed is Favipiravir. The objective of the current work was aimed towards Examining the cause, severity, preventability, predictability, and outcome of favipiravir-associated adverse events that had been reported in Iraq. In terms of adverse drug responses, \"Gastrointestinal disorders\" accounted for the majority (57.4%), followed by \"Cardiac disorders\" (35.2%), and \"Investigations\" (abnormal lab test results) (13%). The causality of these reactions Is majorly “Possible” (62%). Severity level 1 (40.9%) and 2 (41.8%). Ninety-nine percent of the ADRs are expected. The majority of the ADRs are non-Preventable (76.3%). The main outcome is Recovered / Resolved (44.5%). About (50%) of the ADRs were serious.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"36 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid 组蛋白去乙酰化酶 8 抑制活性的硅学分析：与羟肟酸交联的新型二肽化合物的计算分析

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1059

Omer mohammed Ammash, S. Alwan, A. R. Albakaa, İsmail Alshrif, Ibrheam ben Sulaiman

{"title":"In Silico Profiling of Histone Deacetylase 8 Inhibitory Activity: A Computational Analysis of Novel Dipeptide-Based Compounds Cross-Linked with Hydroxamic Acid","authors":"Omer mohammed Ammash, S. Alwan, A. R. Albakaa, İsmail Alshrif, Ibrheam ben Sulaiman","doi":"10.32947/ajps.v24i2.1059","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1059","url":null,"abstract":"This study involved the development of innovative compounds consisting of dipeptide cross-links combined with hydroxamic acid. Our objective was to assess their binding affinities with histone deacetylase 8 (HDAC8) by conducting a docking study, comparing the results with the reference ligand, suberoylanilide hydroxamic acid (SAHA).\u0000Docking scores were measured in terms of ΔG (Kcal/mol), and the recorded scores for compounds 2A-D were found to be higher than that of SAHA, with values of 87.36, 80.46, 79.42, and 74.14, respectively. Notably, compound 2A, a dipeptide consisting of L-tryptophyl-L-tyrosine linked to a hydroxamic acid moiety, exhibited the highest docking score of 87.36. This finding suggests that compound 2A may possess the most potent HDAC8 inhibitory activity among the other designed compounds. Furthermore, we utilized the SwissADME server to predict the physicochemical properties and additional ADME parameters for the designed compounds. The analysis revealed that all investigated compounds exhibited a high potential for passive oral absorption and demonstrated no penetration into the blood-brain barrier. Compound 2A, 2B, and 2D exhibited one Lipinski's rule violation each, whereas Compound 2C demonstrated no such violations in all parameters. Additionally, compounds 2A and 2C exhibited potential as P-glycoprotein (P-gp) substrates. SAHA did not exhibit inhibition of any of the cytochrome P450 (CYP) enzymes used in this study, whereas compounds 2B, 2C and 2D displayed possible inhibitory activities. These compelling findings provide encouraging prospects for the future synthesis of the designed compounds and warrant further evaluation through in vitro and in vivo biological studies.\u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"274 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Docking, Synthesis, Characterization and Antimicrobial Evaluation of 5-methylthiazolidine-4-ones 5- 甲基噻唑烷-4-酮的分子对接、合成、表征和抗菌评估

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1033

Sarmad Saadi Hussein, K. Ali, Fouad A. A. Al-saady, Atheer Atiroğlu

引用次数: 0

The incidence of coxiella infection in Iraqi women with early pregnancy loss 伊拉克早孕流产妇女的柯西氏菌感染率

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1032

Noor Hasan, Baydaa Hameed, Abdulkarreem Abbas, Mamdouh Mohamed Elbahnasawy

{"title":"The incidence of coxiella infection in Iraqi women with early pregnancy loss","authors":"Noor Hasan, Baydaa Hameed, Abdulkarreem Abbas, Mamdouh Mohamed Elbahnasawy","doi":"10.32947/ajps.v24i2.1032","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1032","url":null,"abstract":"Query fever is a bacterial disease resulting from Coxiella burnetii (CB) infection in animals. It is well known that small ruminants who get Q fever lose their babies. People think pregnant women may also have lousy gestation results if they get the infection or the infection comes back to life during pregnancy.\u0000This study looks at how serologic results of Q fever and early pregnancy loss (EPL) are linked. In Baghdad, including Madinat Al-Imamain Al-Kadhmain Teaching Hospital and Abu Ghraib Hospital, multicenter case-control research was conducted from September to December 2022. A total of 90 women were enrolled in this investigation. Sixty clinically suffered from early pregnancy loss by having a nonviable intrauterine pregnancy. The other 30 women were subjects of comparable age, the week of pregnancy, and the healthy subjects as controls. Using a commercial enzyme-linked immunosorbent assay (ELISA), serum samples were screened for antibodies against CB. Three (5%) cases tested positive for CB by ELISA. The study reveals no association between adverse gestation outcomes and positive Q fever serology. Age and abortion history were not significantly correlated with C. burnetii seropositivity, according to the findings of CB cases that tested positive results.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"193 S550","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140730876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect Of Different Variables On The Formulation Of Sodium Alginate Beads 不同变量对海藻酸钠珠配方的影响

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1007

Surra Lateef, Masar Basim, Afrah Mohammed

{"title":"Effect Of Different Variables On The Formulation Of Sodium Alginate Beads","authors":"Surra Lateef, Masar Basim, Afrah Mohammed","doi":"10.32947/ajps.v24i2.1007","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1007","url":null,"abstract":"This work examined the possibility of encapsulating prednisolone as drug modelling in Na-alginate polymeric beads. Our beads were formulated by ionotropic gelation method using Na-alginate as an anionic natural polysaccharide polymer and Cacl2 as a positive charge cross-linker. Eleven formulations were successfully created, and different variations were evaluated, including Na-alginate concentration ( 0.5, 2, 3) w/v %, Cacl2 concentration (1, 3, 5) w/v % stirring speed (100, 300, 400) rpm, the addition of tween-80 (0, 2.5, 5) ml, washing beads with alcohol, change curing time. The beads were assayed by bead size, morphology, drug loading, encapsulation efficiency, yield and FTIR. The results showed that the best formula was F2 which can be obtained when using a high concentration of Na-alginate (2 w/v %), Cacl2 (5 w/v %), the addition of tween-80 (5ml) with the lowest stirring speed (100 rpm) without increase curing time or washing with alcohol. Also, the FTIR result revealed a shifting of the carbonyl group and a low intensity of the hydroxyl group in the spectrogram of F2, indicating potential hydrogen bond interactions that might have resulted in the creation of beads.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"28 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of C-Reactive Protein, Interleukin-6, and Neutrophil-Lymphocyte Ratio as Inflammatory Markers in Patients with Chronic Bronchitis Taking Oral Prednisolone in Maysan City Population 对迈桑市人群中口服泼尼松龙的慢性支气管炎患者炎症标志物 C-反应蛋白、白细胞介素-6 和中性粒细胞-淋巴细胞比率的评估

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1034

Mohammed Taha yaseen, Dalya Hanna, A. M. Hadi

{"title":"Evaluation of C-Reactive Protein, Interleukin-6, and Neutrophil-Lymphocyte Ratio as Inflammatory Markers in Patients with Chronic Bronchitis Taking Oral Prednisolone in Maysan City Population","authors":"Mohammed Taha yaseen, Dalya Hanna, A. M. Hadi","doi":"10.32947/ajps.v24i2.1034","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1034","url":null,"abstract":"Background: Clinically, chronic bronchitis is defined as a persistent cough lasting at least three months over the course of two years in a patient where all other causes have been excluded. It is almost invariably described as a feature of Chronic Obstructive Pulmonary Disease (COPD) secondary to smoking.\u0000Patients and methods: Ninety-five Iraqi patients newly diagnosed with chronic bronchitis were selected to participate in this study. Sixty patients (40 male and 20 female) were enrolled in the current study their ages were ranged from (40-65 years).\u0000The patients were divided into two groups, in the first group (responders’ group) the patients were responded to oral prednisolone therapy, and in the other group the patients were not responded to oral prednisolone therapy (non-responders’ group). The assessment of responsiveness to prednisolone will be according to ATS (American Thoracic Society) which define the responders as those with a response of >12% baseline and >200 ml of FEV1. This study is a prospective observational clinical trial was carried out in thoracic consultant clinic at Al- Sader teaching Hospital in Maysan city from March 2022 until March 2023. The prednisolone tablets given in a dose of 30mg /day for 14 days.\u0000Aim of the study: The current study was aimed to identify the association of the inflammatory markers C-reactive protein, interleukin-6 and neutrophils-lymphocytes ratio with the response of chronic bronchitis patients to oral prednisolone therapy.\u0000Results and Conclusions: CRP, IL-6, and NLR consider as good predictive markers (P value<0.001) to determine the responsivity of patients with chronic bronchitis taking oral prednisolone tablets for 14 days.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"65 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Modeling, Synthesis, and preliminary pharmacological evaluation of New Sulfonamide Derivatives as Selective Carbonic Anhydrase XII and IX inhibitors (Research) 作为选择性碳酸酐酶 XII 和 IX 抑制剂的新型磺酰胺衍生物的分子建模、合成和初步药理评估（研究）

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1055

S. T. Jasim, M. Mahdi

引用次数: 0

Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice 葡萄籽提取物中的石油醚和乙酸乙酯外用馏分对咪喹莫特诱导的小鼠牛皮癣样皮肤炎症的影响

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2024-04-08 DOI: 10.32947/ajps.v24i2.1062

Mohammed Fareed, Ayah F. Al-Qrimli

{"title":"Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice","authors":"Mohammed Fareed, Ayah F. Al-Qrimli","doi":"10.32947/ajps.v24i2.1062","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1062","url":null,"abstract":"Background: Grape seed is a natural herb with many suggested pharmacological effects related to many biologically active compounds in its extract and fractions. Grape seed pharmacological effect is investigated in mice psoriasis like model.\u0000Methods: A thirty male albino mice, six weeks’ age used in this research and were divided into five groups. Group I apparently healthy. Group II induction group, imiquimod 5% cream once daily used at the back skin of the animal for five days. Group III, IV and V treatments groups. Group III clobetasol ointment 0.05%, group IV Grape seed extract and group V Grape seed petroleum ether fraction for five days. Results: A high significant increase was found between the apparently healthy and imiquimod induced group for all of the investigated parameters except munro abscess was significant increase. For the grape seed extract group, it was found A significant difference in immunohistochemistry score of IL17, also significant decrease in vascular endothelial growth factor (VEGF) with high significant decrease of other immunohistopathology measurement like parakeratosis. Conclusion: Grape seed extract may have a role in imiquimod-induced psoriasis like skin inflammation in mice treatment which make it a future candidate therapy for psoriasis.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"95 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0