Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献_第10页

Nuclear Factor Erythroid-2 Linked Factor (Nrf2) as a Potential Mediator of Hepatotoxicity 核因子-红细胞-2相关因子(Nrf2)作为肝毒性的潜在介质

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i4.796

Inam Sameh Arif, Israa Burhan Raoof, Hayder Hussein Luaibi

引用次数: 1

Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. 设计，分子对接，合成与头孢氨苄连接的芳香氨基酸。

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i3.794

Yasir F. Muhsin, Shakir M. Alwan, Ayad Kareem Khan

{"title":"Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.","authors":"Yasir F. Muhsin, Shakir M. Alwan, Ayad Kareem Khan","doi":"10.32947/ajps.v21i3.794","DOIUrl":"https://doi.org/10.32947/ajps.v21i3.794","url":null,"abstract":"Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This is a new \u0000approach of incorporating, tryptophan and histidine into the the primary amino group of cephalexin, in order to provide a bulky group very close to the β-lactam ring. This chemical addition act as isosteric group to the alkoximino that protect beta lactam ring from bacterial beta lactamase enzyme. The new derivatives may show resistance to β-lactamases, improve activity and pharmacokinetic properties and may give new life for old drugs that are susceptible to hydrolysis by most β-lactamases. The chemical structures of these derivatives were confirmed by: FTIR, 1H-NMR spectroscopy, elemental micro analysis and some physical properties. Molecular docking on serine beta lactamase and prediction of ADME parameters were recorded using GOLD suite and Swiss ADME software respectively. Docking scores of the new derivatives of Cephalexin on β-lactamases were higher than those of Cephalexin, which may indicate better activity","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75194664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Misuse of antibiotics in Iraq: A review of Iraqi published studies 伊拉克滥用抗生素:伊拉克已发表研究综述

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i2.805

Khulood Saadoon Salim, Atheer S. Alsabah, Hassanian S. Taghi

引用次数: 0

Study the antibacterial effect of N_butanol extract of Urtica dioica 研究白荨麻疹正丁醇提取物的抑菌作用

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i1.800

Ahmed Abdulaziz Ahmed, Baydaa Hameed Abdulah, Yaser Mustafa Kamal

{"title":"Study the antibacterial effect of N_butanol extract of Urtica dioica","authors":"Ahmed Abdulaziz Ahmed, Baydaa Hameed Abdulah, Yaser Mustafa Kamal","doi":"10.32947/ajps.v21i1.800","DOIUrl":"https://doi.org/10.32947/ajps.v21i1.800","url":null,"abstract":"Since ancient times Urtica dioica has been used as an herbal medicine in Western Asia. The current study demonstrates the anti-bacterial effect of N_butanol extraction of Urtica dioica. The antibacterial effect was tested against some of gram-positive bacteria and gram-negative bacteria isolated \u0000 \u0000from hospitalized patients having urinary tract infection. Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Pseudomonas aeruginosa was used. Urticasea is a family of plant known for their medicinal activity from folk medicine. Urtica dioica is a member of urticasea and it is known for it is antibacterial effect. \u0000Methods \u0000The leaves of Urtica dioica were collected in Iraq from jisr dayla district in Baghdad province in april 2019.The N_butanol extraction was compared with the drug ciprofloxacin. Disc diffusion method was used to determine the sensitivity of the samples. \u0000Results \u0000The N_ butanol extract shows weak inhibitory effect on Escherichia coli while other strain does not affect by extract comparing with ciprofloxacin. \u0000Conclusion \u0000The N_butanol extract of urtica dioica have weak antibacterial effect when compared with ciproflxacine","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88143240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nrf2 as a modulator of oxidative stress Nrf2作为氧化应激的调节剂

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i4.798

Inam Sameh Arif, Yassir Mustafa Kamal, Israa Burhan Raoof

引用次数: 3

Nano-carriers as a Selective Treatment for Cancer 纳米载体作为癌症的选择性治疗

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i1.802

Ghaidaa S. Hameed, Methaq Hamad Sabar

引用次数: 1

Isolation of umbelliferone from leaves of Conocarpus erectus L. cultivated in Iraq 伊拉克直立木叶片伞形虫的分离

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-18 DOI: 10.32947/ajps.v20i4.778

Tahany Amir Tawfeeq, Ghaith Ali Jasim, Abdulmutalib A. Nasser

引用次数: 2

Types of Attractive Dosage Forms for Primary School Students and Associated Factors in Baghdad/ Iraq 巴格达/伊拉克小学生有吸引力的剂型类型及相关因素

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-18 DOI: 10.32947/ajps.v20i4.770

Sura Zuhair Mahmood, Nora Zawar. Yousif, Zeina Dawood Salman

{"title":"Types of Attractive Dosage Forms for Primary School Students and Associated Factors in Baghdad/ Iraq","authors":"Sura Zuhair Mahmood, Nora Zawar. Yousif, Zeina Dawood Salman","doi":"10.32947/ajps.v20i4.770","DOIUrl":"https://doi.org/10.32947/ajps.v20i4.770","url":null,"abstract":"The lack of age-appropriate and child -friendly formulation of medication for children poses a major challenge to pediatric therapeutic practice, adherence, and health care delivery worldwide, however, formulation acceptability and preferences facilitate medication \u0000 \u0000adherence in children, and they are important factors in achieving the intended treatment outcomes in which this study looks ahead. The present study aims to determine the various medication trends of children through their parents and caregivers, child preference of certain dosage form (chewable gel) in comparison with another solid dosage forms and its popularity among Iraqi primary school, furthermore the study highlights different variables influence student preference for chewable gel. A total of 230 Iraqi primary school students were randomly selected and interviewed with the presence of their parents. It was observed that (51.3%) of the parents/caregivers reported that the liquid dosage form is the most dosage form that commonly used, (72%) of consumers revealed that the capsules and tablets are not easy to swallow, furthermore, this study revealed that (68.6%) of school students preferred to take medication as chewable gel over than other oral solid dosage forms ,and this preference varied significantly with several socioeconomic and other factors.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82258997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis, Antibacterial study and ADME Evaluation of Novel Isonicotinoyl Hydrazide Derivative Containing 1,3,4-Oxadiazole Moiety 新型1,3,4-恶二唑异烟碱酰肼衍生物的合成、抑菌研究及ADME评价

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-18 DOI: 10.32947/ajps.v20i4.781

Mazen Mohammed Jwaid, Karima Fadhil Ali, Mayada Hadi Abd-alwahab

引用次数: 5

Organogel investigations as a floating oral system with depot property 有机凝胶作为一种具有仓库特性的漂浮口服系统的研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-18 DOI: 10.32947/ajps.v20i4.783

Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Nawfal Am. Numan

{"title":"Organogel investigations as a floating oral system with depot property","authors":"Zainab Saad Kaddoori, Masar Basim Mohsin Mohamed, Nawfal Am. Numan","doi":"10.32947/ajps.v20i4.783","DOIUrl":"https://doi.org/10.32947/ajps.v20i4.783","url":null,"abstract":"In this work we investigate span 40, span 60 and SA as a gelators and olive oil (OO) as apolar liquid phase to discover the ability of organogel formed to be floating in acidic media and gain a unique gastroretentive dosage form. In addition, take advantage of the chemical \u0000 \u0000and physical properties of cinnarizine (CN) as a model drug suitable for gastroretentive systems. The floating parameters were studied where the floating lag time and floating duration for organogel in both solid and liquid states. Organogels charecterization were accomplished through the folowing investigatational techniques and analytical methods: table top rheology, optical microscope, Fourier-transform infrared spectroscopy (FTIR) and in- vitro release study. The results showed that all organogels immediately floated and they were floating in both states. Moreover, table top rheology showed that the transition temperature was reversible and higher than 37 ºC except for 7% w/w and 10% w/w SA in OO organogels where, optical images of organogel showed fibrillar network. The FTIR showed peaks associated to carbonyl groups indicated to form gelator-gelator interactions. Moreover, in vitro release study of organogel system showed continuous release CN for 9-12 hours. \u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85340927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3