Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献

{"title":"Effect Of Different Variables On The Formulation Of Sodium Alginate Beads","authors":"Surra Lateef, Masar Basim, Afrah Mohammed","doi":"10.32947/ajps.v24i2.1007","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1007","url":null,"abstract":"This work examined the possibility of encapsulating prednisolone as drug modelling in Na-alginate polymeric beads. Our beads were formulated by ionotropic gelation method using Na-alginate as an anionic natural polysaccharide polymer and Cacl2  as a positive charge cross-linker. Eleven formulations were successfully created, and different variations were evaluated, including Na-alginate concentration ( 0.5, 2, 3) w/v %, Cacl2 concentration (1, 3, 5) w/v % stirring speed (100, 300, 400) rpm, the addition of tween-80 (0, 2.5, 5) ml, washing beads with alcohol,  change curing time. The beads were assayed by bead size, morphology, drug loading, encapsulation efficiency, yield and FTIR. The results showed that the best formula was F2 which can be obtained when using a high concentration of Na-alginate (2 w/v %), Cacl2 (5 w/v %), the addition of tween-80 (5ml) with the lowest stirring speed (100 rpm) without increase curing time or washing with alcohol. Also, the FTIR result revealed a shifting of the carbonyl group and a low intensity of the hydroxyl group in the spectrogram of F2, indicating potential hydrogen bond interactions that might have resulted in the creation of beads.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"28 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of C-Reactive Protein, Interleukin-6, and Neutrophil-Lymphocyte Ratio as Inflammatory Markers in Patients with Chronic Bronchitis Taking Oral Prednisolone in Maysan City Population","authors":"Mohammed Taha yaseen, Dalya Hanna, A. M. Hadi","doi":"10.32947/ajps.v24i2.1034","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1034","url":null,"abstract":"Background: Clinically, chronic bronchitis is defined as a persistent cough lasting at least three months over the course of two years in a patient where all other causes have been excluded. It is almost invariably described as a feature of Chronic Obstructive Pulmonary Disease (COPD) secondary to smoking.\u0000Patients and methods: Ninety-five Iraqi patients newly diagnosed with chronic bronchitis were selected to participate in this study. Sixty patients (40 male and 20 female) were enrolled in the current study their ages were ranged from (40-65 years).\u0000The patients were divided into two groups, in the first group (responders’ group) the patients were responded to oral prednisolone therapy, and in the other group the patients were not responded to oral prednisolone therapy (non-responders’ group). The assessment of responsiveness to prednisolone will be according to ATS (American Thoracic Society) which define the responders as those with a response of >12% baseline and >200 ml of FEV1. This study is a prospective observational clinical trial was carried out in thoracic consultant clinic at Al- Sader teaching Hospital in Maysan city from March 2022 until March 2023. The prednisolone tablets given in a dose of 30mg /day for 14 days.\u0000Aim of the study: The current study was aimed to identify the association of the inflammatory markers C-reactive protein, interleukin-6 and neutrophils-lymphocytes ratio with the response of chronic bronchitis patients to oral prednisolone therapy.\u0000Results and Conclusions: CRP, IL-6, and NLR consider as good predictive markers (P value<0.001) to determine the responsivity of patients with chronic bronchitis taking oral prednisolone tablets for 14 days.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"65 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular Modeling, Synthesis, and preliminary pharmacological evaluation of New Sulfonamide Derivatives as Selective Carbonic Anhydrase XII and IX inhibitors (Research)","authors":"S. T. Jasim, M. Mahdi","doi":"10.32947/ajps.v24i2.1055","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1055","url":null,"abstract":"New benzene sulfonamide compounds 4–10 was modeled at the molecular level to reveal binding opportunities, bond length, angle, and energy scores in the CA II, CAXII, and CAIX active sites. To test their cytotoxic effect against the AMJ-13 Iraqi breast cancer cell line,\u0000researchers synthesized the promising compounds from 4-(2-mercapto-4-oxoquinazolin-3(4H)-yl) benzene sulfonamide 3. Derivatives 4–10 have IC50 values between 0.10 and 6.47 M, indicating potent action against the AMJ-13 cell line. The most effective of these compounds were numbers 4, 7, and 10. The highest binding scores in the active site of CAXII and CAIX were seen for the most active drugs, which may explain their inhibitory profile.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"27 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140732164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects Of Topical Petroleum Ether and Ethyl Acetate Fractions from Grape Seed Extract on Imiquimod-Induced Psoriasis Like Skin Inflammation in Mice","authors":"Mohammed Fareed, Ayah F. Al-Qrimli","doi":"10.32947/ajps.v24i2.1062","DOIUrl":"https://doi.org/10.32947/ajps.v24i2.1062","url":null,"abstract":"Background: Grape seed is a natural herb with many suggested pharmacological effects related to many biologically active compounds in its extract and fractions. Grape seed pharmacological effect is investigated in mice psoriasis like model.\u0000Methods: A thirty male albino mice, six weeks’ age used in this research and were divided into five groups. Group I apparently healthy. Group II induction group, imiquimod 5% cream once daily used at the back skin of the animal for five days. Group III, IV and V treatments groups. Group III clobetasol ointment 0.05%, group IV Grape seed extract and group V Grape seed petroleum ether fraction for five days. Results: A high significant increase was found between the apparently healthy and imiquimod induced group for all of the investigated parameters except munro abscess was significant increase. For the grape seed extract group, it was found A significant difference in immunohistochemistry score of IL17, also significant decrease in vascular endothelial growth factor (VEGF) with high significant decrease of other immunohistopathology measurement like parakeratosis. Conclusion: Grape seed extract may have a role in imiquimod-induced psoriasis like skin inflammation in mice treatment which make it a future candidate therapy for psoriasis.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"95 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140728694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole cross-linked with Hydroxamic acid by certain linkers","authors":"Yazen Alqaysi, Shakir M. Alwan, Ashour H. Dawood","doi":"10.32947/ajps.v24i1.1006","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1006","url":null,"abstract":"New hybrid molecules of Benzothiazole cross-linked with hydroxamic acid through an amino acid or aminoalkanoic acid are suggested. All the synthesized hybrid molecules (2A-E) were subjected to molecular docking to evaluate their binding affinities with histone deacetylase enzyme (HDAC8, PDB ID: 1T69) and recorded lower ΔG (-8.117, -6.322, -8.16, -7.939, - 9.46, respectively)\u0000than Vorinostat (suberoylanilide hydroxamic acid, SAHA), as the reference ligand, which recorded a much less value of -5.375, using the Maestro software (Schrödinger, version 2022-1).  Moreover, compound 2E, which is Benzothiazole-p-amino benzoic acid-hydroxamate has recorded the lowest binding score (-9.460). This may indicate that this compound is the most active hybrid molecule. There were no violations from Lipinski’s rule and all the synthesized hybrid molecules comply with all parameters.  SwissADME server was employed for the in silico molecular docking for prediction of the physicochemical and ADME properties of the investigated compounds.  All hybrid molecules showed low possible passive oral absorption and no penetration into BBB. The hybrid molecules 2B and 2D may be considered as P-gp substrates. SAHA does not inhibit any of the CYP enzymes used in this study, while, the hybrid molecules 2B, 2D and 2E have shown possible inhibitory activities.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"8 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140507175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular modelling, Synthesis and Antiproliferative Evaluation of New Phenyldiazenyl)-Pyrazol Schiff Base Derivatives","authors":"Duha E. Taha, Monther F. Mahdi, Ayad M. R. Raauf","doi":"10.32947/ajps.v24i1.999","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.999","url":null,"abstract":"Lung cancer is the most prevalent worldwide. In addition, it is also the most common cause of cancer-related deaths worldwide, with around 1.8 million new cases annually. With a 5-year survival rate of fewer than 20%.\u0000Cytotoxic medicines are commonly employed in cancer treatment. Although the medicine improves patients' quality of life, several disadvantages diminish its efficacy. This necessitates developing new effective strategies that target tumors with minimal adverse effects. This research aims to overcome these issues by synthesizing a new series of phenyldiazenyl)-pyrazol schiff base derivatives by utilizing the molecular docking (GOLD) suite program and the pharmacokinetic properties determination by utilizing (Swiss) ADME suite; The most appropriate-fitting compounds were subsequently produced and confirmed using spectrum analysis (FTIR, 1HNMR, and 13 CNMR). MTT in vitro assay were performed to assess of antiproliferative activities against A549 lung cancer cell lines. The antiproliferative study showed that compound 3a had an inhibitory concentration (IC50 of 17.37 µM) on lung cancer cells (A549), which was significantly higher inhibitory activity than Erlotinib (IC50 = 25.06 µM). While compound 3b had an inhibitory activity comparable to the reference drug's, The IC50 values for compounds 3c, 3d, and 3e were 47.48, 45.56, and 33.05 µM, respectively","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Quality of Life in a Sample of Short Stature Iraqi Children with Growth Hormone Deficiency","authors":"Saba Rabea, Mohammed Mahmood Mohammed, Dawood S. abdoun, Iman Bashet","doi":"10.32947/ajps.v24i1.1028","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1028","url":null,"abstract":"Background: Short stature (SS) is defined as a height of 2.0 or more standard deviations (SD) below the population-specific mean height for age and gender. 2.5% of children have short stature, and it is one of the most frequent causes for children to see a growth specialist during their childhood.\u0000It is challenging to generalize about the effect of short stature on psycho-social adaption given the data currently available.  Health-related quality of life (HrQoL) was generally shown to be lower in clinically identified short stature children than in population-based normal-sized reference groups. Aim: Examine the behavioral pattern and mental health of SS and its psychological influence on QoL of children/adolescence. In addition, compare the behavioral response and QoL between growth hormone deficiency GHD and control groups. Methods: It is a cross sectional study, included 80 participants (60 with GHD and 20 with normal height as control group) between 4 and 18 years old. The parents of the participants were given a parent-reported version of the written Quality of Life in Short Stature Youth QoLISSY questionnaire in Arabic in order to examine the association with the socio-demographic characteristics of the participants. Results: 51.25% female and 48.75% male included in this study, the mean age at assessment was 12.1 ± 2.7, and 11.8 ± 2.6 of the GHD and control group, respectively. There was significant difference in QoLISSY total score between GHD and control groups. The association between socio-demographic characteristics of the participants was significantly different. Conclusion: The QoL of Iraqi children with GHD showed lower scores in all domains of QoLISSY compared to normal children.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"7 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Pyridoxine Supplement on Oxidative Stress in Type 2 Diabetic Patients","authors":"Moatamad Hanoon Dawood, Manal Khalid Abdulridha, Hayder Saadoon Qasim","doi":"10.32947/ajps.v24i1.1030","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1030","url":null,"abstract":"Background: The physiologically active form of vitamin B6 is pyridoxal 5-phosphate (PLP), which functions as a coenzyme in 150 enzymatic processes such amino acid, carbohydrate, and lipid metabolism and is essential for the production and/or breakdown of neurotransmitters.\u0000. It also acts as an antioxidant by quenching Reactive Oxygen Species (ROS) and counteracting the formation of Advanced Glycation End-Product (AGEs). PLP is recycled by mammals from B6 vitamins found in diet and has been linked to a number of clinically significant disorders. This study aim was to evaluate the impact of pyridoxine supplementation on oxidative stress status in type 2 diabetic patients.\u0000Method: This prospective controlled randomized open-labeled study of newly diagnosed T2DM patients. The study was conducted from November 2022 to February 2023 at the Mesan Center for Diabetes and Endocrinology under the supervision of a specialist endocrinologist. The total number of participants whose data were collected in this study was one hundred and eight participants, eighty-eight patients newly diagnosed with type 2 diabetes were included in the study, and twenty of the participants were healthy subjects. The patients were allocated into three groups: Group 1: Control group, 20 T2DM patients were treated with non-pharmacological therapy (lifestyle modification) for one month, Group 2: 34 T2DM patients treated with metformin 500 mg/day in addition to non-pharmacological therapy (lifestyle modification) for one month, Group 3: 34 T2DM patients treated with metformin 500 mg/day plus vitamin B6 300 mg/day in addition to non-pharmacological therapy (lifestyle modification) for one month, in addition to Healthy subjects: 20 subjects were taken to compare the study parameters between type 2 diabetic patients and healthy persons at baseline. Measurement of Vitamin B6 (pyridoxine) blood level (PLP), body mass index (BMI) and Serum malondialdehyde level (MDA) was done in this study.\u0000Results: The results of the study showed that the use of pyridoxine supplementation plus metformin decreased the level of MDA. There was significant decrease in (MDA) level (P<0.01) pretreatment when compared to after treatment (3.85 μmole/L vs 1.66 μmole/L) respectively.\u0000Conclusion: Restoration of vitamin B6 level can leads to a decreased blood level of MDA in diabetic patients.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"21 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Dialysis Adequacy, Physical and Emotional Symptoms with Erythropoietin-stimulating agent Responsiveness in Iraqi Patients Undergoing Hemodialysis","authors":"Salar Ahmed, Mohammed Mahmood, Arif Sami, Salim Hamadi","doi":"10.32947/ajps.v24i1.1038","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1038","url":null,"abstract":"Background: Erythropoietin (EPO)-deficient anemia occurs in patients with chronic kidney disease (CKD). Erythropoietin-stimulating agents (ESAs) are the standard treatment for CKD anemia, but patient responses vary.\u0000Hemodialysis patients are often anemic due to hypo erythropoiesis and their chronic inflammatory state. Inadequate dialysis is considered one of the factors that are linked to ESA hypo responsiveness. Dialysis patients may experience many symptoms that lower their quality of life.  End stage renal disease (ESRD) symptoms are assessed using Dialysis Symptom Index (DSI). Objective: The current study was designed to measure the association between physical, and emotional symptoms and ESA responsiveness. Also, to determine how dialysis adequacy affects response level.Materials and Methods: The current study included 150 CKD anemic patients  in a multicenter dialysis units. patients were examined for the response to Epoetin alfa (Eprex) after 12 weeks in this cross-sectional study. Clinical, demographic, and laboratory data were collected. The erythropoietin resistance index (ERI) evaluated the effect of erythropoietin dosage on hemoglobin levels. Dialysis adequacy (Kt/V) measured the efficacy of dialysis. The severity of symptoms was evaluated using the 30-question Dialysis Symptom Index (DSI). Results: 150 patients in all were enrolled, with a mean age of 51.6 ± 14.9 for the male patients. There was a significant difference in kt/v among study groups, mainly between hypo response and resistance groups (P-value < 0.01). However, there was no statistically significant difference in the DSI mean (P = 0.4). kt/v was positively correlated with the duration of dialysis and parathyroid hormone (PTH) (R = 0.27, P-value < 0.001), (R = 0.19, P-value = 0.01). additionally, The DSI was strongly connected with the age of the patients (R = 0.18, P-value = 0.02).\u0000Conclusion: One of the main causes of Eprex resistance in this study was insufficient dialysis. Patients who received longer hemodialysis sessions exhibited higher hemodialysis sufficiency. However, there was no significant association between DSI and degree of response across research groups, and older hemodialysis patients experienced higher dialysis-related symptoms.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Prothrombin Time,International Normalized Ratio, and Activated Partial Thromboplastin Time in Hepatitis B Virus Patients, Sudan2020 -2021","authors":"G. Modawe, Esra Awad Mohamed, Ozaz Yagoup Mohamed, AbdelrahmanEldaw Mohammed, Hiba Awadelkareem Osman Fadl, Abdelrahman Hamza Abdelmoneim","doi":"10.32947/ajps.v24i1.977","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.977","url":null,"abstract":"Background: Hepatitis B virus is a growing problem worldwide leading to increasing incidences of life-threatening complications of which liver diseases play a major part of it.\u0000Materials and Methods: To evaluate these effects in Sudanese patients, a cross-sectional study was carried out in Wad Medani teaching hospital from October 2020 to February 2021 for assessing the effect of the disease on the coagulation profile. Patients were randomly selected according to inclusion and exclusion criteria. 2.5ml of blood samples were collected from each patient in tri-sodium citrate containers, and then semi-automated Coatron M4 was used to estimate Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) after calibrated and controlled setting according to the manufacturer’s instructions. SPSS (version 25) was used to analysed data.\u0000Results: A total of 100 hepatitis B virus patients were included in the study, with males representing (79%) and females were (21%), their age were between 18 to 60 years. The study results showed PT prolonged in (98%) of the study population and only (2%) were normal. regarding the APTT (99%) of them had prolonged results (more than the upper normal), and the remaining (1%) was normal. Also, the study results showed there were slight statistically insignificant differences in coagulation profile in hepatitis B virus patients according to gender, age group, family history, and duration of the disease.\u0000Conclusion:  hepatitis B infection had a great effect on Coagulation profiles. Therefore, it is recommended on the basis of these results to request PT, INR, and APTT as routine works up for hepatitis B virus patients.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"43 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}