Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献

{"title":"Association of Dialysis Adequacy, Physical and Emotional Symptoms with Erythropoietin-stimulating agent Responsiveness in Iraqi Patients Undergoing Hemodialysis","authors":"Salar Ahmed, Mohammed Mahmood, Arif Sami, Salim Hamadi","doi":"10.32947/ajps.v24i1.1038","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1038","url":null,"abstract":"Background: Erythropoietin (EPO)-deficient anemia occurs in patients with chronic kidney disease (CKD). Erythropoietin-stimulating agents (ESAs) are the standard treatment for CKD anemia, but patient responses vary.\u0000Hemodialysis patients are often anemic due to hypo erythropoiesis and their chronic inflammatory state. Inadequate dialysis is considered one of the factors that are linked to ESA hypo responsiveness. Dialysis patients may experience many symptoms that lower their quality of life.  End stage renal disease (ESRD) symptoms are assessed using Dialysis Symptom Index (DSI). Objective: The current study was designed to measure the association between physical, and emotional symptoms and ESA responsiveness. Also, to determine how dialysis adequacy affects response level.Materials and Methods: The current study included 150 CKD anemic patients  in a multicenter dialysis units. patients were examined for the response to Epoetin alfa (Eprex) after 12 weeks in this cross-sectional study. Clinical, demographic, and laboratory data were collected. The erythropoietin resistance index (ERI) evaluated the effect of erythropoietin dosage on hemoglobin levels. Dialysis adequacy (Kt/V) measured the efficacy of dialysis. The severity of symptoms was evaluated using the 30-question Dialysis Symptom Index (DSI). Results: 150 patients in all were enrolled, with a mean age of 51.6 ± 14.9 for the male patients. There was a significant difference in kt/v among study groups, mainly between hypo response and resistance groups (P-value < 0.01). However, there was no statistically significant difference in the DSI mean (P = 0.4). kt/v was positively correlated with the duration of dialysis and parathyroid hormone (PTH) (R = 0.27, P-value < 0.001), (R = 0.19, P-value = 0.01). additionally, The DSI was strongly connected with the age of the patients (R = 0.18, P-value = 0.02).\u0000Conclusion: One of the main causes of Eprex resistance in this study was insufficient dialysis. Patients who received longer hemodialysis sessions exhibited higher hemodialysis sufficiency. However, there was no significant association between DSI and degree of response across research groups, and older hemodialysis patients experienced higher dialysis-related symptoms.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"29 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Prothrombin Time,International Normalized Ratio, and Activated Partial Thromboplastin Time in Hepatitis B Virus Patients, Sudan2020 -2021","authors":"G. Modawe, Esra Awad Mohamed, Ozaz Yagoup Mohamed, AbdelrahmanEldaw Mohammed, Hiba Awadelkareem Osman Fadl, Abdelrahman Hamza Abdelmoneim","doi":"10.32947/ajps.v24i1.977","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.977","url":null,"abstract":"Background: Hepatitis B virus is a growing problem worldwide leading to increasing incidences of life-threatening complications of which liver diseases play a major part of it.\u0000Materials and Methods: To evaluate these effects in Sudanese patients, a cross-sectional study was carried out in Wad Medani teaching hospital from October 2020 to February 2021 for assessing the effect of the disease on the coagulation profile. Patients were randomly selected according to inclusion and exclusion criteria. 2.5ml of blood samples were collected from each patient in tri-sodium citrate containers, and then semi-automated Coatron M4 was used to estimate Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) after calibrated and controlled setting according to the manufacturer’s instructions. SPSS (version 25) was used to analysed data.\u0000Results: A total of 100 hepatitis B virus patients were included in the study, with males representing (79%) and females were (21%), their age were between 18 to 60 years. The study results showed PT prolonged in (98%) of the study population and only (2%) were normal. regarding the APTT (99%) of them had prolonged results (more than the upper normal), and the remaining (1%) was normal. Also, the study results showed there were slight statistically insignificant differences in coagulation profile in hepatitis B virus patients according to gender, age group, family history, and duration of the disease.\u0000Conclusion:  hepatitis B infection had a great effect on Coagulation profiles. Therefore, it is recommended on the basis of these results to request PT, INR, and APTT as routine works up for hepatitis B virus patients.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"43 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140509013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Aescin in Psoriatic-Induced Animal Model: Immunohistochemical and Pathological Study","authors":"Rafal Wadhah, Basma Talib, Ghaith Ali, Wamidh H Talib","doi":"10.32947/ajps.v24i1.1035","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1035","url":null,"abstract":"Background: Aescin is a mixture of the triterpene saponins extracted from the seeds of the horse chestnut tree Aesculus hippocastanum. Aescin has a venotonic, anti-inflammatory, antioxidant and anti-edematous characteristics that are mostly connected to the agent molecular mechanism.\u0000Objective: The present study aim to investigate the potential effects of Aescin on psoriasis induced by Imiquimod in male rats, ncluding its effect on the level of tumor necrosis factor alpha, Ki-67 and the histopathologic features of the psoriatic skin.\u0000Methods: Thirty-six albino male rats were divided into six groups each group containing 6 animals, psoriasis was induced by Imiquimod to five of the groups, while for the last group vasaline was applied and the group served as a control group. The animals were then treated with topical Aescin, topical clobetasol, combination of topical Aescin and clobetasol and oral Aescin, finally all animals were sacrificed and the dorsal back skin was taken to perform histopathological and immunohistochemical analysis.\u0000Results: regarding the level of Ki-67, Strong expression of Ki-67 was seen in the group who received Imiquimod only, where the scoring of Ki-67 was notably lowered among the other groups. However, the lowest expression was noticed in the group that were treated with the combination of topical Aescin and clobetasol. While the number of TNF-α positive cells and the intensity of immunostaining were higher in the induction group who received Imiquimod only and the lowest among the group who received the combination of topical Aescin and Clobetasol. Lastly the histopathologic analysis shows that the histopathologic features of psoriasis was markedly affected by the anti-inflammatory effect of Aescin and clobetasol, which was noticed through inhibition of proinflammatory markers, and the decrease in capillary permeability.\u0000Conclusion: Topical Aescin alone or in combination with clobetasol reduced Ki-67 expression successfully; furthermore, the combination of topical Aescin and Clobetasol decreased TNF- score and had the strongest anti-inflammatory activity more than the other groups. Lastly Aescin was able to alter the histopathologic features of the psoriatic skin through its anti-inflammatory, venotonic and anti-edematous activity.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"2 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Benefit of Evening Primrose Oil and Soybean Oil on Treatment Satisfaction and Quality of Life among Postmenopausal Women","authors":"Raghad Mohammed, Manal Khalid Abdulridha, Bushrah Abd Al-Jbori","doi":"10.32947/ajps.v24i1.993","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.993","url":null,"abstract":"Background: Medicinal herbs as alternative therapies, commonly used to treat menopausal symptoms, and some studies have shown that they can be useful in treating menopausal syndrome, which have been linked to worse self-rated health, and decreased work productivity. \u0000Aim of the study: This study compared the effectiveness of EPO and Soybean Oil herbal supplement in a sample of Iraqi postmenopausal women on treatment satisfaction and their quality of life. \u0000Patients and methods: This prospective study conducted on 20 post-menopausal women who received 500 mg EPO compared to other 20 received 233 mg soybean oil extract, as a capsule twice a day for 8 weeks. The subjective and clinical assessments of Menopause Symptom Treatment Satisfaction, and Menopause-Specific Quality of Life. Data was collected by the researcher via face-to-face interviews with women at baseline and after 2 months of treatment. \u0000Results: In this study, Menopause Symptoms Treatment Satisfaction score was not significant within each group post treatment (P>0.05). While after 2 months of treatment, EPO significantly improved the quality of life by decreasing all MEN-QoL domains more than soybean oil, except for the sexual domain (P<0.01). \u0000Conclusions: This study revealed that both EPO and soya bean oil supplements had the beneficial effect in improving the postmenopausal quality of life with less treatment satisfaction.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"50 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC/MS Analysis and Isolation of Stigmasterol from Viola Odorata Cultivated in Iraq","authors":"Zaineb Ali, Ibrahim Saleh Abbas, Widad MK Alani, Farah Al-Mamoori","doi":"10.32947/ajps.v24i1.1002","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1002","url":null,"abstract":"Viola odorata is a viola family flowering plant native to Europe and Asia. This is a small, hardy, herbaceous, perennial plant. It is also known as sweet violet and English violet. Numerous pharmacological properties of this flowering plant include anticancer, antibacterial, anti-inflammatory, antioxidant and antipyretic properties.\u0000Previous literature review of different parts of Viola odorata resulted in detection of different chemical constituents such as flavonoids (Quercetin, kaempferol), glycosides (Rutin) and terpenoids (stigma sterol). Stigmasterol was detected using TLC and GC-MS in this study. It was isolated from Viola odorata using preparative layer chromatography. HPLC and FTIR analysis confirmed the isolated Stigmasterol","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Molecular Docking, Characterization, and Preliminary Evaluation of Some New 1, 3-Diazetidin-2-One Derivatives as Anticancer Agents","authors":"Farah Haidar, Monther Faisal Mahdi, Ayad Kareem Khan","doi":"10.32947/ajps.v24i1.1026","DOIUrl":"https://doi.org/10.32947/ajps.v24i1.1026","url":null,"abstract":"A series of novel 1,3-diazetidin-2-one derivatives were designed, synthesized, and evaluated preliminary (In Vitro) for their cytotoxic activity against the lung (A549) cancer cell line. GOLD software (version 2021.2.0) was used to conduct a molecular docking study;\u0000the tested derivatives demonstrated significant anticancer activity compared to the reference drug (erlotinib). PLP-fitness values for the final compounds are 79.81, 80.80, and 81.57, respectively, whereas the reference ligand, erlotinib, had a value of 76.20. The synthesized compounds were identified and characterized using physicochemical parameters (melting points and Rf values), FTIR, 1H-NMR, and 13C-NMR spectroscopy. According to the IC50 values for the synthesized derivatives, compounds N4a and N4b exhibit outstanding anti-proliferative activity with IC50 value of (7.51, 7.68) µM against A549 cell line, compared to erlotinib, which has an IC50 value of (11.5) µM.\u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"28 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140508649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microsponge as a Strategy for Effective Drug Delivery System","authors":"N. Z. Yousif, Z. Salman","doi":"10.32947/ajps.v23i3.1051","DOIUrl":"https://doi.org/10.32947/ajps.v23i3.1051","url":null,"abstract":"The technology of drug delivery has become massively competitive and quickly growing. Enhancing efficacy is the primary objective of delivery system development, and hence cost-effectiveness of the treatment.   \u0000Nevertheless, controlling the rate of delivery of active pharmaceutical moieties to a target site within the body has been one of the major obstacles confronted by the drug industry. Microsponge represents a delivery system considered a promising innovation that overcomes the different challenges, since, this dosage form provides the delivery of active pharmaceutical moieties in a timely manner, in addition to responding to different stimuli (pressure, temperature, pH). Microsponge drug delivery technology proposed capturing of active moieties into tiny spongy spheres thus, donating towards reducing side effects, improving stability, increasing elegance, and enhancing formulation flexibility. The goal behind this contribution is to cover microsponge as a successful innovation, summarizing the characteristics, advantages, and limitations with certain insight into the mechanism and factors triggering the release. Furthermore, shed light on the methodology of preparation. \u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74064844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The possible techniques that used to improve the bioavailablity, pharmacological activity, solubility and permeability of anti-viral drugs: Insight for COVID-19 antiviral drugs","authors":"Ghassan Mudher Hashim, Ghaidaa S. Hameed, D. Hanna","doi":"10.32947/ajps.v23i3.1040","DOIUrl":"https://doi.org/10.32947/ajps.v23i3.1040","url":null,"abstract":"In early March of 2020, the world was hit by a pandemic caused by the new SARS-COV-2 coronavirus dubbed by the WHO (World health organization) as COVID-19. More than two years later and a series of lockdowns \u0000worldwide as a measure to combat the viral spread, had the world facing detrimental effects on health, economic and social fronts. The principal weapon in the worldwide fight against viruses such as corona virus illness in 2019 (COVID-19) is antiviral medicines (AvDs). Because of their low oral bioavailability and limited effectiveness owing to their low solubility/permeability, most AvDs need numerous doses, and their usage commonly results in drug resistance. Solving the issues with AvDs and improving their effectiveness might be aided by a better understanding of their in vivo metabolic and pharmacokinetic properties. In this review the AvDs, were systematically investigated regarding their cellular pharmacology, pharmacokinetics and pharmacodynamics. Additionally, delivery systems used for AvDs to achieve better pharmacology were reviewed. This review assumed that using sophisticated nanotechnology and the right administration routes, together with proper solid dispersion technology and nanosystems, may assist to obtain superior pharmacological activity and pharmacokinetic behavior of AvDs. Antiviral drugs (AvDs) that have been shown to bind to the SARS-CoV-2 receptor are promising candidates for treating COVID-19. These include ribavirin, remdesivir, favipiravir (FAV), chloroquine, lopinavir, and ritonavir.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72842963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Symptoms, Pregnancy Outcome, and Health-Related Quality of Life among PCOS women Treated with Myo inositol and Metformin","authors":"Z. Abdul, Hameed Ibrahim ⃰ ،Manal, Khaled, Abdulrida, Basil Razoqi, Article Info","doi":"10.32947/ajps.v23i3.1045","DOIUrl":"https://doi.org/10.32947/ajps.v23i3.1045","url":null,"abstract":"PCOS is a complicated endocrine disorder that mostly affects between 5% and 10% of women who are of reproductive age. Obesity, hyperandrogenism, and oligo- or anovulation are frequent clinical PCOS signs. \u0000Objective: the study was designed to evaluate the effect of combining Metformin and Myoinositol; the main insulin-sensitizing drugs on improving symptoms and HRQOLQ in PCOS women. \u0000Materials and Methods: A study was a prospective, interventional, comparative clinical study conducted on 54 patients (aged 18-40 y) who are divided into three groups: group1 patients allocated to receive Myo-inositol(4g), group2 patients allocated to receive Metformin(1g) and group3 patients allocated to receive Myo-inositol(4g) + Metformin(1g) all for 3 months. Baseline and after 3 months, patients’ information and health related quality of life were documented. \u0000Result: Metformin and Myoinositol resulted in symptoms improvement within each study groups as (68.8%, 87.5% and 94.1%) for group 1,2 and 3 respectively, only 4 patients from all groups became pregnant. Also, significant change in HRQOLQ in all study groups after three months of treatment were reported. \u0000Conclusion: combining Myoinositol with metformin results in improved PCOS symptoms and pregnancy outcome in addition to improved patient’s quality of life.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86892897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seromucoid and Protein-Bound Hexose as Inflammatory Markers in Sera of COVID-19 Patients","authors":"Jian Lateif","doi":"10.32947/ajps.v23i3.1048","DOIUrl":"https://doi.org/10.32947/ajps.v23i3.1048","url":null,"abstract":"Most common inflammatory markers like C-reactive protein, which is a protein produced by the liver in response to inflammation and infection in the body, is used to quantify circulating molecules that are released as a cause of an inflammatory response in clinical studies.   \u0000The aim of this study is to estimate the levels of serum seromucoid and protein bound-hexose (PBH) as inflammatory markers in sera of COVID-19 patients in comparison with normal subjects. For this purpose, Thirty COVID-19 patients were selected as control (male and female) in addition to 30 healthy subjects as the control group. The findings indicated that seromucoid and PBH levels were highly significant increase in COVID-19 patients (P< 0.0001) comparing with normal subjects This study provides evidence that, despite some potential physiological differences, the levels of seromucoid and PBH showed no significant differences for both male and female patients. The results from both parameters showed that COVID-19 severity is associated with inflammatory markers.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"127 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91357428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}