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Synthesis and Biological Activities of Some 1,2,4-Triazole Derivatives: A Review 1,2,4-三唑类化合物的合成及其生物活性研究进展
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-10-24 DOI: 10.32947/ajps.v22i3.890
Dina Saleem M. Ameen, Mohammed Dheyaa Hamdi, A. K. Khan
{"title":"Synthesis and Biological Activities of Some 1,2,4-Triazole Derivatives: A Review","authors":"Dina Saleem M. Ameen, Mohammed Dheyaa Hamdi, A. K. Khan","doi":"10.32947/ajps.v22i3.890","DOIUrl":"https://doi.org/10.32947/ajps.v22i3.890","url":null,"abstract":"This review is about 1,2,4-triazoles include their synthesis; their physio-chemical properties, SAR, reactions, derivatives. Finally, their biological activities with a demonstrated showing \u0000  \u0000different requirements to achieve different activity","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86508203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Reliability of MM-PB/GB-SA Method for the Protein-Ligand Binding Free Energies Using Penicillopepsin-Inhibitor ligands 评价MM-PB/GB-SA法测定青霉素蛋白酶抑制剂配体蛋白-配体结合自由能的可靠性
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-10-24 DOI: 10.32947/ajps.v22i3.889
Twana Salih
{"title":"Evaluating the Reliability of MM-PB/GB-SA Method for the Protein-Ligand Binding Free Energies Using Penicillopepsin-Inhibitor ligands","authors":"Twana Salih","doi":"10.32947/ajps.v22i3.889","DOIUrl":"https://doi.org/10.32947/ajps.v22i3.889","url":null,"abstract":"An accurate prediction of the ligand-receptor binding free energies (ΔG) is a critical step in the early stages of rational drug design. The Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) method is a popular \u0000  \u0000approach to estimate ΔG. However, correlations between the predicted and the experimental ΔG are variable. The goal of this study is to investigate various approaches to optimize accuracy of the MM-GBSA method. A molecular dynamic (MD) simulations protocol was applied using penicillopepsin receptor against its inhibitor ligands, repeated 50 times for each complex system. After that, ΔG of the five inhibitors were predicted using MM-GBSA method. Moreover, a diverse ΔG values were calculated from the replicate MD simulations of each system. The results were showed correlations not only between the predicted and the experimental binding affinities of the systems but also between the predicted values and root-mean-square deviation. In addition, statistical analysis was evaluated the sample size.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83244190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Messenger RNA Based Vaccines and Their immunological effect on diseases 基于信使RNA的疫苗及其对疾病的免疫作用
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-05 DOI: 10.32947/ajps.v22i2.836
Osama Mohammed Hasan
{"title":"Messenger RNA Based Vaccines and Their immunological effect on diseases","authors":"Osama Mohammed Hasan","doi":"10.32947/ajps.v22i2.836","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.836","url":null,"abstract":"Because of its capabilities for fast development, potency, secure delivery, and promise for   cost effective manufacture, mRNA vaccines are a promising vaccination technique. Many recent research has suggested that mRNA vaccines could be effective intreating a wide range of tumor and viral disorders where standard vaccine techniques have failed to stimulate protective immune responses. The inefficient and unstable in vivo distribution of mRNA has limited their application. Direct electroporation of mRNA vaccines into dendritic cells induced the generation of protective antibodies capable of destroying infected or transformed cells and inducing polyclonal CD8+ and CD4+ that mediated Ag specific T cell responses. in this review mRNA vaccines in detail were examined, as well as future objectives and challenges in the prevention of infectious diseases","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88747404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq 隐绿原酸对伊拉克辣木叶乳腺癌细胞株MCF7的细胞毒性研究
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-05 DOI: 10.32947/ajps.v22i2.837
Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, BasmaTalib Al-Sudani
{"title":"Cytotoxicity of Cryptochlorogenic acid against Breast cancer cell line (MCF7) isolated from Moringa oleifera Leaves Cultivated in Iraq","authors":"Banan Kareem Bedewi, Ghaith Ali Jasim, Ibrahim Saleh Abbas, BasmaTalib Al-Sudani","doi":"10.32947/ajps.v22i2.837","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.837","url":null,"abstract":"\u0000oleifera L., a Moringaceae family is fast-growing tree. M. oleifera's dried leaves are Characterized with high in phenolic compounds. phenolic compounds have anti-cancer, anti-microbial, anti-inflammatory, anti-allergic and antioxidant activities. \u0000 \u0000Therefore, The current study involved isolation Cryptochlorogenic acid by preparative TLC from M.oleifera leaves grown in Iraq,  and study its cytotoxicity effect against a breast cancer cell line (MCF7) using the MTT cell viability assay, and comparing it to a standard anticancer drug (Tamoxifen). The isolated Cryptochlorogenic acid was cytotoxic to the MCF7 cell line, with an IC50 of 20.8M.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83828630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
The Effective Role of Targeted Therapy in Advanced Colorectal Cancer 靶向治疗在晚期结直肠癌中的有效作用
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-05 DOI: 10.32947/ajps.v22i2.835
Sarah K. Obay, Ali N. Wannas, Rana A. Ghaleb
{"title":"The Effective Role of Targeted Therapy in Advanced Colorectal Cancer","authors":"Sarah K. Obay, Ali N. Wannas, Rana A. Ghaleb","doi":"10.32947/ajps.v22i2.835","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.835","url":null,"abstract":"Though chemotherapy is the major strategy to manage patients with advanced-stage colorectal cancer (CRC), the main challenge is the progression of CRC despite using combination of different chemotherapeutic agents. So, to overcome this challenge, a new class \u0000Of therapy was developed naming “Targeted-therapy”. This class of drugs aim to target specific overexpressed or aberrant enzyme, receptor, or gene that have critical role in the growth and survival of colorectal cancerous cells. So that, by using combination of traditional strategy (chemotherapy) and targeted-drug, this will lead to improve survival and prevent the progression of advanced CRC","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81127297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of miRNA in drug-induced hepatic injury miRNA在药物性肝损伤中的作用
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-05 DOI: 10.32947/ajps.v22i2.833
Inam Sameh Arif, Israa Burhan Raoof, Hayder Hussein Luaibi, Shams Khaleel Ibraheem
{"title":"Role of miRNA in drug-induced hepatic injury","authors":"Inam Sameh Arif, Israa Burhan Raoof, Hayder Hussein Luaibi, Shams Khaleel Ibraheem","doi":"10.32947/ajps.v22i2.833","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.833","url":null,"abstract":"Acute liver disease is characterized by loss of liver function within days or weeks however, in the patient who is not previously diagnosed, its less common compared with chronic liver failure, which developed slowly and irreversible process. It’s caused by \u0000  \u0000drug-induced liver damage (DILI) therefore identifying liver injury is challenging for clinical treatment and diagnosis. The major causes of liver failure involve toxic metabolites of some medications that consumed Adenosine Tri Phosphate (ATP) compared with normal conditions and increased oxidative stress due to overexpression of MicroRNAs, it is necessary to do complete diagnosis of patients. Biomarker parameters can be utilized to validate liver damage like microRNAs (miRNAs) analysis, it is a more receptive marker because increased earlier than the transaminases enzymes allowing for a more accurate diagnosis.  we summarized recent signs of progress disease concerning the role of miRNA as a novel DILI biomarker, the miRNA levels can be measured in plasma, saliva, urine, fetal fluid (amniotic), as well as other materials either in human or animals like mice, rats which significantly elevate during illness, therefore, provide e specific biomarker of hepatoinjury.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85470002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Serum Homocysteine with Controlled and Uncontrolled Type2 Diabetes Mellitus in Sulaimani City 苏莱曼尼市血清同型半胱氨酸与控制和未控制2型糖尿病的关系
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-05 DOI: 10.32947/ajps.v22i2.834
Shiraz Mohammed Ahmed, Ban Mousa Rashid, Lana Mustafa Haji Kareim, Sakar Karem Abdulla, Jamal Mahmood Salih, Beston Faiek Nore
{"title":"Association of Serum Homocysteine with Controlled and Uncontrolled Type2 Diabetes Mellitus in Sulaimani City","authors":"Shiraz Mohammed Ahmed, Ban Mousa Rashid, Lana Mustafa Haji Kareim, Sakar Karem Abdulla, Jamal Mahmood Salih, Beston Faiek Nore","doi":"10.32947/ajps.v22i2.834","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.834","url":null,"abstract":"Background: Diabetes mellitus is a serious metabolic disorder of multiple etiologies manifested by chronic hyperglycemia. The type 2 diabetes mellitus is characterized as multifactorial genetic syndrome, induced by mutations of different genes \u0000  \u0000and environmental factors. Circulating homocysteine, a non- essential amino acid containing sulfur, is a broad biochemical marker for health/disease status diagnostics. The aim of our study is to evaluate circulating serum homocysteine levels in type 2 diabetes mellitus patients. \u0000Method: A cohort of 197 individuals randomly identified for this study. Of those, 148 individuals were diagnosed by consultants as type 2 diabetes mellitus and the rest 49 volunteer were normal controls group. In clinical chemistry laboratory, serum samples were analyzed for serum homocysteine, fasting blood sugar, glycated hemoglobin, serum creatinine, blood urea, blood urea   nitrogen and lipid profile. \u0000Results: There was a significant difference in the HbA1c and sugar level between type 2 diabetes mellitus patients and control group. There was non-significant (P-value=0.32), the serum level of homocysteine was (13.6 ± 4.8, 12.5 ± 5.0 and 12.7 ± 6.2) in T2DM glycemic (controlled, poorly controlled and un controlled), respectively and (11.4 ± 4.8) in control group. \u0000Conclusions: Serum level of homocysteine was not differed significantly in type 2 diabetes mellitus when compared with control group. According to ages of T2DM and control group, there was no significant difference in serum level of homocysteine. There was significant difference between male and female in the level of serum homocysteine in glycemic uncontrolled group.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88802062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats 硫辛酸与波生坦联合治疗双氯芬酸致雄性白化大鼠急性肾功能衰竭的组织病理学研究
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.829
L. B. Qasim, G. A. Jasim, Ihsan Rabeea, مساق تجهب, يلع ثيغ, عيبر حلاص ناسحا
{"title":"Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats","authors":"L. B. Qasim, G. A. Jasim, Ihsan Rabeea, مساق تجهب, يلع ثيغ, عيبر حلاص ناسحا","doi":"10.32947/ajps.v22i1.829","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.829","url":null,"abstract":"Acute kidney injury (AKI), formly known as acute renal failure (ARF), is an abrupt and reversible decrease in kidney function as indicated by the glomerular filtration rate (GFR). Diclofenac-induced AKI is due to toxic effect of it on renal glomeruli, resulting in glomerular lesions. \u0000Furthermore, diclofenac causes autolysis, which increase renal intracellular osmolarity that leads to proximal renal tubular dilatations. Lipoic acid (LA) has antioxidant and anti-inflammatory activities. Bosentan is a competitive endothelin A (ETA) and endothelin B (ETB) receptors antagonist. In this study, the evaluation of effectiveness of lipoic acid and bosentan against diclofenac-induced AKI was done by histopathological examination. The results showed that diclofenac caused histopathological changes include; retracted glomerulus, tubular cast, tubule-interstitial inflammation and tubular necrosis. Lipoic acid or bosentan alone could not reduce the histopathological alterations caused by diclofenac. Meanwhile, the combination therapy was able to reduce the histopathological changes significantly (p>0.05). Therefore, the combination therapy of lipoic acid and bosentan showed promising ameliorative effect against diclofenac-induced AKI","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86750911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis 卡托普利对佐剂性关节炎中Toll样受体表达的影响
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.825
A. O. Farooq, N. Mohammed, ديمح ةيدان،, ةحصلا ،دادغب, ةرازو, لوتلاب ةهيبشلا, تلابقتسملا ،ليربوتباكلا, ،يمزيتامورلا لصافملا
{"title":"Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis","authors":"A. O. Farooq, N. Mohammed, ديمح ةيدان،, ةحصلا ،دادغب, ةرازو, لوتلاب ةهيبشلا, تلابقتسملا ،ليربوتباكلا, ،يمزيتامورلا لصافملا","doi":"10.32947/ajps.v22i1.825","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.825","url":null,"abstract":"Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin \u0000enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2. \u0000 ","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87519465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review Isatin衍生物的Bis-Schiff碱合成及其生物活性研究进展
Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.827
May Mohammed Jawad Al-Mudhafar, Tagreed N-A Omar, Shayma L. Abdulhadi
{"title":"Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review","authors":"May Mohammed Jawad Al-Mudhafar, Tagreed N-A Omar, Shayma L. Abdulhadi","doi":"10.32947/ajps.v22i1.827","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.827","url":null,"abstract":"Isatin is a heterocyclic molecule that belongs to one of the most important classes of organic compounds known as indolines. Isatin, isatin analogs, and their Schiff bases have recently attracted a lot of attention in medicinal chemistry. Isatin, itself, shows various biological activities such as antiviral, anticancer, antimicrobial, anti-inflammatory, analgesic, antioxidant, and anticonvulsant. Bis- Schiff bases containing isatin moiety have been known to possess a wide spectrum of pharmacological activities. This review offers up-to-date information on the most active isatin bis-Schiff bases, which would include anticancer, antimicrobial, antiviral, anticonvulsant, anti-inflammatory, and analgesic activities. These observations can lead to new molecular modifications that result in compounds with more desirable pharmacological properties","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87973130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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