Al Mustansiriyah Journal of Pharmaceutical Sciences最新文献_第8页

Association of Serum Homocysteine with Controlled and Uncontrolled Type2 Diabetes Mellitus in Sulaimani City 苏莱曼尼市血清同型半胱氨酸与控制和未控制2型糖尿病的关系

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-05 DOI: 10.32947/ajps.v22i2.834

Shiraz Mohammed Ahmed, Ban Mousa Rashid, Lana Mustafa Haji Kareim, Sakar Karem Abdulla, Jamal Mahmood Salih, Beston Faiek Nore

{"title":"Association of Serum Homocysteine with Controlled and Uncontrolled Type2 Diabetes Mellitus in Sulaimani City","authors":"Shiraz Mohammed Ahmed, Ban Mousa Rashid, Lana Mustafa Haji Kareim, Sakar Karem Abdulla, Jamal Mahmood Salih, Beston Faiek Nore","doi":"10.32947/ajps.v22i2.834","DOIUrl":"https://doi.org/10.32947/ajps.v22i2.834","url":null,"abstract":"Background: Diabetes mellitus is a serious metabolic disorder of multiple etiologies manifested by chronic hyperglycemia. The type 2 diabetes mellitus is characterized as multifactorial genetic syndrome, induced by mutations of different genes \u0000 \u0000and environmental factors. Circulating homocysteine, a non- essential amino acid containing sulfur, is a broad biochemical marker for health/disease status diagnostics. The aim of our study is to evaluate circulating serum homocysteine levels in type 2 diabetes mellitus patients. \u0000Method: A cohort of 197 individuals randomly identified for this study. Of those, 148 individuals were diagnosed by consultants as type 2 diabetes mellitus and the rest 49 volunteer were normal controls group. In clinical chemistry laboratory, serum samples were analyzed for serum homocysteine, fasting blood sugar, glycated hemoglobin, serum creatinine, blood urea, blood urea nitrogen and lipid profile. \u0000Results: There was a significant difference in the HbA1c and sugar level between type 2 diabetes mellitus patients and control group. There was non-significant (P-value=0.32), the serum level of homocysteine was (13.6 ± 4.8, 12.5 ± 5.0 and 12.7 ± 6.2) in T2DM glycemic (controlled, poorly controlled and un controlled), respectively and (11.4 ± 4.8) in control group. \u0000Conclusions: Serum level of homocysteine was not differed significantly in type 2 diabetes mellitus when compared with control group. According to ages of T2DM and control group, there was no significant difference in serum level of homocysteine. There was significant difference between male and female in the level of serum homocysteine in glycemic uncontrolled group.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88802062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats 硫辛酸与波生坦联合治疗双氯芬酸致雄性白化大鼠急性肾功能衰竭的组织病理学研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.829

L. B. Qasim, G. A. Jasim, Ihsan Rabeea, مساق تجهب, يلع ثيغ, عيبر حلاص ناسحا

{"title":"Histopathological study of diclofenac induced acute renal failure under lipoic acid and bosentan therapy in male albino rats","authors":"L. B. Qasim, G. A. Jasim, Ihsan Rabeea, مساق تجهب, يلع ثيغ, عيبر حلاص ناسحا","doi":"10.32947/ajps.v22i1.829","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.829","url":null,"abstract":"Acute kidney injury (AKI), formly known as acute renal failure (ARF), is an abrupt and reversible decrease in kidney function as indicated by the glomerular filtration rate (GFR). Diclofenac-induced AKI is due to toxic effect of it on renal glomeruli, resulting in glomerular lesions. \u0000Furthermore, diclofenac causes autolysis, which increase renal intracellular osmolarity that leads to proximal renal tubular dilatations. Lipoic acid (LA) has antioxidant and anti-inflammatory activities. Bosentan is a competitive endothelin A (ETA) and endothelin B (ETB) receptors antagonist. In this study, the evaluation of effectiveness of lipoic acid and bosentan against diclofenac-induced AKI was done by histopathological examination. The results showed that diclofenac caused histopathological changes include; retracted glomerulus, tubular cast, tubule-interstitial inflammation and tubular necrosis. Lipoic acid or bosentan alone could not reduce the histopathological alterations caused by diclofenac. Meanwhile, the combination therapy was able to reduce the histopathological changes significantly (p>0.05). Therefore, the combination therapy of lipoic acid and bosentan showed promising ameliorative effect against diclofenac-induced AKI","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86750911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis 卡托普利对佐剂性关节炎中Toll样受体表达的影响

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.825

A. O. Farooq, N. Mohammed, ديمح ةيدان،, ةحصلا ،دادغب, ةرازو, لوتلاب ةهيبشلا, تلابقتسملا ،ليربوتباكلا, ،يمزيتامورلا لصافملا

引用次数: 1

Bis-Schiff Bases of Isatin Derivatives Synthesis, and their Biological Activities: A Review Isatin衍生物的Bis-Schiff碱合成及其生物活性研究进展

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.827

May Mohammed Jawad Al-Mudhafar, Tagreed N-A Omar, Shayma L. Abdulhadi

引用次数: 3

Antiproliferative activity of Brassica nigra seeds extract in liver tissue of mice exposed to phenobarbital 黑芸苔籽提取物在苯巴比妥小鼠肝组织中的抗增殖活性

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-07-04 DOI: 10.32947/ajps.v22i1.826

Ibtehal Naseer Salman, Dalya Basil Hanna, Bahir Abdul-Razzaq Mshimesh

{"title":"Antiproliferative activity of Brassica nigra seeds extract in liver tissue of mice exposed to phenobarbital","authors":"Ibtehal Naseer Salman, Dalya Basil Hanna, Bahir Abdul-Razzaq Mshimesh","doi":"10.32947/ajps.v22i1.826","DOIUrl":"https://doi.org/10.32947/ajps.v22i1.826","url":null,"abstract":"Hepatocellular proliferation is one of the most common causes of hepatocellular carcinoma (HCC), a type of cancer that is widely distributed disease. Hepatocellular carcinoma treatment has numerous barriers, including ineffectiveness, side effects, and drug resistance to currently available \u0000treatments. Previous studies showed that a high intake of Brassica vegetables has been associated to a decreased risk of a number of malignancies. The aim of this study is the evaluation of antiproliferative activity of Brassica nigra seeds extract in mice exposed to phenobarbital. Brassica nigra seeds where extracted; phytochemical analysis of the extract was done that including phytochemical screening tests and Gas chromatography-mass spectrometry (GC-MS) analysis. Antiproliferative activity of hydro alcoholic Brassica seeds extract has been studied by 800mg/kg and compare with control group (given normal saline), phenobarbital group (Phenobarbital 75mg/kg) and combination group (Brassica extract 800mg/kg+ Phenobarbital 75mg/kg). The GC-MS analysis revealed the presence of isothiocynate compound. Histologically phenobarbital induced severe hepatocellular proliferation (hyperplasia and hypertrophy), glass ground cytoplasm, while Brassica seeds extract produce improvement in histopathological changes that include mild scattered proliferation picture and eosinophilic cytoplasm. In comparison to phenobarbital group, Combination groups pretreated with Brassica nigra seeds for 14 days and phenobarbital for 7 days caused significant reduction relative liver weight and alanine aminotransferase (ALT) Brassica nigra seeds extract have isothiocynate as main compound it showed antiproliferative action on the liver tissue, implying that it may have a promising effect in minimizing the risk of liver cancer.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79930903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthesis and study of antimicrobial activity of some tetrahydrocarbazole derivatives substituted with NSAID 非甾体抗炎药取代四氢咔唑衍生物的合成及抗菌活性研究

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-06-30 DOI: 10.32947/ajps.v22i2.857

Mustafa H. Mahdi, A. Dawood, D. Q. Shaheed

引用次数: 1

Effect of pioglitazone treatment on serum chemerin and vaspin levels in polycystic ovary syndrome. 吡格列酮治疗对多囊卵巢综合征患者血清趋化素和血管素水平的影响。

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i1.789

Rana Hussein Kutaif, Mustafa G. Alabbassi, Weqar Akram Hussein, Zainab Faleh Ali, Shatha Khayun Jassim

{"title":"Effect of pioglitazone treatment on serum chemerin and vaspin levels in polycystic ovary syndrome.","authors":"Rana Hussein Kutaif, Mustafa G. Alabbassi, Weqar Akram Hussein, Zainab Faleh Ali, Shatha Khayun Jassim","doi":"10.32947/ajps.v21i1.789","DOIUrl":"https://doi.org/10.32947/ajps.v21i1.789","url":null,"abstract":"Abdominal fat synthesizes a variety of adipokines, including vaspin and chemerin, that affect the resistance to insulin. This research was conducted to demonstrate the effect of pioglitazone, one insulin sensitizer used to decrease insulin resistance, on these adipokines in \u0000 \u0000obese patients with polycystic ovary (PCOS). Twenty-five obese women with PCOS were treated with pioglitazone 15mg/bid for 12 weeks. Modifications in fasting blood glucose (FBG), serum fasting insulin (FSI), chemerin and vaspin serum levels, follicle stimulation hormone (FSH), luteinizing hormone (LH), testosterone (T), and in baseline and post-therapy were assessed. Body mass index decreased without any substantial variance after 12 weeks of pioglitazone therapy (P> 0.05). T, FSI, HOMA-IR, LH, and FBG levels have decreased considerably (P≤0.01, P≤0.05) after the therapy. No substantial variations were found in FSH (P>0.05). Serum chemerin and vaspin levels were observed no significant difference than before treatment (P>0.05) in obese women with polycystic ovarian syndrome cases.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74489784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies in anti-adhesion therapy: A review article 抗粘连治疗策略综述

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i1.799

Fitua Al-Saedi

引用次数: 0

Co-occurrence of Wilson disease and Auto-Immune Hepatitis in 14-year-old female: A case report 14岁女性肝豆状核变性合并自身免疫性肝炎1例

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i2.803

Fadwa Ghassan Hameed, Inam Sameh Arif, Mohammed Mahmood Mohammed, Hala S. Arif

引用次数: 1

Effect of human insulin and insulin analogue on some inflammatory markers and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents 人胰岛素和胰岛素类似物对伊拉克1型糖尿病儿童和青少年某些炎症标志物和总抗氧化能力的影响

Al Mustansiriyah Journal of Pharmaceutical Sciences Pub Date : 2022-04-19 DOI: 10.32947/ajps.v21i2.804

Noor Wafaa Hashim, Kadhim Ali Kadhim, Abbas Mahdi Rahmah

{"title":"Effect of human insulin and insulin analogue on some inflammatory markers and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents","authors":"Noor Wafaa Hashim, Kadhim Ali Kadhim, Abbas Mahdi Rahmah","doi":"10.32947/ajps.v21i2.804","DOIUrl":"https://doi.org/10.32947/ajps.v21i2.804","url":null,"abstract":"Background: Both human insulin and insulin analogue used in the treatment of type 1 diabetes mellitus. The modification in amino acids sequences of human insulin lead to produce analogue form which have a pharmacokinetic and pharmacodynamics effect near to normal human endogenous \u0000 \u0000insulin release. \u0000Aim of study: This study designed to compare between the effect of each type of insulin on high sensitive C-reactive protein and interleukin-6 and total antioxidant capacity in a sample of Iraqi type 1 diabetic children and adolescents. \u0000Study design: The study was enrolled on fifty-one Iraqi type 1 diabetic children and adolecence age range (6-18) year. The patients allocated into two groups, Group (1) includes 20 patients assigned to receive conventional human insulin (regular and NPH), and Group (2) includes 20 patients assigned to receive insulin analogue (insulin aspart and glargine) for three months. The inflammatory and antioxidant markers measured at baseline and after three months of intervention. \u0000Results: After three months of treatment, both insulin groups did not affect high sensetive C_reactive protein (hs-CRP) significantly from baseline to 3 months. Only insulin analogue reduced Interleukin-6 (IL-6) significantly, while human insulin reduced level of IL-6 but it was not statistically significant. Both therapies reduced total antioxidant capacity (TAOC) significantly; however, insulin analogue had higher reduction percentage (15.1% vs. 5.7%) compared to the conventional insulin. \u0000Conclusion: Only insulin analogue reduced IL-6 significantly. Both types of insulins did not effect on hs-CRP. Both therapies reduce TAOC significantly.","PeriodicalId":7406,"journal":{"name":"Al Mustansiriyah Journal of Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83170610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3