A. O. Farooq, N. Mohammed, ديمح ةيدان،, ةحصلا ،دادغب, ةرازو, لوتلاب ةهيبشلا, تلابقتسملا ،ليربوتباكلا, ،يمزيتامورلا لصافملا
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引用次数: 1
摘要
类风湿性关节炎(RA)是一种自身免疫性炎症性疾病，首先影响关节，然后发展为全身性疾病。Toll样受体(Toll like receptor, TLR)在本病的发生发展中起重要作用。卡托普利是一种血管紧张素酶抑制剂(ACEI)，广泛用于控制血压升高。该药具有抗炎活性，因此我们试图研究其在RA中的作用。在本研究中我们发现卡托普利降低了TLR2的表达和强度。
Effect of Captopril on Toll Like Receptor Expression in Adjuvant Induced Arthritis
Rheumatoid arthritis (RA) is an inflammatory disease with autoimmune origin that affect joints firstly and then progress to be a systemic disease. Toll like receptor (TLR) play an important role in the evolution and progression of this disease. Captopril is an angiotensin
enzyme inhibitor (ACEI) that is widely used to control elevation in the blood pressure. This drug has anti-inflammatory activities, for this reason we try to investigate its action in RA. In this study we found that captopril decreases both expression and intensity of TLR2.
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