Journal of psychiatry and brain science最新文献

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Sleep Disturbance Mediates the Relationship between Problematic Technology Use and Psychotic-Like Experiences: A Large Cross-Sectional Study in 87,302 Chinese Adolescents 睡眠障碍可调节问题性技术使用与类精神病体验之间的关系:一项针对 87,302 名中国青少年的大型横断面研究
Journal of psychiatry and brain science Pub Date : 2024-07-15 DOI: 10.20900/jpbs.20240004
Aijun Liao, Pu Peng, Youguo Tan, Jingguang Li, Zhangming Chen, Linlin Zhao, Zhenmei Zhang, Jiaqi Chen, Xiaogang Chen
{"title":"Sleep Disturbance Mediates the Relationship between Problematic Technology Use and Psychotic-Like Experiences: A Large Cross-Sectional Study in 87,302 Chinese Adolescents","authors":"Aijun Liao, Pu Peng, Youguo Tan, Jingguang Li, Zhangming Chen, Linlin Zhao, Zhenmei Zhang, Jiaqi Chen, Xiaogang Chen","doi":"10.20900/jpbs.20240004","DOIUrl":"https://doi.org/10.20900/jpbs.20240004","url":null,"abstract":"Background : This study of 87,302 Chinese adolescents aimed to test: (1) the association of psychotic-like experiences (PLEs) with sleep disturbance and three different subtypes of problematic technology use (PTU), including problematic social media use (PSMU), problematic smartphone use (PSU), and internet gaming disorder (IGD); and (2) whether sleep disturbance mediated the relationship between PTU and PLEs. Method : 16-item Prodromal Questionnaire, Smartphone-Application Based Addiction Scale, the Bergen Social Media Addiction Scale, the Internet Gaming Disorder Scale-Short Form, Pittsburgh Sleep Quality Index, and Strength and Difficulties Questionnaires were employed. Results : (1) The prevalence of clinically relevant PLEs, IGD, PSMU, PSU, and sleep disturbance was 18.1%, 2.4%, 1.5%, 17.2%, and 26%, respectively. (2) PSU, PSMU, and IGD displayed comparable levels of association with PLEs","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"52 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141644528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Closing the Digital Divide in Interventions for Substance Use Disorder. 缩小药物使用障碍干预措施中的数字鸿沟。
Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-03-26 DOI: 10.20900/jpbs.20240002
Jazmin Hampton, Purity Mugambi, Emily Caggiano, Reynalde Eugene, Alycia Valente, Melissa Taylor, Stephanie Carreiro
{"title":"Closing the Digital Divide in Interventions for Substance Use Disorder.","authors":"Jazmin Hampton, Purity Mugambi, Emily Caggiano, Reynalde Eugene, Alycia Valente, Melissa Taylor, Stephanie Carreiro","doi":"10.20900/jpbs.20240002","DOIUrl":"10.20900/jpbs.20240002","url":null,"abstract":"<p><p>Digital health interventions are exploding in today's medical practice and have tremendous potential to support the treatment of substance use disorders (SUD). Developers and healthcare providers alike must be cognizant of the potential for digital interventions to exacerbate existing inequities in SUD treatment, particularly as they relate to Social Determinants of Health (SDoH). To explore this evolving area of study, this manuscript will review the existing concepts of the digital divide and digital inequities, and the role SDoH play as drivers of digital inequities. We will then explore how the data used and modeling strategies can create bias in digital health tools for SUD. Finally, we will discuss potential solutions and future directions to bridge these gaps including smartphone ownership, Wi-Fi access, digital literacy, and mitigation of historical, algorithmic, and measurement bias. Thoughtful design of digital interventions is quintessential to reduce the risk of bias, decrease the digital divide, and create equitable health outcomes for individuals with SUD.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Training of Awareness in ADHD: Leveraging Metacognition. 训练多动症患者的意识:利用元认知
Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-10-09 DOI: 10.20900/jpbs.20240006
Agatha Lenartowicz, Brett DeSchepper, Gregory V Simpson
{"title":"Training of Awareness in ADHD: Leveraging Metacognition.","authors":"Agatha Lenartowicz, Brett DeSchepper, Gregory V Simpson","doi":"10.20900/jpbs.20240006","DOIUrl":"10.20900/jpbs.20240006","url":null,"abstract":"<p><p>Attention deficit hyperactivity disorder (ADHD) is a disorder that is prevalent in children and adults, with significant impact on life outcomes. Common treatment strategies include a combination of pharmacological and psychosocial interventions which have recognized limits to their effectiveness. Consequently, there exists interest in additional non-pharmacological interventions. In the current minireview we aim to complement existing surveys by focusing on a complementary approach, namely rooted in metacognition or the training of awareness. We review programs that incorporate metacognitive training of awareness in skill-training, psychosocial interventions, and mindfulness, and discuss existing assessments of metacognitive ability in ADHD. Existing data suggest that metacognitive approaches have potential in supporting symptom management in ADHD, with gains in objective assessments in near and far transfer tasks in educational research and high satisfaction from parents. Further research is warranted in assessment of the relative contribution of metacognitive elements relative to other treatment components, objective assessments of outcomes in psychosocial interventions, and efficacy in adult interventions.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11529823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Focused Review of Gamma Neuromodulation as a Therapeutic Target in Alzheimer's Spectrum Disorders. 伽马神经调控作为阿尔茨海默氏症谱系障碍治疗靶点的集中回顾。
Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-02-28 DOI: 10.20900/jpbs.20240001
I-Wei Shu, Yayu Lin, Eric L Granholm, Fiza Singh
{"title":"A Focused Review of Gamma Neuromodulation as a Therapeutic Target in Alzheimer's Spectrum Disorders.","authors":"I-Wei Shu, Yayu Lin, Eric L Granholm, Fiza Singh","doi":"10.20900/jpbs.20240001","DOIUrl":"10.20900/jpbs.20240001","url":null,"abstract":"<p><p>The aging population of the world is increasing at an unprecedented rate which is expected to lead to a corresponding unparalleled increase in age related diseases. Of particular concern are the large number of older adults expected to develop Alzheimer's disease (AD), which will require extraordinary local, national and worldwide healthcare resources. In this context, innovative interventions are needed urgently to delay AD onset and thereby give our healthcare systems time to prepare and provide meaningful care to our aging populations. This focused review discusses the crucial role of frontal gamma oscillations as a therapeutic target to delay or ameliorate cognitive decline in AD. Frontal gamma oscillations, including from prefrontal cortical areas, serve as a biomarker for working memory and other cognitive functions, and their impairment is observed before clinical symptoms manifest. This review evaluates evidence from animal models and human subjects to highlight the correlation between gamma wave abnormalities and cognitive deterioration. Furthermore, the review summarizes 11 clinical studies using neuromodulation techniques designed to stimulate gamma oscillations in mild cognitive impairment (MCI) and AD patients, including transcranial electrical stimulation, transcranial magnetic stimulation, and rhythmic sensory stimulation. These interventions have shown promise in mitigating early-stage cognitive decline, as evidenced by improved performance on memory tests, increased gamma oscillatory responses, and some have even shown reduced brain atrophy. These early studies suggest that treatments that strengthen frontal gamma oscillatory responses through neuromodulation are a promising approach to delay cognitive decline, that may serve as an adjunct to other therapies or as a standalone treatment in some populations.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reducing Relapse by Enhancing Reward Responsivity in Anorexia Nervosa: The VIBRANT (Virtual Interventions for Bolstering Recovery following Anorexia Nervosa Treatment) Trial . 通过提高神经性厌食症患者的奖赏反应性减少复发:VIBRANT(神经性厌食症治疗后促进康复的虚拟干预)试验†。
Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-08-16 DOI: 10.20900/jpbs.20240005
Ann F Haynos, Kira G Venables, Lisa M Anderson, Michelle G Craske, Carol B Peterson
{"title":"Reducing Relapse by Enhancing Reward Responsivity in Anorexia Nervosa: The VIBRANT (Virtual Interventions for Bolstering Recovery following Anorexia Nervosa Treatment) Trial <sup>†</sup>.","authors":"Ann F Haynos, Kira G Venables, Lisa M Anderson, Michelle G Craske, Carol B Peterson","doi":"10.20900/jpbs.20240005","DOIUrl":"10.20900/jpbs.20240005","url":null,"abstract":"<p><strong>Introduction: </strong>The post-acute phase of anorexia nervosa (AN) following discharge from higher-level care is a high-risk period in which relapse rates are high and many individuals lack access to effective treatment. Even after acute nutritional stabilization, AN is characterized by decreased biobehavioral sensitivity towards general rewards and elevated sensitivity towards weight-loss cues. These reward patterns may continue to maintain eating disorder and comorbid affective symptoms. To address these gaps in the treatment literature for post-acute AN, we propose a randomized controlled trial comparing Positive Affect Treatment for AN (PAT-AN), a neuroscience-informed therapy adapted to target these reward imbalances in AN, to more standard psychoeducational and behavioral treatment (PBT) for eating disorders following acute care.</p><p><strong>Method: </strong>Adult participants (<i>N</i> = 80) with broad AN, including atypical AN, discharged from intensive treatment (e.g., residential, partial hospitalization) for AN within the past 6 months will be randomly assigned to 24 weeks of remotely-delivered PAT-AN or PBT. We will compare the feasibility, acceptability, and efficacy of each treatment to augment post-acute outpatient care for AN. A multimodal neurocognitive and self-report battery will assess eating pathology, comorbid symptom, and putative reward mechanism changes over the course of treatment (i.e., baseline, mid-treatment, post-treatment, three-month follow-up) and on a week-to-week basis.</p><p><strong>Discussion: </strong>This trial will, for the first time, directly target observed reward disturbances in the post-acute period of AN. Thus, this investigation has the potential to simultaneously evaluate a novel, efficacious treatment for AN and to further evaluate the role of reward dysfunction in AN maintenance.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in Utilization and Delivery Outcomes for Women with Perinatal Mood and Anxiety Disorders. 患有围产期情绪和焦虑症的妇女在使用和分娩结果方面的差异。
Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-04-30 DOI: 10.20900/jpbs.20240003
Kara Zivin, Anna Courant
{"title":"Disparities in Utilization and Delivery Outcomes for Women with Perinatal Mood and Anxiety Disorders.","authors":"Kara Zivin, Anna Courant","doi":"10.20900/jpbs.20240003","DOIUrl":"10.20900/jpbs.20240003","url":null,"abstract":"<p><p>Perinatal mood and anxiety disorders (PMAD), which include depression and/or anxiety in the year before and/or after delivery, are common complications of pregnancy, affecting up to one in four perinatal individuals, with costs of over $15 billion per year in the US. In this paper, we provide an overview of the disparities in utilization and delivery outcomes for individuals with perinatal mood and anxiety disorders in the US. In addition, we discuss the current US screening and treatment guidelines as well as the high societal costs of illness of PMAD for both perinatal individuals and children. Finally, we outline opportunities for quality improvement of PMAD care in the US, including leveraging increased engagement with healthcare system during prenatal care, working toward a more cohesive national strategy to address PMAD, leaning into evidence-based policymaking through collaboration with a panel of experts, and generating state-level profiles focused on PMAD.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"9 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11138136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141180316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Suicide over the Life Course Using Data Science Tools within a Triangulation Framework. 在三角测量框架下使用数据科学工具来理解生命过程中的自杀行为。
Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230003
Lily Johns, Chuwen Zhong, Briana Mezuk
{"title":"Understanding Suicide over the Life Course Using Data Science Tools within a Triangulation Framework.","authors":"Lily Johns,&nbsp;Chuwen Zhong,&nbsp;Briana Mezuk","doi":"10.20900/jpbs.20230003","DOIUrl":"https://doi.org/10.20900/jpbs.20230003","url":null,"abstract":"Suicide and suicidal behaviors are important global health concerns. Preventing suicide requires a nuanced understanding of the nature of suicide risk, both acutely during periods of crisis and broader variation over the lifespan. However, current knowledge of the sources of variation in suicide risk is limited due to methodological and conceptual challenges. New methodological approaches are needed to close the gap between research and clinical practice. This review describes the life course framework as a conceptual model for organizing the scientific study of suicide risk across in four major domains: social relationships, health, housing, and employment. In addition, this review discusses the utility of data science tools as a means of identifying novel, modifiable risk factors for suicide, and triangulation as an overarching approach to ensuring rigor in suicide research as means of addressing existing knowledge gaps and strengthening future research.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10168676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating Treatment for Maternal Depression and Young Children's Behavior Problems. 综合治疗母亲抑郁和幼儿行为问题。
Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-12-27 DOI: 10.20900/jpbs.20230011
Danielle Roubinov, Barbara Ivins, Laura Frame, Stephanie Simms, Linda Pfiffner
{"title":"Integrating Treatment for Maternal Depression and Young Children's Behavior Problems.","authors":"Danielle Roubinov, Barbara Ivins, Laura Frame, Stephanie Simms, Linda Pfiffner","doi":"10.20900/jpbs.20230011","DOIUrl":"10.20900/jpbs.20230011","url":null,"abstract":"<p><p>It is important to consider reciprocal associations between maternal and offspring mental health problems during early childhood. Existing interventions often focus narrowly on either adult or child mental health, missing the opportunity for holistic care. We describe the rationale and development of a pilot randomized clinical trial that explores their integration, combining an evidence-based parenting intervention with depression treatment to improve both maternal and child outcomes. Our approach is part of a growing field of two-generation interventions that offer a promising approach to enhance mental health support for caregivers and their young children.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10809929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139565455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study. 有和无非自杀性自残史青少年的临床轨迹:BRIDGES 纵向研究》。
Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-07-01 DOI: 10.20900/jpbs.20230007
Aparna U Nair, Julia A Brekke-Riedl, Michaelle E DiMaggio-Potter, Katherine A Carosella, Carolyn Lasch, Rylee Brower, Victoria Papke, Kristina Reigstad, Bonnie Klimes-Dougan, Kathryn R Cullen
{"title":"Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study.","authors":"Aparna U Nair, Julia A Brekke-Riedl, Michaelle E DiMaggio-Potter, Katherine A Carosella, Carolyn Lasch, Rylee Brower, Victoria Papke, Kristina Reigstad, Bonnie Klimes-Dougan, Kathryn R Cullen","doi":"10.20900/jpbs.20230007","DOIUrl":"10.20900/jpbs.20230007","url":null,"abstract":"<p><strong>Background: </strong>Non-suicidal self-injury (NSSI) is a highly prevalent clinical concern in adolescents and is associated with impaired functioning and suicide risk. The BRIDGES (BRain Imaging Development of Girls' Emotion and Self) study was designed to collect longitudinal clinical and neurobiological data to advance our understanding of NSSI in adolescents. The purpose of this paper is to describe the clinical data collected as part of this study, including psychiatric diagnoses, depression symptoms, episodes of non-suicidal self-injury, suicidal thoughts and behaviors, childhood trauma, and personality domains.</p><p><strong>Methods: </strong>The baseline sample included 164 adolescents aged 12-16 assigned female at birth (Mean age = 14.97, SD = 1.20) with NSSI histories ranging from none to severe. Participants and their parent/guardian were invited to provide data at three time points spaced approximately one year apart. Descriptive analyses were conducted to provide estimates of rates and trajectories of clinical data.</p><p><strong>Results: </strong>Of the 164 study participants, 75.61% and 57.93% completed the second and third time points, respectively. Visual inspection of the data suggests an overall trend of decreasing severity of psychopathology over time, and adolescents with a history of NSSI appeared to have higher rates of psychopathology than those without.</p><p><strong>Conclusions: </strong>This paper describes longitudinal clinical trajectories in adolescents with a range of NSSI histories and presents readers with an overview of the rich, publicly available dataset that we hope will inspire future research to advance the understanding of the neurodevelopmental trajectories associated with NSSI, depression, and suicide risk.</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (OUTLAST-B): Rationale, Design, and Evolution of a Randomized Controlled Trial. 在战略接触点使用丁丙诺啡进行阿片类药物使用障碍治疗链接(OUTLAST-B):随机对照试验的原理、设计和演变。
Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-12-25 DOI: 10.20900/jpbs.20230010
Courtney D Nordeck, Anjalee Sharma, Mishka Terplan, Kristi Dusek, Elizabeth Gilliams, Jan Gryczynski
{"title":"Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (OUTLAST-B): Rationale, Design, and Evolution of a Randomized Controlled Trial.","authors":"Courtney D Nordeck, Anjalee Sharma, Mishka Terplan, Kristi Dusek, Elizabeth Gilliams, Jan Gryczynski","doi":"10.20900/jpbs.20230010","DOIUrl":"10.20900/jpbs.20230010","url":null,"abstract":"<p><strong>Background: </strong>Despite the effectiveness and growing availability of treatment for opioid use disorder (OUD) with buprenorphine, many people with OUD do not access treatment services. This article describes the rationale, methodological design, evolution, and progress of an ongoing clinical trial of treatment linkage strategies for people with untreated OUD.</p><p><strong>Methods: </strong>The study, titled <i>Opioid Use Disorder Treatment Linkage at Strategic Touchpoints using Buprenorphine (OUTLAST-B)</i>, uses \"strategic touchpoints\", initially sexual health clinics and subsequently broadened to other service venues and participant social networks, for recruitment and screening. Adults with untreated OUD (target <i>N</i> = 360) are randomized to one of the three arms: Usual Care (UC, enhanced with overdose education and naloxone distribution), Patient Navigation (PN), or Patient Navigation with an immediate short-term bridge prescription for buprenorphine (PN + BUP). In the PN and PN + BUP arms, the Patient Navigator works with participants for 2 months to facilitate treatment entry and early retention, resolve barriers (e.g., ID cards, transportation), and provide motivational support.</p><p><strong>Results: </strong>The primary outcome is OUD treatment entry within 30 days of enrollment. Participants are assessed at baseline and followed at 3- and 6-months post-enrollment on measures of healthcare utilization, substance use, and general functioning. Challenges and recruitment adaptations pursuant to the COVID-19 pandemic are discussed.</p><p><strong>Conclusions: </strong>This study could provide insights on how to reach people with untreated OUD and link them to care through non-traditional routes.</p><p><strong>Trial registration: </strong>The study is registered at ClinicalTrials.gov (NCT04991974).</p>","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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