Journal of psychiatry and brain science最新文献

Sleep Disturbance Mediates the Relationship between Problematic Technology Use and Psychotic-Like Experiences: A Large Cross-Sectional Study in 87,302 Chinese Adolescents 睡眠障碍可调节问题性技术使用与类精神病体验之间的关系：一项针对 87,302 名中国青少年的大型横断面研究

Journal of psychiatry and brain science Pub Date : 2024-07-15 DOI: 10.20900/jpbs.20240004

Aijun Liao, Pu Peng, Youguo Tan, Jingguang Li, Zhangming Chen, Linlin Zhao, Zhenmei Zhang, Jiaqi Chen, Xiaogang Chen

引用次数: 0

Closing the Digital Divide in Interventions for Substance Use Disorder. 缩小药物使用障碍干预措施中的数字鸿沟。

Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-03-26 DOI: 10.20900/jpbs.20240002

Jazmin Hampton, Purity Mugambi, Emily Caggiano, Reynalde Eugene, Alycia Valente, Melissa Taylor, Stephanie Carreiro

{"title":"Closing the Digital Divide in Interventions for Substance Use Disorder.","authors":"Jazmin Hampton, Purity Mugambi, Emily Caggiano, Reynalde Eugene, Alycia Valente, Melissa Taylor, Stephanie Carreiro","doi":"10.20900/jpbs.20240002","DOIUrl":"10.20900/jpbs.20240002","url":null,"abstract":"Digital health interventions are exploding in today's medical practice and have tremendous potential to support the treatment of substance use disorders (SUD). Developers and healthcare providers alike must be cognizant of the potential for digital interventions to exacerbate existing inequities in SUD treatment, particularly as they relate to Social Determinants of Health (SDoH). To explore this evolving area of study, this manuscript will review the existing concepts of the digital divide and digital inequities, and the role SDoH play as drivers of digital inequities. We will then explore how the data used and modeling strategies can create bias in digital health tools for SUD. Finally, we will discuss potential solutions and future directions to bridge these gaps including smartphone ownership, Wi-Fi access, digital literacy, and mitigation of historical, algorithmic, and measurement bias. Thoughtful design of digital interventions is quintessential to reduce the risk of bias, decrease the digital divide, and create equitable health outcomes for individuals with SUD.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11081399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140900516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Focused Review of Gamma Neuromodulation as a Therapeutic Target in Alzheimer's Spectrum Disorders. 伽马神经调控作为阿尔茨海默氏症谱系障碍治疗靶点的集中回顾。

Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-02-28 DOI: 10.20900/jpbs.20240001

I-Wei Shu, Yayu Lin, Eric L Granholm, Fiza Singh

{"title":"A Focused Review of Gamma Neuromodulation as a Therapeutic Target in Alzheimer's Spectrum Disorders.","authors":"I-Wei Shu, Yayu Lin, Eric L Granholm, Fiza Singh","doi":"10.20900/jpbs.20240001","DOIUrl":"10.20900/jpbs.20240001","url":null,"abstract":"The aging population of the world is increasing at an unprecedented rate which is expected to lead to a corresponding unparalleled increase in age related diseases. Of particular concern are the large number of older adults expected to develop Alzheimer's disease (AD), which will require extraordinary local, national and worldwide healthcare resources. In this context, innovative interventions are needed urgently to delay AD onset and thereby give our healthcare systems time to prepare and provide meaningful care to our aging populations. This focused review discusses the crucial role of frontal gamma oscillations as a therapeutic target to delay or ameliorate cognitive decline in AD. Frontal gamma oscillations, including from prefrontal cortical areas, serve as a biomarker for working memory and other cognitive functions, and their impairment is observed before clinical symptoms manifest. This review evaluates evidence from animal models and human subjects to highlight the correlation between gamma wave abnormalities and cognitive deterioration. Furthermore, the review summarizes 11 clinical studies using neuromodulation techniques designed to stimulate gamma oscillations in mild cognitive impairment (MCI) and AD patients, including transcranial electrical stimulation, transcranial magnetic stimulation, and rhythmic sensory stimulation. These interventions have shown promise in mitigating early-stage cognitive decline, as evidenced by improved performance on memory tests, increased gamma oscillatory responses, and some have even shown reduced brain atrophy. These early studies suggest that treatments that strengthen frontal gamma oscillatory responses through neuromodulation are a promising approach to delay cognitive decline, that may serve as an adjunct to other therapies or as a standalone treatment in some populations.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10976397/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disparities in Utilization and Delivery Outcomes for Women with Perinatal Mood and Anxiety Disorders. 患有围产期情绪和焦虑症的妇女在使用和分娩结果方面的差异。

Journal of psychiatry and brain science Pub Date : 2024-01-01 Epub Date: 2024-04-30 DOI: 10.20900/jpbs.20240003

Kara Zivin, Anna Courant

引用次数: 0

Understanding Suicide over the Life Course Using Data Science Tools within a Triangulation Framework. 在三角测量框架下使用数据科学工具来理解生命过程中的自杀行为。

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230003

Lily Johns, Chuwen Zhong, Briana Mezuk

引用次数: 0

Integrating Treatment for Maternal Depression and Young Children's Behavior Problems. 综合治疗母亲抑郁和幼儿行为问题。

Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-12-27 DOI: 10.20900/jpbs.20230011

Danielle Roubinov, Barbara Ivins, Laura Frame, Stephanie Simms, Linda Pfiffner

引用次数: 0

Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study. 有和无非自杀性自残史青少年的临床轨迹：BRIDGES 纵向研究》。

Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-07-01 DOI: 10.20900/jpbs.20230007

Aparna U Nair, Julia A Brekke-Riedl, Michaelle E DiMaggio-Potter, Katherine A Carosella, Carolyn Lasch, Rylee Brower, Victoria Papke, Kristina Reigstad, Bonnie Klimes-Dougan, Kathryn R Cullen

{"title":"Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study.","authors":"Aparna U Nair, Julia A Brekke-Riedl, Michaelle E DiMaggio-Potter, Katherine A Carosella, Carolyn Lasch, Rylee Brower, Victoria Papke, Kristina Reigstad, Bonnie Klimes-Dougan, Kathryn R Cullen","doi":"10.20900/jpbs.20230007","DOIUrl":"10.20900/jpbs.20230007","url":null,"abstract":"Background: Non-suicidal self-injury (NSSI) is a highly prevalent clinical concern in adolescents and is associated with impaired functioning and suicide risk. The BRIDGES (BRain Imaging Development of Girls' Emotion and Self) study was designed to collect longitudinal clinical and neurobiological data to advance our understanding of NSSI in adolescents. The purpose of this paper is to describe the clinical data collected as part of this study, including psychiatric diagnoses, depression symptoms, episodes of non-suicidal self-injury, suicidal thoughts and behaviors, childhood trauma, and personality domains.Methods: The baseline sample included 164 adolescents aged 12-16 assigned female at birth (Mean age = 14.97, SD = 1.20) with NSSI histories ranging from none to severe. Participants and their parent/guardian were invited to provide data at three time points spaced approximately one year apart. Descriptive analyses were conducted to provide estimates of rates and trajectories of clinical data.Results: Of the 164 study participants, 75.61% and 57.93% completed the second and third time points, respectively. Visual inspection of the data suggests an overall trend of decreasing severity of psychopathology over time, and adolescents with a history of NSSI appeared to have higher rates of psychopathology than those without.Conclusions: This paper describes longitudinal clinical trajectories in adolescents with a range of NSSI histories and presents readers with an overview of the rich, publicly available dataset that we hope will inspire future research to advance the understanding of the neurodevelopmental trajectories associated with NSSI, depression, and suicide risk.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (OUTLAST-B): Rationale, Design, and Evolution of a Randomized Controlled Trial. 在战略接触点使用丁丙诺啡进行阿片类药物使用障碍治疗链接（OUTLAST-B）：随机对照试验的原理、设计和演变。

Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-12-25 DOI: 10.20900/jpbs.20230010

Courtney D Nordeck, Anjalee Sharma, Mishka Terplan, Kristi Dusek, Elizabeth Gilliams, Jan Gryczynski

{"title":"Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (OUTLAST-B): Rationale, Design, and Evolution of a Randomized Controlled Trial.","authors":"Courtney D Nordeck, Anjalee Sharma, Mishka Terplan, Kristi Dusek, Elizabeth Gilliams, Jan Gryczynski","doi":"10.20900/jpbs.20230010","DOIUrl":"10.20900/jpbs.20230010","url":null,"abstract":"Background: Despite the effectiveness and growing availability of treatment for opioid use disorder (OUD) with buprenorphine, many people with OUD do not access treatment services. This article describes the rationale, methodological design, evolution, and progress of an ongoing clinical trial of treatment linkage strategies for people with untreated OUD.Methods: The study, titled Opioid Use Disorder Treatment Linkage at Strategic Touchpoints using Buprenorphine (OUTLAST-B), uses \"strategic touchpoints\", initially sexual health clinics and subsequently broadened to other service venues and participant social networks, for recruitment and screening. Adults with untreated OUD (target N = 360) are randomized to one of the three arms: Usual Care (UC, enhanced with overdose education and naloxone distribution), Patient Navigation (PN), or Patient Navigation with an immediate short-term bridge prescription for buprenorphine (PN + BUP). In the PN and PN + BUP arms, the Patient Navigator works with participants for 2 months to facilitate treatment entry and early retention, resolve barriers (e.g., ID cards, transportation), and provide motivational support.Results: The primary outcome is OUD treatment entry within 30 days of enrollment. Participants are assessed at baseline and followed at 3- and 6-months post-enrollment on measures of healthcare utilization, substance use, and general functioning. Challenges and recruitment adaptations pursuant to the COVID-19 pandemic are discussed.Conclusions: This study could provide insights on how to reach people with untreated OUD and link them to care through non-traditional routes.Trial registration: The study is registered at ClinicalTrials.gov (NCT04991974).","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Gap between Self-Reported Transgender and Gender Dysphoria in Chinese Youth 中国青少年跨性别自我报告与性别焦虑差异的探讨

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230009

{"title":"Exploring the Gap between Self-Reported Transgender and Gender Dysphoria in Chinese Youth","authors":"","doi":"10.20900/jpbs.20230009","DOIUrl":"https://doi.org/10.20900/jpbs.20230009","url":null,"abstract":"Background: Despite the growing focus on transgender individuals, there is still a paucity of coherent research on the association between self-reported gender identity and the diagnosis of gender dysphoria (GD). This study explores the gap between the self-reported gender identity and the diagnosed condition. Methods: Data from high school and college in Hunan, China, were collected from September 2019 to December 2019. Students who self-reported as gender minority (including transgender and other gender minorities) were interviewed by psychiatrists to confirm their GD diagnosis. Rates of the self-identified gender minority and GD clinical diagnosis were the present study’s primary outcomes. Depression, social avoidance and distress, social support, and suicidal ideation were measured with the Beck Depression Inventory (BDI), Social Avoidance and Distress Scale (SAD), Social Support Rating Scale (SSRS), and Beck Scale for Suicide Ideation (BSI), respectively. Results: Despite the relatively high rate of self-reported gender minorities in the sample (6.5%), none of them matched the clinical diagnosis of GD, as confirmed by psychiatrists. Nevertheless, even with the absence of GD diagnosis","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135662375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity. 预防性和治疗性自身抗体对神经元兴奋性毒性的保护。

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230006

Xianjin Zhou

{"title":"Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity.","authors":"Xianjin Zhou","doi":"10.20900/jpbs.20230006","DOIUrl":"https://doi.org/10.20900/jpbs.20230006","url":null,"abstract":"High titers of anti-NMDAR1 IgG autoantibodies were found in the brains of patients with anti-NMDAR1 encephalitis that exhibits psychosis, impaired memory, and many other psychiatric symptoms in addition to neurological symptoms. Low titers of blood circulating anti-NMDAR1 IgG autoantibodies are sufficient to robustly impair spatial working memory in mice with intact blood-brain barriers (BBB). On the other hand, anti-NMDAR1 autoantibodies were reported to protect against neuronal excitotoxicity caused by excessive glutamate in neurological diseases. Activation of extrasynaptic NMDARs is responsible for neuronal excitotoxicity, whereas activation of synaptic NMDARs within the synaptic cleft is pro-survival and essential for NMDAR-mediated neurotransmission. Unlike small IgG, IgM antibodies are large and pentameric (diameter of ~30 nm). It is plausible that IgM anti-NMDAR1 autoantibodies may be restricted to bind extrasynaptic NMDARs and thereby specifically inhibit neuronal excitotoxicity, but physically too large to enter the synaptic cleft (width: 20-30 nm) to suppress synaptic NMDAR-mediated neurotransmission in modulation of cognitive function and neuronal pro-survival signaling. Hence, blood circulating anti-NMDAR1 IgM autoantibodies are both neuroprotective and pro-cognitive, whereas blood circulating anti-NMDAR1 IgG and IgA autoantibodies are detrimental to cognitive function. Investigation of anti-NMDAR1 IgM autoantibodies may open up a new avenue for the development of long-lasting preventive and therapeutic IgM anti-NMDAR1 autoantibodies that protect from neuronal excitotoxicity in many neurological diseases and psychiatric disorders.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10260961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0