Journal of psychiatry and brain science最新文献_第2页

Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study. 有和无非自杀性自残史青少年的临床轨迹：BRIDGES 纵向研究》。

Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-07-01 DOI: 10.20900/jpbs.20230007

Aparna U Nair, Julia A Brekke-Riedl, Michaelle E DiMaggio-Potter, Katherine A Carosella, Carolyn Lasch, Rylee Brower, Victoria Papke, Kristina Reigstad, Bonnie Klimes-Dougan, Kathryn R Cullen

{"title":"Clinical Trajectories in Adolescents with and without a History of Non-Suicidal Self-Injury: The BRIDGES Longitudinal Study.","authors":"Aparna U Nair, Julia A Brekke-Riedl, Michaelle E DiMaggio-Potter, Katherine A Carosella, Carolyn Lasch, Rylee Brower, Victoria Papke, Kristina Reigstad, Bonnie Klimes-Dougan, Kathryn R Cullen","doi":"10.20900/jpbs.20230007","DOIUrl":"10.20900/jpbs.20230007","url":null,"abstract":"Background: Non-suicidal self-injury (NSSI) is a highly prevalent clinical concern in adolescents and is associated with impaired functioning and suicide risk. The BRIDGES (BRain Imaging Development of Girls' Emotion and Self) study was designed to collect longitudinal clinical and neurobiological data to advance our understanding of NSSI in adolescents. The purpose of this paper is to describe the clinical data collected as part of this study, including psychiatric diagnoses, depression symptoms, episodes of non-suicidal self-injury, suicidal thoughts and behaviors, childhood trauma, and personality domains.Methods: The baseline sample included 164 adolescents aged 12-16 assigned female at birth (Mean age = 14.97, SD = 1.20) with NSSI histories ranging from none to severe. Participants and their parent/guardian were invited to provide data at three time points spaced approximately one year apart. Descriptive analyses were conducted to provide estimates of rates and trajectories of clinical data.Results: Of the 164 study participants, 75.61% and 57.93% completed the second and third time points, respectively. Visual inspection of the data suggests an overall trend of decreasing severity of psychopathology over time, and adolescents with a history of NSSI appeared to have higher rates of psychopathology than those without.Conclusions: This paper describes longitudinal clinical trajectories in adolescents with a range of NSSI histories and presents readers with an overview of the rich, publicly available dataset that we hope will inspire future research to advance the understanding of the neurodevelopmental trajectories associated with NSSI, depression, and suicide risk.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10426765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10022060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (OUTLAST-B): Rationale, Design, and Evolution of a Randomized Controlled Trial. 在战略接触点使用丁丙诺啡进行阿片类药物使用障碍治疗链接（OUTLAST-B）：随机对照试验的原理、设计和演变。

Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-12-25 DOI: 10.20900/jpbs.20230010

Courtney D Nordeck, Anjalee Sharma, Mishka Terplan, Kristi Dusek, Elizabeth Gilliams, Jan Gryczynski

{"title":"Opioid Use Disorder Treatment Linkage at Strategic Touchpoints Using Buprenorphine (OUTLAST-B): Rationale, Design, and Evolution of a Randomized Controlled Trial.","authors":"Courtney D Nordeck, Anjalee Sharma, Mishka Terplan, Kristi Dusek, Elizabeth Gilliams, Jan Gryczynski","doi":"10.20900/jpbs.20230010","DOIUrl":"10.20900/jpbs.20230010","url":null,"abstract":"Background: Despite the effectiveness and growing availability of treatment for opioid use disorder (OUD) with buprenorphine, many people with OUD do not access treatment services. This article describes the rationale, methodological design, evolution, and progress of an ongoing clinical trial of treatment linkage strategies for people with untreated OUD.Methods: The study, titled Opioid Use Disorder Treatment Linkage at Strategic Touchpoints using Buprenorphine (OUTLAST-B), uses \"strategic touchpoints\", initially sexual health clinics and subsequently broadened to other service venues and participant social networks, for recruitment and screening. Adults with untreated OUD (target N = 360) are randomized to one of the three arms: Usual Care (UC, enhanced with overdose education and naloxone distribution), Patient Navigation (PN), or Patient Navigation with an immediate short-term bridge prescription for buprenorphine (PN + BUP). In the PN and PN + BUP arms, the Patient Navigator works with participants for 2 months to facilitate treatment entry and early retention, resolve barriers (e.g., ID cards, transportation), and provide motivational support.Results: The primary outcome is OUD treatment entry within 30 days of enrollment. Participants are assessed at baseline and followed at 3- and 6-months post-enrollment on measures of healthcare utilization, substance use, and general functioning. Challenges and recruitment adaptations pursuant to the COVID-19 pandemic are discussed.Conclusions: This study could provide insights on how to reach people with untreated OUD and link them to care through non-traditional routes.Trial registration: The study is registered at ClinicalTrials.gov (NCT04991974).","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10919199/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140061471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Gap between Self-Reported Transgender and Gender Dysphoria in Chinese Youth 中国青少年跨性别自我报告与性别焦虑差异的探讨

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230009

{"title":"Exploring the Gap between Self-Reported Transgender and Gender Dysphoria in Chinese Youth","authors":"","doi":"10.20900/jpbs.20230009","DOIUrl":"https://doi.org/10.20900/jpbs.20230009","url":null,"abstract":"Background: Despite the growing focus on transgender individuals, there is still a paucity of coherent research on the association between self-reported gender identity and the diagnosis of gender dysphoria (GD). This study explores the gap between the self-reported gender identity and the diagnosed condition. Methods: Data from high school and college in Hunan, China, were collected from September 2019 to December 2019. Students who self-reported as gender minority (including transgender and other gender minorities) were interviewed by psychiatrists to confirm their GD diagnosis. Rates of the self-identified gender minority and GD clinical diagnosis were the present study’s primary outcomes. Depression, social avoidance and distress, social support, and suicidal ideation were measured with the Beck Depression Inventory (BDI), Social Avoidance and Distress Scale (SAD), Social Support Rating Scale (SSRS), and Beck Scale for Suicide Ideation (BSI), respectively. Results: Despite the relatively high rate of self-reported gender minorities in the sample (6.5%), none of them matched the clinical diagnosis of GD, as confirmed by psychiatrists. Nevertheless, even with the absence of GD diagnosis","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135662375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity. 预防性和治疗性自身抗体对神经元兴奋性毒性的保护。

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230006

Xianjin Zhou

{"title":"Preventive and Therapeutic Autoantibodies Protect against Neuronal Excitotoxicity.","authors":"Xianjin Zhou","doi":"10.20900/jpbs.20230006","DOIUrl":"https://doi.org/10.20900/jpbs.20230006","url":null,"abstract":"High titers of anti-NMDAR1 IgG autoantibodies were found in the brains of patients with anti-NMDAR1 encephalitis that exhibits psychosis, impaired memory, and many other psychiatric symptoms in addition to neurological symptoms. Low titers of blood circulating anti-NMDAR1 IgG autoantibodies are sufficient to robustly impair spatial working memory in mice with intact blood-brain barriers (BBB). On the other hand, anti-NMDAR1 autoantibodies were reported to protect against neuronal excitotoxicity caused by excessive glutamate in neurological diseases. Activation of extrasynaptic NMDARs is responsible for neuronal excitotoxicity, whereas activation of synaptic NMDARs within the synaptic cleft is pro-survival and essential for NMDAR-mediated neurotransmission. Unlike small IgG, IgM antibodies are large and pentameric (diameter of ~30 nm). It is plausible that IgM anti-NMDAR1 autoantibodies may be restricted to bind extrasynaptic NMDARs and thereby specifically inhibit neuronal excitotoxicity, but physically too large to enter the synaptic cleft (width: 20-30 nm) to suppress synaptic NMDAR-mediated neurotransmission in modulation of cognitive function and neuronal pro-survival signaling. Hence, blood circulating anti-NMDAR1 IgM autoantibodies are both neuroprotective and pro-cognitive, whereas blood circulating anti-NMDAR1 IgG and IgA autoantibodies are detrimental to cognitive function. Investigation of anti-NMDAR1 IgM autoantibodies may open up a new avenue for the development of long-lasting preventive and therapeutic IgM anti-NMDAR1 autoantibodies that protect from neuronal excitotoxicity in many neurological diseases and psychiatric disorders.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10373126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10260961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk. 潜在的精神分裂症风险神经影像学生物标志物综述。

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230005

Daniel Mamah

{"title":"A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.","authors":"Daniel Mamah","doi":"10.20900/jpbs.20230005","DOIUrl":"https://doi.org/10.20900/jpbs.20230005","url":null,"abstract":"The risk for developing schizophrenia is increased among first-degree relatives of those with psychotic disorders, but the risk is even higher in those meeting established criteria for clinical high risk (CHR), a clinical construct most often comprising of attenuated psychotic experiences. Conversion to psychosis among CHR youth has been reported to be about 15-35% over three years. Accurately identifying individuals whose psychotic symptoms will worsen would facilitate earlier intervention, but this has been difficult to do using behavior measures alone. Brain-based risk markers have the potential to improve the accuracy of predicting outcomes in CHR youth. This narrative review provides an overview of neuroimaging studies used to investigate psychosis risk, including studies involving structural, functional, and diffusion imaging, functional connectivity, positron emission tomography, arterial spin labeling, magnetic resonance spectroscopy, and multi-modality approaches. We present findings separately in those observed in the CHR state and those associated with psychosis progression or resilience. Finally, we discuss future research directions that could improve clinical care for those at high risk for developing psychotic disorders.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10327607/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10225647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders. 星形胶质细胞作为髓磷脂和Ranvier淋巴结参与抑郁和应激相关疾病病理生理的背景。

Journal of psychiatry and brain science Pub Date : 2023-01-01 DOI: 10.20900/jpbs.20230001

José Javier Miguel-Hidalgo

{"title":"Astrocytes as Context for the Involvement of Myelin and Nodes of Ranvier in the Pathophysiology of Depression and Stress-Related Disorders.","authors":"José Javier Miguel-Hidalgo","doi":"10.20900/jpbs.20230001","DOIUrl":"https://doi.org/10.20900/jpbs.20230001","url":null,"abstract":"Astrocytes, despite some shared features as glial cells supporting neuronal function in gray and white matter, participate and adapt their morphology and neurochemistry in a plethora of distinct regulatory tasks in specific neural environments. In the white matter, a large proportion of the processes branching from the astrocytes' cell bodies establish contacts with oligodendrocytes and the myelin they form, while the tips of many astrocyte branches closely associate with nodes of Ranvier. Stability of myelin has been shown to greatly depend on astrocyte-to-oligodendrocyte communication, while the integrity of action potentials that regenerate at nodes of Ranvier has been shown to depend on extracellular matrix components heavily contributed by astrocytes. Several lines of evidence are starting to show that in human subjects with affective disorders and in animal models of chronic stress there are significant changes in myelin components, white matter astrocytes and nodes of Ranvier that have direct relevance to connectivity alterations in those disorders. Some of these changes involve the expression of connexins supporting astrocyte-to-oligodendrocyte gap junctions, extracellular matrix components produced by astrocytes around nodes of Ranvier, specific types of astrocyte glutamate transporters, and neurotrophic factors secreted by astrocytes that are involved in the development and plasticity of myelin. Future studies should further examine the mechanisms responsible for those changes in white matter astrocytes, their putative contribution to pathological connectivity in affective disorders, and the possibility of leveraging that knowledge to design new therapies for psychiatric disorders.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"8 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9976698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10833203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Intranasal Oxytocin in Pediatric Populations: Exploring the Potential for Reducing Irritability and Modulating Neural Responses: A Mini Review. 鼻内催产素在儿科人群中的应用:探索减少易怒和调节神经反应的潜力:一个小型综述。

Journal of psychiatry and brain science Pub Date : 2023-01-01 Epub Date: 2023-08-31 DOI: 10.20900/jpbs.20230008

Kennet Sorenson, Emilee Kendall, Hannah Grell, Minjoo Kang, Christopher Shaffer, Soonjo Hwang

{"title":"Intranasal Oxytocin in Pediatric Populations: Exploring the Potential for Reducing Irritability and Modulating Neural Responses: A Mini Review.","authors":"Kennet Sorenson, Emilee Kendall, Hannah Grell, Minjoo Kang, Christopher Shaffer, Soonjo Hwang","doi":"10.20900/jpbs.20230008","DOIUrl":"10.20900/jpbs.20230008","url":null,"abstract":"Endogenous neuropeptide Oxytocin (OXT) plays a crucial role in modulating pro-social behavior and the neural response to social/emotional stimuli. Intranasal administration is the most common method of delivering OXT. Intranasal OXT has been implemented in clinical studies of various psychiatric disorders with mixed results, mainly related to lack of solid pharmacodynamics and pharmacokinetics model. Due to intranasal OXT's mechanism of reducing the activation of neural areas implicated in emotional responding and emotion regulation, a psychopathology with this target mechanism could be potentially excellent candidate for future clinical trial. In this regard, irritability in youth may be a very promising target for clinical studies of intranasal OXT. Here we provide a mini-review of fifteen randomized controlled trials in pediatric patients with diagnoses of autism spectrum disorder (ASD), Prader-Willi syndrome (PWS), or Phelan-McDermid syndrome (PMS). Most studies had small sample sizes and varying dosages, with changes in irritability, mainly as adverse events (AEs). Neuroimaging results showed modulation of the reward processing system and the neural areas implicated in social-emotional information processing by intranasal OXT administration. Further research is needed to determine the most effective dose and duration of OXT treatment, carefully select target psychopathologies, verify target engagement, and measure adverse event profiles.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67610256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Sleep on Neurocognition and Functioning in Schizophrenia—Is It Time to Wake-Up? 睡眠对精神分裂症患者神经认知和功能的影响——是时候醒来了吗？

Journal of psychiatry and brain science Pub Date : 2022-01-25 DOI: 10.20900/jpbs.20220001

D. Kimhy, L. Ospina, K. Beck-Felts, A. Fakhoury, A. Mullins, A. Varga

引用次数: 1

The Role of Sex in Genetic Association Studies of Depression. 性别在抑郁症遗传关联研究中的作用。

Journal of psychiatry and brain science Pub Date : 2022-01-01 DOI: 10.20900/jpbs.20220013

Karin F Hoth, Kirsten Voorhies, Ann Chen Wu, Christoph Lange, James B Potash, Sharon M Lutz

引用次数: 1

The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review. 生酮代谢治疗在严重精神疾病中对大脑的作用综述

Journal of psychiatry and brain science Pub Date : 2022-01-01 DOI: 10.20900/jpbs.20220009

Shebani Sethi, Judith M Ford

{"title":"The Role of Ketogenic Metabolic Therapy on the Brain in Serious Mental Illness: A Review.","authors":"Shebani Sethi, Judith M Ford","doi":"10.20900/jpbs.20220009","DOIUrl":"https://doi.org/10.20900/jpbs.20220009","url":null,"abstract":"In search of interventions targeting brain dysfunction and underlying cognitive impairment in schizophrenia, we look at the brain and beyond to the potential role of dysfunctional systemic metabolism on neural network instability and insulin resistance in serious mental illness. We note that disrupted insulin and cerebral glucose metabolism are seen even in medication-naïve first-episode schizophrenia, suggesting that people with schizophrenia are at risk for Type 2 diabetes and cardiovascular disease, resulting in a shortened life span. Although glucose is the brain’s default fuel, ketones are a more efficient fuel for the brain. We highlight evidence that a ketogenic diet can improve both the metabolic and neural stability profiles. Specifically, a ketogenic diet improves mitochondrial metabolism, neurotransmitter function, oxidative stress/inflammation, while also increasing neural network stability and cognitive function. To reverse the neurodegenerative process, increasing the brain’s access to ketone bodies may be needed. We describe evidence that metabolic, neuroprotective, and neurochemical benefits of a ketogenic diet potentially provide symptomatic relief to people with schizophrenia while also improving their cardiovascular or metabolic health. We review evidence for KD side effects and note that although high in fat it improves various cardiovascular and metabolic risk markers in overweight/obese individuals. We conclude by calling for controlled clinical trials to confirm or refute the findings from anecdotal and case reports to address the potential beneficial effects of the ketogenic diet in people with serious mental illness.","PeriodicalId":73912,"journal":{"name":"Journal of psychiatry and brain science","volume":"7 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10333688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4