临床前帕金森病与衰老的运动功能障碍的时空动力学。

Journal of psychiatry and brain science Pub Date : 2025-01-01 Epub Date: 2025-08-06 DOI:10.20900/jpbs.20250009
Navya Nair, Grace Hey, Alexander Becsey, Tara Kari, Xavier Becsey, Julia Root, Vinata Vedam-Mai
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引用次数: 0

摘要

步态评估已在几种帕金森病(PD)小鼠模型中进行,但M83+/- PD小鼠模型在此背景下的研究相对不足。采用外周注射α-syn预形成原纤维(PFF)的M83+/-小鼠和不注射原纤维的老年M83+/-小鼠,采用DigiGait™系统收集步态摆动、步幅、频率和共济失调指标。与年龄匹配的对照组相比,pff小鼠的四肢摆动明显减少(0.11±0.02比0.13±0.03,p = 0.007)。pff处理小鼠四肢步频显著增加(3.9±0.4比3.0±0.5,p = 0.010)。幼龄M83+/-+PFF小鼠后肢摆动明显大于老年M83+/-小鼠(0.11(0.5)比0.08 (0.3),p = 0.015)。年轻M83+/-+PFF小鼠前肢(1.1±1.0比0.6±0.5,p = 0.027)、后肢(0.9±1.0比0.3±0.2,p = 0.016)和所有肢体(1.0±1.0比0.3±0.5,p = 0.015)共济失调显著高于对照组。M83+/-小鼠表现出与PD特征一致的明显步态异常。本研究支持M83+/-小鼠模型在帕金森病临床前步态分析中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Temporal and Spatial Dynamics of Motor Dysfunction in Preclinical Parkinson's Disease and Aging.

Temporal and Spatial Dynamics of Motor Dysfunction in Preclinical Parkinson's Disease and Aging.

Temporal and Spatial Dynamics of Motor Dysfunction in Preclinical Parkinson's Disease and Aging.

Temporal and Spatial Dynamics of Motor Dysfunction in Preclinical Parkinson's Disease and Aging.

Gait assessments have been performed in several murine models of Parkinson's Disease (PD), but the M83+/- mouse model of PD has been relatively understudied in this context. Metrics of gait swing, stride length and frequency, and ataxia were collected in M83+/- mice with peripheral injections of α-syn preformed fibrils (PFF) and in aged M83+/- mice without fibrils using the DigiGait system. PFF-mice showed significantly decreased swing in all limbs (0.11 ± 0.02 vs. 0.13 ± 0.03, p = 0.007) compared to age-matched controls. Stride frequency was significantly increased in all limbs (3.9 ± 0.4 vs. 3.0 ± 0.5, p = 0.010) of PFF-treated mice. Swing was significantly greater in the hindlimbs of young M83+/-+PFF mice compared to aged M83+/- mice (0.11(0.5) vs. 0.08 (0.3), p = 0.015). Ataxia was significantly higher in young M83+/-+PFF mice compared to control for forelimbs (1.1 ± 1.0 vs. 0.6 ± 0.5, p = 0.027), hindlimbs (0.9 ± 1.0 vs. 0.3 ± 0.2, p = 0.016), and all limbs (1.0 ± 1.0 vs. 0.3 ± 0.5, p = 0.015). M83+/- mice demonstrate significant gait abnormalities consistent with features of PD. This study supports the utility of the M83+/- murine model for preclinical gait analyses in PD.

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