Journal of ocular diseases and therapeutics最新文献

{"title":"Internal Revision with Bleb Needling: An Effective, Safe Option for Failing Blebs","authors":"Kirti Singh, Neha Sachdev, Arshi Singh","doi":"10.12974/2309-6136.2023.10.02","DOIUrl":"https://doi.org/10.12974/2309-6136.2023.10.02","url":null,"abstract":"Aim: To report the outcomes of internal revision with bleb needling in cases of failing blebs with the internal sclerostomy blocked by iris tissue. Methods: Prospective study of 26 eyes of 26 patients with failing blebs where target IOP was not achieved with 2 anti-glaucoma drugs and sclerostomy was blocked by iris (confirmed on gonioscopy). Patients were divided into 3 groups depending on the time from the first surgery- early (<3 months), intermediate (4-12 months) and late (>1 year). Patients underwent internal revision with bleb needling with either 5-Fluorouracil (5-FU) or Mitomycin C (MMC) Results: 26 eyes of 26 patients were included in the study. Mean age was 51.35±14.5 years. Time from the filtration surgery was early in 3, intermediate in 5 and late in 18 eyes. Mean IOP reduction at 3 months was 32±18% with maximum reduction in early group (40%). Mean IOP decreased from 24.5±3.4 mmHg to 16.2±4.3 mmHg in 5-FU group (12 patients) and 27.4±9 mmHg to 18.2±6.6 mmHg in MMC group (14 patients). Self-limiting complications were hyphema in 2 patients and subconjunctival haemorrhage in 1 patient. Conclusion: Internal revision with bleb needling is a safe and effective procedure for reviving failing blebs.","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139239987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Opinion on Long-Lasting Therapy in CI-DME","authors":"A. Nowinska","doi":"10.12974/2309-6136.2023.10.01","DOIUrl":"https://doi.org/10.12974/2309-6136.2023.10.01","url":null,"abstract":"Diabetes has been recognized by the World Health Organization (WHO) as a noncommunicable, chronic disease and a 21st century epidemic. Diabetic retinopathy (DR) is one of the three leading causes of blindness among the working-age population aged 20 to 74 years. \u0000Diabetic macular edema (DME) is the most common cause of vision loss in diabetic patients, and the impact of DME on quality of life is very significant. Currently, first-line treatment recommendations for center-involved DME (CI-DME) include intravitreal anti-VEGF injections on a monthly or bimonthly regimen. It is essential to understand the burden that treatment regimens have on patients, as well as on healthcare systems. The most significant improvement to the regimen would be to have fewer injections and monitoring visits while maintaining satisfactory vision outcomes. A lower number of intravitreal injections could optimize disease outcomes by improving patient compliance. \u0000This article discusses novel agents targeting alternative pathways and mechanisms involved in the pathogenesis of DME, as well as high-dose drugs and novel approaches to treatment regimens aimed at extending treatment intervals, decreasing treatment burden, and increasing treatment efficacy. This knowledge will enhance the selection of treatments, thereby improving patient compliance with therapy and optimizing healthcare system resources.","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44942496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pressure Related Ocular Parameters in Caucasian Patients with Primary Open-Angle Glaucoma","authors":"Dimitrova Galina, Ljubic Antonela, Tojtovska Biljana, Tagasovska Keti, Tomasevic Urosh","doi":"10.12974/2309-6136.2021.09.2","DOIUrl":"https://doi.org/10.12974/2309-6136.2021.09.2","url":null,"abstract":"","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46200687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Ipsilateral, Focal-Simple Limbal Epithelial Transplantation for Large Primary Nasal Pterygia Treatment","authors":"S. Thatte, Y. Goyal","doi":"10.12974/2309-6136.2021.09.1","DOIUrl":"https://doi.org/10.12974/2309-6136.2021.09.1","url":null,"abstract":"Purpose: The long-term success of pterygium surgery is subject to treatment of the limbal stem cell defect. The purpose of this study is to present an alternative method to conjunctival autografting in patients with large pterygia and consequently a large limbal stem cell defect.\u0000Methods: 38 Patients with primary nasal pterygium of more than 5 mm limbal involvement were selected for the procedure. Simple limbal epithelial transplantation with human amniotic membrane graft placement over the bare sclera after pterygium excision was done. Patients were followed-up for a period of 12 months.\u0000Results: From post-operative day 7, patients had significant improvement in complaints and ocular surface morphology. We reported only one case of graft failure which was a consequence of patient’s non-compliance with post-operative medications and follow-up.\u0000Conclusion: Focal-simple limbal epithelial transplantation is an effective alternative to conjunctival limbal autografting in patients with large pterygia where preservation of virgin conjunctiva is prudent for future ocular surgeries. ","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41521928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Posterior Uveitis with Retinitis Revealing Primary Sjögren’s Syndrome","authors":"S. Bouomrani, Nesrine Regaïeg","doi":"10.12974/2309-6136.2018.06.04","DOIUrl":"https://doi.org/10.12974/2309-6136.2018.06.04","url":null,"abstract":"","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45861637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerance of Laser Panretinal Photocoagulation Treatment Under Topical Anaesthesia Using Slit Lamp Delivery vs Indirect Ophthalmoscope Laser Panretinal Photocoagulation Under Peribulbar Anaesthesia","authors":"S. Raman, Derriford Plymouth Pl Dh Uk Royal Eye Infirmary, M. Mitra, N. Evans, J. Jacob, P. Ewing","doi":"10.12974/2309-6136.2017.05.02","DOIUrl":"https://doi.org/10.12974/2309-6136.2017.05.02","url":null,"abstract":"","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48087532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Cationic Antimicrobial Protein CAP37 on Cytokine Profile during Corneal Wound Healing","authors":"A. Kasus‐Jacobi, Gina L. Griffith, M. Lerner, H. Pereira","doi":"10.12974/2309-6136.2017.05.04","DOIUrl":"https://doi.org/10.12974/2309-6136.2017.05.04","url":null,"abstract":"The cationic antimicrobial protein of 37 kDa (CAP37) mediates proliferation, migration, and adhesion of human corneal epithelial cells and promotes corneal re-epithelialization in mouse. The purpose of this study was to investigate the cytokine profile following abrasion of the corneal epithelium, and to identify the cytokines modulated by topical treatment with CAP37 to determine the mechanism by which CAP37 contributes to the recruitment of inflammatory cells and healing of the cornea. The corneal epithelium in mouse eyes was removed and wounds were treated with a saline vehicle or human recombinant CAP37. Wounds were visualized with fluoresce in staining at 0, 16, 24 and 48 h. Mouse corneas were excised at 0, 6, 16, 24 and 48 h post corneal abrasion. The excised corneas were analyzed by immunohistochemistry for re-epithelialization and infiltration of inflammatory cells while the expression profiles of thirty-two cytokines were investigated by multiplex analysis. Results corroborating previous studies showed accelerated wound closure in corneas treated with CAP37 compared to those treated with the saline vehicle. Immunohistochemistry revealed less neutrophil infiltration in CAP37-treated corneas when compared to controls at 24 h. By 48 h post-wounding, histological analysis revealed more staining for neutrophils than the staining observed in the controls. Modulation of cytokine expression occurred for the majority of the cytokines tested at the time of corneal abrasion, during re-epithelialization, and/or by CAP37 treatment. Cytokines monocyte chemoattractant protein-1 (MCP-1) and regulated on activation, normal T cell expressed and secreted (RANTES) were induced during re-epithelialization, at the early 16 h time point. Interleukin 6 (IL-6), leukemia inhibitory factor (LIF), granulocyte colony-stimulating factor (G-CSF), IL-12p70, macrophage inflammatory protein 1 beta (MIP-1β), and interferon gamma-induced protein 10 (IP-10) were induced at 24 h and unchanged during CAP37 treatment. By contrast, IL-15, monokine induced by gamma interferon (MIG), keratinocyte-derived cytokine (KC), tumor necrosis factor alpha (TNF-α), MIP-1α, IL-1β, and macrophage colony-stimulating factor (M-CSF) were modulated by CAP37 treatment. In general, CAP37 appeared to decrease pro-inflammatory cytokines at 24 h and increase them at 48 h when compared to the control group. These data demonstrate that CAP37 modulates the production of cytokines in the cornea and suggest that limiting the number of neutrophils recruited during the early inflammatory phase may support corneal re-epithelialization.","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":"5 1","pages":"19 - 27"},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42626846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy with Autologous Conjunctival Implant Associated with Phototherapeutic Keratectomy (PTK) in the Treatment of the Pterygium","authors":"P. Fiorini, A. Mularoni, L. Di Silvestre, L. Inferrera, P. Aragona, A. Meduri","doi":"10.12974/2309-6136.2017.05.03","DOIUrl":"https://doi.org/10.12974/2309-6136.2017.05.03","url":null,"abstract":"Purpose: To evaluate the efficacy of new formula of the PTK calculated with the head-limbus-distance (=height) and limbal base length of the pterygium and ablation thickness on the anterior corneal curvature and visual acuity, associated with autologous conjuntival implant in patients with primary (Group A)and secondary(Group B) pterygium.\u0000Setting: This study was developed in the Department of Ophthalmology, Maggiore Hospital of Bologna.\u0000Design: Prospective non randomized study was conducted in 18 eyes of 18 subjects (9 eyes primary and 9 eyes with recurrent pterygium) operated with a dedicated PTK program.\u0000Methods: All patients signed informed consent before the start of the research. BCVA (Best Corrected Visual Acuity), mean refractive error (ME) and topographic astigmatism and recurrence of pterygium was followed. Mean follow up was 18.67 ± 6.13 months Min: 12 Max: 24 months.\u0000Results: Mean post-operative BCVA increased at 3-24 months compared with pre-op BCVA (p= 0.003). Mean post-op BCVA improved independent of the optical zone involvement in the pre-op (p= 0.845).\u0000Mean Pre-op astigmatism (Group A): was: 0,97 ± 2,7 (MIN: -2,8 Max: +5). Mean pre-op Astigmatism (Group B) :-0,33 ± 1,98 (MIN: -3 Max:+4). Astigmatism reduction in the group A: 0 D; Group B: -0,1D ± 0,74D MIN: -1 Max: +1. No statistically difference at 24 months from two groups in BCVA (p=0,59), Sf ( P=0,7), ME(p=0,7), astigmatism ( p=0,96) ANOVA. Recurrence of pterygium was: 0%.\u0000Conclusions: The dedicated programme of PTK was shown to be safe and effective for the treatment of the pterygium. BCVA can be improved by providing a smooth corneal surface in cases of optical zone involvement. ","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43776856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Phosphate Buffered Saline on Corneal Chemical Alkali Burns","authors":"J. McDaniel, B. Wirostko, Cassie Sprague, A. Johnson, Gina L. Griffith","doi":"10.12974/2309-6136.2017.05.05","DOIUrl":"https://doi.org/10.12974/2309-6136.2017.05.05","url":null,"abstract":"Background: Treatments administered after a corneal burn injury can have long term implications on wound healing. Initial treatments can include the administration of lubricants, anti inflammatories, and antibiotic eye drops, many of which contain phosphate buffered saline (PBS) as a vehicle. As a result, the purpose of this study was to observe the effects of the commonly used PBS ophthalmic drop vehicle on corneal alkali burns over 30 days when treated 4X daily for the first 14 days.\u0000Materials and Methods: Corneal alkali burns 5.5 mm in diameter were created on 10 anesthetized, male New Zealand White rabbits Animals (5) with corneal wounds were treated with PBS 4X daily or left untreated (5). Control animals (5) were not wounded, but were treated with PBS drops 4X daily. Corneal alkali burns were created by centrally placing NaOH (1N) soaked filter paper onto the cornea for 30 seconds. After removal of the filter paper, the surface of the eye was immediately debrided with a Weck-Cel® sponge and irrigated with 15 ml of sterile buffered salt solution (BSS). At days 0, 3, 7, 14 and 30 post-chemical alkali burn creation, eyes were evaluated by white light imaging and fluorescein staining. On days 14 and 30, corneal thickness was assessed via optical coherence tomography (OCT).\u0000Results: A significant decrease in fluorescein staining indicating a significant increase in wound healing was observed on day 7 (P< 0.05) in the PBS treatment group when compared to the non-treated corneal alkali burns. A significant increase in fluorescein staining or decrease in wound healing was observed on day 30 (P< 0.0005) in the PBS treatment group when compared to non-treated corneal alkali burns. White light imaging and OCT results, respectively, showed no significant differences in corneal opacity or corneal swelling between treatment groups at any time point.\u0000Conclusions: This study suggests that the treatment of corneal alkali burns with ophthalmic solutions containing PBS may impact wound closure while having no significant effect on corneal opacity or corneal swelling.","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49181492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Results of Excimer Laser Surface Ablation with Smoothing for High Myopia","authors":"P. Vinciguerra, Ingrid Torres, Adriana Sergio, E. Legrottaglie, F. Camesasca","doi":"10.12974/2309-6136.2017.05.01","DOIUrl":"https://doi.org/10.12974/2309-6136.2017.05.01","url":null,"abstract":"Purpose: To evaluate long-term refractive, aberrometric and anatomical results of surface ablation plus corneal PTK-style smoothing for myopia greater than –7.00 D.\u0000Methods: One-hundred-and-fourteen eyes of 69 patients (mean age: 37.7 ± 8.3 years) underwent PRK with the NIDEK EC-5000 excimer laser (NIDEK Co. Ltd., Gamagori, Japan) using multiple optical zones ranging in diameter from 4.89 mm to 7.0 mm, and transition zones (TZ) that were at least 3 mm wider than the optical zones (OZ). A cross-cylinder technique was used for treating astigmatism greater than 0.50 D. All eyes underwent a phototherapeutic keratectomy (PTK) smoothing technique using masking fluid. The Student’s t-test was used to determine a statistically significant change after surgery. A p value less than 0.05 was considered statistically significant.\u0000Results: Preoperative corrected distance visual acuity (CDVA) was 0.88 ± 0.16 with –9.53 ± 1.18 D cycloplegic spherical equivalent (SE). Preoperative corneal pachymetry was 560.4 ± 30.1 µ. Three years after surgery uncorrected visual acuity (UCVA) was 0.79 ± 0.26, CDVA was 0.92 ± 0.19 with –0.56 ± 0.90 D SE. Mean corneal haze was highest 1 month after surgery (0.58 ± 0.35), then progressively decreased to 0.11 ± 0.32 by 3 months postoperatively. Following year one, refraction and corneal curvature remained stable. There were no cases of keractasia to date. There was no hyperopic induction due to PTK. Two eyes required retreatment due to undercorrection. Total wavefront error did not change significantly, while astigmatism decreased and coma increased (both with p< 0.001).\u0000Conclusion: Surface ablation for the treatment of high myopia using PTK smoothing with a masking fluid was safe and effective. Wide optical and transition zones prevented induction of spherical aberration and the incorporation of the smoothing technique created a regular corneal surface with regular healing and trace to no haze after surgery.","PeriodicalId":73874,"journal":{"name":"Journal of ocular diseases and therapeutics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48375621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}