Journal of mother and child最新文献_第3页

Surgical Treatment of Lip Pits in Van der Woude Syndrome: A Preliminary Retrospective Study of 24 Patients. 范德乌德综合征唇凹陷的手术治疗：24 例患者的初步回顾性研究

Journal of mother and child Pub Date : 2024-06-26 eCollection Date: 2024-02-01 DOI: 10.34763/jmotherandchild.20242801.d-24-00020

Łukasz Wieprzowski, Zbigniew Surowiec, Ewa Sawicka, Andrzej Brudnicki

{"title":"Surgical Treatment of Lip Pits in Van der Woude Syndrome: A Preliminary Retrospective Study of 24 Patients.","authors":"Łukasz Wieprzowski, Zbigniew Surowiec, Ewa Sawicka, Andrzej Brudnicki","doi":"10.34763/jmotherandchild.20242801.d-24-00020","DOIUrl":"10.34763/jmotherandchild.20242801.d-24-00020","url":null,"abstract":"Background: Van der Woude syndrome (VWS) is a rare congenital malformation characterized by lower lip pits among patients with a lip and/or palate cleft. It is transmitted by an autosomal dominant inheritance with variable expressivity.Methods: The study group consisted of 24 consecutive patients (13 males and 11 females) with VWS operated on at a single center between 2009 and 2022. They suffered from: bilateral cleft lip and palate - 6 patients; unilateral cleft lip and palate - 9 patients; cleft lip - 1 patient; and isolated cleft palate - 8 patients.Results: In 16 (66%) cases pits of lower lip occurred on both side of midline, while in 8 (34%) the pits were detected unilaterally. The primary cleft repairs were performed according to one-stage principle at the mean age of 8.6 months (SD 1.4, range 6-12). In all patients lower lip pits repairs were performed after the primary cleft repairs as a separate procedure at the mean age of 37 months (SD 11.3 range 14-85). The mean number of all primary repairs of the syndrome-both cleft defect and lower lip pits repairs-was 2.46. Nine patients (37.5%) required additional secondary corrections of the lower lip due to the poor aesthetic post-operative outcome.Conclusions: The frequent need for secondary corrections of residual lower lip deformities indicates the considerable difficulties in obtaining a satisfactory outcome of the repairs to lip pits caused by VWS. The average number of the primary surgical interventions in evaluated material remained low.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"28 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of a Pharmacy Developed, Outpatient Lactation Consultant Initiated Domperidone Programme. 分析由药房开发、由门诊哺乳顾问发起的多潘立酮计划。

Journal of mother and child Pub Date : 2024-04-19 eCollection Date: 2024-02-01 DOI: 10.34763/jmotherandchild.20242801.d-23-00093

Katherine Chinnery, Stephanie Wai Khuan Teoh, Tamara Lebedevs, Myra Kildunne, Nabeelah Mukadam

{"title":"Analysis of a Pharmacy Developed, Outpatient Lactation Consultant Initiated Domperidone Programme.","authors":"Katherine Chinnery, Stephanie Wai Khuan Teoh, Tamara Lebedevs, Myra Kildunne, Nabeelah Mukadam","doi":"10.34763/jmotherandchild.20242801.d-23-00093","DOIUrl":"10.34763/jmotherandchild.20242801.d-23-00093","url":null,"abstract":"Background: Domperidone is a commonly prescribed galactagogue used off-label for lactation insufficiency. Prescriber unfamiliarity or safety concerns can lead to therapeutic delay and potential early breastfeeding discontinuation. To facilitate access, the study site pharmacy department developed a Structured Administration and Supply Arrangement (SASA) for International Board-Certified Lactation Consultants (IBCLC) to screen and initiate domperidone using a checklist.Material: To validate a domperidone screening tool via analysis of its use and compliance, together with a staff satisfaction survey.Methods: Records were extracted from the REDCap® database for women with documented domperidone supply between 06/05/2022 and 27/01/2023 and reviewed with medical records. A staff survey was distributed assessing compliance and attitudes towards the SASA.Results: Records of supply revealed that 34% (17/50) of patients were referred to a physician, revealing a discrepancy between database documentation and checklists, as no referrals were documented. Overall staff satisfaction with the SASA was rated 4.6 out of 5. 77.7% (7/9) felt confident counselling and supplying domperidone with the SASA in place. 88.9% (8/9) felt confident using the checklist to identify the appropriateness of therapy and referral to a physician.Conclusions: The system in place allows the IBCLCs to initiate and supply domperidone in a timely manner to breastfeeding mothers with lactation insufficiency. The support tools, including domperidone SASA, REDCap® documentation database and the checklist domperidone as a Galactagogue Checklist, can be greatly appreciated by the LCs. Continued discussion with IBCLCs to refine and improve the SASA and associated education package will result in more consistent compliance.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"28 1","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Biochemical Bone Turnover Markers in Polish Healthy Children and Adolescents. 评估波兰健康儿童和青少年的生化骨转换标志物

Journal of mother and child Pub Date : 2024-04-19 eCollection Date: 2024-02-01 DOI: 10.34763/jmotherandchild.20242801.d-23-00105

Joanna Gajewska, Magdalena Chełchowska, Grażyna Rowicka, Witold Klemarczyk, Ewa Głąb-Jabłońska, Jadwiga Ambroszkiewicz

{"title":"Assessment of Biochemical Bone Turnover Markers in Polish Healthy Children and Adolescents.","authors":"Joanna Gajewska, Magdalena Chełchowska, Grażyna Rowicka, Witold Klemarczyk, Ewa Głąb-Jabłońska, Jadwiga Ambroszkiewicz","doi":"10.34763/jmotherandchild.20242801.d-23-00105","DOIUrl":"10.34763/jmotherandchild.20242801.d-23-00105","url":null,"abstract":"Background: Assessing bone turnover in paediatric populations is crucial for understanding the physiological changes occurring during skeletal development and identifying potential abnormalities. The objective of this study was to assess osteocalcin (OC), bone alkaline phosphatase (BALP), and C-terminal telopeptide of type I collagen (CTX-I) levels reflecting bone formation and resorption for age and sex in Polish healthy children and adolescents.Materials and methods: A total of 355 healthy normal-weight children and adolescents (46.5% girls) aged 1-18 years old were recruited. Total body less head (TBLH) and spine L1-L4 were used in children to assess bone mineral density (BMD) by dual-energy X-ray absorptiometry (DXA). Bone marker concentrations were determined by immunoenzymatic methods.Results: Bone marker levels in girls and boys started with higher values in the first year of life and subsequently decreased until reaching a nadir during the prepubertal period. The pubertal peak values of bone markers were reached at 11-13 years old in boys and at 9-11 years old in girls. After puberty, the adolescents showed a gradual decline in bone marker concentrations to the values observed in adults. We found positive correlations between OC level and TBLH-BMD (r = 0.329, p = 0.002), TBLH-BMD Z-score (r = 0.245, p = 0.023), and L1-L4 BMD (r = 0.280, p = 0.009) in the prepubertal group.Conclusions: We showed serum levels of bone turnover markers-BALP, OC, and CTX-I-in relation to age and sex in healthy Polish children and adolescents. The age intervals of these markers for girls and boys aged 1-18 years old may be clinically useful in the assessment of bone metabolism in individuals with skeletal disorders.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"28 1","pages":"14-22"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review. 通过近红外光谱（NIRS）测量缺氧缺血性脑病新生儿治疗性低温期间的大脑 rScO2：系统综述。

Journal of mother and child Pub Date : 2024-04-19 eCollection Date: 2024-02-01 DOI: 10.34763/jmotherandchild.20242801.d-24-00010

Sergio Agudelo-Pérez, Gloria Troncoso, Alejandra Roa, Ana Gabriela Ariza, Georgina Doumat, Natalia M Reinoso, Daniel Botero-Rosas

{"title":"Cerebral rScO2 Measured by Near-Infrared Spectroscopy (NIRS) During Therapeutic Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy: A Systematic Review.","authors":"Sergio Agudelo-Pérez, Gloria Troncoso, Alejandra Roa, Ana Gabriela Ariza, Georgina Doumat, Natalia M Reinoso, Daniel Botero-Rosas","doi":"10.34763/jmotherandchild.20242801.d-24-00010","DOIUrl":"10.34763/jmotherandchild.20242801.d-24-00010","url":null,"abstract":"Introduction: Perinatal asphyxia, a leading cause of neonatal mortality and neurological sequelae, necessitates early detection of pathophysiological neurologic changes during hypoxic-ischaemic encephalopathy (HIE). This study aimed to review published data on rScO2 monitoring during hypothermia treatment in neonates with perinatal asphyxia to predict short- and long-term neurological injury.Methods: A systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Study identification was performed through a search between November and December 2021 in the electronic databases PubMed, Embase, Lilacs, Scopus, Web of Science, and Cochrane Central Register of Controlled Trials (CENTRAL). The main outcome was short-term (Changes in brain magnetic resonating imaging) and long-term (In neurodevelopment) neurological injury. The study protocol was registered in PROSPERO (International Prospective Register of Systematic Reviews) with CRD42023395438.Results: 380 articles were collected from databases in the initial search. Finally, 15 articles were selected for extraction and analysis of the information. An increase in rScO2 measured by NIRS (Near-infrared spectroscopy) at different moments of treatment predicts neurological injury. However, there exists a wide variability in the methods and outcomes of the studies.Conclusion: High rScO2 values were found to predict negative outcomes, with substantial discord among studies. NIRS is proposed as a real-time bedside tool for predicting brain injury in neonates with moderate to severe HIE.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"28 1","pages":"33-44"},"PeriodicalIF":0.0,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11027033/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140863810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition of Newborns with Hypoxic-Ischaemic Encephalopathy during Therapeutic Hypothermia - A Survey of Practice in Polish Neonatal Care Units. 治疗性低温时缺氧缺血性脑病新生儿的营养--波兰新生儿护理病房实践调查。

Journal of mother and child Pub Date : 2024-03-05 eCollection Date: 2024-02-01 DOI: 10.34763/jmotherandchild.20242801.d-23-00115

Aleksandra Warchoł, Przemko Kwinta

{"title":"Nutrition of Newborns with Hypoxic-Ischaemic Encephalopathy during Therapeutic Hypothermia - A Survey of Practice in Polish Neonatal Care Units.","authors":"Aleksandra Warchoł, Przemko Kwinta","doi":"10.34763/jmotherandchild.20242801.d-23-00115","DOIUrl":"10.34763/jmotherandchild.20242801.d-23-00115","url":null,"abstract":"Background: The nutritional practice for newborns with hypoxic-ischaemic encephalopathy during therapeutic hypothermia differs among Polish neonatal care units, as no guidelines are provided. We assessed the prevailing procedures.Material and methods: Data was collected through an anonymous, web-based questionnaire. We surveyed aspects of the current nutritional practices and the reasoning behind the choice of the feeding strategy.Results: Thirty-one responses were obtained (31/33, 94%). Based on participants' estimations, 342 newborns are diagnosed with hypoxic-ischaemic encephalopathy and qualified for therapeutic hypothermia annually. Among them, almost ⅓ is fed exclusively parenterally, while 71% both ways-parenterally and enterally. In the vast majority of units, the introduction of enteral nutrition takes place during the first 48 hours of therapeutic hypothermia, and breast milk is primarily provided, although with substantial first feeding volume differentiation (an average of 2,9 ml/kg (0,3 - 10ml/kg)). Adverse events, such as necrotising enterocolitis, sepsis, and glycemia level disturbances that derive from the initiation of enteral nutrition, are difficult to estimate as no official statistics are provided.Conclusions: The majority of newborns after hypoxic-ischaemic encephalopathy treated with therapeutic hypothermia are fed both parenterally and enterally during the procedure, predominantly with expressed or donor breast milk. However, due to the lack of nutritional guidelines, significant variability of nutritional strategies concerning initiation time, type and volume of enteral feeds given is noted. Therefore, further studies are required to clarify feeding recommendations.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"28 1","pages":"8-13"},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10911959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bolus Feeding Via Gastric Versus Oral Routes in Very Preterm Neonates. 极早产新生儿经胃与经口途径的给药方式

Journal of mother and child Pub Date : 2024-02-27 eCollection Date: 2024-02-01 DOI: 10.34763/jmotherandchild.20242801.d-23-00060

Rita P Verma, Deepank Sahni, Joshua Fogel

{"title":"Bolus Feeding Via Gastric Versus Oral Routes in Very Preterm Neonates.","authors":"Rita P Verma, Deepank Sahni, Joshua Fogel","doi":"10.34763/jmotherandchild.20242801.d-23-00060","DOIUrl":"10.34763/jmotherandchild.20242801.d-23-00060","url":null,"abstract":"Background: We intend to investigate the association of bolus orogastric tube (BOG) and nipple bottle (N) feedings with postnatal growth in very premature neonates (VPN: gestational age between 28 and 33 weeks).Material and methods: The days of life (DOL) to achieve full combined oral and gastric enteral nutrition (FEN) and attain body weight (BW) of 2200 g (Wt22) and the length of hospitalization (LOH) were retrospectively associated with clinical and BOG and N feeding-related variables via multivariate regression analyses. Correlations were performed to ascertain the strength of associations.Results: In a cohort of 127 VPN, FEN demonstrated negative associations with gestational age (GA) and LOH and Wt22 with birth weight (BW). FEN showed positive associations with nil by mouth and intravenous fluid-nutrition days and with DOL to start and achieve full nipple feeding. LOH was associated with days on antibiotics and DOL to start and achieve full nipple feeding. Wt22 was associated with DOL to achieve full nipple feeding. The start day of BOG feeding had no independent associations and weak, highly significant positive correlations with Wt22, LOH, and FEN.Conclusion: Bolus orogastric tube feeding has no independent implications for postnatal growth, duration of hospitalization, or chronological age to attain full enteral nutrition in VPN unless combined with nipple feeding to provide enteral nutrition. Oral bottle feeding accelerates postnatal catch-up growth and full enteral nutrition acquisition while reducing hospitalization duration. Initiating nipple feeding at 32 weeks of postmenstrual age may be safe in stable VPN. Antibiotic therapy increases hospitalization duration.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"28 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10898621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139974860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Position Statement of the Polish Academy of Sciences' Committee of Human Nutrition Science on the Principles for the Nutrition of Preschool Children (4-6 Years of Age) and Early School-Age Children (7-9 Years of Age). 波兰科学院人类营养科学委员会关于学龄前儿童（4-6 岁）和学龄早期儿童（7-9 岁）营养原则的立场声明。

Journal of mother and child Pub Date : 2023-12-31 eCollection Date: 2023-06-01 DOI: 10.34763/jmotherandchild.20232701.d-23-00094

Halina Weker, Mariola Friedrich, Katarzyna Zabłocka-Słowińska, Joanna Sadowska, Anna Długosz, Jadwiga Hamułka, Jadwiga Charzewska, Piotr Socha, Lidia Wądołowska

引用次数: 0

The Mental Health Implications of Obstetric Brachial Plexus Injuries (OBPI) on Parents. 产科臂丛神经损伤对父母心理健康的影响。

Journal of mother and child Pub Date : 2023-11-22 eCollection Date: 2023-06-01 DOI: 10.34763/jmotherandchild.20232701.d-23-00024

Catherine Miller, Karan Dua, Nathan N O'Hara, Catherine C May, Joshua M Abzug

{"title":"The Mental Health Implications of Obstetric Brachial Plexus Injuries (OBPI) on Parents.","authors":"Catherine Miller, Karan Dua, Nathan N O'Hara, Catherine C May, Joshua M Abzug","doi":"10.34763/jmotherandchild.20232701.d-23-00024","DOIUrl":"10.34763/jmotherandchild.20232701.d-23-00024","url":null,"abstract":"Background: Obstetric brachial plexus injuries (OBPI) can have mental health implications on parents coping with this injury to their newborn. The purpose of this study was to assess the mental health of mothers with newborns with an OBPI and identify resources that can help screen and treat mental health needs.Material and methods: Three groups of mothers were prospectively given a self-reported survey: 1) Newborns with OBPI; 2) Newborns in the nursery without OBPI; 3) Newborns in the neonatal intensive care unit (NICU). The survey consisted of demographic questions, the PHQ-9 and PCL-S screening tools, and parents' exposure to community violence, family support and use of drugs or alcohol.Results: Fifty-seven mothers were prospectively enrolled, and 30% (17/57) of mothers screened in for post-traumatic stress disorder (PTSD). OBPI mothers had significantly higher rates of PTSD symptoms when compared to mothers of children in the full-term nursery (difference = 36.4%; p < 0.01). No statistically significant difference was found between groups regarding depression symptoms.Conclusions: OBPI can be very difficult to cope with for parents and family members. Forty-two percent of mothers with newborns with OBPI or children in the NICU screened in for PTSD symptoms. OBPI clinics should be staffed similarly to the NICU with clinical social workers to appropriately screen and treat parents with PTSD and depression symptoms.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"27 1","pages":"217-221"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Fibrin Glue in the Treatment of Persistent Pneumothorax in Premature Infants at the Limit of Viability: Ethical Issues and Two and A Half Years Follow-Up. 使用纤维蛋白胶治疗生存极限早产儿持续性气胸:伦理问题和两年半随访。

Journal of mother and child Pub Date : 2023-11-22 eCollection Date: 2023-06-01 DOI: 10.34763/jmotherandchild.20232701.d-23-00061

Magdalena Rutkowska, Martyna Woynarowska, Iwona Terczyńska, Małgorzata Seroczyńska, Dariusz Mydlak, Jarosław Mądzik, Ewa Nowakowska, Katarzyna Niepokój, Sławomir Szczepaniak, Krystyna Polak

{"title":"Use of Fibrin Glue in the Treatment of Persistent Pneumothorax in Premature Infants at the Limit of Viability: Ethical Issues and Two and A Half Years Follow-Up.","authors":"Magdalena Rutkowska, Martyna Woynarowska, Iwona Terczyńska, Małgorzata Seroczyńska, Dariusz Mydlak, Jarosław Mądzik, Ewa Nowakowska, Katarzyna Niepokój, Sławomir Szczepaniak, Krystyna Polak","doi":"10.34763/jmotherandchild.20232701.d-23-00061","DOIUrl":"10.34763/jmotherandchild.20232701.d-23-00061","url":null,"abstract":"Introduction: Due to the extreme immaturity of many internal organs, including lungs, infants at the limit of viability are more predisposed to a pneumothorax (PTX). In some cases, PTX becomes persistent. Previously, only a few attempts of PTX treatment with fibrin glue were reported. However, its impact on further lung development is unknown.Case report: We present a case of an extremely preterm infant with persistent PTX who was successfully treated with fibrin glue. In addition, we present a two-and-a-half-year corrected age follow-up focusing on respiratory problems, motor development and sensory organs. Furthermore, we touch upon the related ethical issues.Conclusions: Fibrin glue should be used to treat persistent PTX even in an extremely preterm infant. No adverse effects were observed. At the two-and-a-half-year corrected age follow-up, despite severe bronchopulmonary dysplasia development, no serious pulmonary problems were observed. However, the child's development is uncertain. This situation raises important ethical issues concerning saving the lives of infants at the limit of viability.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"27 1","pages":"190-197"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664837/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced Endothelial Progenitor Cells: A Possible Biomarker for Idiopathic Fetal Growth Restriction in Human Pregnancies. 内皮祖细胞减少:人类妊娠中特发性胎儿生长限制的可能生物标志物。

Journal of mother and child Pub Date : 2023-11-22 eCollection Date: 2023-06-01 DOI: 10.34763/jmotherandchild.20232701.d-23-00014

Apurva Singh, Shyam Pyari Jaiswar, Apala Priyadarshini, Sujata Deo

{"title":"Reduced Endothelial Progenitor Cells: A Possible Biomarker for Idiopathic Fetal Growth Restriction in Human Pregnancies.","authors":"Apurva Singh, Shyam Pyari Jaiswar, Apala Priyadarshini, Sujata Deo","doi":"10.34763/jmotherandchild.20232701.d-23-00014","DOIUrl":"10.34763/jmotherandchild.20232701.d-23-00014","url":null,"abstract":"Background: Circulating endothelial progenitor cells (EPCs) may be necessary throughout pregnancy by ensuring proper placentation and embryonic growth. The lack of standardized EPC quantification techniques has prevented conclusive proof of an increase in EPC during pregnancy.Objectives: The purpose of this study was to determine whether EPC levels change for healthy and idiopathic fetal growth restriction (FGR) pregnancies.Materials and methods: The study population consisted of 48 healthy pregnant females with no previous history of IUGR (10 in the first trimester, 15 in the second, and 23 in the third), 48 women with pregnancy complicated by idiopathic FGR, and 15 non-pregnant women. By using flow cytometry, EPCs in maternal blood were recognized as CD45dim/CD34/KDR cells. ELISA was used to measure plasmatic cytokines.Results: We ascertained a progressive rise in EPCs in healthy pregnancies that was apparent in the first but more pronounced in the third trimester. At comparable gestational ages, FGR-complicated pregnancies had impaired EPC growth. Placental growth factor and stromal-derived factor-1 levels in the blood were significantly lower in FGR than in healthy pregnancies, which may have contributed to the degradation of the EPCs.Conclusion: The count in EPCs might hold considerable promise toward developing a peculiar authentication marker for observing pregnancies, and could be the focus of cutting-edge tactics for the prognosis and treatment of FGR pregnancies.","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"27 1","pages":"182-189"},"PeriodicalIF":0.0,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138296732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0