Journal of mother and child最新文献

{"title":"ReNU Syndrome and the RNU4-2 Mutation: A Missed Cause of Childhood Neurodevelopmental Delay.","authors":"Jawairya Muhammad Hussain, Laiba Ilyas, Areeba Amir, Muhammad Azlan","doi":"10.34763/jmotherandchild.20263001.d-26-00014","DOIUrl":"10.34763/jmotherandchild.20263001.d-26-00014","url":null,"abstract":"<p><p>ReNU syndrome is a rare but increasingly recognized syndromic neurodevelopmental disorder caused by heterozygous de novo variants in the non-coding gene RNU4-2, which encodes the U4 small nuclear RNA (snRNA), a critical component of the major spliceosome. Recurrent pathogenic variants cluster within an 18-base-pair critical region of RNU4-2 and disrupt normal spliceosome function by altering 5' splice-site usage. In large cohorts, most affected individuals harbor a recurrent single-base insertion (n.64_65insT), accounting for the majority of pathogenic variants, and RNU4-2 variants may explain ~0.4% of undiagnosed neurodevelopmental disorders. Clinically, ReNU syndrome is characterized by global developmental delay, intellectual disability, hypotonia, delayed motor milestones, limited speech, feeding difficulties, distinctive facial features, and structural brain anomalies. Given the emerging understanding of its prevalence and severe phenotype, we highlight the urgent need to incorporate RNU4-2 analysis into diagnostic genomic testing for pediatric neurodevelopmental disorders. Increasing awareness and equitable access to comprehensive genetic testing will improve diagnosis and counseling for affected families worldwide.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"102-105"},"PeriodicalIF":0.0,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Awareness of Genetic Risks among Pregnant Mothers in Consanguineous Marriages: A Cross-Sectional Study in Government Healthcare Settings.","authors":"Saim Mahmood Khan, Jawairiya Muhammad Hussain, Laiba Bukhari, Mahnoor Khan, Zarnab Saleem, Aroobah Jawwad, Mahnoor Sheikh, Fizzah Iftikhar, Surraiya Riaz Mahmood Khan","doi":"10.34763/jmotherandchild.20263001.d-26-00013","DOIUrl":"10.34763/jmotherandchild.20263001.d-26-00013","url":null,"abstract":"<p><strong>Background: </strong>Consanguineous-marriages are highly prevalent among the Pakistani population, leading to an increased risk of genetic disorders in offspring. However, awareness of these genetic risks remains low, which delays diagnosis and contributes to poor health outcomes. This study's objective is to assess awareness of the genetic risks of consanguineous marriage and examine its effects on pregnancy outcomes.</p><p><strong>Materials and methods: </strong>A descriptive cross-sectional-study was conducted among 365 pregnant women attending antenatal clinics in Peshawar. Data were collected using a self-structured questionnaire. Sample size was calculated using an estimated prevalence of 36% from prior NCBI-indexed studies. Participants were selected through systematic random sampling, including women in consanguineous marriages who consented to participate. Data were analyzed using descriptive statistics and Chi-square test, with p ≤ 0.05 considered statistically significant.</p><p><strong>Results: </strong>Among 365 pregnant women, 41.0% had low awareness of genetic risks, 29.3% had no knowledge, and only 10.6% demonstrated good understanding of consanguineous marriage. Genetic screening was reported by 20.4%. Higher awareness was associated with older age, higher education, and prior screening. Family history of genetic disorders was significantly associated with age (p = 0.003), education (p = 0.010), duration of marriage (p = 0.003), awareness (p = 0.004), prior screening (p < 0.001), and consanguinity (p = 0.011). It was strongly linked to adverse pregnancy outcomes, including miscarriages, stillbirth, and developmental delay (p < 0.001).</p><p><strong>Conclusion: </strong>Awareness of genetic risks in consanguineous marriages is low among pregnant women in this setting. Improving education and genetic counseling during antenatal care could help increase understanding and screening.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"2026-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148240752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomised Controlled Trial of Elective Induction of Labour at 40 and 41 Weeks to Prevent Prolonged Pregnancy.","authors":"Oluwadare Martins Ipinnimo, Olusola Peter Aduloju, Pius Idowu Ade-Ojo, Tope Michael Ipinnimo, Adeyemi Sunday Adefisan, Oluseyi Igbekele Ipinnimo, Babatunde Ajayi Olofinbiyi, Oluwamuyiwa Temitope Fagbohun, Benedict Tolulope Adeyanju, Adewale Temitope Adeyiolu","doi":"10.34763/jmotherandchild.20263001.d-25-00024","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00024","url":null,"abstract":"<p><strong>Background: </strong>There have been discussions as to the time of elective induction of labour to curb the continuation of pregnancy that might endanger the lives of both the mother and child. This research was conducted to assess foetal and maternal consequences of planned delivery at 40 and 41weeks in women with low-risk singleton pregnancy.</p><p><strong>Material and methods: </strong>A randomised controlled trial with equal allocation of participants (96 pregnant women in each arm) into 40weeks and 41weeks. Participants were randomised at the antenatal clinic at 39 weeks for induction of labour. The main outcome was the caesarean section rate. Secondary outcomes were maternal (genital tract laceration rate) and foetal (rates of meconium staining of amniotic fluid, SCBU admission, perinatal mortality, birth trauma, birth weight, and neonatal APGAR score at 1 and 5 minutes). Student t-test and chi-square test were used for inter-group comparison.</p><p><strong>Results: </strong>Incidence of caesarean delivery (26.6% vs. 21.3%; p=0.406), and genital laceration (2.1% vs. 5.6%; p=0.268) did not differ between groups. Significantly higher birth weight was noted among women induced at 41weeks (3.41 ± 0.37kg) than 40weeks (3.28 ± 0.46kg) (p=0.043). Also, there was significant variation in meconium staining of amniotic fluid between 40weeks (11.7%) and 41weeks (25.8%) (p=0.014). Other foetal outcomes showed no significant difference.</p><p><strong>Conclusion: </strong>Inducing labour at 40weeks is safe for low-risk women as it does not significantly increase the cesarean delivery rate and adverse perinatal outcomes. Therefore, elective induction of labour at 40weeks should be recommended and introduced into obstetric practice without the fear of adverse outcomes.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"72-80"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Validation of a Clinical Risk Score for Predicting Postpartum Hemorrhage in Women with Antepartum Hemorrhage.","authors":"Swati Asati, Pranshi Asati, Anubhav Gupta, Meenakshi Gothwal","doi":"10.34763/jmotherandchild.20263001.d-25-00041","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00041","url":null,"abstract":"<p><strong>Background: </strong>Postpartum hemorrhage (PPH) remains a leading cause of maternal morbidity and mortality globally, particularly in women with antepartum hemorrhage (APH). Current risk assessment methods lack standardized predictive tools that are both simple and reliable for clinical application.</p><p><strong>Material and methods: </strong>We conducted a secondary analysis of a prospectively collected cohort of 100 pregnant women presenting with APH at ≥28 weeks' gestation at a tertiary care centre in northern India. Multivariable logistic regression was used to identify significant predictors of PPH. A point-based clinical risk score was then developed based on the multivariable model and internally validated using bootstrap techniques with 1000 replicates.</p><p><strong>Results: </strong>PPH occurred in 30% of patients (n=30). Multivariable analysis identified four independent predictors of PPH: maternal age (adjusted odds ratio [OR] 1.29 per year; 95% confidence interval [CI] 1.10-1.51; p=0.002), gravidity (OR 2.11 per unit; 95% CI 1.00-4.43; p=0.049), gestational age at delivery (OR 0.64 per week; 95% CI 0.44-0.94; p=0.021), and antepartum blood transfusion (OR 2.44; 95% CI 1.02-5.84; p=0.045). The prediction model demonstrated excellent discrimination with an area under the receiver operating characteristic (ROC) curve of 0.86 (95% CI 0.80-0.92) and good calibration (slope 0.95). Bootstrap internal validation yielded an optimism-corrected AUC of 0.84. The resulting four-factor risk score stratified patients into four risk categories with PPH rates ranging from 4% (low risk) to 100% (very high risk).</p><p><strong>Conclusion: </strong>The four-variable score provides an accurate, easily applicable tool with excellent predictive performance. The score is a promising tool that, pending external validation, may facilitate early identification of high-risk patients and improve maternal outcomes. Further research should focus on external validation of this tool in diverse populations and its integration into clinical practice.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"81-92"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Management of a Huge Pulmonary Hydatid Cyst in a Young Child: A Case Report.","authors":"Manel Kammoun, Saloua Ammar, Hela Fendri, Hayet Zitouni, Riadh Mhiri, Anouar Jarraya","doi":"10.34763/jmotherandchild.20263001.d-26-00005","DOIUrl":"10.34763/jmotherandchild.20263001.d-26-00005","url":null,"abstract":"<p><p>Hydatid cyst disease is a parasitic disease induced by Echinococcus granulosus, which is still endemic in northern African countries. We report the case of a late-discovered pulmonary hydatid cyst in a four-year-old boy revealed by recent dyspnoea. The chest X-ray showed a complete white-out of the left hemithorax with mediastinal deviation, and the thoracoabdominal CT scan showed a giant pulmonary hydatid cyst encompassing the entire left lung associated with a hepatic cyst. An emergent superior pulmonary lobe resection was performed under deep general anaesthesia and selective intubation to prevent contralateral lung inundation. The evolution was favourable postoperatively.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"67-71"},"PeriodicalIF":0.0,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Markers, Including hsCRP, TGFβ 1, IL-6, and T-regs, and their Predictive Value as Early Warning Signs for Preeclampsia: Insights from a Tertiary Care Medical Centre in Eastern India.","authors":"Prakruti Dash, Bharath Kumar Koppisetty, Saubhagya Kumar Jena, Saurav Nayak","doi":"10.34763/jmotherandchild.20263001.d-25-00031","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00031","url":null,"abstract":"<p><strong>Background: </strong>Regulatory T cells (T-regs), a subset of CD4+ T-lymphocytes play a crucial role in the maintenance of immunological tolerance and immune homeostasis. The study has been done to evaluate the threshold values and reference intervals of Regulatory T cells, TGF-β1, IL-6, and hsCRP as a comprehensive panel for preeclampsia.</p><p><strong>Materials and methods: </strong>In this cross-sectional study the T-regulatory cells (CD4, CD25, FOXP3) were assessed using a flow-cytometer, and TGF-β1, and IL-6 were analysed by sandwich ELISA method and hsCRP analysed by Beckman Coulter autoanalyser.</p><p><strong>Statistical analysis: </strong>The reference range for the parameters in the studied groups was estimated based on CLSI C28-A3 guidelines. The lower and upper limits were estimated by a non-parametric method with 90% CI. Threshold values were estimated from the ROC curve based on optimal sensitivity and specificity measured by the Youden Index.</p><p><strong>Results: </strong>The study established a threshold value level for CD3+CD4+T-cells, CD4+CD25+T-regs, and CD4+FOXP3+ T-regs to separate individuals with preeclampsia from those without the condition. The threshold values for TGF-β1, IL-6, and hsCRP were chosen as they demonstrated significant differences between the two groups, indicating an association with the presence of preeclampsia.</p><p><strong>Conclusion: </strong>The statistical analysis of the study population aimed to establish a clear difference between the two groups, thereby providing a dependable foundation to differentiate impending preeclampsia from a normal pregnancy in order to assist in theranostics.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"58-66"},"PeriodicalIF":0.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12998698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147476531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Topical Nitroglycerin in the Treatment of Acute Limb Ischemia: Four-Year Experience in a Mixed Neonatal and Pediatric Intensive Care Unit.","authors":"Ana Rita Jesus, Ana Rita Fradique, Catarina Teixeira, Leonor Carvalho, Teresa Dionísio","doi":"10.34763/jmotherandchild.20263001.d-25-00039","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00039","url":null,"abstract":"<p><strong>Background: </strong>Pediatric Acute Limb Ischemia (ALI) is a rare condition, sometimes encountered in the Intensive Care Unit (ICU). Optimal treatment remains to be established. Topical nitroglycerin has been suggested as a vasodilator agent, used to improve limb reperfusion.</p><p><strong>Materials and methods: </strong>We performed a retrospective descriptive study, with data from a PICU of a tertiary hospital, from 2021 to 2024.</p><p><strong>Results: </strong>Seven children presented with ALI treated with topical nitroglycerin, with a median age of 244 days. Wrongful arterial catheterization was established as the cause of ALI in four out of seven children. Six out of seven children showed at least partial recovery. Complete recovery was achieved in three children. Three children underwent partial or total amputation. No adverse side effects were recorded.</p><p><strong>Conclusion: </strong>Topical nitroglycerin appears to be a beneficial and safe intervention in children with ALI.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"49-57"},"PeriodicalIF":0.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Do Or Not To Do: Therapeutic Hypothermia Treatment For An Infant With HIE And Prenatal Spinal Muscular Atrophy With Congenital Bone Fractures.","authors":"Viktoryia Parfenchyk, Mateusz Jagła","doi":"10.34763/jmotherandchild.20263001.d-25-00033","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00033","url":null,"abstract":"<p><p>Spinal muscular atrophy with congenital bone fractures is a rare, severe neuromuscular disorder with autosomal recessive inheritance, characterised by hypotonia, congenital contractures, and respiratory distress. We present the case of a newborn girl with a homozygous mutation in the ASCC1 gene, who was diagnosed with hypoxic-ischaemic encephalopathy after birth and underwent therapeutic hypothermia (TH). Although TH did not cause any side effects, it also did not improve the prognosis or quality of life of the patient. The decision whether to perform TH in neonates with congenital or genetic abnormalities remains challenging. Current exclusion criteria for TH should be re-evaluated to support clinicians in determining whether to include newborns with severe congenital abnormalities but favourable neurological prognosis, and conversely, to exclude those with congenital or suspected genetic syndromes associated with poor life expectancy and quality of life, in order to avoid futile interventions.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"44-48"},"PeriodicalIF":0.0,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12974224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147370914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Therapeutic Approaches for Treating Moderate-to-Severe Atopic Dermatitis in Infants with Polyvalent Allergic Sensitisation.","authors":"Maria Zofia Lisiecka","doi":"10.34763/jmotherandchild.20263001.d-25-00037","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00037","url":null,"abstract":"<p><p>The aim of this study was to evaluate the therapeutic efficacy of a comprehensive treatment approach in infants with moderate-to-severe eczema complicated by polyvalent allergic sensitisation. The methodology involved a randomised controlled trial that included 87 children aged 3 to 12 months. Participants were divided into two groups. The experimental group received combined therapy comprising pseudoceramides, a calcineurin inhibitor, and an oral synbiotic, while the control group received standard therapy with emollients and antihistamines. The results demonstrated that by the eighth week, patients in the experimental group exhibited a reduction in SCORAD index of more than 60% (to 21.4 ± 6.5); a 2.7-fold decrease in pruritus severity according to the VAS scale (to 2.9±1.3); and a 61% reduction in POEM score (to 7.3). This was accompanied by improved sleep, reduced irritability, and decreased behavioural disturbances. The control group showed less-pronounced positive dynamics. Immunological changes included a significant decrease in total and specific IgE levels, as well as a marked reduction in IL-4 and IL-13 concentrations, indicating attenuation of the Th2-mediated immune response. The prevalence of severe sensitisation decreased by 20%. Microbiota analysis demonstrated increased Bifidobacterium spp. abundance (+89%; p = 0.011); higher alpha-diversity (Shannon index + 27%; p = 0.004); and reduced E. coli levels (-36%; p = 0.018), suggesting restoration of microbial balance. Thus, this combined therapy demonstrated significant superiority, providing clinical improvement, suppression of the Th2 response, and normalisation of gut microbiota in infants with atopic dermatitis and multiple allergic sensitisation.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"33-43"},"PeriodicalIF":0.0,"publicationDate":"2026-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12908000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis and Non-Surgical Treatment of Cranial Deformities in Children Under 2 Years of Age: Modern Methods and Approaches.","authors":"Marat Rabandiyarov, Aleksandr Boiko, Anton Zolotukhin, Kirill Loviannikov, Azamat Zhailganov","doi":"10.34763/jmotherandchild.20263001.d-25-00021","DOIUrl":"10.34763/jmotherandchild.20263001.d-25-00021","url":null,"abstract":"<p><strong>Background: </strong>Cranial deformities in children under 2 can lead to functional and cosmetic issues, with their frequency increasing due to sleep positioning practices. This study aimed to evaluate the effectiveness of custom-made corrective helmets in treating these deformities.</p><p><strong>Material and methods: </strong>The study included 30 children under 2 in Astana, Kazakhstan, using 3D scanning to create custom corrective helmets worn for 23 hours a day over 5 months.</p><p><strong>Results: </strong>The results showed a significant improvement in the shape and symmetry of the skull after therapy. The asymmetry between the left and right front dimensions decreased from 9 mm to 3 mm, which corresponds to the age norm. The anterior-posterior size of the skull increased from 129 mm to 142 mm, the lateral size - from 123 mm to 129 mm, and the head circumference - from 41.5 cm to 43.5 cm, which indicates normal development of the skull. The majority of parents (90%) noted that children adapted easily to wearing helmets and experienced high levels of comfort. The data obtained indicate that the use of corrective helmets is an effective and safe method of non-surgical treatment of cranial deformities in young children. This avoids surgery and the associated risks, ensuring an improvement in the shape of the skull and the quality of life of patients.</p><p><strong>Conclusions: </strong>This study highlights the effectiveness of orthotic therapy for treating cranial deformities in young children, emphasizing the importance of early intervention and the potential for improved outcomes with timely, non-invasive treatment.</p>","PeriodicalId":73842,"journal":{"name":"Journal of mother and child","volume":"30 1","pages":"11-32"},"PeriodicalIF":0.0,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12907999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146196347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}