Journal of mood and anxiety disorders最新文献

{"title":"Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma","authors":"Caitlin M. Pinciotti ,&nbsp;Paul J. Rathouz ,&nbsp;Andrew G. Guzick ,&nbsp;Jeffrey D. Shahidullah ,&nbsp;Emily J. Bivins ,&nbsp;David B. Riddle ,&nbsp;Ogechi “Cynthia” Onyeka ,&nbsp;Eric A. Storch ,&nbsp;Wayne K. Goodman ,&nbsp;Kelli Franco ,&nbsp;Justin F. Rousseau ,&nbsp;D. Jeffrey Newport ,&nbsp;Karen Dineen Wagner ,&nbsp;Charles B. Nemeroff","doi":"10.1016/j.xjmad.2025.100117","DOIUrl":"10.1016/j.xjmad.2025.100117","url":null,"abstract":"<div><div>Childhood trauma exposure is associated with posttraumatic stress symptoms (PTSS) and suicidality, however it is also a risk factor for obsessive-compulsive disorder (OCD) in adults. Research examining the relationship between childhood trauma and OCD in youth is mixed, and there is a dearth of research examining the associations among OCD, PTSS, and suicidality. As a result, conclusions have been drawn from primarily cross-sectional adult samples. No study has examined the clinical characteristics associated with OCD in trauma-exposed youth, nor its associations with PTSS and suicidality over time. To address this gap, the present study used logistic regressions and generalized estimating equations in 2068 trauma-exposed youth aged 8—20 who completed assessments at baseline, 6-month, and 12-month follow-ups. In total, trauma-exposed youth with OCD (<em>n</em> = 222, 10.7 %) were more likely to be female (OR = 0.646), had more severe PTSS (OR = 1.032), and more psychiatric comorbidities (OR = 1.391) compared to trauma-exposed youth without OCD. Interpersonal traumas (OR = 1.549) and bullying (OR = 1.294) were associated with a greater likelihood of having OCD; however, these effects were nonsignificant when adjusting for other mental health symptoms. There was no evidence that OCD was associated with the trajectory of PTSS nor suicidality at 6- and 12-month follow-ups. Trauma-exposed youth with OCD may cross-sectionally have more severe clinical presentations overall, but OCD may not be related to the trajectory of these symptoms over time. Future research is needed to understand the directionality of clinical characteristics associated with pediatric OCD and whether interpersonal traumas convey risk uniquely for OCD or for distress in general.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100117"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rollercoaster of obsessive-compulsive disorder: How chronotype and time of day affect behavioral inhibition in adults with OCD","authors":"Eyal Kalanthroff ,&nbsp;Yuval Seror ,&nbsp;Noa Sagi ,&nbsp;Shachar Hochman ,&nbsp;Omer Linkovski ,&nbsp;Hadar Naftalovich ,&nbsp;Helen Blair Simpson","doi":"10.1016/j.xjmad.2025.100113","DOIUrl":"10.1016/j.xjmad.2025.100113","url":null,"abstract":"<div><div>Chronotype, a person's circadian preference, reflects individuals’ natural pattern of alertness levels throughout the day. It has been shown that chronotype contributes to within-day symptom fluctuations in obsessive-compulsive disorder (OCD). However, the underlying mechanism of this effect is not yet clear. Inhibitory control, an executive function crucial for suppressing unwanted behaviors and thoughts, is essential for managing OCD symptoms and is highly influenced by alertness levels. Hence, the current study investigated the impact of chronotype and time of day on inhibitory control in OCD patients, particularly in response to individually tailored symptom-provoking images, using a novel version of the stop signal task. Ninety-three treatment-seeking OCD patients completed an individually tailored Symptom-Provocation Stop-Signal Task, every morning and evening for four consecutive days. Chronotype was assessed using the Morningness-Eveningness Questionnaire (MEQ). Stop-signal reaction time (SSRT) was assessed for neutral and individually tailored symptom-provoking images separately. Patients exhibited longer SSRTs (worse inhibition) to symptom-provoking trials compared to neutral trials. Most importantly, chronotype and time of day significantly interacted to affect SSRTs in the symptom-provocation condition: A significant correlation was found between optimal alertness periods and improved inhibitory control in the symptom-provocation condition. Taken together, these results indicate that inhibitory control in OCD varies with chronotype and time of day. These findings suggest that aligning treatment sessions with patients' chronotype may enhance therapeutic outcomes and that heightening alertness—by increasing the chances of successful inhibition—might be a way to mitigate the vicious cycle of OCD.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighing the predictive role of neural factors for adolescent anhedonia in the presence of demographic and clinical factors","authors":"Anisha Reddy ,&nbsp;Michele Bertocci ,&nbsp;Tina Gupta ,&nbsp;Kristen L. Eckstrand ,&nbsp;Manivel Rengasamy ,&nbsp;Erika E. Forbes","doi":"10.1016/j.xjmad.2025.100116","DOIUrl":"10.1016/j.xjmad.2025.100116","url":null,"abstract":"<div><div>Anhedonia, a transdiagnostic symptom of psychopathology associated with pernicious clinical course, has putative mechanisms in neural reward systems and emerges during adolescence. However, the relative contributions of neural, demographic, and clinical factors to its development are unclear. 73 adolescents (13–19 years) at varying familial risk for developing anhedonia reported demographic and clinical characteristics at study entry, reported anhedonia up to three times annually, and underwent fMRI during a monetary reward paradigm. Least absolute shrinkage and selection operator (LASSO) regression, which allows for a large number of intercorrelated predictors for feature selection, revealed that among demographic, clinical, and neural factors, 10 features predicted peak anhedonia over two years: impulsivity; activation in dorsal caudate, sub-gyral temporal lobe, and cuneus; and negative FC between the ventral striatum and six regions implicated in motor and/or decision-making aspects of reward. Neural factors explained an additional 40 % of variance above impulsivity. Findings indicate that in adolescents at risk for severe mental illness, disrupted motor and decision-making reward pathways could contribute to the development of anhedonia. Additionally, anhedonia should be defined in multiple domains, beyond mere phenomenology.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"10 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer victimization but not social anxiety negatively influences predicted enjoyment during peer interactions","authors":"Isabel Leiva ,&nbsp;Samantha S. Reisman ,&nbsp;Chelsea Helion ,&nbsp;Vishnu P. Murty ,&nbsp;Johanna Jarcho","doi":"10.1016/j.xjmad.2025.100105","DOIUrl":"10.1016/j.xjmad.2025.100105","url":null,"abstract":"<div><div>We often underestimate how much others enjoy initial interactions with us - a phenomenon known as the liking gap. While widely documented, less research has explored how individual differences such as social anxiety and negative social experiences influence the liking gap. To test this, female and non-binary dyads (N = 23) varying in severity of social anxiety and exposure to peer victimization, completed semi-structured dialogues with strangers. Following the interaction, participants rated their own enjoyment and their assumption of their partner’s enjoyment of the interaction. Consistent with past literature, participants underestimated their partner’s enjoyment. The magnitude of the liking gap was greater for participants with more exposure to peer victimization, but not social anxiety. The relationship with peer victimization was specifically linked to incorrect perceptions about their partner’s enjoyment. This suggests that the liking gap may be susceptible to individual differences in peer victimization, rather than a broader phenotype of social anxiety.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric evaluation of a novel measure of trauma-related eating to cope","authors":"Sage E. Hawn ,&nbsp;Taylor Kliebhan ,&nbsp;Niya Richardson ,&nbsp;Mellyssa Deoliveira ,&nbsp;Kristin E. Heron ,&nbsp;Karen Mitchell","doi":"10.1016/j.xjmad.2024.100102","DOIUrl":"10.1016/j.xjmad.2024.100102","url":null,"abstract":"<div><div>Posttraumatic stress disorder (PTSD) and disordered eating often co-occur, and this comorbidity is linked to a heightened clinical burden compared to either condition alone. One possible explanation for this co-occurrence is the self-medication model, which proposes that individuals may use food to cope with PTSD symptoms, a concept we refer to as trauma-related eating to cope. Although there is both theoretical and empirical support for this construct, no specific measure has been developed until now. In this study, we aimed to create and validate a novel measure, the Trauma-Related Eating to Cope (TREC) questionnaire, among a diverse sample of 726 trauma-exposed undergraduate students (<em>M</em>_age=22.87, <em>SD</em>=7.20; 49.9 % White; 77 % women). Our data support the 20-item TREC questionnaire as a four-factor scale that can be used to evaluate eating to cope with symptoms specific to each of the four <em>DSM-5</em> PTSD symptom clusters (χ²(164)= 330.23, <em>p</em> &lt; .001; CFI= .959; TLI= .953; RMSEA= .038). The study findings indicate that the TREC questionnaire is a more precise and targeted tool for measuring eating to cope with PTSD symptoms compared to existing measures of eating to cope motives. Strong evidence was found for the construct and criterion validity of the TREC questionnaire, particularly in relation to PTSD symptoms and a range of disordered eating behaviors, including binge eating, caloric restriction, and emotional eating. These results underscore the potential of the TREC questionnaire for future research on self-medication and its clinical utility as a screening tool for identifying individuals with PTSD who are at risk for developing pathological eating behaviors.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Care trajectories of people with mood disorders in Quebec using latent class and latent profile analysis methods","authors":"Christian Roger Claver Kouakou ,&nbsp;Matea Bélan ,&nbsp;Thomas G. Poder ,&nbsp;Maude Laberge","doi":"10.1016/j.xjmad.2024.100101","DOIUrl":"10.1016/j.xjmad.2024.100101","url":null,"abstract":"<div><div>The prevalence of mood disorders has increased globally. People with mood disorders have been found to use more health services than the general population, although a mood disorder diagnosis does not necessarily entail utilization of health services. This heterogeneity in health services utilization could make it difficult for governments to plan resources to meet the needs of people with mood disorders. A patient-level linked database from residents of Quebec, Canada was used to model care trajectories of people who self-reported having been diagnosed with a mood disorder. The data from the Canadian Community Health Survey were linked to health administrative data for a 21-year period. We used latent class analysis and latent profile analysis to group people into categories. Four care trajectories were identified using the latent class analysis: 1) people who only used services of a general practitioner; 2) people having seen a psychiatrist or having at least one ED visit or hospitalization; 3) people consulting other types of specialists; 4) null utilization. The latent profile analysis on medical services yielded four profiles, with average numbers of services of 41, 33, 7, and 1, while that on hospitalization yielded two profiles, with 20 % of the population having had at least one hospitalization and the remainder none. By classifying people into service utilization groups, these methods enable determining needs for a given population and can support resource allocation for health care decision makers.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Program evaluation of internet-delivered cognitive behavioral treatments for anxiety and depression in a digital clinic","authors":"Alexandra L. Silverman ,&nbsp;IreLee Ferguson ,&nbsp;Jacqueline R. Bullis ,&nbsp;Harris Bajwa ,&nbsp;Sara Mei ,&nbsp;Courtney Beard","doi":"10.1016/j.xjmad.2025.100106","DOIUrl":"10.1016/j.xjmad.2025.100106","url":null,"abstract":"<div><div>SilverCloud and THIS WAY UP (TWU) are two internet-delivered cognitive-behavioral therapy (iCBT) programs that have demonstrated effectiveness for anxiety and depression, yet little is known about their comparative effectiveness. This non-randomized program evaluation compared client satisfaction, subjective engagement, and treatment outcomes between the SilverCloud and TWU programs. Participants were 195 adult patients (106 using TWU and 89 using SilverCloud) enrolled in a digital CBT clinic who completed assessment measures at pre-treatment, mid-treatment, post-treatment, and one-, two-, three-, and four-month follow-ups. As hypothesized (preregistration: <span><span>osf.io/x6bmy</span><svg><path></path></svg></span>), patients in both programs reported high client satisfaction, and experienced improvements in depression (<em>d</em>s = -0.79 and −0.78), anxiety (<em>d</em>s = -0.95 and −0.84), and functional impairment (<em>d</em>s = -0.42 and −0.45), from pre- to post-treatment that were maintained at four-month follow-up. However, according to exploratory analyses, the slope of change in treatment outcomes was not significantly different between programs during the treatment and follow-up phases. As hypothesized, patients who used SilverCloud self-reported significantly greater subjective engagement with their iCBT program compared to patients who used TWU (<em>d</em>=0.36). However, contrary to hypotheses, client satisfaction was not significantly different between programs. This non-randomized program evaluation offers minimal evidence that one program was better than the other, though findings require replication in a randomized controlled trial and larger sample. Results provide further support for iCBT as a viable option to extend access to high-quality treatment for anxiety and depression.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural activity to reward and loss predicting treatment outcomes for adults with generalized anxiety disorder: A randomized clinical trial","authors":"Hannah Berg ,&nbsp;Yu-Jin Eun ,&nbsp;Xiaoqian Yu ,&nbsp;Timothy J. McDermott ,&nbsp;Elisabeth Akeman ,&nbsp;Rayus Kuplicki ,&nbsp;Hung-Wen Yeh ,&nbsp;Wesley Thompson ,&nbsp;Christopher R. Martell ,&nbsp;Kate B. Wolitzky-Taylor ,&nbsp;Michelle G. Craske ,&nbsp;Martin P. Paulus ,&nbsp;Robin L. Aupperle","doi":"10.1016/j.xjmad.2025.100107","DOIUrl":"10.1016/j.xjmad.2025.100107","url":null,"abstract":"<div><div>Aberrant reward processing has been predominantly associated with depressive disorders, with evidence that pre-treatment abnormalities in striatal reward responsiveness relates to treatment outcomes. Emerging research also implicates reward processing differences in anxiety disorders, particularly generalized anxiety disorder (GAD). The current study examined whether pre-treatment reward- and loss- related neural activity predicts symptom improvement with behavioral activation (BA) and exposure therapy (EXP) for GAD. In this randomized clinical trial (ClinicalTrials.gov NCT02807480) conducted from 2016 to 2021, treatment-seeking adults with GAD completed the monetary incentive delay task during functional magnetic resonance imaging pre-treatment, then were randomized to 10-session EXP or BA. The primary outcome measure was the GAD-7. Of 101 participants consented, 69 completed treatment, the 46 completers with quality imaging data were included in analyses (22 EXP, 24 BA; mean 32.7 years, 10.9 % male). <em>A priori</em> region-of-interest analysis revealed that greater left caudate activity during loss receipt predicted greater symptom improvement in EXP, and did not relate to symptom change in BA (<em>F</em>(1, 428)= 5.24, <em>p</em> = 0.023), though this was not significant after correction for multiple comparisons. Whole-brain analysis further identified that greater activity during reward receipt in left frontoparietal regions and anterior insula / ventrolateral prefrontal cortex was associated with better outcomes in BA and worse outcomes in EXP. These findings highlight the role of reward and loss reactivity in GAD treatment. In particular, patients with elevated reactivity to reward salience may benefit most from BA or other reward-focused treatments. Future clinical trials are warranted to further elucidate reward-related predictors of anxiety treatment.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of modified COVID-19 Phobia Scale (MC19P-SE) to examine the relationships between corona anxiety and COVID-19 symptoms: A case-control study","authors":"Luthful Alahi Kawsar ,&nbsp;Syed Toukir Ahmed Noor ,&nbsp;Md. Atiqul Islam ,&nbsp;Mohammad Romel Bhuia","doi":"10.1016/j.xjmad.2025.100108","DOIUrl":"10.1016/j.xjmad.2025.100108","url":null,"abstract":"<div><h3>Purpose</h3><div>The main purpose of the present study is to validate the modified COVID-19 phobia scale (MC19P-SE) in Bangla and use it to identify the link between COVID-related anxiety and the onset of COVID-19 symptoms.</div></div><div><h3>Methods</h3><div>A retrospective case-control study was conducted in Sylhet, a northeastern district in Bangladesh, focusing on a population of 18 years or older. The MC19P-SE scale was used to gather data on coronaphobia among the respondents, and factor analysis was used to derive reliable factors. We employed a multivariable logistic regression model to identify the relationships between coronavirus anxiety and COVID-19 symptoms.</div></div><div><h3>Results</h3><div>Among the 482 participants, 42 % manifested COVID-19 symptoms. Factor analysis revealed four underlying factors: psychological anxiety, psychosomatic anxiety, economic anxiety, and social or excessive protective anxiety. MC19P-SE exhibited reliability with a Cronbach alpha coefficient of 0.91 for full-scale. According to the model, psychosomatic anxiety increased (AOR= 1.14, 95 % CI: 1.07, 1.22) the risk while social or excessive protective anxiety decreased (AOR=0.88, 95 % CI: 0.78, 0.99) the risk of developing COVID-19 symptoms significantly.</div></div><div><h3>Conclusion</h3><div>The research found a significant relation in the Bangladeshi district of Sylhet between the onset of COVID-19 symptoms and anxiety associated with the virus. Furthermore, the findings affirm the potential reliability and validity of the MC19P-SE scale, strengthening its efficacy for future research and evaluations.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100108"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-function coupling in network connectivity and associations with negative affectivity in a group of transdiagnostic adolescents","authors":"Dana Kanel ,&nbsp;Andre Zugman ,&nbsp;Grace Stohr ,&nbsp;Beck Scheinberg ,&nbsp;Elise Cardinale ,&nbsp;Anderson M. Winkler ,&nbsp;Katharina Kircanski ,&nbsp;Nathan A. Fox ,&nbsp;Melissa A. Brotman ,&nbsp;Julia O. Linke ,&nbsp;Daniel S. Pine","doi":"10.1016/j.xjmad.2024.100094","DOIUrl":"10.1016/j.xjmad.2024.100094","url":null,"abstract":"<div><div>The study of brain connectivity, both functional and structural, can inform us on the development of psychopathology. The use of multimodal MRI methods allows us to study associations between structural and functional connectivity, and how this relates to psychopathology. This may be especially useful during childhood and adolescence, a period where most forms of psychopathology manifest for the first time. The current paper explores structure-function coupling, measured through diffusion and resting-state functional MRI, and quantified as the correlation between structural and functional connectivity matrices. We investigate associations between psychopathology and coupling in a transdiagnostic group of adolescents, including many treatment-seeking youth with relatively high levels of symptoms (<em>n</em> = 72, M_age = 13.3). We used a bifactor model to extract our main outcome measure, Negative Affectivity, from anxiety and irritability ratings. This provided the principal measure of psychopathology. Supplementary analyses investigated ‘domain-specific’ factors of anxiety and irritability. Findings indicate a positive association between negative affectivity and structure-function coupling between the default mode and the fronto-parietal control networks. Higher structure-function coupling may indicate heightened structural constraints on function, which limit functional network reorganization during adolescence required for healthy psychological outcomes.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100094"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142746941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}