Journal of mood and anxiety disorders最新文献

{"title":"Assessing in-session rumination during CBT for depression: Replication and further evaluation of an observational measure","authors":"J.C. Kennedy ,&nbsp;B.W. Dunlop ,&nbsp;S.E. Baldwin ,&nbsp;C.J. Liu ,&nbsp;H.S. Mayberg ,&nbsp;W.E. Craighead","doi":"10.1016/j.xjmad.2024.100060","DOIUrl":"10.1016/j.xjmad.2024.100060","url":null,"abstract":"<div><p>This study sought to further evaluate an observational measure of rumination that occurs during psychotherapy (i.e., in-session rumination). Specifically, the study aimed to replicate the reliability of an observational rating procedure in new therapy sessions and a new sample, clarify the relationship between in-session rumination and depressive symptoms, and evaluate for the first time the relationship between in-session rumination and self-reported rumination. A team of trained research assistants produced observational ratings of in-session rumination occurring during video-taped sessions of CBT from two separate treatment studies. Thirty-five patients with major depressive disorder (MDD) from one study had their final session rated, and 17 patients with MDD from another study had their first session rated. Results showed that the observational ratings were reliable, and that in-session rumination generally correlated with depressive symptom severity as expected, with higher in-session rumination predicting higher depressive symptom levels both cross-sectionally and longitudinally. Preliminary evidence also found that in-session rumination correlated with self-reported rumination, and exploratory analyses provided preliminary evidence supporting the incremental validity of in-session rumination for predicting depression severity after treatment. The results indicate that in-session rumination can be reliably identified during CBT sessions and consistently predicts higher depressive severity, both of which support efforts to develop treatments that specifically target rumination.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000142/pdfft?md5=3276c6e51d2c0e72c230a96edef924aa&pid=1-s2.0-S2950004424000142-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective measurement of skin conductance response during trauma interview predicts future PTSD severity in trauma exposed children","authors":"Sattvik Basarkod ,&nbsp;Shaurel Valbrun ,&nbsp;Charis Wiltshire ,&nbsp;John McClellan France ,&nbsp;William Davie ,&nbsp;Sterling Winters ,&nbsp;Sophie A. George ,&nbsp;Anais F. Stenson ,&nbsp;Tanja Jovanovic","doi":"10.1016/j.xjmad.2024.100061","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100061","url":null,"abstract":"<div><p>Previous cross-sectional studies have shown that sympathetic nervous system (SNS) arousal is positively associated with posttraumatic stress disorder (PTSD) symptoms in children with trauma exposure. One of the ways that SNS activity is measured is through skin conductance response (SCR), which has been shown to predict future PTSD severity in adults. In this study, we explored the utility of a novel, low-cost mobile SCR device, eSense, to predict future PTSD symptom severity in trauma exposed children. We recruited children (N = 43, age 9 years at initial visit) for a longitudinal study in which SCR was recorded at baseline visit, and PTSD symptoms were assessed two years later. Results indicated an interaction between SCR and trauma exposure, such that children with lower trauma exposure who demonstrated greater SCR reported higher PTSD severity two years later. This association remained significant even after controlling for baseline PTSD symptoms. Children with higher levels of trauma exposure did not show this association, potentially due to ceiling effects of PTSD symptoms. Together these findings suggest the utility of SCR as a biomarker for predicting trauma related disorders in children, and that it may be a valuable tool in clinical interventions targeting sympathetic arousal.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000154/pdfft?md5=8dac04e991170b0303f1ee1b445296ec&pid=1-s2.0-S2950004424000154-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT study","authors":"Warren D. Taylor ,&nbsp;Olusola Ajilore ,&nbsp;Helmet T. Karim ,&nbsp;Meryl A. Butters ,&nbsp;Robert Krafty ,&nbsp;Brian D. Boyd ,&nbsp;Layla Banihashemi ,&nbsp;Sarah M. Szymkowicz ,&nbsp;Claire Ryan ,&nbsp;Jason Hassenstab ,&nbsp;Bennett A. Landman ,&nbsp;Carmen Andreescu","doi":"10.1016/j.xjmad.2023.100038","DOIUrl":"10.1016/j.xjmad.2023.100038","url":null,"abstract":"<div><h3>Background</h3><p>Late-life depression is characterized by disability, cognitive impairment and decline, and a high risk of recurrence following remission. Aside from past psychiatric history, prognostic neurobiological and clinical factors influencing recurrence risk are unclear. Moreover, it is unclear if cognitive impairment predisposes to recurrence, or whether recurrent episodes may accelerate brain aging and cognitive decline. The purpose of the REMBRANDT study (Recurrence markers, cognitive burden, and neurobiological homeostasis in late-life depression) is to better elucidate these relationships and identify phenotypic, cognitive, environmental, and neurobiological factors contributing to and predictive of depression recurrence.</p></div><div><h3>Methods</h3><p>Across three sites, REMBRANDT will enroll 300 depressed elders who will receive antidepressant treatment. The goal is to enroll 210 remitted depressed participants and 75 participants with no mental health history into a two-year longitudinal phase focusing on depression recurrence. Participants are evaluated every 2 months with deeper assessments occurring every 8 months, including structural and functional neuroimaging, environmental stress assessments, deep symptom phenotyping, and two weeks of ‘burst’ ecological momentary assessments to elucidate variability in symptoms and cognitive performance. A broad neuropsychological test battery is completed at the beginning and end of the longitudinal study.</p></div><div><h3>Significance</h3><p>REMBRANDT will improve our understanding of how alterations in neural circuits and cognition that persist during remission contribute to depression recurrence vulnerability. It will also elucidate how these processes may contribute to cognitive impairment and decline. This project will obtain deep phenotypic data that will help identify vulnerability and resilience factors that can help stratify individual clinical risk.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442300038X/pdfft?md5=a665d147ef663d558c020ee436646f7c&pid=1-s2.0-S295000442300038X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “A randomized clinical trial of behavioral activation and exposure-based therapy for adults with generalized anxiety disorder” [J. Mood Anxiety Disord., vol. 1, June 2023, 100004]","authors":"Hannah Berg ,&nbsp;Elisabeth Akeman ,&nbsp;Timothy J. McDermott ,&nbsp;Kelly T. Cosgrove ,&nbsp;Namik Kirlic ,&nbsp;Ashley Clausen ,&nbsp;Mallory Cannon ,&nbsp;Hung-Wen Yeh ,&nbsp;Evan White ,&nbsp;Wesley K. Thompson ,&nbsp;Emily M. Choquette ,&nbsp;Cassandra A. Sturycz-Taylor ,&nbsp;Gabe Cochran ,&nbsp;Sam Ramirez ,&nbsp;Christopher R. Martell ,&nbsp;Kate B. Wolitzky-Taylor ,&nbsp;Michelle G. Craske ,&nbsp;James L. Abelson ,&nbsp;Martin P. Paulus ,&nbsp;Robin L. Aupperle","doi":"10.1016/j.xjmad.2023.100044","DOIUrl":"10.1016/j.xjmad.2023.100044","url":null,"abstract":"","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100044"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000445/pdfft?md5=2172218953a4ba91c29545d006cd84e4&pid=1-s2.0-S2950004423000445-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139394277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate variability during inpatient treatment of depression","authors":"Lennard Geiss ,&nbsp;Beate Beck ,&nbsp;Mark Stemmler ,&nbsp;Thomas Hillemacher ,&nbsp;Katharina M. Hösl","doi":"10.1016/j.xjmad.2024.100059","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100059","url":null,"abstract":"<div><h3>Background</h3><p>Major depressive disorder (MDD) is linked to reduced heart rate variability, an index of cardiovascular autonomic modulation (CAM). However, treatment effects on CAM are poorly known. Our objective was to assess if initiation of inpatient treatment has a beneficial effect on CAM in MDD patients.</p></div><div><h3>Methods</h3><p>In 30 MDD inpatients, we recorded RR-intervals (RRI), continuous blood pressure (BPsys, BPdia), skin conductance levels (SCL), respiration frequency (RESP) and current medication within 24 h (T1) and 3 weeks after hospital admission (T2) during resting state and metronomic breathing. The same parameters were recorded once at baseline in 30 controls without mental disorders. We computed indices of sympathetic modulation, parasympathetic modulation and parameters reflecting total CAM. Physiological parameters were compared using MANCOVAS. Symptoms of depression were assessed using Hamilton rating scale for depression (HAM-D) and Beck Depression Inventory (BDI), we used rmANOVAs to compare t1 and t2 questionnaire data.</p></div><div><h3>Results</h3><p>BDI and HAM-D scores were lower at T2 than T1 (both p &lt; 0.01). RRI was lower in T1 patients than in controls (p = 0.021), while BPdia (p = 0.038) and RESP (p = 0.014) were higher in T1 patients than controls. MDD patients showed lower parameters of parasympathetic modulation and total CAM than controls during resting state (parasympathetic p = 0.003; total CAM p = 0.017) and metronomic breathing (parasympathetic p = 0.040; total CAM p = 0.007). Analysis unveiled lower parameters of parasympathetic modulation in T1 patients compared to T2 patients during baseline (p = 0.046). No differences between T1 and T2 patients during metronomic breathing were found.</p></div><div><h3>Conclusion</h3><p>MDD patients showed lower CAM than controls. Contrary to our assumption, we found a decline of parasympathetic modulation in MDD patients over the observation span despite symptomatic improvement. The decline is presumably due to the initiation of psychopharmacotherapy and changes in premedication.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100059"},"PeriodicalIF":0.0,"publicationDate":"2024-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000130/pdfft?md5=87a73fd161efebc0e39ace845c9013c8&pid=1-s2.0-S2950004424000130-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139999619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in mindfulness facets across yoga, CBT and stress education in individuals with generalized anxiety disorder","authors":"Danielle Moskow Diamond ,&nbsp;David Rosenfield ,&nbsp;Nikki Kaiser ,&nbsp;Amanda W. Baker ,&nbsp;Elizabeth A. Hoge ,&nbsp;Sat Bir S. Khalsa ,&nbsp;Stefan G. Hofmann ,&nbsp;Naomi M. Simon","doi":"10.1016/j.xjmad.2024.100058","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100058","url":null,"abstract":"<div><p>Improving mindfulness is an important treatment target for generalized anxiety disorder (GAD). However, less is known about how different treatments impact specific aspects of mindfulness. In a clinical trial (Simon et al., 2021), 226 individuals with GAD were randomized to 12 weeks of Kundalini Yoga (KY), cognitive behavioral therapy (CBT) or stress education (SE). To examine whether specific facets of mindfulness, as measured by the Five Facet Mindfulness Questionnaire (FFMQ) change more than others across treatment and between treatments, we ran a multi-variate multilevel growth curve model (MMLM). Results indicated that while the Non-judge, Act with Awareness, and Non-react facets increased significantly during treatment, the Observe and Describe facets did not. Improvement in the Acting with Awareness facet during treatment was significantly greater for KY than CBT. These findings reveal the need to better understand how behavioral treatments can influence specific components of mindfulness for those with anxiety.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100058"},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000129/pdfft?md5=2f4896c334a1686806e2ca7faaac57fe&pid=1-s2.0-S2950004424000129-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive, behavioral, and affective mechanisms underlying the efficacy of Applied Relaxation in reducing psychopathological symptoms: A randomized controlled trial","authors":"Eva Asselmann ,&nbsp;Frank Rückert ,&nbsp;Hanna Kische ,&nbsp;Monique Zenker ,&nbsp;Lars Pieper ,&nbsp;Katja Beesdo-Baum","doi":"10.1016/j.xjmad.2024.100055","DOIUrl":"10.1016/j.xjmad.2024.100055","url":null,"abstract":"<div><h3>Background</h3><p>This study examined the cognitive, behavioral, and affective mechanisms underlying the efficacy of Applied Relaxation (AR) in reducing psychopathological symptoms. AR is a cognitive-behavioral technique that allows for rapid relaxation at the first sign of stress or tension in daily life.</p></div><div><h3>Methods</h3><p>A randomized controlled trial was conducted in 277 adults (18–55 years) with elevated symptoms of depression, anxiety, or stress but without a 12-month DSM-5 mental disorder at study entry. Participants were randomized to an intervention group receiving AR training (10 weeks, N = 139) and an assessment-only control group (N = 138). Mental health outcomes (depressive, anxiety, and stress symptoms) and potential cognitive (self-efficacy, perceived control), behavioral (coping behaviors) and affective (positive and negative affect) mediators of the intervention efficacy were assessed at baseline and post-assessment in both groups.</p></div><div><h3>Results</h3><p>Structural equation models indicated that baseline to post reductions in psychopathological symptoms due to AR partially passed through less avoidance-oriented and less other dysfunctional coping (proportion of total effect mediated; ratio of indirect to total effect: resignation: 55.0%, rumination: 27.9%, escape: 27.4%, aggression: 21.3%), less negative affect (46.3%), more positive affect (41.8%), lower external control beliefs (14.5%), and higher self-efficacy (13.3%).</p></div><div><h3>Conclusions</h3><p>Our results suggest that improvements in cognitive, behavioral, and affective mediator variables partially explain the intervention efficacy of AR in improving mental health.</p></div><div><h3>Trial registration and data statement</h3><p>The study protocol has been pre-registered on ClinicalTrials.gov (NCT03311529). The study protocol, minimum dataset, and analysis codes are available at OpARA - Open Access Repository and Archive. Supplementary materials (e.g., the course manual and additional training materials) are available on request from the last author ([email protected]).</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100055"},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000099/pdfft?md5=cb07cef1960460dede381e82364672ab&pid=1-s2.0-S2950004424000099-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social support mediates the effects of childhood unpredictability on anhedonia: A retrospective investigation in an online adult community sample","authors":"Kaylee E. Null ,&nbsp;Jessica M. Duda ,&nbsp;Diego A. Pizzagalli","doi":"10.1016/j.xjmad.2024.100057","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100057","url":null,"abstract":"<div><p>Increasingly, research is highlighting the implications of exposure to unpredictable environments during childhood (i.e., “childhood unpredictability”) on outcomes in adulthood. Converging evidence from preclinical and clinical studies has implicated childhood unpredictability in disrupted reward processing and anhedonia. From the stress generation literature, altered social support has emerged as a possible mechanism by which this effect may occur. In the current study, our goal was to understand whether the pathway from childhood unpredictability to anhedonia occurs through reduced perceptions of social support. Toward this end, we recruited an online community sample of adults in the US (<em>N</em> = 242) to complete surveys assessing childhood unpredictability, depressive symptoms, anhedonia, and social support, as well as a novel online version of the Probabilistic Reward Task. We found that childhood unpredictability was associated with increased depressive symptoms and anhedonia (but not objective measure of anhedonia), and reduced perceptions of social support in adulthood. Mediation analyses revealed a significant indirect effect of perceived social support on the association between childhood unpredictability and anhedonia, controlling for age, sex, and non-anhedonic depressive symptoms. Unexpectedly, measures of reward responsiveness from the behavioral task were not related to childhood unpredictability. The current findings replicate previous reports linking childhood unpredictability and self-reported anhedonia, and extend them to incorporate the potential mediating pathway of reduced social support. Implications for treatment for anhedonia are discussed.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100057"},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000117/pdfft?md5=13a70927f42aadd0e8274e9946cf7a7f&pid=1-s2.0-S2950004424000117-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The state of anxiety treatments for adolescents and adults down syndrome: Results from a scoping rapid review","authors":"Jill C. Fodstad ,&nbsp;Lauren B. Jones ,&nbsp;Micah Iticovici ,&nbsp;Rachel M. Russell ,&nbsp;Molly Bullington ,&nbsp;Emily Meudt","doi":"10.1016/j.xjmad.2024.100056","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100056","url":null,"abstract":"<div><p>Adolescents and adults with Down syndrome are noted to display symptoms consistent with various anxiety disorders. While evidenced-based practices, including psychotherapies and psychopharmacology, exist and effectively treat anxiety in neurotypical populations, less is known about anxiety treatments for persons with Down syndrome. A scoping rapid review was conducted in April 2023 to determine what treatments are being used to target anxiety in adolescents and adults with Down syndrome, the quality of those treatments, and their alignment with current evidence-based practices. A total of eleven articles, primarily single case or case series, published between 1981 and 2022 were identified targeting adolescents and adults with Down syndrome diagnosed with specific phobias, selective mutism, generalized anxiety disorder, agoraphobia with panic, and non-specific anxiety symptoms. Interventions used most often aligned with evidence-based anxiety treatment guidelines and included psychotherapy, complementary and alternative medicine, and psychopharmacology. While most studies reported positive treatment responses showing reductions in anxiety symptoms post-treatment, the quality and generalizability of the studies was primarily poor. More rigorous research evaluating the effects of treatment for anxiety symptoms in the DS population are needed to develop guidelines to address anxiety disorders in this vulnerable population.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100056"},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000105/pdfft?md5=8273d53d779be8156ecce4dbea1b4080&pid=1-s2.0-S2950004424000105-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139935900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music interventions for posttraumatic stress disorder: A systematic review","authors":"Crystal C. Wang ,&nbsp;Mariel Emrich ,&nbsp;Hal Rives ,&nbsp;Annell Ovalles ,&nbsp;Drew Wright ,&nbsp;Katarzyna Wyka ,&nbsp;JoAnn Difede","doi":"10.1016/j.xjmad.2024.100053","DOIUrl":"10.1016/j.xjmad.2024.100053","url":null,"abstract":"<div><p>There is growing literature supporting the efficacy of music interventions for a range of conditions, including anxiety, stress, and pain. Alongside this, research on neurobiological processes involved in the experience of music has illuminated potential mechanisms for music’s role in mental health treatments. Music has the potential to act on the circuitry of the brain involved in the autonomic dysregulation associated with posttraumatic stress disorder (PTSD). We conducted a systematic review to identify studies examining the effects of music interventions on PTSD symptoms in adults. Five databases were searched which resulted in 2454 articles, with 1478 screened on title and abstract, and 288 screened at full text. 14 studies met inclusion criteria for the review. Study samples ranged from 6 to 330 participants who endorsed PTSD symptoms consequent to various traumas. Most studies were feasibility studies (<em>n</em> = 9), which employed the traditional music therapy format of therapist-led interventions (<em>n</em> = 11). While effective, these require active participation and are resource-intensive. Studies that used passive listening also showed a benefit of the music intervention (<em>n</em> = 5). All but one study reported a decrease in PTSD symptoms (<em>n</em> = 13). Although these findings should be interpreted considering the limitations of the studies (including small sample sizes and lack of rigorous control groups), these results demonstrate the promise of music interventions. Thus, as interest in music medicine grows rapidly amidst the increasing public health burden of PTSD, additional studies of the effect of music on PTSD symptoms are warranted. Studies that employ brief, self-directed, passive-listening music interventions that are delivered in inexpensive, scalable, and flexible formats may be especially promising.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100053"},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000075/pdfft?md5=48791924f6aef4a1a8f2f8449da22bba&pid=1-s2.0-S2950004424000075-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139829323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}