Journal of mood and anxiety disorders最新文献

{"title":"A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes","authors":"Jessica Bomyea ,&nbsp;Morgan M. Caudle ,&nbsp;Nathalie Dugas ,&nbsp;Raeanne C. Moore ,&nbsp;Alan N. Simmons ,&nbsp;Michael L. Thomas","doi":"10.1016/j.xjmad.2024.100095","DOIUrl":"10.1016/j.xjmad.2024.100095","url":null,"abstract":"<div><div>Individuals with mood, anxiety, and traumatic stress disorders frequently experience distressing repetitive negative thinking (RNT) symptoms, which are characterized by pervasive, uncontrollable negative thoughts. Dysfunction in executive functioning processes, particularly the ability to regulate the contents of working memory, are implicated in the development and maintenance of RNT. Guided by the National Institute of Mental Health experimental therapeutics framework, this study aimed to investigate the cognitive effects and effects of two doses of a novel working memory training (WMT) intervention in individuals with elevated RNT across mood, anxiety, and traumatic stress disorders. We conducted a three-arm randomized controlled trial with 8-session and 16-session WMT interventions and a waitlist control group (N = 73). Our primary goal was to establish target engagement of WMT as measured by behavioral and neural indicators of working memory performance. Results revealed that WMT significantly improved working memory performance and resulted in reduced frontoparietal neural activity during a working memory task compared to the waitlist control group, providing evidence of target engagement. Exploratory analyses revealed a potential transfer of training effects to fluid intelligence, a construct related to but distinct from working memory, suggesting broader cognitive benefits of WMT. These data provide evidence that WMT can enhance working memory performance in individuals with RNT. This intervention holds promise as a transdiagnostic approach for ameliorating RNT-related clinical burden, with the 8-session regimen showing pragmatic advantages. Further research is needed to elucidate its impact on clinical symptoms and explore potential cognitive benefits beyond working memory.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100095"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between depressive symptoms and limitations in disability domains among US adults","authors":"Shakila Meshkat ,&nbsp;Qiaowei Lin ,&nbsp;Vanessa K. Tassone ,&nbsp;Reinhard Janssen-Aguilar ,&nbsp;Wendy Lou ,&nbsp;Venkat Bhat","doi":"10.1016/j.xjmad.2024.100103","DOIUrl":"10.1016/j.xjmad.2024.100103","url":null,"abstract":"<div><div>This study aims to evaluate the association of depressive symptoms and their severity with overall disability and disability domains, and to assess temporal changes in these associations. Data from the National Health and Nutrition Examination Survey (NHANES) 2013–2018 were analyzed. A total of 15,565 participants were included, with 1383 (8.19 %) reporting depressive symptoms. Depressive symptoms were strongly associated with overall disability (aOR = 7.82; 95 % CI = 6.27, 9.75; p &lt; 0.001) and with six specific domains (aOR = 2.54 for hearing, 2.84 for seeing, 10.53 for concentrating, 4.42 for walking, 6.01 for dressing or bathing, and 7.36 for doing errands alone; all p &lt; 0.001). Each unit increase in PHQ-9 score was linked to a 21 % increase in the odds of overall disability (aOR = 1.21; 95 % CI = 1.19, 1.23; p &lt; 0.001) and to a 9 %-25 % increase in the odds of domain-specific difficulties. Both cognitive-affective (aOR = 1.35; 95 % CI = 1.30, 1.40) and somatic scores (aOR = 1.36; 95 % CI = 1.33, 1.39) were associated with overall disability and domain-specific difficulties, with each unit increase linked to 13 %-45 % higher odds. Temporal analysis indicated that depressive symptoms are linked to a higher prevalence of disability, with this association persisting and slightly increasing over time. Our findings indicated the association between depressive symptoms and disability. Future studies should further replicate our results and evaluate the mechanisms underlying this phenomenon.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100103"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI","authors":"Diane Joss ,&nbsp;Michael Datko ,&nbsp;Charisma I. Washington ,&nbsp;Mary A. Tresvalles ,&nbsp;Mihriye Mete ,&nbsp;Sara W. Lazar ,&nbsp;Zev Schuman-Olivier ,&nbsp;Elizabeth A. Hoge","doi":"10.1016/j.xjmad.2024.100096","DOIUrl":"10.1016/j.xjmad.2024.100096","url":null,"abstract":"<div><div>Self-judgment is a trans-diagnostic symptom among various psychological disorders, therefore can be a therapeutic target for many common psychiatric conditions. Self-judgment often arises among those who experienced childhood maltreatment, which increases the risk for developing comorbid psychiatric disorders that are resistant to traditional pharmacological and psychological interventions. Understanding the neural correlates of the therapeutic effect of behavioral interventions for reducing self-judgment is key for developing and refining evidence-based intervention programs. This single arm pilot study (N = 24) explored the neural correlates of reduction in self-judgment after an eight-week mindful self-compassion (MSC) intervention program for a sample of adult patients with either anxiety or depressive disorders, with 83 % having more than one diagnoses. The results demonstrated significant reduction of self-judgment after the intervention (<em>p</em> &lt; 0.001, <em>d</em> = −1.04) along with increased self-compassion (<em>p</em> &lt; 0.001, <em>d</em> =1.20); in particular, participants with above median score on the Childhood Trauma Questionnaire had significantly more improvement than those with below median scores (<em>p</em> &lt; 0.05). Resting state fMRI was used to study neural correlates and showed that reduced self-judgment was associated with increased posterior cingulate cortex functional connectivity with dorsal lateral prefrontal cortex, inferior frontal gyrus, and dorsal medial prefrontal cortex, accompanied by reduced posterior cingulate cortex functional connectivity with the amygdala-hippocampal complex. These findings suggest reduced self-judgment after MSC training was substantiated by reduced fear circuitry influences on self-referential processes along with enhanced frontal regulation from the executive network and language network.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Driven by rewards or punishments? Understanding real world social functioning in anxiety and depressive disorders","authors":"Angie M. Gross ,&nbsp;Madeleine Rassaby ,&nbsp;Samantha N. Hoffman ,&nbsp;Colin A. Depp ,&nbsp;Raeanne C. Moore ,&nbsp;Charles T. Taylor","doi":"10.1016/j.xjmad.2024.100097","DOIUrl":"10.1016/j.xjmad.2024.100097","url":null,"abstract":"<div><h3>Background</h3><div>Social disconnection is prevalent in anxiety and depressive disorders and adversely impacts well-being. Prevailing treatment approaches assume social disconnection is a by-product of anxiety or depressive symptoms; however, social impairments often persist following symptom reduction. To advance understanding of why people with anxiety or depression experience social disconnection, we tested a framework in which daily social experiences were predicted from dispositional sensitivities to positive (rewarding) vs. negative (aversive) outcomes.</div></div><div><h3>Method</h3><div>Adults (<em>N</em> = 112; aged 18–55) seeking treatment for anxiety or depression completed a measure assessing approach temperament (i.e., general sensitivity to positive outcomes) and avoidance temperament (i.e., general sensitivity to negative outcomes). They subsequently received 20 ecological momentary assessment (EMA) surveys over five consecutive days measuring current social activity, perceived connectedness, loneliness, and positive and negative affect.</div></div><div><h3>Results</h3><div>Individuals higher in approach temperament reported greater momentary social connectedness, lower loneliness, and more frequent social interactions (medium to large effects). They also experienced greater momentary positive affect, which was associated with all real-time social outcomes (medium to large effects). Avoidance temperament overall was not associated with daily social experiences nor affect; however, in subjects with low approach temperament, higher avoidance temperament predicted greater momentary negative affect. Real-time loneliness was linked to momentary negative affect, but only when momentary positive affect was low.</div></div><div><h3>Limitations</h3><div>The study was correlational; thus, causal claims cannot be made.</div></div><div><h3>Conclusions</h3><div>Approach temperament and its associated affective states may be uniquely related to daily social experiences in anxiety and depression and could serve as targets for interventions intended to remediate social disconnection.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"9 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens.","authors":"Katia M. Harlé ,&nbsp;Danielle N. Dun ,&nbsp;Andrea D. Spadoni ,&nbsp;Jonathon R. Howlett ,&nbsp;Alan N. Simmons","doi":"10.1016/j.xjmad.2024.100088","DOIUrl":"10.1016/j.xjmad.2024.100088","url":null,"abstract":"<div><p>Anhedonia, a reduced ability to experience positive affect and seek rewards, is present across many psychiatric disorders, notably among individuals who experienced trauma. Within the social domain, anhedonia manifests as an altered sense of belonging and social isolation and is associated with poorer clinical outcomes. Yet, mechanistic operationalizations of social anhedonia are lacking, limiting our understanding of the relationship between these mechanisms and affective symptoms. To address these questions, we developed a social reward exploration task which was administered to a transdiagnostic sample of trauma-exposed Veterans (N = 33) while they underwent functional magnetic resonance imaging. The goal was to maximize compliments from two unknown partners, as participants were told these partners selected compliments based on seeing their picture. A Bayesian reinforcement learning modeling approach was used to extract cognitive and neural markers of compliment (reward) exploration. To address these questions, we developed a social reward exploration task which was administered to a transdiagnostic sample of trauma-exposed Veterans (N = 33) while they underwent functional magnetic resonance imaging. The goal was to maximize compliments from two unknown partners, as participants were told these partners selected compliments based on seeing their picture. A Bayesian reinforcement learning modeling approach was used to extract cognitive and neural markers of compliment (reward) exploration. Higher social connectedness (β = 0.51; 95 % CI=[0.11,0.94]) and anxiety (β = 0.57; 95 % CI=[0.13,1.00]) were independently associated with more model-based choices of the partner they anticipated to be most complimenting. In the dorsal anterior cingulate cortex (ACC; z = 3.89, <em>p</em> .001) and left inferior parietal lobule (z = 3.96, <em>p</em> .001), neural responses to reward prediction errors (RPE) were more positive in response to compliment relative to non-compliment outcomes. Greater positive RPE ACC activation was associated with lower anxiety (β = −0.51; 95 % CI=[−0.99,−0.10]. Computational approaches to social reinforcement learning can help identify important neurocognitive differences in social reward sensitivity among individuals with complex affective profiles, such as trauma-exposed individuals. Understanding these differences may help develop new prediction and treatment tools for social anhedonia.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000427/pdfft?md5=fa995f6e76f3d9693b000dc7e18cf59f&pid=1-s2.0-S2950004424000427-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on the bidirectional relationship between trauma-related psychopathology and reproductive aging","authors":"Amanda R. Arnold ,&nbsp;Trinidi Prochaska ,&nbsp;Maximilian Fickenwirth ,&nbsp;Abigail Powers ,&nbsp;Alicia K. Smith ,&nbsp;E. Britton Chahine ,&nbsp;Jennifer S. Stevens ,&nbsp;Vasiliki Michopoulos","doi":"10.1016/j.xjmad.2024.100082","DOIUrl":"10.1016/j.xjmad.2024.100082","url":null,"abstract":"<div><h3>Objective</h3><p>Natural variation in ovarian steroid hormones across the female lifespan contributes to an increased risk for depressive and posttraumatic stress disorder (PTSD) symptoms in women. However, minimal work has focused on understanding the impacts of reproductive aging on the brain and behavioral health of trauma-exposed women. This systematic review examines the bidirectional relationship between trauma-related psychopathology and reproductive aging.</p></div><div><h3>Method</h3><p>Following PRISMA guidelines, a systematic review of PubMed, PsychInfo, and Medline databases was undertaken to identify controlled studies on how trauma history impacts psychopathology and menopause symptoms during reproductive aging.</p></div><div><h3>Results</h3><p>Twenty-one studies met the eligibility criteria, with only four utilizing the gold standard STRAW+ 10 criteria for defining reproductive aging stages. The peri and postmenopausal periods appear to be particularly vulnerable phases for individuals with trauma exposure. Menopause symptoms and trauma-related psychopathology symptom severity increase during reproductive aging with increases in the degree of trauma exposure. However, mechanistic insights that may explain this interaction are currently neglected in this area of research.</p></div><div><h3>Conclusion</h3><p>There is a significant lack of understanding regarding how reproductive aging and its related neuroendocrine changes impact the brain to influence PTSD and depression symptoms related to trauma exposure. This lack of basic understanding impedes the ability to identify, assess, and treat PTSD and depressive symptoms in trauma-exposed women most effectively, and mitigate the long-term consequences of these behavioral health symptoms on morbidity and mortality in aging women.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000361/pdfft?md5=fbe0427ff840923868dc6c2ed86f7afd&pid=1-s2.0-S2950004424000361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heteronormative and cisnormative stereotypes in commonly-used social anxiety scales: A scoping review","authors":"Chantal Kasch ,&nbsp;Cameron E. Lindsay ,&nbsp;Stefan G. Hofmann","doi":"10.1016/j.xjmad.2024.100091","DOIUrl":"10.1016/j.xjmad.2024.100091","url":null,"abstract":"<div><div>Social anxiety is a common, but under-researched topic in the LGBTQIA+ community. We conducted a scoping review of studies between January 2014 and April 2024 that included LGBTQIA+ samples with social anxiety scales evaluating scales for outdated language. The search produced 1155 results out of which 17 articles fit the inclusion criteria. The results suggest that 47 % of the measures include items that reinforce heteronormative or cisnormative stereotypes and 29.4 % of studies included scales inappropriate for the population under investigation. Therefore, the wordings of certain items need to be adapted to fit the investigated population and a re-examination of the psychometric properties of the revised scales is needed.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100091"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142538336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent negative autobiographical memories and mental health","authors":"M. Alexandra Kredlow ,&nbsp;Hayley E. Fitzgerald ,&nbsp;Joseph K. Carpenter ,&nbsp;Nadine R. Taghian ,&nbsp;Michael W. Otto ,&nbsp;Stefan G. Hofmann ,&nbsp;Elizabeth A. Phelps","doi":"10.1016/j.xjmad.2024.100074","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100074","url":null,"abstract":"<div><h3>Background</h3><p>Recurrent symptom-relevant negative autobiographical memories are common in patients with emotional disorders such as anxiety and depression, even among those without a trauma-related diagnosis. Recurrent negative autobiographical memories may also contribute to distress in non-clinical populations.</p></div><div><h3>Methods</h3><p>To examine the prevalence of recurrent negative autobiographical memories and associated psychological features, we recruited a student sample (<em>n</em> = 101) and a treatment-seeking sample of patients with emotional disorders (<em>n</em> = 123). We hypothesized that recurrent negative autobiographical memories would be associated with higher levels of psychological symptoms and rumination. We also conducted exploratory analyses of participants’ most bothersome memory.</p></div><div><h3>Results</h3><p>In each sample, individuals who endorsed recurrent negative autobiographical memories had significantly higher depression, anxiety, and stress symptoms as well as greater rumination. In the treatment-seeking sample, where memories also had to be identified by patients as symptom-relevant, those who endorsed memories also had significantly higher clinician-rated symptom severity for their primary diagnosis. The majority of participants in each sample endorsed moderate or greater re-experiencing (sample 1: 79 %, sample 2: 66 %) and avoidance symptoms (sample 1: 78 %, sample 2: 58 %) related to their most bothersome memory.</p></div><div><h3>Conclusion</h3><p>Recurrent negative autobiographical memories relate to mental health symptoms in both clinical and non-clinical samples. Further research should explore whether targeting such memories reduces distress or improves wellbeing in these populations.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100074"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000282/pdfft?md5=2da2d86b7f7561b27bf29c0f8af5923e&pid=1-s2.0-S2950004424000282-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141291412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program","authors":"A. Irem Sonmez ,&nbsp;Ryan Webler ,&nbsp;Alyssa M. Krueger ,&nbsp;Clara Godoy-Henderson ,&nbsp;Christi Sullivan ,&nbsp;Saydra Wilson ,&nbsp;Sarah Olsen ,&nbsp;Sabine Schmid ,&nbsp;Alexander Herman ,&nbsp;Alik Widge ,&nbsp;Carol Peterson ,&nbsp;Ziad Nahas ,&nbsp;C. Sophia Albott","doi":"10.1016/j.xjmad.2024.100073","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100073","url":null,"abstract":"<div><h3>Background</h3><p>A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between changes in anhedonia and suicidal ideation (SI) related to transcranial magnetic stimulation (TMS), independent of any overall changes in depression.</p></div><div><h3>Methods</h3><p>Pre and post treatment PHQ-9 and IDS-SR data were collected from 181 TRD patients who received dorsolateral prefrontal cortex ( dlPFC) TMS using the Figure-8 or H1-coil. Changes in overall depression symptoms, anhedonia, and SI were analyzed using chi square tests, repeated measure ANOVAS, and linear regression for repeated measures.</p></div><div><h3>Results</h3><p>TMS yielded changes in overall depression symptoms (PHQ-9 Cohen’s <em>d</em> = 1.02; IDS-SR Cohen’s <em>d</em> = 1.05), with 23.9 % and 41.7 % of patients experiencing response as measured by IDS-SR and PHQ-9, respectively. TMS treatment was also associated with large changes in both anhedonia (<em>d</em> = 1.03) and SI (<em>d</em> = 0.88), which were similar in magnitude to changes in all other depression symptoms (<em>d</em> = 0.97). Importantly, changes in anhedonia predicted changes in SI, even after controlling for baseline depression severity and change in other depression symptoms.</p></div><div><h3>Limitations</h3><p>The lack of a control arm and a neuroimaging measure temper mechanistic conclusion.</p></div><div><h3>Conclusion</h3><p>Our results reinforce the effectiveness of TMS in TRD and provide new evidence that anhedonia and SI may belong to a broader symptom cluster potentially undergirded by a shared circuitry accessible to dlPFC TMS.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000270/pdfft?md5=ed1926cd46c298926013b8be92ba242a&pid=1-s2.0-S2950004424000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing research domain criteria symptoms among psychiatric inpatients using large language models","authors":"Thomas H. McCoy ,&nbsp;Roy H. Perlis","doi":"10.1016/j.xjmad.2024.100079","DOIUrl":"10.1016/j.xjmad.2024.100079","url":null,"abstract":"<div><p>We sought to characterize the ability of large language models to estimate NIMH Research Domain Criteria dimensions from narrative clinical notes of adult psychiatric inpatients, deriving estimate of overall burden of symptoms in each domain. We extracted consecutive admissions to a psychiatric inpatient unit between December 23, 2009 and September 27, 2015 from the electronic health records of a large academic medical center. Admission and discharge notes were scored with a HIPAA-compliant instance of a large language model (gpt-4–1106-preview). To examine convergent validity, the resulting estimates were correlated with those derived using an earlier method; for predictive validity, they were examined for association with length of hospitalization and probability of readmission. The cohort included 3619 individuals, 1779 female (49 %), 1840 male (51 %) with mean age 44 (SD=16.6). We identified modest correlations between LLM-derived RDoC scores and a previously validated scoring method, with Kendall’s tau between from.07 for arousal and 0.27 for positive and cognitive domains (p &lt; .001 for all of these). For admission notes, greater scores on cognitive, sensorimotor, negative, and social domains were significantly associated with longer length of hospitalization in linear regression models including sociodemographic features (p &lt; .01 for all of these); positive valence was associated with shorter hospitalization (p &lt; .001). For discharge notes, social, arousal, and positive valence were associated with likelihood of readmission within 180 days in adjusted logistic regression models (p &lt; .05 for social and arousal, p &lt; .001 for positive valence). Overall, LLM-derived estimates of RDoC psychopathology demonstrated promising convergent and predictive validity, suggesting this approach may make real-world application of the RDoC framework more feasible.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000336/pdfft?md5=713aa34765aff14b5d678c6003870dac&pid=1-s2.0-S2950004424000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}