Journal of mood and anxiety disorders最新文献

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Temporal dynamics of positive and negative affect in adolescents: Associations with depressive disorders and risk 青少年积极和消极情绪的时间动态:与抑郁障碍和风险的关系
Journal of mood and anxiety disorders Pub Date : 2024-04-15 DOI: 10.1016/j.xjmad.2024.100069
George Abitante , David A. Cole , Christian Bean , Madison Politte-Corn , Qimin Liu , Anh Dao , Lindsay Dickey , Samantha Pegg , Autumn Kujawa
{"title":"Temporal dynamics of positive and negative affect in adolescents: Associations with depressive disorders and risk","authors":"George Abitante ,&nbsp;David A. Cole ,&nbsp;Christian Bean ,&nbsp;Madison Politte-Corn ,&nbsp;Qimin Liu ,&nbsp;Anh Dao ,&nbsp;Lindsay Dickey ,&nbsp;Samantha Pegg ,&nbsp;Autumn Kujawa","doi":"10.1016/j.xjmad.2024.100069","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100069","url":null,"abstract":"<div><p>Alterations in dynamic affective processes are associated with dysregulated affect and depression. Although depression is often associated with heightened inertia (i.e., greater moment-to-moment correlation) and variability (i.e., larger departures from typical levels) of affect in adults, less is known about whether altered affect dynamics are present in youth at risk for depression. This study investigated the association of clinical depression and depression risk with the inertia and variability of positive and negative affect in a sample of youth at varying risk for depression. Our sample included 147 adolescents aged 14 to 17, categorized into three groups: never-depressed lower-risk, never-depressed higher-risk (based on maternal history of depression), and currently depressed adolescents. Adolescents completed ecological momentary assessments of positive and negative affect up to seven times per day for a week. Multilevel models and ANOVAs were used to examine associations of affective inertia and variability with adolescent depression and risk based on maternal history, controlling for average affect. Depressed adolescents showed more inert and diminished positive affect, and more variable and elevated negative affect compared to lower- and higher-risk youth, though associations attenuated after controlling for average affect. No differences were identified between never-depressed higher-risk and lower-risk youth. Additional longitudinal studies are needed to evaluate whether altered affect dynamics in daily life precede depression onset to understand their utility for developing preventive interventions.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100069"},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000233/pdfft?md5=647d368a471b6a45377d5a2d66f2f6c0&pid=1-s2.0-S2950004424000233-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140631645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abnormal neural sensitivity to rewards as a candidate process of high depression risk in the FMR1 premutation: A pilot study 神经对奖赏的异常敏感性是 FMR1 预突变高抑郁风险的候选过程:试点研究
Journal of mood and anxiety disorders Pub Date : 2024-04-03 DOI: 10.1016/j.xjmad.2024.100068
Roslyn Harold , Bridgette Kelleher , Keisha Novak , Wei Siong Neo , Teagan Stump , Taylor Lee , Tessa Garwood , Elizabeth Berry-Kravis , Dan Foti
{"title":"Abnormal neural sensitivity to rewards as a candidate process of high depression risk in the FMR1 premutation: A pilot study","authors":"Roslyn Harold ,&nbsp;Bridgette Kelleher ,&nbsp;Keisha Novak ,&nbsp;Wei Siong Neo ,&nbsp;Teagan Stump ,&nbsp;Taylor Lee ,&nbsp;Tessa Garwood ,&nbsp;Elizabeth Berry-Kravis ,&nbsp;Dan Foti","doi":"10.1016/j.xjmad.2024.100068","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100068","url":null,"abstract":"<div><p>The etiological heterogeneity of depression poses a challenge for prevention and intervention efforts. One solution is to map unique etiological pathways for subgroups defined by a singular risk factor. A relevant population for this approach is women who carry the premutation of the <em>fragile X messenger ribonucleoprotein</em> 1 (<em>FMR</em>1) gene, who are at high risk for adult-onset depression. This study explores a candidate neurophysiological marker of depression risk: reduced reward sensitivity, indexed by the reward positivity (RewP). The RewP has been linked to depression risk in the general population, but is unexplored within <em>FMR</em>1 premutation carriers. 16 women with the <em>FMR</em>1 premutation and a matched control group completed a simple guessing task while the electroencephalogram was recorded. Among premutation carriers, RewP difference score (win versus loss) was reduced. These preliminary finding suggest that the <em>FMR</em>1 premutation may confer increased risk for depression in part through abnormal neural sensitivity to rewards.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100068"},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000221/pdfft?md5=27a3828560b7939a7261f4feff08f003&pid=1-s2.0-S2950004424000221-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140348331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions between anxiety and impulsive dimensions are differentially associated with experiential avoidance 焦虑和冲动维度之间的相互作用与体验回避有不同的关联
Journal of mood and anxiety disorders Pub Date : 2024-03-30 DOI: 10.1016/j.xjmad.2024.100067
Sonalee A. Joshi , D. Angus Clark , James L. Abelson , Elizabeth R. Duval
{"title":"Interactions between anxiety and impulsive dimensions are differentially associated with experiential avoidance","authors":"Sonalee A. Joshi ,&nbsp;D. Angus Clark ,&nbsp;James L. Abelson ,&nbsp;Elizabeth R. Duval","doi":"10.1016/j.xjmad.2024.100067","DOIUrl":"10.1016/j.xjmad.2024.100067","url":null,"abstract":"<div><p>Anxiety and impulsivity often co-occur, but due to broad conceptualizations of impulsive behavior, it remains unclear whether anxiety could be positively associated with global impulsivity or specific facets of impulsivity. Negative urgency, or rash behavior that specifically occurs during negative emotional states, may provide common ground to examine the overlap between high anxiety and high impulsivity. Limited work has examined relationships between negative urgency and behavioral processes that are often associated with both anxiety and global impulsivity, such as experiential avoidance. In this study, we examined self-report data collected from a non-clinical sample of adult participants (n = 589) to test relationships between anxiety and experiential avoidance through both negative urgency and global impulsivity. Contrary to hypotheses, we found that negative urgency alone did not alter the relationship between anxiety and experiential avoidance. However, follow-up analyses including data-driven factors of impulsivity revealed that in combination, anxiety and both emotion-based impulsivity (i.e. negative and positive urgency) and hyperactivity were linked to greater experiential avoidance. By contrast, anxiety and non-planning were associated with lower experiential avoidance. These results provide targets for future studies to examine individual differences in profiles of co-occurring anxiety and impulsivity.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100067"},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442400021X/pdfft?md5=15e7e0ab14cbfab3d3da642818d4e6b3&pid=1-s2.0-S295000442400021X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140403390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing generalized anxiety disorder screening in young adults perinatally affected by HIV: A psychometric analysis 优化围产期感染艾滋病毒的年轻成人的广泛焦虑症筛查:心理计量分析
Journal of mood and anxiety disorders Pub Date : 2024-03-30 DOI: 10.1016/j.xjmad.2024.100066
Corey Morrison , Claude A. Mellins , Clayton Synder , Eileen Shea , Luke Kluisza , Reuben Robbins , Ohemaa Poku , Prudence Fisher , Elaine Abrams , Andrew Wiznia , Laura Mufson
{"title":"Optimizing generalized anxiety disorder screening in young adults perinatally affected by HIV: A psychometric analysis","authors":"Corey Morrison ,&nbsp;Claude A. Mellins ,&nbsp;Clayton Synder ,&nbsp;Eileen Shea ,&nbsp;Luke Kluisza ,&nbsp;Reuben Robbins ,&nbsp;Ohemaa Poku ,&nbsp;Prudence Fisher ,&nbsp;Elaine Abrams ,&nbsp;Andrew Wiznia ,&nbsp;Laura Mufson","doi":"10.1016/j.xjmad.2024.100066","DOIUrl":"10.1016/j.xjmad.2024.100066","url":null,"abstract":"<div><h3>Background</h3><p>Generalized Anxiety Disorder (GAD) is prevalent among people with HIV and is associated with adverse health outcomes. This study investigates the suitability of the Generalized Anxiety Disorder Scale-7 item (GAD-7) screening tool and its 2-item (GAD-2) version for use in young adults with perinatally-acquired HIV (YAPHIV) and young adults perinatally exposed to HIV but uninfected (YAPHEU).</p></div><div><h3>Methods</h3><p>Data come from the 7th follow-up interview (FU7) from a longitudinal study of youth with PHIV and PHEU, first recruited when 9–16 years. The GAD-7 was administered along with a diagnostic psychiatric interview (DISC-IV). Receiver Operating Characteristic analysis assessed accuracy, sensitivity, and specificity of the GAD7 and GAD-2. Subgroup analyses considered HIV status, ethnicity, and race.</p></div><div><h3>Results</h3><p>At FU7, participants (n = 204) were ages 20–29; 54% female; and the majority African-American and/or Latinx. 12% met diagnostic criteria for GAD. Recommended GAD-7 (&gt;10) and GAD-2 (&gt;3) cut-scores showed suboptimal sensitivity (0.52 and 0.48, respectively) and high specificity (0.91 and 0.90, respectively). Lowering cut-scores (GAD-7 &gt;6 and GAD-2 &gt;2) improved sensitivity (0.76 and 0.80) while sacrificing specificity (0.77 and 0.78). Stratified analyses by HIV status revealed similar accuracy in YAPHIV and YAPHEU. Race/ethnicity did not significantly affect cut-scores.</p></div><div><h3>Discussion</h3><p>Anxiety disorders are common in YAPHIV, and efficient screening is essential. While the GAD-7 and GAD-2 show promise, recommended cut-scores may not be optimal. Lowering cut-scores may enhance sensitivity without losing clinical utility. Further research is needed to refine cut-scores based on demographic characteristics and in global contexts, ensuring effective anxiety screening in this population.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100066"},"PeriodicalIF":0.0,"publicationDate":"2024-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000208/pdfft?md5=b48ae3cfe7e849065df71095aa993c1a&pid=1-s2.0-S2950004424000208-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140404532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suicide without warning: Results from the Army Study to Assess Risk and Resilience in Servicemembers (STARRS) 无预警自杀:评估军人风险和复原力的陆军研究(STARRS)结果
Journal of mood and anxiety disorders Pub Date : 2024-03-16 DOI: 10.1016/j.xjmad.2024.100064
Catherine L. Dempsey , Jingning Ao , Matthew W. Georg , Pablo A. Aliaga , David A. Brent , David M. Benedek , Kelly L. Zuromski , Matthew K. Nock , Steven G. Heeringa , Ronald C. Kessler , Murray B. Stein , Robert J. Ursano
{"title":"Suicide without warning: Results from the Army Study to Assess Risk and Resilience in Servicemembers (STARRS)","authors":"Catherine L. Dempsey ,&nbsp;Jingning Ao ,&nbsp;Matthew W. Georg ,&nbsp;Pablo A. Aliaga ,&nbsp;David A. Brent ,&nbsp;David M. Benedek ,&nbsp;Kelly L. Zuromski ,&nbsp;Matthew K. Nock ,&nbsp;Steven G. Heeringa ,&nbsp;Ronald C. Kessler ,&nbsp;Murray B. Stein ,&nbsp;Robert J. Ursano","doi":"10.1016/j.xjmad.2024.100064","DOIUrl":"10.1016/j.xjmad.2024.100064","url":null,"abstract":"<div><h3>Objectives</h3><p>The rate of suicide increased in members of the United States Army since 2011 after the Iraq and Afghanistan wars and continues to be a major concern. In order to reverse this disturbing trend, it is vital to understand the risk and protective factors for suicide death in servicemembers.</p></div><div><h3>Methods</h3><p>Data were obtained from a case-control psychological autopsy study, which compared U.S. Army suicide decedent cases (n = 135) to a probability sample of living controls (n = 255) who are also service members weighted to be representative of the Army. Interviews were conducted with next-of-kin (NOK) and supervisor (SUP) informants. Multivariable logistic regressions models were constructed using predictors significant after controlling for multiple comparisons.</p></div><div><h3>Results</h3><p>The most parsimonious multivariable model controlling for deployment status, as reported by SUP predicting suicide death consisted of four significant variables: a spouse or partner left him or her in the past month (OR = 28.5 [95% CI = 1.8, 442.7] χ² = 5.72, <em>p</em> = .0168); a smaller social network (OR = 4.2 [95% CI = 1.0, 17.3] χ² = 3.97, <em>p</em> = .0462), less likely to seek help from a mental health counselor (OR = 3.4 [95% CI = 1.2, 9.7] χ² = 5.35, <em>p</em> = .0207) and more likely to be described as incautious (OR = 3.8 [95% CI = 1.2, 11.7] χ² = 5.42, <em>p</em> = .0199). The AUC = .88 [95%CI = 0.82, 0.94] for this regression model suggests strong prediction.</p></div><div><h3>Conclusions</h3><p>Our findings suggest that recent relationship problems, especially in soldiers who are less likely to seek out support from others, may be warning signs for detection and prevention of imminent risk of suicide and according to supervisor informant surveys, had neither evidence of a mental health disorder, nor disclosed suicidal ideation or self-harm. Implications for suicide prevention are discussed.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100064"},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442400018X/pdfft?md5=5d8332cbaf9f1926576b2e3d2357881d&pid=1-s2.0-S295000442400018X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140270739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Smaller hippocampal volume is associated with anxiety symptoms in high-risk Black youth 海马体积较小与高危黑人青年的焦虑症状有关
Journal of mood and anxiety disorders Pub Date : 2024-03-14 DOI: 10.1016/j.xjmad.2024.100065
Rebecca Lipschutz , Abigail Powers , Sean T. Minton , Anais F. Stenson , Timothy D. Ely , Jennifer S. Stevens , Tanja Jovanovic , Sanne J.H. van Rooij
{"title":"Smaller hippocampal volume is associated with anxiety symptoms in high-risk Black youth","authors":"Rebecca Lipschutz ,&nbsp;Abigail Powers ,&nbsp;Sean T. Minton ,&nbsp;Anais F. Stenson ,&nbsp;Timothy D. Ely ,&nbsp;Jennifer S. Stevens ,&nbsp;Tanja Jovanovic ,&nbsp;Sanne J.H. van Rooij","doi":"10.1016/j.xjmad.2024.100065","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100065","url":null,"abstract":"<div><p>Although there is an established link between smaller hippocampal volume and anxiety, the longitudinal relations between hippocampus structure and anxiety in diverse youth are not well understood. The present longitudinal study investigated hippocampal volumes related to anxiety symptoms in a sample of Black 8–14-year-old youth (N = 64), a population historically underrepresented in neuroimaging research. Smaller hippocampal volumes were associated with greater anxiety symptoms independent of age, sex, intracranial volume and trauma exposure. Exploratory longitudinal analyses showed smaller hippocampal volume as a predictor for anxiety symptoms (n = 37) and not a consequence of anxiety symptoms (n = 32), however results were inconclusive as this finding was no longer significant after correcting for baseline anxiety symptoms. Overall, this data increases our understanding of potential neurobiological mechanisms for anxiety in a high-risk sample of Black youth and suggests future directions into studying trajectories of developmental risk.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100065"},"PeriodicalIF":0.0,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000191/pdfft?md5=1f33074d0b5b457e8d37b1b1c8101dc1&pid=1-s2.0-S2950004424000191-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140141873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing in-session rumination during CBT for depression: Replication and further evaluation of an observational measure 评估抑郁症 CBT 治疗过程中的会话反刍:对观察性测量方法的复制和进一步评估
Journal of mood and anxiety disorders Pub Date : 2024-03-02 DOI: 10.1016/j.xjmad.2024.100060
J.C. Kennedy , B.W. Dunlop , S.E. Baldwin , C.J. Liu , H.S. Mayberg , W.E. Craighead
{"title":"Assessing in-session rumination during CBT for depression: Replication and further evaluation of an observational measure","authors":"J.C. Kennedy ,&nbsp;B.W. Dunlop ,&nbsp;S.E. Baldwin ,&nbsp;C.J. Liu ,&nbsp;H.S. Mayberg ,&nbsp;W.E. Craighead","doi":"10.1016/j.xjmad.2024.100060","DOIUrl":"10.1016/j.xjmad.2024.100060","url":null,"abstract":"<div><p>This study sought to further evaluate an observational measure of rumination that occurs during psychotherapy (i.e., in-session rumination). Specifically, the study aimed to replicate the reliability of an observational rating procedure in new therapy sessions and a new sample, clarify the relationship between in-session rumination and depressive symptoms, and evaluate for the first time the relationship between in-session rumination and self-reported rumination. A team of trained research assistants produced observational ratings of in-session rumination occurring during video-taped sessions of CBT from two separate treatment studies. Thirty-five patients with major depressive disorder (MDD) from one study had their final session rated, and 17 patients with MDD from another study had their first session rated. Results showed that the observational ratings were reliable, and that in-session rumination generally correlated with depressive symptom severity as expected, with higher in-session rumination predicting higher depressive symptom levels both cross-sectionally and longitudinally. Preliminary evidence also found that in-session rumination correlated with self-reported rumination, and exploratory analyses provided preliminary evidence supporting the incremental validity of in-session rumination for predicting depression severity after treatment. The results indicate that in-session rumination can be reliably identified during CBT sessions and consistently predicts higher depressive severity, both of which support efforts to develop treatments that specifically target rumination.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100060"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000142/pdfft?md5=3276c6e51d2c0e72c230a96edef924aa&pid=1-s2.0-S2950004424000142-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140087560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective measurement of skin conductance response during trauma interview predicts future PTSD severity in trauma exposed children 创伤访谈期间皮肤传导反应的前瞻性测量可预测受创伤儿童未来创伤后应激障碍的严重程度
Journal of mood and anxiety disorders Pub Date : 2024-03-02 DOI: 10.1016/j.xjmad.2024.100061
Sattvik Basarkod , Shaurel Valbrun , Charis Wiltshire , John McClellan France , William Davie , Sterling Winters , Sophie A. George , Anais F. Stenson , Tanja Jovanovic
{"title":"Prospective measurement of skin conductance response during trauma interview predicts future PTSD severity in trauma exposed children","authors":"Sattvik Basarkod ,&nbsp;Shaurel Valbrun ,&nbsp;Charis Wiltshire ,&nbsp;John McClellan France ,&nbsp;William Davie ,&nbsp;Sterling Winters ,&nbsp;Sophie A. George ,&nbsp;Anais F. Stenson ,&nbsp;Tanja Jovanovic","doi":"10.1016/j.xjmad.2024.100061","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100061","url":null,"abstract":"<div><p>Previous cross-sectional studies have shown that sympathetic nervous system (SNS) arousal is positively associated with posttraumatic stress disorder (PTSD) symptoms in children with trauma exposure. One of the ways that SNS activity is measured is through skin conductance response (SCR), which has been shown to predict future PTSD severity in adults. In this study, we explored the utility of a novel, low-cost mobile SCR device, eSense, to predict future PTSD symptom severity in trauma exposed children. We recruited children (N = 43, age 9 years at initial visit) for a longitudinal study in which SCR was recorded at baseline visit, and PTSD symptoms were assessed two years later. Results indicated an interaction between SCR and trauma exposure, such that children with lower trauma exposure who demonstrated greater SCR reported higher PTSD severity two years later. This association remained significant even after controlling for baseline PTSD symptoms. Children with higher levels of trauma exposure did not show this association, potentially due to ceiling effects of PTSD symptoms. Together these findings suggest the utility of SCR as a biomarker for predicting trauma related disorders in children, and that it may be a valuable tool in clinical interventions targeting sympathetic arousal.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100061"},"PeriodicalIF":0.0,"publicationDate":"2024-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000154/pdfft?md5=8dac04e991170b0303f1ee1b445296ec&pid=1-s2.0-S2950004424000154-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140051802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT study 评估晚年抑郁症复发、认知负担和神经生物学平衡:REMBRANDT 研究的设计与原理
Journal of mood and anxiety disorders Pub Date : 2024-03-01 DOI: 10.1016/j.xjmad.2023.100038
Warren D. Taylor , Olusola Ajilore , Helmet T. Karim , Meryl A. Butters , Robert Krafty , Brian D. Boyd , Layla Banihashemi , Sarah M. Szymkowicz , Claire Ryan , Jason Hassenstab , Bennett A. Landman , Carmen Andreescu
{"title":"Assessing depression recurrence, cognitive burden, and neurobiological homeostasis in late life: Design and rationale of the REMBRANDT study","authors":"Warren D. Taylor ,&nbsp;Olusola Ajilore ,&nbsp;Helmet T. Karim ,&nbsp;Meryl A. Butters ,&nbsp;Robert Krafty ,&nbsp;Brian D. Boyd ,&nbsp;Layla Banihashemi ,&nbsp;Sarah M. Szymkowicz ,&nbsp;Claire Ryan ,&nbsp;Jason Hassenstab ,&nbsp;Bennett A. Landman ,&nbsp;Carmen Andreescu","doi":"10.1016/j.xjmad.2023.100038","DOIUrl":"10.1016/j.xjmad.2023.100038","url":null,"abstract":"<div><h3>Background</h3><p>Late-life depression is characterized by disability, cognitive impairment and decline, and a high risk of recurrence following remission. Aside from past psychiatric history, prognostic neurobiological and clinical factors influencing recurrence risk are unclear. Moreover, it is unclear if cognitive impairment predisposes to recurrence, or whether recurrent episodes may accelerate brain aging and cognitive decline. The purpose of the REMBRANDT study (Recurrence markers, cognitive burden, and neurobiological homeostasis in late-life depression) is to better elucidate these relationships and identify phenotypic, cognitive, environmental, and neurobiological factors contributing to and predictive of depression recurrence.</p></div><div><h3>Methods</h3><p>Across three sites, REMBRANDT will enroll 300 depressed elders who will receive antidepressant treatment. The goal is to enroll 210 remitted depressed participants and 75 participants with no mental health history into a two-year longitudinal phase focusing on depression recurrence. Participants are evaluated every 2 months with deeper assessments occurring every 8 months, including structural and functional neuroimaging, environmental stress assessments, deep symptom phenotyping, and two weeks of ‘burst’ ecological momentary assessments to elucidate variability in symptoms and cognitive performance. A broad neuropsychological test battery is completed at the beginning and end of the longitudinal study.</p></div><div><h3>Significance</h3><p>REMBRANDT will improve our understanding of how alterations in neural circuits and cognition that persist during remission contribute to depression recurrence vulnerability. It will also elucidate how these processes may contribute to cognitive impairment and decline. This project will obtain deep phenotypic data that will help identify vulnerability and resilience factors that can help stratify individual clinical risk.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"5 ","pages":"Article 100038"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442300038X/pdfft?md5=a665d147ef663d558c020ee436646f7c&pid=1-s2.0-S295000442300038X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135411597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to “A randomized clinical trial of behavioral activation and exposure-based therapy for adults with generalized anxiety disorder” [J. Mood Anxiety Disord., vol. 1, June 2023, 100004] 对 "行为激活和暴露疗法治疗成人广泛性焦虑症的随机临床试验 "的更正[J. Mood Anxiety Disord.,第 1 卷,2023 年 6 月,100004]
Journal of mood and anxiety disorders Pub Date : 2024-03-01 DOI: 10.1016/j.xjmad.2023.100044
Hannah Berg , Elisabeth Akeman , Timothy J. McDermott , Kelly T. Cosgrove , Namik Kirlic , Ashley Clausen , Mallory Cannon , Hung-Wen Yeh , Evan White , Wesley K. Thompson , Emily M. Choquette , Cassandra A. Sturycz-Taylor , Gabe Cochran , Sam Ramirez , Christopher R. Martell , Kate B. Wolitzky-Taylor , Michelle G. Craske , James L. Abelson , Martin P. Paulus , Robin L. Aupperle
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引用次数: 0
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