Journal of mood and anxiety disorders最新文献

{"title":"Predicting OCD severity from religiosity and personality: A machine learning and neural network approach","authors":"Brian A. Zaboski ,&nbsp;Alixandra Wilens ,&nbsp;Joseph P.H. McNamara ,&nbsp;Gregory N. Muller","doi":"10.1016/j.xjmad.2024.100089","DOIUrl":"10.1016/j.xjmad.2024.100089","url":null,"abstract":"<div><div>Obsessive-compulsive disorder (OCD) affects a significant portion of the United States population. The present study investigated the complex relationships among OCD severity, personality traits, religiosity, and spirituality with a dataset of 229 participants. We applied advanced machine and deep learning techniques to identify key predictors of OCD severity, uncovering nuanced relationships and unexpected findings. Notably, item-level features were more influential than aggregate scores, challenging traditional analytical approaches. Moreover, a neural network model, despite not surpassing a linear regression in predictive accuracy, provided a more comprehensive understanding of OCD’s heterogeneity and of the nonlinear relationships between our variables. The inclusion of demographic factors provided further explanatory power for predicting OCD severity, emphasizing the multifaceted nature of the disorder. Our results show that machine learning models can nearly match traditional linear models in predictive power while retaining nonlinear relationships essential to understanding OCD. Our study advocates for the adoption of sophisticated predictive models in examining complex psychological phenomena, encouraging a reevaluation of conventional analytical approaches when prediction is central to research questions.</div></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100089"},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing social anhedonia in a transdiagnostic sample: Insights from a computational psychiatry lens.","authors":"Katia M. Harlé ,&nbsp;Danielle N. Dun ,&nbsp;Andrea D. Spadoni ,&nbsp;Jonathon R. Howlett ,&nbsp;Alan N. Simmons","doi":"10.1016/j.xjmad.2024.100088","DOIUrl":"10.1016/j.xjmad.2024.100088","url":null,"abstract":"<div><p>Anhedonia, a reduced ability to experience positive affect and seek rewards, is present across many psychiatric disorders, notably among individuals who experienced trauma. Within the social domain, anhedonia manifests as an altered sense of belonging and social isolation and is associated with poorer clinical outcomes. Yet, mechanistic operationalizations of social anhedonia are lacking, limiting our understanding of the relationship between these mechanisms and affective symptoms. To address these questions, we developed a social reward exploration task which was administered to a transdiagnostic sample of trauma-exposed Veterans (N = 33) while they underwent functional magnetic resonance imaging. The goal was to maximize compliments from two unknown partners, as participants were told these partners selected compliments based on seeing their picture. A Bayesian reinforcement learning modeling approach was used to extract cognitive and neural markers of compliment (reward) exploration. To address these questions, we developed a social reward exploration task which was administered to a transdiagnostic sample of trauma-exposed Veterans (N = 33) while they underwent functional magnetic resonance imaging. The goal was to maximize compliments from two unknown partners, as participants were told these partners selected compliments based on seeing their picture. A Bayesian reinforcement learning modeling approach was used to extract cognitive and neural markers of compliment (reward) exploration. Higher social connectedness (β = 0.51; 95 % CI=[0.11,0.94]) and anxiety (β = 0.57; 95 % CI=[0.13,1.00]) were independently associated with more model-based choices of the partner they anticipated to be most complimenting. In the dorsal anterior cingulate cortex (ACC; z = 3.89, <em>p</em> .001) and left inferior parietal lobule (z = 3.96, <em>p</em> .001), neural responses to reward prediction errors (RPE) were more positive in response to compliment relative to non-compliment outcomes. Greater positive RPE ACC activation was associated with lower anxiety (β = −0.51; 95 % CI=[−0.99,−0.10]. Computational approaches to social reinforcement learning can help identify important neurocognitive differences in social reward sensitivity among individuals with complex affective profiles, such as trauma-exposed individuals. Understanding these differences may help develop new prediction and treatment tools for social anhedonia.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100088"},"PeriodicalIF":0.0,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000427/pdfft?md5=fa995f6e76f3d9693b000dc7e18cf59f&pid=1-s2.0-S2950004424000427-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142274836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on the bidirectional relationship between trauma-related psychopathology and reproductive aging","authors":"Amanda R. Arnold ,&nbsp;Trinidi Prochaska ,&nbsp;Maximilian Fickenwirth ,&nbsp;Abigail Powers ,&nbsp;Alicia K. Smith ,&nbsp;E. Britton Chahine ,&nbsp;Jennifer S. Stevens ,&nbsp;Vasiliki Michopoulos","doi":"10.1016/j.xjmad.2024.100082","DOIUrl":"10.1016/j.xjmad.2024.100082","url":null,"abstract":"<div><h3>Objective</h3><p>Natural variation in ovarian steroid hormones across the female lifespan contributes to an increased risk for depressive and posttraumatic stress disorder (PTSD) symptoms in women. However, minimal work has focused on understanding the impacts of reproductive aging on the brain and behavioral health of trauma-exposed women. This systematic review examines the bidirectional relationship between trauma-related psychopathology and reproductive aging.</p></div><div><h3>Method</h3><p>Following PRISMA guidelines, a systematic review of PubMed, PsychInfo, and Medline databases was undertaken to identify controlled studies on how trauma history impacts psychopathology and menopause symptoms during reproductive aging.</p></div><div><h3>Results</h3><p>Twenty-one studies met the eligibility criteria, with only four utilizing the gold standard STRAW+ 10 criteria for defining reproductive aging stages. The peri and postmenopausal periods appear to be particularly vulnerable phases for individuals with trauma exposure. Menopause symptoms and trauma-related psychopathology symptom severity increase during reproductive aging with increases in the degree of trauma exposure. However, mechanistic insights that may explain this interaction are currently neglected in this area of research.</p></div><div><h3>Conclusion</h3><p>There is a significant lack of understanding regarding how reproductive aging and its related neuroendocrine changes impact the brain to influence PTSD and depression symptoms related to trauma exposure. This lack of basic understanding impedes the ability to identify, assess, and treat PTSD and depressive symptoms in trauma-exposed women most effectively, and mitigate the long-term consequences of these behavioral health symptoms on morbidity and mortality in aging women.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100082"},"PeriodicalIF":0.0,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000361/pdfft?md5=fbe0427ff840923868dc6c2ed86f7afd&pid=1-s2.0-S2950004424000361-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142173804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Negative affect influences suicide-specific attentional biases","authors":"Beverlin Rosario-Williams,&nbsp;Regina Miranda","doi":"10.1016/j.xjmad.2024.100081","DOIUrl":"10.1016/j.xjmad.2024.100081","url":null,"abstract":"<div><h3>Background</h3><p>Studies using tasks that measure suicide-specific attentional biases have not specified which attentional processes are related to risk for suicidal thoughts and behaviors. This study distinguished suicide-specific engagement and disengagement biases from other forms of cognitive processing and investigated under which affective conditions suicide-specific biases emerged.</p></div><div><h3>Method</h3><p>An ethnoracially and socioeconomically diverse sample of 153 young adults (87 % female; 52 % Non-Hispanic White), ages 18–34, with moderate-to-high symptoms of anxiety, depression, or recent suicide ideation were randomly assigned to experience positive, negative, or neutral affect, completed cognitive tasks of attention, construct accessibility, and threat bias, and self-report measures.</p></div><div><h3>Results</h3><p>Individuals with recent ideation displayed facilitated disengagement from suicide-specific stimuli irrespective of affective state. Those with distal ideation showed slower disengagement from suicide-specific stimuli in the sad condition only.</p></div><div><h3>Conclusions</h3><p>Individuals with recent suicide ideation display automatic processing of suicide-related information, perhaps due to recent rehearsal of suicide-related content. In contrast, individuals with distal ideation experiencing negative affect appear to have difficulty disengaging attention from suicide-related content. Limits to generalizability of the findings include a predominantly female sample, although the sample’s racial, ethnic, and socioeconomic diversity increase generality of the research.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"7 ","pages":"Article 100081"},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S295000442400035X/pdfft?md5=3efed9b660dcd1c99fb9b7203c99d195&pid=1-s2.0-S295000442400035X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between prescriber practices and major depression treatment outcomes","authors":"Sarah Rathnam ,&nbsp;Abhishek Sharma ,&nbsp;Kamber L. Hart ,&nbsp;Pilar F. Verhaak ,&nbsp;Thomas H. McCoy ,&nbsp;Roy H. Perlis ,&nbsp;Finale Doshi-Velez","doi":"10.1016/j.xjmad.2024.100080","DOIUrl":"10.1016/j.xjmad.2024.100080","url":null,"abstract":"<div><p>Practice variability may represent an opportunity to improve care by identifying the differences in outcomes associated with differences in practice. To characterize differences in depression treatment outcomes among individual providers in outpatient psychiatry practices and primary care practices, we examined a longitudinal cohort derived from outpatient electronic health records from two academic medical centers and six community hospitals in Eastern Massachusetts. This cohort included antidepressant-treated individuals with an ICD-9/10 diagnosis of major depressive disorder, and deidentified health care providers treating at least 10 such patients per year between 2008 and 2022. We examined the association between individual provider prescribing characteristics and proportions of treated patients who do not follow up after initial antidepressant prescription or who achieve a stable ongoing prescription. In binomial regression models, among 104 psychiatrists, greater heterogeneity in antidepressant prescribing and lesser proportion of serotonin reuptake inhibitors (SSRIs)¹ prescribed were associated with greater rates of achieving stability (for heterogeneity, adjusted odds ratio AOR, 1.55 [95 % CI, 1.22 – 2.06]; for proportion of SSRIs, AOR, 0.01 [95 % CI, 0.00–0.59]). Among 369 primary care physicians, greater volume of depression encounters per year, but not prescribing heterogeneity, was associated with greater rates of achieving stability (for encounters, AOR, 2.15 [95 % CI, 1.61 – 2.89]; for heterogeneity, AOR, 0.99 [95 % CI, 0.85 – 1.15]). Primary care and psychiatry predictors are not the same and therefore suggest potentially distinct strategies to improve clinical outcomes in each setting. <strong>Trial Registration</strong>: N/A</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100080"},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000348/pdfft?md5=7f358efa07edf57de3e43d7cdb14a667&pid=1-s2.0-S2950004424000348-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141963825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing research domain criteria symptoms among psychiatric inpatients using large language models","authors":"Thomas H. McCoy ,&nbsp;Roy H. Perlis","doi":"10.1016/j.xjmad.2024.100079","DOIUrl":"10.1016/j.xjmad.2024.100079","url":null,"abstract":"<div><p>We sought to characterize the ability of large language models to estimate NIMH Research Domain Criteria dimensions from narrative clinical notes of adult psychiatric inpatients, deriving estimate of overall burden of symptoms in each domain. We extracted consecutive admissions to a psychiatric inpatient unit between December 23, 2009 and September 27, 2015 from the electronic health records of a large academic medical center. Admission and discharge notes were scored with a HIPAA-compliant instance of a large language model (gpt-4–1106-preview). To examine convergent validity, the resulting estimates were correlated with those derived using an earlier method; for predictive validity, they were examined for association with length of hospitalization and probability of readmission. The cohort included 3619 individuals, 1779 female (49 %), 1840 male (51 %) with mean age 44 (SD=16.6). We identified modest correlations between LLM-derived RDoC scores and a previously validated scoring method, with Kendall’s tau between from.07 for arousal and 0.27 for positive and cognitive domains (p &lt; .001 for all of these). For admission notes, greater scores on cognitive, sensorimotor, negative, and social domains were significantly associated with longer length of hospitalization in linear regression models including sociodemographic features (p &lt; .01 for all of these); positive valence was associated with shorter hospitalization (p &lt; .001). For discharge notes, social, arousal, and positive valence were associated with likelihood of readmission within 180 days in adjusted logistic regression models (p &lt; .05 for social and arousal, p &lt; .001 for positive valence). Overall, LLM-derived estimates of RDoC psychopathology demonstrated promising convergent and predictive validity, suggesting this approach may make real-world application of the RDoC framework more feasible.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100079"},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000336/pdfft?md5=713aa34765aff14b5d678c6003870dac&pid=1-s2.0-S2950004424000336-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141849994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eye-tracking measurement of attention bias to social threat among youth: A replication and extension study","authors":"Meghan E. Byrne ,&nbsp;Sara Kirschner ,&nbsp;Anita Harrewijn ,&nbsp;Rany Abend ,&nbsp;Amit Lazarov ,&nbsp;Lucrezia Liuzzi ,&nbsp;Katharina Kircanski ,&nbsp;Simone P. Haller ,&nbsp;Yair Bar-Haim ,&nbsp;Daniel S. Pine","doi":"10.1016/j.xjmad.2024.100075","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100075","url":null,"abstract":"<div><p>Attentional bias to social threat cues has been linked to heightened anxiety and irritability in youth. Yet, inconsistent methodology has limited replication and led to mixed findings. The current study aims to 1) replicate and extend two previous pediatric studies demonstrating a relationship between negative affectivity and attentional bias to social threat and 2) examine the test-retest reliability of an eye-tracking paradigm among a subsample of youth. Attention allocation to negative versus non-negative emotional faces was measured using a free-viewing eye-tracking task among youth (<em>N =</em> 185 total, 60 % female, <em>M</em>_age = 13.10 years, <em>SD</em>_age = 2.77) with three face-pair conditions: happy-angry, neutral-disgust, sad-happy. Replicating procedures of two previous studies, linear mixed-effects models compared attention bias between children with anxiety disorders and healthy controls. Bifactor analysis was used to parse shared versus unique facets of general negative affectivity (i.e., anxiety, irritability), which were then examined in relation to attention bias. Test-retest reliability of the bias-index was estimated among a subsample of youth (<em>N</em> = 36). No significant differences in attention allocation or bias emerged between anxiety and healthy control groups. While general negative affectivity across the sample was not associated with attention bias, there was a positive relationship for anxiety and irritability on duration of attention allocation toward negative faces. Test-retest reliability for attention bias was moderate (<em>r</em> = 0.50, <em>p</em> &lt; .01). While anxiety-related findings from the two previous studies were not replicated, the relationship between attention bias and facets of negative affect suggests a potential target for treatment. Evidence for test-retest reliability encourages future use of the eye-tracking task for researchers.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100075"},"PeriodicalIF":0.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000294/pdfft?md5=1b7e7c53ad07458570fd3c413efa2d7e&pid=1-s2.0-S2950004424000294-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141434249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment","authors":"Christopher Hunt ,&nbsp;Meghan Vinograd ,&nbsp;Laura M. Glynn ,&nbsp;Elysia Poggi Davis ,&nbsp;Tallie Z. Baram ,&nbsp;Hal Stern ,&nbsp;Caroline Nievergelt ,&nbsp;Bruna Cuccurazzu ,&nbsp;Cindy Napan ,&nbsp;Dylan Delmar ,&nbsp;Dewleen G. Baker ,&nbsp;Victoria B. Risbrough","doi":"10.1016/j.xjmad.2023.100045","DOIUrl":"https://doi.org/10.1016/j.xjmad.2023.100045","url":null,"abstract":"<div><p>High unpredictability has emerged as a dimension of early-life adversity that may contribute to a host of deleterious consequences later in life. Early-life unpredictability affects development of limbic and reward circuits in both rodents and humans, with a potential to increase sensitivity to stressors and mood symptoms later in life. Here, we examined the extent to which unpredictability during childhood was associated with changes in mood symptoms (anhedonia and general depression) after two adult life stressors, combat deployment and civilian reintegration, which were assessed ten years apart. We also examined how perceived stress and social support mediated and /or moderated links between childhood unpredictability and mood symptoms. To test these hypotheses, we leveraged the Marine Resiliency Study, a prospective longitudinal study of the effects of combat deployment on mental health in Active-Duty Marines and Navy Corpsman. Participants (<em>N</em> = 273) were assessed for depression and anhedonia before (pre-deployment) and 3–6 months after (acute post-deployment) a combat deployment. Additional assessment of depression and childhood unpredictability were collected 10 years post-deployment (chronic post-deployment). Higher childhood unpredictability was associated with higher anhedonia and general depression at both acute and chronic post-deployment timepoints (<em>β</em>s <u>&gt;</u> 0.16, <em>p</em>s <u>&lt;</u>.007). The relationship between childhood unpredictability and subsequent depression at acute post-deployment was partially mediated by lower social support (<em>b</em> = 0.07, 95% CI [0.03, 0.15]) while depression at chronic post-deployment was fully mediated by a combination of lower social support (<em>b</em> = 0.14, 95% CI [0.07, 0.23]) and higher perceived stress (<em>b</em> = 0.09, 95% CI [0.05, 0.15]). These findings implicate childhood unpredictability as a potential risk factor for depression in adulthood and suggest that increasing the structure and predictability of childhood routines and developing social support interventions after life stressors could be helpful for preventing adult depression.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100045"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004423000457/pdfft?md5=ebed24e0834e247233b508ef00594226&pid=1-s2.0-S2950004423000457-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune cell markers associated with early life major depressive episodes","authors":"Roxann Roberson-Nay ,&nbsp;Dana M. Lapato ,&nbsp;Amanda Gentry ,&nbsp;Eva E. Lancaster ,&nbsp;Timothy P. York","doi":"10.1016/j.xjmad.2024.100049","DOIUrl":"10.1016/j.xjmad.2024.100049","url":null,"abstract":"<div><p>Emerging evidence indicates an association between altered immune system functioning, inflammatory response activation, and major depression (MD). This study examined the association between major depression in young people and the monocyte-to-lymphocyte (MLR) and neutrophil-to-lymphocyte ratio (NLR). Inflammation markers were estimated from DNA methylation data using an established cell-mixture deconvolution algorithm and examined in a well-characterized, antidepressant free epidemiological sample of young twins (N = 170). No statistically significant differences were observed between young persons with and without Lifetime MD for the MLR and NLR. A post-hoc analysis of time since last major depressive episode (MDE) indicated that more recent MDEs were associated with higher MLR and NLR levels compared to temporally distant MDEs. A second post-hoc analysis using the full sample determined that past year MDEs were associated with elevated MLR and NLR scores compared to persons unaffected by lifetime MD and person experiencing their last MDE over one year ago. Finally, T cell immunity was most consistently associated with recent MDEs, suggesting that levels of this adaptive immune cell were diminished. Young people experiencing a recent MDE demonstrated increased levels of inflammation with T cells exhibiting the most persistent associations with depression outcomes. Etiological and treatment implications of results are discussed.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"6 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000038/pdfft?md5=a5c028d6ba5af3dfa4d1115d9678d05c&pid=1-s2.0-S2950004424000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of TMS on anhedonia and suicidal ideation in treatment-resistant depression: Outcomes from the University of Minnesota Interventional Psychiatry Program","authors":"A. Irem Sonmez ,&nbsp;Ryan Webler ,&nbsp;Alyssa M. Krueger ,&nbsp;Clara Godoy-Henderson ,&nbsp;Christi Sullivan ,&nbsp;Saydra Wilson ,&nbsp;Sarah Olsen ,&nbsp;Sabine Schmid ,&nbsp;Alexander Herman ,&nbsp;Alik Widge ,&nbsp;Carol Peterson ,&nbsp;Ziad Nahas ,&nbsp;C. Sophia Albott","doi":"10.1016/j.xjmad.2024.100073","DOIUrl":"https://doi.org/10.1016/j.xjmad.2024.100073","url":null,"abstract":"<div><h3>Background</h3><p>A developing literature suggests that transcranial magnetic stimulation (TMS) can target anhedonia and suicidal ideation (SI), core symptoms of treatment-resistant depression (TRD). This present naturalistic study extends the existing literature by investigating the connection between changes in anhedonia and suicidal ideation (SI) related to transcranial magnetic stimulation (TMS), independent of any overall changes in depression.</p></div><div><h3>Methods</h3><p>Pre and post treatment PHQ-9 and IDS-SR data were collected from 181 TRD patients who received dorsolateral prefrontal cortex ( dlPFC) TMS using the Figure-8 or H1-coil. Changes in overall depression symptoms, anhedonia, and SI were analyzed using chi square tests, repeated measure ANOVAS, and linear regression for repeated measures.</p></div><div><h3>Results</h3><p>TMS yielded changes in overall depression symptoms (PHQ-9 Cohen’s <em>d</em> = 1.02; IDS-SR Cohen’s <em>d</em> = 1.05), with 23.9 % and 41.7 % of patients experiencing response as measured by IDS-SR and PHQ-9, respectively. TMS treatment was also associated with large changes in both anhedonia (<em>d</em> = 1.03) and SI (<em>d</em> = 0.88), which were similar in magnitude to changes in all other depression symptoms (<em>d</em> = 0.97). Importantly, changes in anhedonia predicted changes in SI, even after controlling for baseline depression severity and change in other depression symptoms.</p></div><div><h3>Limitations</h3><p>The lack of a control arm and a neuroimaging measure temper mechanistic conclusion.</p></div><div><h3>Conclusion</h3><p>Our results reinforce the effectiveness of TMS in TRD and provide new evidence that anhedonia and SI may belong to a broader symptom cluster potentially undergirded by a shared circuitry accessible to dlPFC TMS.</p></div>","PeriodicalId":73841,"journal":{"name":"Journal of mood and anxiety disorders","volume":"8 ","pages":"Article 100073"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2950004424000270/pdfft?md5=ed1926cd46c298926013b8be92ba242a&pid=1-s2.0-S2950004424000270-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141481340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}