Journal of metabolic and bariatric surgery最新文献

Cost-Effectiveness of Obesity Treatments: Glucagon-Like Peptide-1 Receptor Agonists, Endoscopic Sleeve Gastroplasty, and Metabolic/Bariatric Surgery. 肥胖治疗的成本-效果：胰高血糖素样肽-1受体激动剂、内窥镜套管胃成形术和代谢/减肥手术。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-18 DOI: 10.17476/jmbs.2025.14.2.97

Yeon-Ju Huh

{"title":"Cost-Effectiveness of Obesity Treatments: Glucagon-Like Peptide-1 Receptor Agonists, Endoscopic Sleeve Gastroplasty, and Metabolic/Bariatric Surgery.","authors":"Yeon-Ju Huh","doi":"10.17476/jmbs.2025.14.2.97","DOIUrl":"10.17476/jmbs.2025.14.2.97","url":null,"abstract":"Obesity represents a major global health challenge, requiring interventions that are both effective and economically sustainable. This review examines the cost-effectiveness of commonly discussed treatment options: glucagon-like peptide-1 receptor agonists (GLP-1 RAs), endoscopic sleeve gastroplasty (ESG), and metabolic/bariatric surgery (MBS). We synthesized evidence from published clinical studies and economic analyses, comparing incremental cost-effectiveness ratios (ICERs) and cost per quality-adjusted life year across obesity severity classes, with particular consideration of implications for Korea's healthcare context. Clinical trial data indicate that GLP-1 RAs can achieve approximately 15-20% weight reduction, but high cost often places ICERs above conventional willingness-to-pay benchmarks. ESG, a less invasive endoscopic procedure, yields around 15% weight loss and has demonstrated favorable cost-effectiveness, particularly in class I obesity. MBS offers the most durable weight loss, generally 25-30%, along with improvements in survival and quality of life. Economic evaluations consistently report MBS as highly cost-effective-and in some cases cost-saving-especially for class II and III obesity. Comparative findings suggest that ESG is generally more economically favorable than GLP-1 RAs in class I obesity, whereas head-to-head comparisons with MBS are limited. At current pricing, GLP-1 RAs rarely meet accepted cost-effectiveness thresholds. MBS is the most cost-effective intervention for moderate-to-severe obesity globally, while ESG is promising in lower body mass index groups. Despite their efficacy, GLP-1 RAs are limited by cost. As ESG is not yet available in Korea and evidence supporting MBS in class I obesity continues to accumulate, reassessment of cost-effectiveness in the Korean context is warranted.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"97-105"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bariatric Surgery in Patients With Prader-Willi Syndrome. Prader-Willi综合征患者的减肥手术。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-12 DOI: 10.17476/jmbs.2025.14.2.85

Maximilian Herbert Dressler, Jong-Ho Choi, Kyoyoung Park, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee

{"title":"Bariatric Surgery in Patients With Prader-Willi Syndrome.","authors":"Maximilian Herbert Dressler, Jong-Ho Choi, Kyoyoung Park, Seong-Ho Kong, Do Joong Park, Hyuk-Joon Lee","doi":"10.17476/jmbs.2025.14.2.85","DOIUrl":"10.17476/jmbs.2025.14.2.85","url":null,"abstract":"Prader-Willi Syndrome (PWS) is a genetic disorder characterized by insatiable hyperphagia, resulting in severe, early-onset obesity that is often refractory to conventional management. The associated comorbidities and reduced life expectancy in PWS present a significant therapeutic challenge. This review synthesizes the existing literature on the controversial role, outcomes, and complexities of bariatric surgery in patients with PWS. In recent decades, bariatric surgical techniques have evolved from malabsorptive or restrictive operations to modern procedures such as sleeve gastrectomy (SG) and Roux-en-Y gastric bypass (RYGB). We present a 21-year-old male's SG case to illustrate key themes. Published series from specialized, high-volume centers demonstrate that SG and RYGB yield significant short- to mid-term weight loss and metabolic improvement with an acceptable perioperative risk profile. However, the fundamental challenge in PWS remains the persistent, inherent hyperphagia. As exemplified by the presented case and supported by the broader literature, this insatiable hunger severely limits long-term surgical success and frequently leads to substantial weight regain. Maintaining durable success requires rigorous, lifelong external dietary supervision and intensive multidisciplinary support. Moreover, ethical considerations, particularly regarding informed consent and procedural choice, complicate the application of bariatric surgery in this population. Bariatric surgery should therefore be considered an adjunctive tool rather than a definitive cure for PWS-related obesity. Its use must be reserved for carefully selected individuals who have severe comorbidities and robust, long-term support structures in place. This perspective highlights the critical need for ongoing research into optimal patient selection, procedural approaches, and adjuvant therapies to improve durable outcomes.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"85-96"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic Sleeve Gastrectomy: Efficacy and Safety of Classic vs. Hard Techniques in Long-Term Weight Loss: A Retrospective Cohort Study. 腹腔镜袖式胃切除术：经典技术与硬技术在长期减肥中的有效性和安全性：一项回顾性队列研究。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-13 DOI: 10.17476/jmbs.2025.14.2.150

Oktyabr Ruhullaevich Teshaev, Umid S Ruziyev

{"title":"Laparoscopic Sleeve Gastrectomy: Efficacy and Safety of Classic vs. Hard Techniques in Long-Term Weight Loss: A Retrospective Cohort Study.","authors":"Oktyabr Ruhullaevich Teshaev, Umid S Ruziyev","doi":"10.17476/jmbs.2025.14.2.150","DOIUrl":"10.17476/jmbs.2025.14.2.150","url":null,"abstract":"Purpose: This study aimed to compare the efficacy and safety of Classic and Hard laparoscopic sleeve gastrectomy (LSG) techniques, with a focus on long-term weight loss outcomes and complication rates over a 3-year follow-up period.Materials and methods: A retrospective cohort study was conducted on 785 patients who underwent LSG between January 2019 and December 2022, with follow-up completed by 2023. Patients were divided into 2 groups according to surgical technique: Classic LSG (n=372), involving standard resection along the lesser curvature using a 36-French bougie; and Hard LSG (n=413), characterized by more extensive fundal mobilization and creation of a narrower gastric tube using a 32-French bougie.Results: Both techniques resulted in significant body mass index (BMI) reductions; however, Hard LSG demonstrated superior weight loss. At 12 months, 70.7% of Hard LSG patients achieved a normal BMI (<25 kg/m2), compared to 42.2% in the Classic group. At 3 years, 59.3% and 20.4% maintained normal BMI, respectively (P<0.001). However, Hard LSG was associated with higher complication rates: early metabolic complications occurred in 64.3% vs. 25.7% (P<0.001), and late surgical complications in 10.4% vs. 2.4% (P<0.001).Conclusion: While Hard LSG provides greater and more durable weight loss, it is associated with increased risks of complications. These findings support the need for individualized surgical decision-making to balance efficacy and safety in the management of obesity.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"150-156"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Significance of Early Postoperative Weight Loss in Bariatric Surgery: A Narrative Review. 减肥手术术后早期减重的临床意义：综述。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-22 DOI: 10.17476/jmbs.2025.14.2.139

Su-Mi Kim

引用次数: 0

Atypical Biliary Fistula After Revisional Bariatric Surgery: A Case Report. 矫正减肥手术后不典型胆道瘘1例报告。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-22 DOI: 10.17476/jmbs.2025.14.2.157

Venkata Pavan Kumar Karanam, Aarsh Mukeshbhai Panchal, Suresh Kumar Sepuri, Lakshmi Kumar Chalamarla, Phani Krishna Ravula

{"title":"Atypical Biliary Fistula After Revisional Bariatric Surgery: A Case Report.","authors":"Venkata Pavan Kumar Karanam, Aarsh Mukeshbhai Panchal, Suresh Kumar Sepuri, Lakshmi Kumar Chalamarla, Phani Krishna Ravula","doi":"10.17476/jmbs.2025.14.2.157","DOIUrl":"10.17476/jmbs.2025.14.2.157","url":null,"abstract":"Obesity affects about 39% of the global population, and bariatric surgery is a leading treatment option. As the number of primary bariatric procedures increases, so does the demand for revisional bariatric surgeries (RBSs), which are often more complex and associated with increased risks of complications. This case report details an unusual complication of RBS that surgeons should be aware of. A 41-year-old male patient with morbid obesity, after an initial sleeve gastrectomy, experienced weight regain due to gastric pouch dilatation and underwent conversion to mini-gastric bypass. Postoperatively however, he presented with recurrent left subhepatic abscess. Evaluation revealed left ductal leak from undersurface of liver as cause of recurrent liver abscess. Surgical intervention in the form of left lateral sectionectomy, resolved the symptoms. This case underscores the complexities and potential complications associated with RBS, highlighting the need for meticulous adhesiolysis between stomach and left liver during revisional gastric surgeries.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"157-163"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Impact of Bariatric Surgery on Brain Functionality. 减肥手术对脑功能的早期影响。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-22 DOI: 10.17476/jmbs.2025.14.2.106

Bruna Barros Fernandes, Larissa Espindola da Silva, Stefanny da Silva Willemann, Mariella Reinol Steiner, Mariana Pacheco de Oliveira, Richard Simon Machado, Francisco J Cidral-Filho, Patrick Porter, Daniel Fernandes Martins, Gislaine Tezza Rezin

{"title":"Early Impact of Bariatric Surgery on Brain Functionality.","authors":"Bruna Barros Fernandes, Larissa Espindola da Silva, Stefanny da Silva Willemann, Mariella Reinol Steiner, Mariana Pacheco de Oliveira, Richard Simon Machado, Francisco J Cidral-Filho, Patrick Porter, Daniel Fernandes Martins, Gislaine Tezza Rezin","doi":"10.17476/jmbs.2025.14.2.106","DOIUrl":"10.17476/jmbs.2025.14.2.106","url":null,"abstract":"Obesity is a chronic inflammatory disease with an alarming number of cases recorded, becoming a global public health problem. Thus, an increasing number of eligible individuals choose to undergo metabolic and bariatric surgery (MBS), known for its effective results in weight reduction and improvement of metabolic conditions. Despite reversing the damage to the central nervous system caused by obesity, these procedures also present neuronal complications. Therefore, in this review, we explore the early impact of MBS on the brain of postoperative patients, with effects observed up to 6 months after surgery, covering hormonal changes, reward mechanisms, as well as influence on mood and mental health. Although improvements in mood and quality of life are reported, the early postoperative phases can be marked by emotional vulnerability, nutritional deficiencies, and psychiatric complications. These findings highlight the benefits and risks associated with MBS, underscoring the need for interventions to maintain quality of life in the postoperative period.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"106-123"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and Venous Thromboembolism: Mechanisms, Clinical Implications, and Prevention Strategies With a Focus on Bariatric Surgery. 肥胖和静脉血栓栓塞：机制、临床意义和预防策略，重点是减肥手术。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-18 DOI: 10.17476/jmbs.2025.14.2.131

Yoon Ju Jung

{"title":"Obesity and Venous Thromboembolism: Mechanisms, Clinical Implications, and Prevention Strategies With a Focus on Bariatric Surgery.","authors":"Yoon Ju Jung","doi":"10.17476/jmbs.2025.14.2.131","DOIUrl":"10.17476/jmbs.2025.14.2.131","url":null,"abstract":"Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary thromboembolism (PTE), constitutes a significant global health concern due to its substantial morbidity and mortality, especially among hospitalized and surgical individuals. DVT commonly presents in the lower extremities with symptoms such as calf pain, swelling potentially spreading to the ankle and foot, localized warmth, and skin discoloration. PTE, arising from acute pulmonary artery obstruction by a thrombus, frequently manifests as sudden dyspnea, chest pain, tachycardia, diaphoresis, hemoptysis, and lightheadedness, posing a life-threatening emergency demanding prompt medical intervention. Obesity stands out as a critical and modifiable risk factor for VTE, elevating its incidence in both the general population and during the perioperative period. Despite its efficacy in weight reduction, bariatric surgery markedly increases VTE risk, establishing it as a primary contributor to postoperative fatalities in surgical patients with obesity. The interplay between obesity and VTE involves a complex network of pathophysiological mechanisms and is further complicated by surgical and postoperative factors, necessitating comprehensive understanding and vigilant preventive strategies, especially within Asian populations, where specific anatomical and clinical factors may influence VTE risk profiles. This review comprehensively examines these pathophysiological links, clinical implications with a focus on bariatric surgery, and current prevention strategies, drawing insights from both Asian and Western guidelines and highlighting the evolving role of direct oral anticoagulants.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"131-138"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amino Acid Metabolite Profiling for Predicting and Understanding the Metabolic Effects of Metabolic and Bariatric Surgery. 氨基酸代谢物分析预测和理解代谢和减肥手术的代谢影响。

Journal of metabolic and bariatric surgery Pub Date : 2025-08-01 Epub Date: 2025-08-14 DOI: 10.17476/jmbs.2025.14.2.124

Hyeon-Seong Lee, Jaeyoung Kwon, Yeongkeun Kwon

{"title":"Amino Acid Metabolite Profiling for Predicting and Understanding the Metabolic Effects of Metabolic and Bariatric Surgery.","authors":"Hyeon-Seong Lee, Jaeyoung Kwon, Yeongkeun Kwon","doi":"10.17476/jmbs.2025.14.2.124","DOIUrl":"10.17476/jmbs.2025.14.2.124","url":null,"abstract":"Metabolic and bariatric surgery induces metabolic benefits beyond weight loss, including improved insulin sensitivity, type 2 diabetes (T2D) remission, and reduced inflammation. Recent metabolomics research highlights amino acid metabolites-branched-chain amino acids, aromatic amino acids, and tryptophan-derived compounds-as key biomarkers for predicting surgical outcomes. Elevated preoperative levels of isoleucine, phenylalanine, levodopa, and 3-hydroxyanthranilic acid are associated with improved glycemic control and T2D remission. Gut microbiota-derived metabolites, including indole-3-propionic acid and indole-3-pyruvic acid, contribute to insulin sensitivity and lean mass preservation. Additionally, serotonin-related indicators predict postoperative weight loss rates. These metabolites reflect individual metabolic heterogeneity and may outperform conventional clinical models in predicting surgical responsiveness. Integration of metabolomics into preoperative assessment may enhance precision medicine approaches and identify new therapeutic targets.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 2","pages":"124-130"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12411142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145016836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of Combined Lifestyle Interventions as a Complement to Bariatric Surgery (ECLIBS): Short Term Outcomes of a Pilot Study. 联合生活方式干预作为减肥手术（ECLIBS）补充的疗效：一项试点研究的短期结果

Journal of metabolic and bariatric surgery Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.17476/jmbs.2025.14.1.65

Pieter de Jong, Robert Smeenk, Miranda Janssen

{"title":"Efficacy of Combined Lifestyle Interventions as a Complement to Bariatric Surgery (ECLIBS): Short Term Outcomes of a Pilot Study.","authors":"Pieter de Jong, Robert Smeenk, Miranda Janssen","doi":"10.17476/jmbs.2025.14.1.65","DOIUrl":"https://doi.org/10.17476/jmbs.2025.14.1.65","url":null,"abstract":"Purpose: Combined lifestyle interventions (CLI) is a program designed to treat (morbid) obesity and can possibly be an adjunct to bariatric surgery. Bariatric surgery can lead to 25-50% total weight loss (TWL) and up to 71% excess weight loss, yet the longevity of the weight reduction remains variable, primarily attributed to a lack of lifestyle change. This pilot study aims to assess the effect of a 3-year structured CLI program, additional to a 5-year bariatric surgery program in a regional hospital, on the short-term outcome following bariatric surgery.Materials and methods: A single-center prospective cohort study was performed on patients who underwent bariatric surgery between September 2021 and October 2022 (n=28). A structured CLI program was organized and offered by an official out-of-hospital CLI provider. CLI participants were matched with patients following regular follow-up. Primary outcome was quarterly measured excess weight loss (EWL). Secondary outcomes were TWL, fat measurements, sports participation and comorbidities.Results: There were significant differences in sports participation after 1 year (92.9% vs. 62.5%; P=0.050), EWL at 21 months (18.3 kg; 95% confidence interval [CI], 0.14-36.4; P=0.049), fat mass at 18 months (-8.7 kg; 95% CI, -14.1, -3.3; P=0.008) and fat percentage at 18 months (-10.0%; 95% CI, -17.9, -2.0; P=0.017) in the CLI group compared to the control group.Conclusion: Preliminary short-term results show that a structured additional CLI program to bariatric surgery could benefit in terms of weight loss, perhaps due to better sports participation, but long-term results have to be awaited for.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 1","pages":"65-75"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bariatric Surgery Reduces Lipid Profile and Oxidative Stress in Patients With Obesity: A Prospective Cohort Study. 减肥手术降低肥胖患者的脂质和氧化应激：一项前瞻性队列研究。

Journal of metabolic and bariatric surgery Pub Date : 2025-04-01 Epub Date: 2025-04-29 DOI: 10.17476/jmbs.2025.14.1.32

Gabriela de Souza Bett, Fabiana Schuelter-Trevisol, Ricardo Reis do Nascimento, Bruna Barros Fernandes, Larissa Espindola da Silva, Mariella Reinol da Silva, Jefferson Luiz Traebert, Eliane da Silva Azevedo Traebert, Gislaine Tezza Rezin, Daisson José Trevisol

{"title":"Bariatric Surgery Reduces Lipid Profile and Oxidative Stress in Patients With Obesity: A Prospective Cohort Study.","authors":"Gabriela de Souza Bett, Fabiana Schuelter-Trevisol, Ricardo Reis do Nascimento, Bruna Barros Fernandes, Larissa Espindola da Silva, Mariella Reinol da Silva, Jefferson Luiz Traebert, Eliane da Silva Azevedo Traebert, Gislaine Tezza Rezin, Daisson José Trevisol","doi":"10.17476/jmbs.2025.14.1.32","DOIUrl":"https://doi.org/10.17476/jmbs.2025.14.1.32","url":null,"abstract":"Purpose: To evaluate inflammatory and biochemical parameters in the serum of patients with obesity before and after bariatric surgery.Materials and methods: An epidemiological study of the prospective cohort type was conducted to follow patients classified with grade II or III obesity undergoing bariatric surgery. Body mass index (BMI), lipid profile, C-reactive protein (CRP), reactive oxygen species production using dichlorofluorescein (DCF), and antioxidant defenses superoxide dismutase (SOD) and reduced glutathione (GSH) were analyzed before and 3 months after Roux-en-Y bariatric surgery.Results: A paired analysis was conducted, evaluating 23 patients in the pre- and post-surgical period. A statistically significant reduction was observed after bariatric surgery in BMI (P value<0.001), total cholesterol (CT) (P value=0.0006), total triglycerides (P value=0.0025), high-density lipoprotein cholesterol (P value=0.0010), low-density lipoprotein cholesterol (P value=0.0189), CRP (P value=0.0130), DCF (P value=0.0069), and GSH (P value<0.0001), as well as an increase in SOD activity (P value=0.0005).Conclusion: Bariatric surgery effectively reduced inflammatory and lipid markers and reversed oxidative stress, indicating that the procedure improves the health of bariatric patients across various parameters.","PeriodicalId":73828,"journal":{"name":"Journal of metabolic and bariatric surgery","volume":"14 1","pages":"32-42"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0