Advances in protein chemistry and structural biology最新文献_第5页

Pattern recognition receptors as potential therapeutic targets for developing immunological engineered plants. 模式识别受体是开发免疫工程植物的潜在治疗目标。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-04-29 DOI: 10.1016/bs.apcsb.2024.02.006

Deeksha Singh, Shivangi Mathur, Rajiv Ranjan

{"title":"Pattern recognition receptors as potential therapeutic targets for developing immunological engineered plants.","authors":"Deeksha Singh, Shivangi Mathur, Rajiv Ranjan","doi":"10.1016/bs.apcsb.2024.02.006","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2024.02.006","url":null,"abstract":"There is an urgent need to combat pathogen infestations in crop plants to ensure food security worldwide. To counter this, plants have developed innate immunity mediated by Pattern Recognition Receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and damage- associated molecular patterns (DAMPs). PRRs activate Pattern-Triggered Immunity (PTI), a defence mechanism involving intricate cell-surface and intracellular receptors. The diverse ligand-binding ectodomains of PRRs, including leucine-rich repeats (LRRs) and lectin domains, facilitate the recognition of MAMPs and DAMPs. Pathogen resistance is mediated by a variety of PTI responses, including membrane depolarization, ROS production, and the induction of defence genes. An integral part of intracellular immunity is the Nucleotide-binding Oligomerization Domain, Leucine-rich Repeat proteins (NLRs) which recognize and respond to effectors in a potent manner. Enhanced understanding of PRRs, their ligands, and downstream signalling pathways has contributed to the identification of potential targets for genetically modified plants. By transferring PRRs across plant species, it is possible to create broad-spectrum resistance, potentially offering innovative solutions for plant protection and global food security. The purpose of this chapter is to provide an update on PRRs involved in disease resistance, clarify the mechanisms by which PRRs recognize ligands to form active receptor complexes and present various applications of PRRs and PTI in disease resistance management for plants.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"140 ","pages":"525-555"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding macrophage immunometabolism in human viral infection. 解码人类病毒感染中的巨噬细胞免疫代谢

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-03-13 DOI: 10.1016/bs.apcsb.2023.12.003

Takhellambam Malemnganba, Aditi Rattan, Vijay Kumar Prajapati

{"title":"Decoding macrophage immunometabolism in human viral infection.","authors":"Takhellambam Malemnganba, Aditi Rattan, Vijay Kumar Prajapati","doi":"10.1016/bs.apcsb.2023.12.003","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2023.12.003","url":null,"abstract":"Immune-metabolic interactions play a pivotal role in both host defense and susceptibility to various diseases. Immunometabolism, an interdisciplinary field, seeks to elucidate how metabolic processes impact the immune system. In the context of viral infections, macrophages are often exploited by viruses for their replication and propagation. These infections trigger significant metabolic reprogramming within macrophages and polarization of distinct M1 and M2 phenotypes. This metabolic reprogramming involves alterations in standard- pathways such as the Krebs cycle, glycolysis, lipid metabolism, the pentose phosphate pathway, and amino acid metabolism. Disruptions in the balance of key intermediates like spermidine, itaconate, and citrate within these pathways contribute to the severity of viral diseases. In this chapter, we describe the manipulation of metabolic pathways by viruses and how they crosstalk between signaling pathways to evade the immune system. This intricate interplay often involves the upregulation or downregulation of specific metabolites, making these molecules potential biomarkers for diseases like HIV, HCV, and SARS-CoV. Techniques such as Nuclear Magnetic Resonance (NMR) and Mass Spectrometry, are the evaluative ways to analyze these metabolites. Considering the importance of macrophages in the inflammatory response, addressing their metabolome holds great promise for the creating future therapeutic targets aimed at combating a wide spectrum of viral infections.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"140 ","pages":"493-523"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of functional proteomics in understanding RNA virus-mediated infection. 应用功能蛋白质组学了解 RNA 病毒介导的感染。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2023-06-14 DOI: 10.1016/bs.apcsb.2023.04.004

Mamta Panda, Elora Kalita, Satyendra Singh, Abhishek Rao, Vijay Kumar Prajapati

{"title":"Application of functional proteomics in understanding RNA virus-mediated infection.","authors":"Mamta Panda, Elora Kalita, Satyendra Singh, Abhishek Rao, Vijay Kumar Prajapati","doi":"10.1016/bs.apcsb.2023.04.004","DOIUrl":"10.1016/bs.apcsb.2023.04.004","url":null,"abstract":"Together with the expansion of genome sequencing research, the number of protein sequences whose function is yet unknown is increasing dramatically. The primary goals of functional proteomics, a developing area of study in the realm of proteomic science, are the elucidation of the biological function of unidentified proteins and the molecular description of cellular systems at the molecular level. RNA viruses have emerged as the cause of several human infectious diseases with large morbidity and fatality rates. The introduction of high-throughput sequencing tools and genetic-based screening approaches over the last few decades has enabled researchers to find previously unknown and perplexing elements of RNA virus replication and pathogenesis on a scale never feasible before. Viruses, on the other hand, frequently disrupt cellular proteostasis, macromolecular complex architecture or stoichiometry, and post-translational changes to take over essential host activities. Because of these consequences, structural and global protein and proteoform monitoring is highly necessiated. Mass spectrometry (MS) has the potential to elucidate key details of virus-host interactions and speed up the identification of antiviral targets, giving precise data on the stoichiometry of cellular and viral protein complexes as well as mechanistic insights, has lately emerged as a key part of the RNA virus biology toolbox as a functional proteomics approach. Affinity-based techniques are primarily employed to identify interacting proteins in stable complexes in living organisms. A protein's biological role is strongly suggested by its relationship with other members of a certain protein complex that is involved in a particular process. With a particular emphasis on the most recent advancements in defining host responses and their translational implications to uncover novel tractable antiviral targets, this chapter provides insight on several functional proteomics techniques in RNA virus biology.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"138 ","pages":"301-325"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139465942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proteomics provides insights into the theranostic potential of extracellular vesicles. 蛋白质组学有助于深入了解细胞外囊泡的治疗潜力。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.1016/bs.apcsb.2023.08.001

Morteza Abyadeh, Mehdi Alikhani, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh

{"title":"Proteomics provides insights into the theranostic potential of extracellular vesicles.","authors":"Morteza Abyadeh, Mehdi Alikhani, Mehdi Mirzaei, Vivek Gupta, Faezeh Shekari, Ghasem Hosseini Salekdeh","doi":"10.1016/bs.apcsb.2023.08.001","DOIUrl":"10.1016/bs.apcsb.2023.08.001","url":null,"abstract":"Extracellular vesicles (EVs) encompass a diverse range of membranous structures derived from cells, including exosomes and microvesicles. These vesicles are present in biological fluids and play vital roles in various physiological and pathological processes. They facilitate intercellular communication by enabling the exchange of proteins, lipids, and genetic material between cells. Understanding the cellular processes that govern EV biology is essential for unraveling their physiological and pathological functions and their potential clinical applications. Despite significant advancements in EV research in recent years, there is still much to learn about these vesicles. The advent of improved mass spectrometry (MS)-based techniques has allowed for a deeper characterization of EV protein composition, providing valuable insights into their roles in different physiological and pathological conditions. In this chapter, we provide an overview of proteomics studies conducted to identify the protein contents of EVs, which contribute to their therapeutic and pathological features. We also provided evidence on the potential of EV proteome contents as biomarkers for early disease diagnosis, progression, and treatment response, as well as factors that influence their composition. Additionally, we discuss the available databases containing information on EV proteome contents, and finally, we highlight the need for further research to pave the way toward their utilization in clinical settings.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"138 ","pages":"101-133"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach. 了解 eEF1 翻译延伸因子在翻译之外的功能。蛋白质组学方法。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2023-12-01 DOI: 10.1016/bs.apcsb.2023.10.001

Boris S Negrutskii, Larysa V Porubleva, Agata Malinowska, Oleksandra V Novosylna, Michal Dadlez, Charlotte R Knudsen

{"title":"Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach.","authors":"Boris S Negrutskii, Larysa V Porubleva, Agata Malinowska, Oleksandra V Novosylna, Michal Dadlez, Charlotte R Knudsen","doi":"10.1016/bs.apcsb.2023.10.001","DOIUrl":"10.1016/bs.apcsb.2023.10.001","url":null,"abstract":"Mammalian translation elongation factors eEF1A1 and eEF1A2 are 92% homologous isoforms whose mutually exclusive tissue-specific expression is regulated during development. The isoforms have similar translation functionality, but show differences in spatial organization and participation in various processes, such as oncogenesis and virus reproduction. The differences may be due to their ability to interact with isoform-specific partner proteins. We used the identified sets of eEF1A1 or eEF1A2 partner proteins to identify cell complexes and/or processes specific to one particular isoform. As a result, we found isoform-specific interactions reflecting the involvement of different eEF1A isoforms in different cellular processes, including actin-related, chromatin-remodeling, ribonuclease H2, adenylyl cyclase, and Cul3-RING ubiquitin ligase complexes as well as initiation of mitochondrial transcription. An essential by-product of our analysis is the elucidation of a number of cellular processes beyond protein biosynthesis, where both isoforms appear to participate such as large ribosomal subunit biogenesis, mRNA splicing, DNA mismatch repair, 26S proteasome activity, P-body and exosomes formation, protein targeting to the membrane. This information suggests that a relatively high content of eEF1A in the cell may be necessary not only to maintain efficient translation, but also to ensure its participation in various cellular processes, where some roles of eEF1A have not yet been described. We believe that the data presented here will be useful for deciphering new auxiliary functions of eEF1A and its isoforms, and provide a new look at the known non-canonical functions of this main component of the human translation-elongation machinery.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"138 ","pages":"67-99"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139466029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genome-based solutions for managing mucormycosis. 基于基因组的粘孢子虫病管理解决方案。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-02-14 DOI: 10.1016/bs.apcsb.2023.11.014

Ritu Tomer, Sumeet Patiyal, Dilraj Kaur, Shubham Choudhury, Gajendra P S Raghava

{"title":"Genome-based solutions for managing mucormycosis.","authors":"Ritu Tomer, Sumeet Patiyal, Dilraj Kaur, Shubham Choudhury, Gajendra P S Raghava","doi":"10.1016/bs.apcsb.2023.11.014","DOIUrl":"10.1016/bs.apcsb.2023.11.014","url":null,"abstract":"An uncommon opportunistic fungal infection known as mucormycosis is caused by a class of molds called mucoromycetes. Currently, antifungal therapy and surgical debridement are the primary treatment options for mucormycosis. Despite the importance of comprehensive knowledge on mucormycosis, there is a lack of well-annotated databases that provide all relevant information. In this study, we have gathered and organized all available information related to mucormycosis that include disease's genome, proteins, diagnostic methods. Furthermore, using the AlphaFold2.0 prediction tool, we have predicted the tertiary structures of potential drug targets. We have categorized the information into three major sections: \"genomics/proteomics,\" \"immunotherapy,\" and \"drugs.\" The genomics/proteomics module contains information on different strains responsible for mucormycosis. The immunotherapy module includes putative sequence-based therapeutics predicted using established tools. Drugs module provides information on available drugs for treating the disease. Additionally, the drugs module also offers prerequisite information for designing computationally aided drugs, such as putative targets and predicted structures. In order to provide comprehensive information over internet, we developed a web-based platform MucormyDB (https://webs.iiitd.edu.in/raghava/mucormydb/).","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"139 ","pages":"383-403"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140048545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal basis of seasonal metabolic changes in mammalian species. 哺乳动物季节性代谢变化的激素基础。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-04-04 DOI: 10.1016/bs.apcsb.2024.02.005

N V Kuzmenko, M M Galagudza

引用次数: 0

Current status and future prospective of breast cancer immunotherapy. 乳腺癌免疫疗法的现状与前景。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-01-13 DOI: 10.1016/bs.apcsb.2023.12.006

Anurag S Rathore, Narendra Chirmule, Rozaleen Dash, Anandi Chowdhury

{"title":"Current status and future prospective of breast cancer immunotherapy.","authors":"Anurag S Rathore, Narendra Chirmule, Rozaleen Dash, Anandi Chowdhury","doi":"10.1016/bs.apcsb.2023.12.006","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2023.12.006","url":null,"abstract":"The immune system is complicated, interconnected, and offers a powerful defense system that protects its host from foreign pathogens. Immunotherapy involves boosting the immune system to kill cancer cells, and nowadays, is a major emerging treatment for cancer. With the advances in our understanding of the immunology of cancer, there has been an explosion of studies to develop and evaluate therapies that engage the immune system in the fight against cancer. Nevertheless, conventional therapies have been effective in reducing tumor burden and prolonging patient life, but the overall efficacy of these treatment regimens has been somewhat mixed and often with severe side effects. A common reason for this is the activation of molecular mechanisms that lead to apoptosis of anti-tumor effector cells. The competency to block tumor escape entirely depends on our understanding of the cellular and molecular pathways which operate in the tumor microenvironment. Numerous strategies have been developed for activating the immune system to kill tumor cells. Breast cancer is one of the major causes of cancer death in women, and is characterized by complex molecular and cellular events that closely intertwine with the host immune system. In this regard, predictive biomarkers of immunotherapy, use of nanotechnology, personalized cancer vaccines, antibodies to checkpoint inhibitors, engineered chimeric antigen receptor-T cells, and the combination with other therapeutic modalities have transformed cancer therapy and optimized the therapeutic effect. In this chapter, we will offer a holistic view of the different therapeutic modalities and recent advances in immunotherapy. Additionally, we will summarize the recent advances and future prospective of breast cancer immunotherapies, as a case study.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"140 ","pages":"293-326"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered CAR-T cells: An immunotherapeutic approach for cancer treatment and beyond. 工程 CAR-T 细胞：癌症治疗及其他领域的免疫治疗方法。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-01-04 DOI: 10.1016/bs.apcsb.2023.12.001

Purva Khodke, Bajarang Vasant Kumbhar

{"title":"Engineered CAR-T cells: An immunotherapeutic approach for cancer treatment and beyond.","authors":"Purva Khodke, Bajarang Vasant Kumbhar","doi":"10.1016/bs.apcsb.2023.12.001","DOIUrl":"https://doi.org/10.1016/bs.apcsb.2023.12.001","url":null,"abstract":"Chimeric Antigen Receptor (CAR) T cell therapy is a type of adoptive immunotherapy that offers a promising avenue for enhancing cancer treatment since traditional cancer treatments like chemotherapy, surgery, and radiation therapy have proven insufficient in completely eradicating tumors, despite the relatively positive outcomes. It has been observed that CAR-T cell therapy has shown promising results in treating the majority of hematological malignancies but also have a wide scope for other cancer types. CAR is an extra receptor on the T-cell that helps to increase and accelerate tumor destruction by efficiently activating the immune system. It is made up of three domains, the ectodomain, transmembrane, and the endodomain. The ectodomain is essential for antigen recognition and binding, whereas the co-stimulatory signal is transduced by the endodomain. To date, the Food and Drug Administration (FDA) has granted approval for six CAR-T cell therapies. However, despite its remarkable success, CAR-T therapy is associated with numerous adverse events and has certain limitations. This chapter focuses on the structure and function of the CAR domain, various generations of CAR, and the process of CAR-T cell development, adverse effects, and challenges in CAR-T therapy. CAR-T cell therapy also has scopes in other disease conditions which include systemic lupus erythematosus, multiple sclerosis, and myocardial fibrosis, etc.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"140 ","pages":"157-198"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metalloproteins structural and functional insights into immunological patterns. Metalloproteins 结构和功能对免疫模式的启示。

3区生物学

Advances in protein chemistry and structural biology Pub Date : 2024-01-01 Epub Date: 2024-06-13 DOI: 10.1016/bs.apcsb.2024.03.009

Chandrabose Selvaraj, Periyasamy Vijayalakshmi, Asha Monica Alex, Abdulaziz S Alothaim, Rajendran Vijayakumar, Vidhya Rekha Umapathy

{"title":"Metalloproteins structural and functional insights into immunological patterns.","authors":"Chandrabose Selvaraj, Periyasamy Vijayalakshmi, Asha Monica Alex, Abdulaziz S Alothaim, Rajendran Vijayakumar, Vidhya Rekha Umapathy","doi":"10.1016/bs.apcsb.2024.03.009","DOIUrl":"10.1016/bs.apcsb.2024.03.009","url":null,"abstract":"Metalloproteins play a crucial role in regulating different aspects of the immune system in humans. They have various functions in immunity, including recognizing and presenting antigens, aiding in the movement and effectiveness of immune cells, and facilitating interactions between the host and pathogens. Understanding how these proteins work can help us develop new methods to control the immune response in different diseases. Metalloproteins contain metal ions in their structure, which allows them to perform these diverse functions. They encompass a wide range of enzymes, signaling molecules, and structural proteins that utilize metal ions as cofactors for their activities. Examples of metalloproteins include superoxide dismutase, catalase, and metalloproteases, which regulate oxidative stress, inflammation, and tissue remodelling processes associated with immune activation. By studying their functions and the effects of their dysfunction, researchers can develop strategies to improve immune function and combat various diseases. This review explores the diverse functions of metalloproteins in immune processes, highlighting their significance in both health and disease.","PeriodicalId":7376,"journal":{"name":"Advances in protein chemistry and structural biology","volume":"141 ","pages":"67-86"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141496830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0