解码人类病毒感染中的巨噬细胞免疫代谢

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Takhellambam Malemnganba, Aditi Rattan, Vijay Kumar Prajapati
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引用次数: 0

摘要

免疫-代谢相互作用在宿主防御和易患各种疾病方面发挥着关键作用。免疫代谢是一个跨学科领域,旨在阐明代谢过程如何影响免疫系统。在病毒感染的情况下,巨噬细胞往往被病毒利用进行复制和传播。这些感染会引发巨噬细胞内的重大新陈代谢重编程以及不同 M1 和 M2 表型的极化。这种新陈代谢重编程涉及克雷布斯循环、糖酵解、脂质代谢、磷酸戊糖途径和氨基酸代谢等标准途径的改变。在这些途径中,精胺、伊他康酸和柠檬酸盐等关键中间产物的平衡被打破会导致病毒性疾病的严重性。在本章中,我们将介绍病毒对代谢途径的操纵,以及它们如何通过信号途径之间的串扰来躲避免疫系统。这种错综复杂的相互作用往往涉及特定代谢物的上调或下调,从而使这些分子成为 HIV、HCV 和 SARS-CoV 等疾病的潜在生物标记物。核磁共振(NMR)和质谱分析等技术是分析这些代谢物的评估方法。考虑到巨噬细胞在炎症反应中的重要性,研究巨噬细胞的代谢组将为未来创建治疗靶点、抗击各种病毒感染带来巨大希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decoding macrophage immunometabolism in human viral infection.

Immune-metabolic interactions play a pivotal role in both host defense and susceptibility to various diseases. Immunometabolism, an interdisciplinary field, seeks to elucidate how metabolic processes impact the immune system. In the context of viral infections, macrophages are often exploited by viruses for their replication and propagation. These infections trigger significant metabolic reprogramming within macrophages and polarization of distinct M1 and M2 phenotypes. This metabolic reprogramming involves alterations in standard- pathways such as the Krebs cycle, glycolysis, lipid metabolism, the pentose phosphate pathway, and amino acid metabolism. Disruptions in the balance of key intermediates like spermidine, itaconate, and citrate within these pathways contribute to the severity of viral diseases. In this chapter, we describe the manipulation of metabolic pathways by viruses and how they crosstalk between signaling pathways to evade the immune system. This intricate interplay often involves the upregulation or downregulation of specific metabolites, making these molecules potential biomarkers for diseases like HIV, HCV, and SARS-CoV. Techniques such as Nuclear Magnetic Resonance (NMR) and Mass Spectrometry, are the evaluative ways to analyze these metabolites. Considering the importance of macrophages in the inflammatory response, addressing their metabolome holds great promise for the creating future therapeutic targets aimed at combating a wide spectrum of viral infections.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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