模式识别受体是开发免疫工程植物的潜在治疗目标。

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Deeksha Singh, Shivangi Mathur, Rajiv Ranjan
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引用次数: 0

摘要

为确保全球粮食安全,迫切需要防治作物中的病原体侵袭。为了应对这一问题,植物已经发展出了由模式识别受体(PRRs)介导的先天免疫,这种受体能够识别病原体相关分子模式(PAMPs)和损害相关分子模式(DAMPs)。模式识别受体激活模式触发免疫(PTI),这是一种涉及复杂的细胞表面和细胞内受体的防御机制。PRRs 的配体结合外域多种多样,包括富亮氨酸重复序列(LRR)和凝集素结构域,有助于识别 MAMP 和 DAMP。病原体抗性由各种 PTI 反应介导,包括膜去极化、ROS 生成和诱导防御基因。核苷酸结合寡聚化域、富亮氨酸重复蛋白(NLRs)是细胞内免疫不可或缺的一部分,它们能以有效的方式识别效应物并做出反应。对 PRRs、其配体和下游信号通路的深入了解有助于确定转基因植物的潜在靶标。通过跨植物物种转移 PRRs,有可能产生广谱抗性,从而为植物保护和全球粮食安全提供创新解决方案。本章旨在介绍参与抗病的 PRRs 的最新情况,阐明 PRRs 识别配体以形成活性受体复合物的机制,并介绍 PRRs 和 PTI 在植物抗病管理中的各种应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pattern recognition receptors as potential therapeutic targets for developing immunological engineered plants.

There is an urgent need to combat pathogen infestations in crop plants to ensure food security worldwide. To counter this, plants have developed innate immunity mediated by Pattern Recognition Receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) and damage- associated molecular patterns (DAMPs). PRRs activate Pattern-Triggered Immunity (PTI), a defence mechanism involving intricate cell-surface and intracellular receptors. The diverse ligand-binding ectodomains of PRRs, including leucine-rich repeats (LRRs) and lectin domains, facilitate the recognition of MAMPs and DAMPs. Pathogen resistance is mediated by a variety of PTI responses, including membrane depolarization, ROS production, and the induction of defence genes. An integral part of intracellular immunity is the Nucleotide-binding Oligomerization Domain, Leucine-rich Repeat proteins (NLRs) which recognize and respond to effectors in a potent manner. Enhanced understanding of PRRs, their ligands, and downstream signalling pathways has contributed to the identification of potential targets for genetically modified plants. By transferring PRRs across plant species, it is possible to create broad-spectrum resistance, potentially offering innovative solutions for plant protection and global food security. The purpose of this chapter is to provide an update on PRRs involved in disease resistance, clarify the mechanisms by which PRRs recognize ligands to form active receptor complexes and present various applications of PRRs and PTI in disease resistance management for plants.

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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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