Exploring metalloproteins found in the secretion of venomous species: Biological role and therapeutical applications.

3区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Cícero Alves Lopes Júnior, Mikael Kélvin de Albuquerque Mendes, Michely da Silva Sousa, Edivan Carvalho Vieira, Tatianny de Araujo Andrade, Jemmyson Romário de Jesus
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引用次数: 0

Abstract

Several species during evolution suffered random mutations in response to various environmental factors, which resulted in the formation of venom in phylogenetically distant species. The composition of the venom of most species is poorly known. Snake venom is well characterized while most species have poorly known composition. In contrast, snake venoms are well characterized which proteins and peptides are the main active and most abundant constituents. 42 protein families have been identified, including metalloproteins known as metalloproteinases. These macromolecules are enzymes with zinc in their active site derived from the disintegrin A and metalloproteinase (ADAM) cellular family and are categorized into three classes (PI, PII and PIII) according to their domain organization. The snake venom metalloproteinases (SVMP) are cytotoxic, neurotoxic, myotoxic and/or hematotoxic with a crucial role in the defense and restraint of prey. In this scenario envenoming represents a danger to human health and has been considered a neglected disease worldwide, particularly in tropical and subtropical countries. Nevertheless, recently advances in "omics" technologies have demonstrated interesting biological activities of SVMPs such as antimicrobial, anticancer, against cardiovascular diseases and nervous system disorders. Metalloproteins have the therapeutic potential to be converted into drugs as other components of the venom have undergone this process (e.g., captopril, tirefiban and eptifibatide). So, this chapter is focused on the metalloproteins found in the secretions of venomous species, highlight some aspects such as structure, biological activity, pharmacological therapeutic potential and on.

探索毒物分泌物中的金属蛋白:生物作用和治疗应用。
在进化过程中,一些物种因各种环境因素而发生随机变异,从而在系统发育较远的物种中形成毒液。大多数物种的毒液成分鲜为人知。蛇的毒液特征明显,而大多数物种的毒液成分却鲜为人知。相比之下,蛇毒的蛋白质和肽是主要的活性成分,也是最丰富的成分。目前已发现 42 个蛋白质家族,其中包括被称为金属蛋白酶的金属蛋白。这些大分子是活性位点含锌的酶,来自细胞分解蛋白 A 和金属蛋白酶(ADAM)家族,根据其结构域可分为三类(PI、PII 和 PIII)。蛇毒金属蛋白酶(SVMP)具有细胞毒性、神经毒性、肌毒性和/或血液毒性,在防御和抑制猎物方面起着至关重要的作用。在这种情况下,毒蛇咬伤对人类健康构成了威胁,在世界范围内一直被认为是一种被忽视的疾病,尤其是在热带和亚热带国家。尽管如此,最近 "全息 "技术的进步已经证明了 SVMPs 有趣的生物活性,如抗菌、抗癌、防治心血管疾病和神经系统疾病。金属蛋白具有转化为药物的治疗潜力,因为毒液中的其他成分也经历了这一过程(如卡托普利、替菲班和依替巴肽)。因此,本章将重点介绍毒液物种分泌物中的金属蛋白,着重介绍其结构、生物活性、药理治疗潜力等方面。
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来源期刊
Advances in protein chemistry and structural biology
Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
7.40
自引率
0.00%
发文量
66
审稿时长
>12 weeks
期刊介绍: Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.
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