Journal of frailty, sarcopenia and falls最新文献_第2页

Adaptive or Maladaptive Fear of Falling in Multiple Sclerosis: What Are We Overlooking? 多发性硬化症患者对跌倒的适应性或非适应性恐惧：我们忽视了什么？

Journal of frailty, sarcopenia and falls Pub Date : 2026-06-01 DOI: 10.22540/JFSF-11-141

Libak Abou

{"title":"Adaptive or Maladaptive Fear of Falling in Multiple Sclerosis: What Are We Overlooking?","authors":"Libak Abou","doi":"10.22540/JFSF-11-141","DOIUrl":"10.22540/JFSF-11-141","url":null,"abstract":"Fear of falling is a common and distressing concern among people with multiple sclerosis due to the gait and balance impairments associated with the disease. Clinicians and researchers often assume that the degree of fear of falling, typically measured with the Falls Efficacy Scale International (FES-I), is proportional to activity restrictions or rehabilitation engagement. However, a low or high level of fear of falling alone does not indicate whether fear of falling influences individual's performance of daily living activities. Fear of falling can either be adaptive (when aligned with functional capacity and actual fall risk) or maladaptive (when disproportionate to functional capacity and actual fall risk). In this personal viewpoint, I discuss the importance of contextualizing fear of falling assessment within the performance of daily living activities and propose that a function-focused assessment of fear of falling may enhance our understanding of whether it is adaptive or maladaptive. This approach may also provide targeted information to guide the development of interventions to address fear of falling in people with multiple sclerosis, help identify who requires intervention, and the type of intervention needed.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 2","pages":"141-144"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Phase Angle as a Clinical Marker of Sarcopenia in Older Adults: Exploring the Structure-Quality-Strength-Mobility (SQSM) Framework. 低相位角作为老年人肌肉减少症的临床标志：探索结构-质量-力量-活动（SQSM）框架。

Journal of frailty, sarcopenia and falls Pub Date : 2026-06-01 DOI: 10.22540/JFSF-11-110

Salwa Abdul Rahman, Chia Wei Tan, Shyh Poh Teo, Asmah Husaini, Khadizah H Abdul-Mumin, Sarena Hashim, Deeni Rudita Idris, Zirwatul Zulkifli, Sharimawati Sharbini

{"title":"Low Phase Angle as a Clinical Marker of Sarcopenia in Older Adults: Exploring the Structure-Quality-Strength-Mobility (SQSM) Framework.","authors":"Salwa Abdul Rahman, Chia Wei Tan, Shyh Poh Teo, Asmah Husaini, Khadizah H Abdul-Mumin, Sarena Hashim, Deeni Rudita Idris, Zirwatul Zulkifli, Sharimawati Sharbini","doi":"10.22540/JFSF-11-110","DOIUrl":"10.22540/JFSF-11-110","url":null,"abstract":"Objectives: This study aimed to evaluate phase angle (PhA) as a clinical marker of sarcopenia within the multidimensional Structure-Quality-Strength-Mobility (SQSM) framework and to compare its associations with muscle strength and physical performance against sarcopenia defined by appendicular skeletal muscle mass index (ASMI).Methods: A cross-sectional study was conducted on 87 older adults (mean age 68.8 years; 70.1% female) recruited into a structured exercise program. PhA and ASMI were measured via bioelectrical impedance analysis in the program's final week. Muscle strength and physical performance were measured using the Asian Working Group for Sarcopenia definitions. The SQSM-operationalised definition(OD) of sarcopenia was classified as low PhA combined with either low handgrip strength (HGS) or gait speed(GS). Logistic regression assessed associations.Results: Phase angle ≤4.25° was associated with low HGS (OR = 2.51, p = 0.058), GS (OR = 3.96, p = 0.010), and falls (OR = 4.20, p = 0.024). SQSM-OD of sarcopenia showed higher prevalence and stronger association with falls (OR = 5.77, p = 0.008) than ASMI-defined sarcopenia.Conclusion: PhA was associated with low muscle strength, gait speed and falls supporting its role as a marker of muscle quality. SQSM-OD identified more at-risk individuals highlighting the utility of incorporating muscle quality into sarcopenia assessment.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 2","pages":"110-117"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Osteosarcopenia with Functional Outcomes in Older Adult Patients Undergoing Rehabilitation. 老年康复患者骨骼肌减少症与功能预后的关系。

Journal of frailty, sarcopenia and falls Pub Date : 2026-06-01 DOI: 10.22540/JFSF-11-118

Ryo Mannen, Keisuke Maeda, Tatsuro Inoue, Akio Shimizu

{"title":"Association of Osteosarcopenia with Functional Outcomes in Older Adult Patients Undergoing Rehabilitation.","authors":"Ryo Mannen, Keisuke Maeda, Tatsuro Inoue, Akio Shimizu","doi":"10.22540/JFSF-11-118","DOIUrl":"10.22540/JFSF-11-118","url":null,"abstract":"Objectives: Osteosarcopenia is characterized by the coexistence of sarcopenia and osteoporosis. This comorbid condition is thought to negatively affect functional outcomes. In this study, we investigated the negative impact of osteosarcopenia on the functional outcomes of older patients undergoing rehabilitation.Methods: This single-center retrospective cohort study was conducted at Hamamatsu City Rehabilitation Hospital in Japan and included 184 participants ≥65 years. Functional outcomes were assessed using the functional independence measure (FIM), the minimum clinically important difference (MCID) achieved on the FIM, and home discharge. Multiple linear and logistic regression analyses were conducted to assess the independent association of osteosarcopenia with FIM score at discharge and the FIM MCID. Additionally, the association between osteosarcopenia and home discharge was examined.Results: Osteosarcopenia was present in 30.4% of participants. Osteosarcopenia did not reach a statistically significant association with FIM at discharge (95% confidence interval [CI]: -2.518-8.489; β, 0.058), FIM MCID (odds ratio [OR]: 1.919; 95% CI: 0.698-5.277), or discharge to home (OR: 0.525; 95% CI: 0.126-2.189).Conclusions: Osteosarcopenia was prevalent among older patients undergoing rehabilitation, but its association with functional outcomes at discharge did not reach statistical significance. Intensive rehabilitation may have masked its adverse effects, warranting further longitudinal studies.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 2","pages":"118-128"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Predictors of Frailty and Kidney Disease Burden in Patients with End-stage Renal Disease Receiving Dialysis. 接受透析的终末期肾病患者虚弱和肾病负担的功能预测因子

Journal of frailty, sarcopenia and falls Pub Date : 2026-06-01 DOI: 10.22540/JFSF-11-129

Rick R Ward, Mary E Thompson, Elaine E Trudelle-Jackson, Kelli J Brizzolara

{"title":"Functional Predictors of Frailty and Kidney Disease Burden in Patients with End-stage Renal Disease Receiving Dialysis.","authors":"Rick R Ward, Mary E Thompson, Elaine E Trudelle-Jackson, Kelli J Brizzolara","doi":"10.22540/JFSF-11-129","DOIUrl":"10.22540/JFSF-11-129","url":null,"abstract":"Objectives: In patients receiving dialysis, the prevalence of frailty can be as high as 73%; however, systematic identification of frailty and the relation to disease burden is not standard practice. This study examined whether functional outcome measures would predict frailty and kidney disease burden among patients receiving dialysis, which would enable more efficient assessments.Methods: The study included twenty-eight patients receiving dialysis to analyze the number of falls in the past year, Timed Up and Go time, and 30-second sit-to-stand repetitions as predictors of the (a) Fried frailty score and (b) Kidney Disease Quality of Life burden of kidney disease subscale score.Results: The functional outcome measures were significant predictors of frailty score (R 2 = 0.784, F = 29.4, P < .001). The number of falls in the past year was a significant predictor of kidney disease burden (R 2 = 0.22, F = 7.20, P = .01).Conclusions: The results provide evidence for the use of higher Timed Up and Go times and fewer 30-second sit-to-stand repetitions as predictors of the Fried frailty score. An increased number of self-reported falls in the past year predicted a higher burden of kidney disease.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 2","pages":"129-136"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148152395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Sarcopenia and Metabolic Abnormalities in HIV Patients Stable on Antiretroviral Therapy: A Cross-Sectional Analysis of an Indian Cohort. 在抗逆转录病毒治疗稳定的HIV患者中肌减少症和代谢异常的评估：印度队列的横断面分析。

Journal of frailty, sarcopenia and falls Pub Date : 2026-06-01 DOI: 10.22540/JFSF-11-091

Amitkumar Chavan, Prayas Sethi, Pratheek Choppala, Lakshmi Kattamuri, Naval K Vikram, Neeraj Nischal, Naveet Wig

{"title":"Assessment of Sarcopenia and Metabolic Abnormalities in HIV Patients Stable on Antiretroviral Therapy: A Cross-Sectional Analysis of an Indian Cohort.","authors":"Amitkumar Chavan, Prayas Sethi, Pratheek Choppala, Lakshmi Kattamuri, Naval K Vikram, Neeraj Nischal, Naveet Wig","doi":"10.22540/JFSF-11-091","DOIUrl":"10.22540/JFSF-11-091","url":null,"abstract":"Objectives: Successful ART prolongs PLHIV survival, but metabolic complications like dyslipidemia and sarcopenia are rising. Research on these issues, particularly with newer integrase inhibitor-based regimens, remains limited.Methods: We evaluated 84 PLHIV on stable ART (> 2 years) for sarcopenia and metabolic abnormalities using functional assessments (HGS, SPPB), BIA, and detailed biochemical screening for dyslipidemia and insulin resistance.Results: Of 84 participants (71.4% male, mean age 38.97 ± 9.77 years), probable sarcopenia prevalence was 8.33% (using AWGS (Asian Working Group for Sarcopenia) criteria), while none had confirmed sarcopenia using BIA for measurement of muscle mass. Dysglycemia affected 33.0%, with 8.33% having diabetes. Dyslipidemia was observed in 76.19%. Metabolic syndrome prevalence was 16.6%. Compared to non-sarcopenic participants, those with probable sarcopenia had significantly lower median MUAC (23 vs. 26 cm, p=0.02 for both sides) and mid-thigh circumferences (Right: 41.5 vs. 45.5 cm, p=0.04; Left: 41 vs. 45 cm, p=0.05). Physical performance, measured by the SPPB score, was also significantly reduced (median 10 vs. 11; p=0.02).Conclusion: We identified probable sarcopenia and its correlates in stable PLHIV. Findings suggest current AWGS cutoffs require regional validation. High metabolic morbidity underscores significant cardiovascular risks, necessitating early intervention to optimize quality of life.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 2","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13223531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148151393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Composition and Muscle Performance and Muscle-Specific Strength in Adults: Age-Sex Related Findings and Rehabilitation Considerations. 成人的身体组成、肌肉表现和肌肉强度：与年龄性别相关的发现和康复考虑。

Journal of frailty, sarcopenia and falls Pub Date : 2026-03-01 DOI: 10.22540/JFSF-11-054

Roberto Coronado-Zarco, Jimena Quinzaños-Fresnedo, Heriberto Aguirre-Meneses, Marco A Núñez-Gaona, Zahira C Aguilar-Mancilla

{"title":"Body Composition and Muscle Performance and Muscle-Specific Strength in Adults: Age-Sex Related Findings and Rehabilitation Considerations.","authors":"Roberto Coronado-Zarco, Jimena Quinzaños-Fresnedo, Heriberto Aguirre-Meneses, Marco A Núñez-Gaona, Zahira C Aguilar-Mancilla","doi":"10.22540/JFSF-11-054","DOIUrl":"10.22540/JFSF-11-054","url":null,"abstract":"Objective: To compare body composition, muscle performance, and muscle quality across age and sex groups.Methods: A cross-sectional analytical study was conducted in healthy-self-referred adults stratified in age groups: 18-35, 50-64, and ≥65 years. Evaluations included BMI (kg/m2), DXA-derived body composition (ALM, kg; body-fat, %), handgrip-dynamometry, and isokinetic knee-extensor testing concentric/eccentric low/high angular velocities. MQIs were calculated as force normalized to LM. Group comparisons, effect sizes, and correlation analyses were performed. Statistical significance was set at p < 0.05.Results: A total of 152 adults were analyzed. Body composition showed significant age-related differences, with increased body-fat percentage from young to middle adulthood and reduced ALM in older adults, while BMI showed limited discriminatory capacity. Handgrip-strength declined significantly only in the oldest group and showed small effect sizes after normalization by body-weight. In contrast, isokinetic knee extensor strength (particularly high-velocity concentric-torque) demonstrated pronounced age-related declines with moderate-to-large effect sizes. Eccentric/concentric torque ratios increased with age, indicating relative preservation of eccentric strength. Handgrip-based MQIs showed no age-group discrimination, whereas isokinetic-derived MQIs did.Conclusion: Muscle aging is characterized by early adiposity increase and later deterioration of lower-limb, velocity-dependent muscle performance, better captured by isokinetic-based measures than by BMI or handgrip-derived indices.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 1","pages":"54-64"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951584/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic Performance of Four Screening Tools for Detecting Low Muscle Mass and Sarcopenia in Preoperative Older Japanese Patients with Colorectal Cancer According to the AWGS 2019 Criteria. 根据AWGS 2019标准，四种筛查工具检测日本老年结直肠癌术前低肌量和肌肉减少的诊断性能

Journal of frailty, sarcopenia and falls Pub Date : 2026-03-01 DOI: 10.22540/JFSF-11-023

Yasuhiro Shimamura, Naomi Akazawa, Sanae Nakajima, Yukiko Kobayashi, Wataru Aoi, Masashi Kuwahata

{"title":"Diagnostic Performance of Four Screening Tools for Detecting Low Muscle Mass and Sarcopenia in Preoperative Older Japanese Patients with Colorectal Cancer According to the AWGS 2019 Criteria.","authors":"Yasuhiro Shimamura, Naomi Akazawa, Sanae Nakajima, Yukiko Kobayashi, Wataru Aoi, Masashi Kuwahata","doi":"10.22540/JFSF-11-023","DOIUrl":"10.22540/JFSF-11-023","url":null,"abstract":"Objectives: Sarcopenia and low muscle mass are distinct clinical conditions associated with adverse outcomes after colorectal cancer (CRC) surgery. Due to limited effective screening methods, we evaluated the diagnostic performance of four tools for these conditions in preoperative patients with CRC.Methods: This cross-sectional study included patients aged ≥65 years with stage I-III CRC scheduled for elective surgery. Sarcopenia and low appendicular skeletal muscle mass (ASM) were diagnosed according to the Asian Working Group for Sarcopenia 2019 criteria. Diagnostic performance of calf circumference (CC), SARC-F, SARC-CalF, and the Ishii score was evaluated.Results: Ninety-eight patients (48.0% females, mean age 77.4 ± 6.2 years) were included. Prevalences of low ASM and sarcopenia were 56.1% and 41.8%, respectively. For low ASM, CC demonstrated the highest accuracy (AUC 0.907, sensitivity 80.0%, specificity 86.0%), significantly outperforming SARC-F and SARC-CalF (AUCs 0.617 and 0.854; p<0.005), and comparable to the Ishii score (AUC 0.895). For sarcopenia, the Ishii score exhibited the highest accuracy (AUC 0.957, sensitivity 100%, specificity 75.4%), significantly surpassing CC, SARC-F, and SARC-CalF (AUCs 0.875, 0.704, and 0.865; p<0.001).Conclusions: The Ishii score demonstrated superior diagnostic performance for sarcopenia, underscoring the importance of muscle strength assessment for effective screening.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 1","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physical Indicators and Cutoff Values Associated with Improvement in Sarcopenia in Older Adults Undergoing Rehabilitation. 接受康复治疗的老年人肌肉减少症改善的物理指标和临界值。

Journal of frailty, sarcopenia and falls Pub Date : 2026-03-01 DOI: 10.22540/JFSF-11-004

Takuro Ohtsubo, Masafumi Nozoe, Katsuhiro Ueno, Takako Matsubara, Yosuke Morimoto

{"title":"Physical Indicators and Cutoff Values Associated with Improvement in Sarcopenia in Older Adults Undergoing Rehabilitation.","authors":"Takuro Ohtsubo, Masafumi Nozoe, Katsuhiro Ueno, Takako Matsubara, Yosuke Morimoto","doi":"10.22540/JFSF-11-004","DOIUrl":"10.22540/JFSF-11-004","url":null,"abstract":"Objectives: This study aimed to determine baseline physical indicators and their cutoff values associated with improvement in sarcopenia (IS) in older individuals undergoing rehabilitation.Methods: We retrospectively reviewed 343 older individuals with sarcopenia (median age = 81 years) admitted to a rehabilitation hospital between January 2020 and September 2023 after discharge from acute care hospitals. Sarcopenia was diagnosed using the 2019 Asian Working Group for Sarcopenia criteria; IS was defined as no longer meeting the diagnostic criteria at discharge. Baseline assessments included handgrip strength (HGS), gait speed (GS), skeletal muscle mass index (SMI), and the Short Physical Performance Battery. We used sex-wise multivariate logistic regression analyses to identify factors associated with IS and receiver operating characteristic curve analyses to determine cutoff values.Results: IS was seen in 16 males (17%) and 46 females (18%). Associated indicators were GS (p = 0.019; cutoff: 0.78 m/s) and SMI (p = 0.004; cutoff: 6.7 kg/m2) in males, and HGS (p < 0.001; cutoff: 15.0 kg) and SMI (p < 0.001; cutoff: 5.1 kg/m2) in females.Conclusions: Baseline SMI, plus GS in males and HGS in females, was associated with IS. These cutoff values may help to characterize individuals with different likelihoods of diagnostic improvement.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 1","pages":"4-22"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951586/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Intimate Relationship between Adipose Tissue, Fertility, and Bone. 脂肪组织、生育能力和骨骼之间的密切关系。

Journal of frailty, sarcopenia and falls Pub Date : 2026-03-01 DOI: 10.22540/JFSF-11-080

Olympia Michalopoulou, Ifigenia Kostoglou-Athanassiou, Georgios Troupis, George Mastorakos

{"title":"The Intimate Relationship between Adipose Tissue, Fertility, and Bone.","authors":"Olympia Michalopoulou, Ifigenia Kostoglou-Athanassiou, Georgios Troupis, George Mastorakos","doi":"10.22540/JFSF-11-080","DOIUrl":"10.22540/JFSF-11-080","url":null,"abstract":"Nowadays, adipose tissue is recognized as a dynamic endocrine organ that profoundly affects metabolic, reproductive and skeletal physiology. Apart from its role in energy storage, adipocytes secrete cytokines and bioactive proteins, known as adipokines, that contribute to the regulation of the hypothalamic-pituitary-gonadal axis, gonadal steroidogenesis and bone remodeling. Reciprocal signaling between adipose tissue, bone and the reproductive system forms a complex endocrine network linking energy balance to fertility and bone homeostasis. Key mediators, including leptin, adiponectin, resistin, visfatin and bone marrow adipose tissue, interact with osteoblast-derived proteins, such as osteocalcin, to modulate steroidogenesis and metabolic function. Vitamin D, stored in adipose tissue and acting through its receptor, further integrates these pathways by coordinating calcium metabolism, reproduction and skeletal integrity. This review aims to present mechanistic and clinical evidence demonstrating how metabolic signals derived from adipose depots communicate with gonadal and skeletal tissues through overlapping endocrine, paracrine and autocrine networks. Attention is paid to depot-specific effects, bidirectional feedback between adipose tissue and bone signaling, as well as in emerging implications for infertility, osteoporosis and metabolic bone disease. Finally, we discuss critical knowledge gaps and research priorities, to elucidate novel therapeutic approaches for reproductive and skeletal disorders.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 1","pages":"80-90"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification and Evaluation of the Additional Effect of Cognitive Training in Balance Physiotherapy. 认知训练在平衡理疗中附加效果的识别与评价。

Journal of frailty, sarcopenia and falls Pub Date : 2026-03-01 DOI: 10.22540/JFSF-11-065

Christos Nikitas, Dimitris Kikidis, Michalis Tsoukatos, Sofia Papadopoulou, Marousa Pavlou, Doris-Eva Bamiou

{"title":"Identification and Evaluation of the Additional Effect of Cognitive Training in Balance Physiotherapy.","authors":"Christos Nikitas, Dimitris Kikidis, Michalis Tsoukatos, Sofia Papadopoulou, Marousa Pavlou, Doris-Eva Bamiou","doi":"10.22540/JFSF-11-065","DOIUrl":"10.22540/JFSF-11-065","url":null,"abstract":"This systematic review examines whether adding cognitive training to a multicomponent balance rehabilitation protocol provides additional benefits for older people with balance disorders who have no or mild cognitive impairment. A comprehensive search of electronic databases was conducted to identify eligible studies. The target population consists of community-dwelling older people at risk of falling and/or with a persistent history of imbalance, with an absence of or mild cognitive impairment. The GRADE system was used to assess the risk of bias. Sixteen RCTs were identified as eligible, integrating at least balance and cognitive training as modules of a multicomponent rehabilitation protocol. Strengthening exercises, endurance training, and advanced technology were also included. In almost all studies (except one), balance exercises were provided simultaneously with cognitive exercises. The recommended exercise dosage consisted of 40-60 minutes per session, performed 2-3 per week over a period of 12 weeks. Μotor-cognitive training improved standing posture, gait speed, functional mobility, domains of cognitive function, and motor-cognitive performance. Duration of interventions was correlated with the level of clinical improvement. Specific methodological issues may limit the overall reliability and generalizability of the findings. Cognitive training provided additional benefits for posture, gait speed, functional mobility, and dual-task performance in older people with balance disorders by optimizing the allocation of attentional demands.","PeriodicalId":73754,"journal":{"name":"Journal of frailty, sarcopenia and falls","volume":"11 1","pages":"65-79"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12951589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147349429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0