Journal of experimental neurology最新文献_第3页

Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease 肌肉及其神经肌肉突触——运动神经元疾病发病机制的参与者

Journal of experimental neurology Pub Date : 2023-01-23 DOI: 10.33696/neurol.4.067

P. G. Noakes, W. Phillips, R. Jeffree, F. Steyn, E. Wolvetang, R. Henderson, P. Mccombe, S. Ngo

引用次数: 1

Therapeutic Effectiveness of Brain Computer Interfaces in Stroke Patients: A Systematic Review. 脑机接口在脑卒中患者中的治疗效果：一项系统综述。

Journal of experimental neurology Pub Date : 2023-01-01 DOI: 10.33696/neurol.4.077

Yordan P Penev, Alice Beneke, Kevin T Root, Emily Meisel, Sean Kwak, Michael J Diaz, Julia L Root, Mohammad R Hosseini, Brandon Lucke-Wold

{"title":"Therapeutic Effectiveness of Brain Computer Interfaces in Stroke Patients: A Systematic Review.","authors":"Yordan P Penev, Alice Beneke, Kevin T Root, Emily Meisel, Sean Kwak, Michael J Diaz, Julia L Root, Mohammad R Hosseini, Brandon Lucke-Wold","doi":"10.33696/neurol.4.077","DOIUrl":"10.33696/neurol.4.077","url":null,"abstract":"Background: Brain-computer interfaces (BCIs) are a rapidly advancing field which utilizes brain activity to control external devices for a myriad of functions, including the restoration of motor function. Clinically, BCIs have been especially impactful in patients who suffer from stroke-mediated damage. However, due to the rapid advancement in the field, there is a lack of accepted standards of practice. Therefore, the aim of this systematic review is to summarize the current literature published regarding the efficacy of BCI-based rehabilitation of motor dysfunction in stroke patients.Methodology: This systematic review was performed in accordance with the guidelines set forth by the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 statement. PubMed, Embase, and Cochrane Library were queried for relevant articles and screened for inclusion criteria by two authors. All discrepancies were resolved by discussion among both reviewers and subsequent consensus.Results: 11/12 (91.6%) of studies focused on upper extremity outcomes and reported larger initial improvements for participants in the treatment arm (using BCI) as compared to those in the control arm (no BCI). 2/2 studies focused on lower extremity outcomes reported improvements for the treatment arm compared to the control arm.Discussion/conclusion: This systematic review illustrates the utility BCI has for the restoration of upper extremity and lower extremity motor function in stroke patients and supports further investigation of BCI for other clinical indications.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"4 3","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Overview of Alzheimer’s Disease 阿尔茨海默病的最新概述

Journal of experimental neurology Pub Date : 2022-12-30 DOI: 10.33696/neurol.3.067

Emmanuel Prikas

引用次数: 1

Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine 降钙素基因相关肽及其在治疗创伤性脑损伤、蛛网膜下腔出血和相关偏头痛中的临床应用

Journal of experimental neurology Pub Date : 2022-12-28 DOI: 10.33696/neurol.3.065

Y. Mehkri, Maxwell G. Woolridge, B. Lucke-Wold

{"title":"Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine","authors":"Y. Mehkri, Maxwell G. Woolridge, B. Lucke-Wold","doi":"10.33696/neurol.3.065","DOIUrl":"https://doi.org/10.33696/neurol.3.065","url":null,"abstract":"Commentary Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury. As the incidence of TBI continues to grow, especially in the United States, it is essential to explore additional therapeutic options such as CGRP inhibition (CGRPi). Given its differential effects in TBI and SAH, an important next step is to see how patients with both TBI and SAH treated with CGRPi respond differently than patients with TBI alone. There is also a need for study in patients with severe TBI who could benefit most from this novel strategy. Calcitonin gene-related peptide (CGRP) is a 37-amino acid neurotransmitter that has been shown to be involved in cranial and facial pathology. Most commonly, CGRP’s role as a potent vasodilator [1,2] has been associated with migraine [3]. It’s use in the treatment of traumatic brain injury [3–5] and subarachnoid hemorrhage (SAH) [6–9] has recently been explored in the literature. While there have been numerous studies on mice and other animal models describing exogenous CGRP’s therapeutic effects, its limited efficacy in humans due to its low half-life [10] has prevented its advancement to human trials. Migraines","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"3 1","pages":"71 - 74"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44417090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Jalisco Mutation: Familiar Alzheimer’s Disease in México 哈利斯科州突变:墨西哥人常见的阿尔茨海默病

Journal of experimental neurology Pub Date : 2022-12-28 DOI: 10.33696/neurol.3.066

M. Meraz-Ríos, E. A. Cabrera-Reyes, Mayte-Lizeth Padilla-Cristerna

引用次数: 0

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Induced by Selective Agonist of Serotonin 5-HT1 Receptor – A Case Report 5-羟色胺5-HT1受体选择性激动剂诱导非动脉性前缺血性视神经病变1例

Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.063

引用次数: 0

Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics 通过整合eqtl和汇总统计发现神经性厌食症新的候选基因

Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.061

引用次数: 0

A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans 反映人类神经和泌尿系统缺陷的啮齿动物腰骶脊髓损伤模型

Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.059

引用次数: 2

Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex 神经炎症和小胶质细胞极性:西罗莫司在结节性硬化症小鼠模型中将小胶质细胞极性转变为M2表型

Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.064

引用次数: 0

Update on Clinical Management with Neurovascular Stents. 神经血管支架临床管理的最新进展。

Journal of experimental neurology Pub Date : 2022-01-01 DOI: 10.33696/neurol.3.062

Danyas Sarathy, Mohammed Elghareeb, Alec Clark, Rebecca Zelmanovich, Brandon Lucke-Wold

引用次数: 0