Journal of experimental neurology最新文献_第3页

Journal of experimental neurology Pub Date : 2023-03-30 DOI: 10.33696/neurol.4.070

Nicholas King, N. Dafny

{"title":"The Ventral Tegmental Area (VTA), the Nucleus Accumbens (NAc), the Caudate Nucleus (CN) and the Prefrontal Cortex (PFC) role in the Response to Acute and Chronic Methylphenidate","authors":"Nicholas King, N. Dafny","doi":"10.33696/neurol.4.070","DOIUrl":"https://doi.org/10.33696/neurol.4.070","url":null,"abstract":"Methylphenidate (MPD) is psychostimulant, similar to cocaine and amphetamine, that is commonly used to treat attention deficit hyperactivity disorder and is increasingly being abused by healthy subjects for its psychoactive effects such as memory retention cognitive enhancement for young, adult and the elderly and recreation. MPD’s action on the brain reward/motive circuit is still under investigation, however it is known that in animals chronic use of MPD leads to behavioral sensitization, an experimental indicator associated with dependence. To investigate this neural circuit’s role in response to acute and chronic MPD, three different lesions (non-specific, dopaminergic specific, and glutaminergic specific lesions) have been conducted at the nucleus accumbens (NAc), the ventral tegmental area (VTA), the caudate nucleus (CN), and the prefrontal cortex (PFC), to assess the structure, dopaminergic signaling, and glutaminergic signaling roles in response to MPD. The three types of lesions show that each one of the above four brain areas participate differently in the acute and chronic effect of MPD and have helped determine which type of signaling is critical for the acute and/or chronic behavioral adaptions to MPD.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41621171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Cisterna Magna Injection Mouse Model of Subarachnoid Hemorrhage (SAH): A Systematic Literature Review of Preclinical SAH Research 大池蛛网膜下腔出血（SAH）小鼠模型：临床前SAH研究的系统文献综述

Journal of experimental neurology Pub Date : 2023-03-23 DOI: 10.33696/neurol.4.069

S. Alpdogan, Ke Li, T. Sander, J. Cornelius, S. Muhammad

{"title":"Cisterna Magna Injection Mouse Model of Subarachnoid Hemorrhage (SAH): A Systematic Literature Review of Preclinical SAH Research","authors":"S. Alpdogan, Ke Li, T. Sander, J. Cornelius, S. Muhammad","doi":"10.33696/neurol.4.069","DOIUrl":"https://doi.org/10.33696/neurol.4.069","url":null,"abstract":"Objective: This review article describes the characteristics of published literature using the cisterna magna blood injection mouse model of subarachnoid hemorrhage (SAH) with the aim to define particular standards and identify moderators of mortality rate, SAH grade, and large artery vasospasm.\u0000\u0000Methods: We searched for English-original peer-reviewed studies which reported the induction of SAH in mice via single or multiple blood injections into the cisterna magna. The search included studies published until 13th February 2023 on PubMed, Embase and Web of Science. Furthermore, we investigated the reporting of mortality rate, vasospasms by measuring large arteries, and SAH grade in cisterna magna blood injection mouse model.\u0000\u0000Results: Seven articles out of 136 identified records matched our inclusion criteria and were therefore included in descriptive analysis. Four articles reported the mortality rate which varied between zero and 22 percent. Five articles displayed vasospasms of large cerebral arteries including basilar artery (BA), anterior cerebral artery (ACA), and middle cerebral artery (MCA). Interestingly, the diameters of the observed arteries started to decrease already within the first hour after blood injection and achieved the lowest values at different times, but mainly between six and twelve hours after SAH induction. The artery diameters reached nearly their pre-SAH (control group) diameters approximately after four to seven days after SAH. However, the SAH severity grade was reported in none of these publications. No uniform model characteristics were observed in current literature.\u0000\u0000Conclusion: A systemic overview of the cisterna magna blood injection mouse model of SAH is presented. An important heterogeneity was observed. Hence, standardized model features and study endpoints have to be defined in order to improve reporting frequency and quality to enhance the reproducibility of preclinical SAH research in the future.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43247760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Current Spinal Cord Injury Animal Models are Too Simplistic for Clinical Translation 目前的脊髓损伤动物模型过于简单，无法进行临床翻译

Journal of experimental neurology Pub Date : 2023-03-23 DOI: 10.33696/neurol.4.068

Lara Gliksten, P. Yip

引用次数: 0

Muscle and Its Neuromuscular Synapse – Players in the Pathogenesis of Motor Neuron Disease 肌肉及其神经肌肉突触——运动神经元疾病发病机制的参与者

Journal of experimental neurology Pub Date : 2023-01-23 DOI: 10.33696/neurol.4.067

P. G. Noakes, W. Phillips, R. Jeffree, F. Steyn, E. Wolvetang, R. Henderson, P. Mccombe, S. Ngo

引用次数: 1

Therapeutic Effectiveness of Brain Computer Interfaces in Stroke Patients: A Systematic Review. 脑机接口在脑卒中患者中的治疗效果：一项系统综述。

Journal of experimental neurology Pub Date : 2023-01-01 DOI: 10.33696/neurol.4.077

Yordan P Penev, Alice Beneke, Kevin T Root, Emily Meisel, Sean Kwak, Michael J Diaz, Julia L Root, Mohammad R Hosseini, Brandon Lucke-Wold

{"title":"Therapeutic Effectiveness of Brain Computer Interfaces in Stroke Patients: A Systematic Review.","authors":"Yordan P Penev, Alice Beneke, Kevin T Root, Emily Meisel, Sean Kwak, Michael J Diaz, Julia L Root, Mohammad R Hosseini, Brandon Lucke-Wold","doi":"10.33696/neurol.4.077","DOIUrl":"10.33696/neurol.4.077","url":null,"abstract":"Background: Brain-computer interfaces (BCIs) are a rapidly advancing field which utilizes brain activity to control external devices for a myriad of functions, including the restoration of motor function. Clinically, BCIs have been especially impactful in patients who suffer from stroke-mediated damage. However, due to the rapid advancement in the field, there is a lack of accepted standards of practice. Therefore, the aim of this systematic review is to summarize the current literature published regarding the efficacy of BCI-based rehabilitation of motor dysfunction in stroke patients.Methodology: This systematic review was performed in accordance with the guidelines set forth by the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 statement. PubMed, Embase, and Cochrane Library were queried for relevant articles and screened for inclusion criteria by two authors. All discrepancies were resolved by discussion among both reviewers and subsequent consensus.Results: 11/12 (91.6%) of studies focused on upper extremity outcomes and reported larger initial improvements for participants in the treatment arm (using BCI) as compared to those in the control arm (no BCI). 2/2 studies focused on lower extremity outcomes reported improvements for the treatment arm compared to the control arm.Discussion/conclusion: This systematic review illustrates the utility BCI has for the restoration of upper extremity and lower extremity motor function in stroke patients and supports further investigation of BCI for other clinical indications.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"4 3","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41156122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Updated Overview of Alzheimer’s Disease 阿尔茨海默病的最新概述

Journal of experimental neurology Pub Date : 2022-12-30 DOI: 10.33696/neurol.3.067

Emmanuel Prikas

引用次数: 1

Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine 降钙素基因相关肽及其在治疗创伤性脑损伤、蛛网膜下腔出血和相关偏头痛中的临床应用

Journal of experimental neurology Pub Date : 2022-12-28 DOI: 10.33696/neurol.3.065

Y. Mehkri, Maxwell G. Woolridge, B. Lucke-Wold

{"title":"Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine","authors":"Y. Mehkri, Maxwell G. Woolridge, B. Lucke-Wold","doi":"10.33696/neurol.3.065","DOIUrl":"https://doi.org/10.33696/neurol.3.065","url":null,"abstract":"Commentary Calcitonin gene related peptide (CGRP) is a potent vasodilator and neurotransmitter that has been extensively studied in the context of migraine pathophysiology. Recently, studies have explored its role in the treatment of traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH). Although a multitude of therapies exist for migraine, there has been little study on the management of migraine following neurologic injury. As the incidence of TBI continues to grow, especially in the United States, it is essential to explore additional therapeutic options such as CGRP inhibition (CGRPi). Given its differential effects in TBI and SAH, an important next step is to see how patients with both TBI and SAH treated with CGRPi respond differently than patients with TBI alone. There is also a need for study in patients with severe TBI who could benefit most from this novel strategy. Calcitonin gene-related peptide (CGRP) is a 37-amino acid neurotransmitter that has been shown to be involved in cranial and facial pathology. Most commonly, CGRP’s role as a potent vasodilator [1,2] has been associated with migraine [3]. It’s use in the treatment of traumatic brain injury [3–5] and subarachnoid hemorrhage (SAH) [6–9] has recently been explored in the literature. While there have been numerous studies on mice and other animal models describing exogenous CGRP’s therapeutic effects, its limited efficacy in humans due to its low half-life [10] has prevented its advancement to human trials. Migraines","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"3 1","pages":"71 - 74"},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44417090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Jalisco Mutation: Familiar Alzheimer’s Disease in México 哈利斯科州突变:墨西哥人常见的阿尔茨海默病

Journal of experimental neurology Pub Date : 2022-12-28 DOI: 10.33696/neurol.3.066

M. Meraz-Ríos, E. A. Cabrera-Reyes, Mayte-Lizeth Padilla-Cristerna

引用次数: 0

Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Induced by Selective Agonist of Serotonin 5-HT1 Receptor – A Case Report 5-羟色胺5-HT1受体选择性激动剂诱导非动脉性前缺血性视神经病变1例

Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.063

引用次数: 0

Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics 通过整合eqtl和汇总统计发现神经性厌食症新的候选基因

Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.061

引用次数: 0