Journal of experimental neurology最新文献_第7页

Targeting the Cancer Stem Cell (CSC) Phenotype: Uprooting the Evil Seed 靶向癌症干细胞(CSC)表型:根除邪恶的种子

Journal of experimental neurology Pub Date : 2020-12-31 DOI: 10.33696/NEUROL.1.027

H. Lopez-Bertoni, J. Laterra

引用次数: 0

Alzheimer and It’s Possible Therapy: A Review 阿尔茨海默病及其可能的治疗方法综述

Journal of experimental neurology Pub Date : 2020-12-31 DOI: 10.33696/NEUROL.1.019

A. Chakraborty, Anil Diwan

引用次数: 1

Cutaneous Side Effects of First-Second Line Oral Disease - Modifying Treatments in Patients with Multiple Sclero 多发性硬化症患者一二线口腔疾病的皮肤副作用-改良治疗

Journal of experimental neurology Pub Date : 2020-12-31 DOI: 10.33696/NEUROL.1.024

Doruk Arslan, A. Tuncer

引用次数: 0

Can ECT Improve the Motor Symptoms of a Neurological Disease? A Case of Dopa-Responsive Dystonia ECT能改善神经系统疾病的运动症状吗？多巴反应性肌张力障碍1例

Journal of experimental neurology Pub Date : 2020-12-31 DOI: 10.33696/NEUROL.1.023

C. Guillet

引用次数: 0

A Commentary on Concomitant Symptomatic Coronary Disease and Carotid Artery Stenosis -The Tufts Medical Center Experience 对伴随症状性冠状动脉疾病和颈动脉狭窄的评论-塔夫茨医疗中心的经验

Journal of experimental neurology Pub Date : 2020-12-31 DOI: 10.33696//NEUROL.1.021

Y. Ikeno, K. Charlton-Ouw, M. Iafrati, Anand Y. Shah

{"title":"A Commentary on Concomitant Symptomatic Coronary Disease and Carotid Artery Stenosis -The Tufts Medical Center Experience","authors":"Y. Ikeno, K. Charlton-Ouw, M. Iafrati, Anand Y. Shah","doi":"10.33696//NEUROL.1.021","DOIUrl":"https://doi.org/10.33696//NEUROL.1.021","url":null,"abstract":"135 Despite the development of surgical outcomes, acute stroke remain a devastating complication following coronary artery bypass grafting (CABG) [1]. Coexistent CAD and carotid artery stenosis are prevalent due to their common background of systemic atherosclerosis (20%) [2]. Naylor, et al. [3,4] demonstrated that the risk of stroke associated with CABG is 3.2% in patients with asymptomatic, unilateral severe carotid stenosis, whereas these figures increase to 5.2% in those with bilateral carotid stenosis and 7% to 11.6% in those with carotid occlusion. The management of concomitant CAD and carotid artery disease has been elucidated over time. The combination of carotid endarterectomy (CEA) and CABG in the same surgical setting was introduced in the 1980s [5]. Nonetheless, the surgical management, particularly the timing and order of surgical procedures, remains varied across North America. This commentary reflects upon the Tufts Medical Center experience on the current knowledge of the prevention of perioperative stroke in patients with concurrent CAD and carotid artery disease, focusing on simultaneous CEA/CABG.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45625841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Protocol for the Generation of Treatment-naïve Biopsyderived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models 一种生成治疗幼稚活检衍生的弥漫性固有脑桥胶质瘤和弥漫性中线胶质瘤模型的方案

Journal of experimental neurology Pub Date : 2020-12-31 DOI: 10.33696/neurol.1.025

{"title":"A Protocol for the Generation of Treatment-naïve Biopsyderived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models","authors":"","doi":"10.33696/neurol.1.025","DOIUrl":"https://doi.org/10.33696/neurol.1.025","url":null,"abstract":"Diffuse intrinsic pontine glioma (DIPG) is a universally fatal tumor of the brainstem, most commonly affecting young children. Due to its location, surgical resection is not achievable, but consideration of a biopsy has become standard practice at children’s hospitals with the appropriate neurosurgical expertise. While the decision to obtain a biopsy should be directed by the presence of atypical radiographic features that call the diagnosis of DIPG into question or the requirement of biopsy tissue for clinical trial enrollment, once this precious tissue is available its use for research should be considered. The majority of DIPG and diffuse midline glioma, H3 K27Mmutant (DMG) models are autopsy-derived or genetically-engineered, each of which has limitations for translational studies, so the use of biopsy tissue for laboratory model development provides an opportunity to create unique model systems. Here, we present a detailed laboratory protocol for the generation of treatment-naïve biopsy-derived DIPG/DMG models. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. http://creativecommons.org/ licenses/by/4.0/ Correspondence should be addressed to Nicholas A. Vitanza; nicholas.vitanza@seattlechildrens.org. Authorship MCB, AN, CM, SMM, CAW, FP, JMO, and NAV participated in the design or interpretation of the reported experiments or results. MCB, AN, CM, SMM, CAW, FP, BLC, SRB, and NAV participated in the acquisition or analysis of data. MCB, AN, and NAV wrote the manuscript with revisions and approval from all authors. NAV supervised all aspects of the research. Conflicts of Interest None. HHS Public Access Author manuscript J Exp Neurol. Author manuscript; available in PMC 2021 March 24. Published in final edited form as: J Exp Neurol. 2020 December ; 1(4): 158–167. doi:10.33696//Neurol.1.025. A uhor M anscript","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42468937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models. 生成未经治疗的活检衍生弥漫性内侧脑桥胶质瘤和弥漫性中线胶质瘤模型的方案。

Journal of experimental neurology Pub Date : 2020-12-01 DOI: 10.33696//Neurol.1.025

Matt C Biery, Alyssa Noll, Carrie Myers, Shelli M Morris, Conrad A Winter, Fiona Pakiam, Bonnie L Cole, Samuel R Browd, James M Olson, Nicholas A Vitanza

{"title":"A Protocol for the Generation of Treatment-naïve Biopsy-derived Diffuse Intrinsic Pontine Glioma and Diffuse Midline Glioma Models.","authors":"Matt C Biery, Alyssa Noll, Carrie Myers, Shelli M Morris, Conrad A Winter, Fiona Pakiam, Bonnie L Cole, Samuel R Browd, James M Olson, Nicholas A Vitanza","doi":"10.33696//Neurol.1.025","DOIUrl":"10.33696//Neurol.1.025","url":null,"abstract":"<p><p>Diffuse intrinsic pontine glioma (DIPG) is a universally fatal tumor of the brainstem, most commonly affecting young children. Due to its location, surgical resection is not achievable, but consideration of a biopsy has become standard practice at children's hospitals with the appropriate neurosurgical expertise. While the decision to obtain a biopsy should be directed by the presence of atypical radiographic features that call the diagnosis of DIPG into question or the requirement of biopsy tissue for clinical trial enrollment, once this precious tissue is available its use for research should be considered. The majority of DIPG and diffuse midline glioma, H3 K27M-mutant (DMG) models are autopsy-derived or genetically-engineered, each of which has limitations for translational studies, so the use of biopsy tissue for laboratory model development provides an opportunity to create unique model systems. Here, we present a detailed laboratory protocol for the generation of treatment-naïve biopsy-derived DIPG/DMG models.</p>","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"1 4","pages":"158-167"},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7990285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25517671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary to the Newly Rising Aquatic Exercise: Ai Chi 新兴的水上运动:艾奇

Journal of experimental neurology Pub Date : 2020-09-23 DOI: 10.33696/neurol.1.013

Pei-Hsin Ku, J. Lambeck, Nai-Chen Yeh, Ray-Yau Wang

引用次数: 0

Managing Acute Urinary Dysfunction for Neurologic Injury Patients 神经损伤患者急性尿功能障碍的处理

Journal of experimental neurology Pub Date : 2020-05-19 DOI: 10.33696/NEUROL.1.008

B. Lucke-Wold

引用次数: 0

Managing Acute Urinary Dysfunction for Neurologic Injury Patients. 神经损伤患者急性尿功能障碍的处理。

Journal of experimental neurology Pub Date : 2020-01-01 Epub Date: 2020-05-19

Brandon Lucke-Wold

引用次数: 0