Journal of experimental neurology最新文献_第2页

CCR3 Expression in Relation to Delayed Microbleeds in a Rat Model of Large Vessel Occlusion. 大血管闭塞大鼠模型中 CCR3 表达与延迟性微出血的关系

Journal of experimental neurology Pub Date : 2024-01-01 DOI: 10.33696/neurol.5.082

Sydney M Claypoole, Jacqueline A Frank, Sarah J Messmer, Keith R Pennypacker

{"title":"CCR3 Expression in Relation to Delayed Microbleeds in a Rat Model of Large Vessel Occlusion.","authors":"Sydney M Claypoole, Jacqueline A Frank, Sarah J Messmer, Keith R Pennypacker","doi":"10.33696/neurol.5.082","DOIUrl":"10.33696/neurol.5.082","url":null,"abstract":"Thirty percent of ischemic stroke patients develop vascular cognitive impairment and dementia (VCID) within 1 year of stroke onset. The expression of C-C motif chemokine receptor 3 (CCR3) is associated with endothelial dysfunction and memory impairment. CCR3 has been reported to increase after experimental stroke and in human stroke patients. Using an in vivo model of stroke, our study aims to link CCR3 expression with endothelial dysfunction in this rodent stroke model.Methods: 5-hour transient Middle Cerebral Artery Occlusion (5t-MCAO) or sham surgery was performed on rats and tissue collected at 3- and 30-days post-stroke. We measured the change in expression of CCR3 and its ligands in the venous blood before and after occlusion in the rat model.Immunohistochemistry was performed on consecutive coronal brain sections using Prussian blue to visualize microbleeds and DAB to visualize CCR3. Images were quantified using HALO.Results: Using linear regression, we found that increased expression of CCR3 and its ligands after stroke were positively correlated with infarct volume. CCR3 expression was significantly increased in the ipsilateral hemisphere at 30 days post 5t-MCAO. Prussian blue staining was significantly increased in ipsilateral sections at 30 days post-stroke. Immunostaining for CCR3 was primarily detected in endothelium in areas of Prussian blue staining.Conclusions: Our results demonstrate that CCR3 expression is associated with the presence of microbleeds at 30 days but not 3 days post-stroke in the ipsilateral hemisphere, and further supports the link between CCR3 and the endothelial dysfunction that is associated with VCID. CCR3 and its inflammatory pathway is a potential target for reducing endothelial dysfunction after ischemic stroke that may lead to VCID.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"5 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10852049/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrovascular Dysfunction in Alzheimer's Disease and Transgenic Rodent Models. 阿尔茨海默病和转基因啮齿动物模型中的脑血管功能障碍

Journal of experimental neurology Pub Date : 2024-01-01 DOI: 10.33696/neurol.5.087

Xing Fang, Fan Fan, Jane J Border, Richard J Roman

{"title":"Cerebrovascular Dysfunction in Alzheimer's Disease and Transgenic Rodent Models.","authors":"Xing Fang, Fan Fan, Jane J Border, Richard J Roman","doi":"10.33696/neurol.5.087","DOIUrl":"10.33696/neurol.5.087","url":null,"abstract":"Alzheimer's Disease (AD) and Alzheimer's Disease-Related Dementia (ADRD) are the primary causes of dementia that has a devastating effect on the quality of life and is a tremendous economic burden on the healthcare system. The accumulation of extracellular beta-amyloid (Aβ) plaques and intracellular hyperphosphorylated tau-containing neurofibrillary tangles (NFTs) in the brain are the hallmarks of AD. They are also thought to be the underlying cause of inflammation, neurodegeneration, brain atrophy, and cognitive impairments that accompany AD. The discovery of APP, PS1, and PS2 mutations that increase Aβ production in families with early onset familial AD led to the development of numerous transgenic rodent models of AD. These models have provided new insight into the role of Aβ in AD; however, they do not fully replicate AD pathology in patients. Familial AD patients with mutations that elevate the production of Aβ represent only a small fraction of dementia patients. In contrast, those with late-onset sporadic AD constitute the majority of cases. This observation, along with the failure of previous clinical trials targeting Aβ or Tau and the modest success of recent trials using Aβ monoclonal antibodies, has led to a reappraisal of the view that Aβ accumulation is the sole factor in the pathogenesis of AD. More recent studies have established that cerebral vascular dysfunction is one of the earliest changes seen in AD, and 67% of the candidate genes linked to AD are expressed in the cerebral vasculature. Thus, there is an increasing appreciation of the vascular contribution to AD, and the National Institute on Aging (NIA) and the Alzheimer's Disease Foundation recently prioritized it as a focused research area. This review summarizes the strengths and limitations of the most commonly used transgenic AD animal models and current views about the contribution of Aβ accumulation versus cerebrovascular dysfunction in the pathogenesis of AD.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"5 2","pages":"42-64"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10906803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Assembly Modulation: A New Approach to Amyotrophic Lateral Sclerosis (ALS) Therapeutics. 蛋白质组装调节：肌萎缩侧索硬化（ALS）治疗的新方法。

Journal of experimental neurology Pub Date : 2024-01-01 DOI: 10.33696/Neurol.5.103

Shao Feng Yu, Kumar Paulvannan, Dennis Solas, Anuradha F Lingappa, Ana Raquel Moreira, Shriya Sahu, Maya Michon, Amanda Macieik, Danielle Goldsmith, Nicholas DeYarman, Suguna Mallesh, M Dharma Prasad, Claudia Maios, Kai Ruan, Giulio S Tomassy, Elizabeth Jensen, Emma McGuirk, Verian Bader, Andreas Mueller-Schiffmann, Jonathan C Reed, Jaisri R Lingappa, Vinod Asundi, Shi Hong, Steve Jacobsen, Nicholas Brandon, Lyle Ostrow, Tom Lloyd, J Alex Parker, Kim A Staats, Justin Ichida, James C Dodge, Debendranath Dey, Carsten Korth, Suganya Selvarajah, Vishwanath R Lingappa, Jeffrey Rosenfeld

{"title":"Protein Assembly Modulation: A New Approach to Amyotrophic Lateral Sclerosis (ALS) Therapeutics.","authors":"Shao Feng Yu, Kumar Paulvannan, Dennis Solas, Anuradha F Lingappa, Ana Raquel Moreira, Shriya Sahu, Maya Michon, Amanda Macieik, Danielle Goldsmith, Nicholas DeYarman, Suguna Mallesh, M Dharma Prasad, Claudia Maios, Kai Ruan, Giulio S Tomassy, Elizabeth Jensen, Emma McGuirk, Verian Bader, Andreas Mueller-Schiffmann, Jonathan C Reed, Jaisri R Lingappa, Vinod Asundi, Shi Hong, Steve Jacobsen, Nicholas Brandon, Lyle Ostrow, Tom Lloyd, J Alex Parker, Kim A Staats, Justin Ichida, James C Dodge, Debendranath Dey, Carsten Korth, Suganya Selvarajah, Vishwanath R Lingappa, Jeffrey Rosenfeld","doi":"10.33696/Neurol.5.103","DOIUrl":"10.33696/Neurol.5.103","url":null,"abstract":"Amyotrophic Lateral Sclerosis (ALS) is a devastating and progressive neurodegenerative disease with a complex, multifactorial pathophysiology, culminating in death of motor neurons. We introduce a new mechanism of ALS pathogenesis via study of a novel drug-like small molecule series that targets a subset of protein disulfide isomerase (PDI) within a previously largely unappreciated transient and energy-dependent multi-protein complex enriched for proteins of the ALS interactome. This drug, found by a novel phenotypic screen, has activity in cellular models for both familial and sporadic ALS, as well as in transgenic worms, flies, and mice bearing a diversity of human genes with ALS-associated mutations. The hit compound was initially identified as a modulator of human immunodeficiency virus (HIV) capsid assembly in cell-free protein synthesis and assembly (CFPSA) systems, with demonstrated antiviral activity against infectious HIV in cell culture. Its advancement for ALS-therapeutics, subsequent separation of activity against HIV and ALS into separate chemical subseries through structure-activity-relationship (SAR) optimization, and identification of the drug target by affinity chromatography as shown here, may provide insights into the molecular mechanisms governing pathophysiology of disordered homeostasis relevant to ALS.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"5 4","pages":"210-230"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12445735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases. 肌萎缩性侧索硬化症和其他神经退行性疾病的瓜氨酸化蛋白。

Journal of experimental neurology Pub Date : 2024-01-01 DOI: 10.33696/neurol.5.101

Issa O Yusuf, Webb Camille, Paul R Thompson, Zuoshang Xu

{"title":"Protein Citrullination in Amyotrophic Lateral Sclerosis and Other Neurodegenerative Diseases.","authors":"Issa O Yusuf, Webb Camille, Paul R Thompson, Zuoshang Xu","doi":"10.33696/neurol.5.101","DOIUrl":"10.33696/neurol.5.101","url":null,"abstract":"Protein citrullination (PC) is a posttranslational modification (PTM) that converts a peptidyl arginine into a peptidyl citrulline. Aberrant PC is a hallmark of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, Parkinson's disease, prion disease, and multiple sclerosis. Common among these diseases is a dramatic increase of PC in reactive astrocytes. Some citrullinated proteins have been identified. The most prominent are astrocytic cytoskeletal proteins such as GFAP and vimentin, and myelin protein MBP. Recent investigation in ALS has revealed new changes, including a decreased PC in neurons and an association of PC with myelin protein aggregates. These findings suggest that PC contributes to protein aggregation, neuronal dysfunction, neuroinflammation, and axonal degeneration. However, how PC impact neurodegeneration remains to be understood. Further studies are needed to understand a range of questions, from how PC modulates individual protein functions to its impact on diseases. Because of the PC's robust changes in neurodegenerative diseases, there are also prospects that this PTM may be harnessed as biomarkers, and modulation of this PTM may be an avenue for therapy. In this review, we summarize the current understanding of PC in ALS and other neurodegenerative diseases, the investigative methods for PC, and PC's potential as a biomarker and a therapeutic target.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"5 4","pages":"183-191"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11661818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Conformationally Altered Tau with α-1-antichymotrypsin in the Nuclei of Neurons in the Alzheimer's Disease Brain 阿尔茨海默病大脑神经元细胞核中构象改变的 Tau 与 α-1-antichymotrypsin 的关系

Journal of experimental neurology Pub Date : 2023-11-24 DOI: 10.33696/neurol.4.080

Perla H. Horta-López, Jan Rícny, B. Florán-Garduño, F. García-Sierra

{"title":"Association of Conformationally Altered Tau with α-1-antichymotrypsin in the Nuclei of Neurons in the Alzheimer's Disease Brain","authors":"Perla H. Horta-López, Jan Rícny, B. Florán-Garduño, F. García-Sierra","doi":"10.33696/neurol.4.080","DOIUrl":"https://doi.org/10.33696/neurol.4.080","url":null,"abstract":"Conformational changes of Tau have been described to occur during its fibrillary and non-fibrillary aggregation inside neurons affected in the brain of Alzheimer’s disease (AD) patients. Two consecutive conformations have been described during the progression of the disease: an early conformation detected with the Alz-50 antibody, recognizing Tau molecules folding its amino terminus over its third repeated domain, and a later conformation involving the bending of the proline-rich region over the third repeated domain. α-1-antichymotrypsin (ACT) is an acute phase serum glycoprotein that is overexpressed in the brain of AD cases and associated with extracellular amyloid-ß aggregates. We have recently reported that in a large population of neurons affected in AD brains, Tau protein undergoing the conformational change detected by Tau-66 antibody accumulates as non-fibrillary aggregates and colocalizes with extensive accumulations of granular diffuse intracellular deposits of ACT. In this report, we further analyzed Tau-ACT interactions in the neurons from the hippocampus of AD brains. By using superresolution confocal microscopy and quantitative colocalization analysis, we corroborated the mutual association and mislocalization of conformationally altered Tau protein and ACT to the nuclear compartment. These results suggest that ACT can play an abnormal pathological role in AD by contributing to the abnormal transport of truncated and conformationally altered Tau protein to the nucleus.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"104 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139239491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination 五价疫苗接种后发热性惊厥儿童脑膜炎患病率的变化

Journal of experimental neurology Pub Date : 2023-11-14 DOI: 10.33696/neurol.4.079

Shadi Shiva, Shokoufeh Khanzadeh, Vahid Shohanizad, Arshin Ghaedi, Brandon Lucke-Wold

{"title":"Change in Prevalence of Meningitis among Children with Febrile Seizure after the Pentavalent Vaccination","authors":"Shadi Shiva, Shokoufeh Khanzadeh, Vahid Shohanizad, Arshin Ghaedi, Brandon Lucke-Wold","doi":"10.33696/neurol.4.079","DOIUrl":"https://doi.org/10.33696/neurol.4.079","url":null,"abstract":"Introduction: One of the most significant current discussions in pediatrics is whether lumbar puncture (LP) should be performed in children with febrile seizure (FS) as in the past. Objectives: We compared the prevalence of meningitis among FS children before and after the pentavalent vaccine to determine the importance of the LP in these children. Methods: We performed a retrospective cross-sectional study on the prevalence and etiology of bacterial meningitis (BM) in 1314 children with FS before and after pentavalent vaccination. Results: We found that complex FS was more prevalent in patients aged under 12 months compared to other patients. The peak incidence of aseptic meningitis and BM was in the age group of 12- to18- and 18- to 36-month-old, respectively (P value <0.001 and <0.05, respectively). Children with complex FS had a significantly higher rate of BM and a lower rate of seizure recurrence than those with simple FS (P value <0.05). There was a significant relationship between getting the pentavalent vaccine and reducing the prevalence of BM and Hib-induced BM, but no SP-induced BM (P value <0.05 and 0.05 and 0.104, respectively). Conclusion: This study offers some insights into the effectiveness of the pentavalent vaccine. In addition, the low prevalence of BM in vaccinated FS cases does not support strong recommendations for LP in FS children.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"17 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134991530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Responsive Neurostimulation for Management of Refractory Precuneus Onset Epilepsy: A Case Report 反应性神经刺激治疗难治性先兆发作性癫痫一例报告

Journal of experimental neurology Pub Date : 2023-08-21 DOI: 10.33696/neurol.4.078

Arun Swaminathan

{"title":"Responsive Neurostimulation for Management of Refractory Precuneus Onset Epilepsy: A Case Report","authors":"Arun Swaminathan","doi":"10.33696/neurol.4.078","DOIUrl":"https://doi.org/10.33696/neurol.4.078","url":null,"abstract":"Posterior quadrant epilepsy is relatively uncommon and refractory seizures from these regions are difficult to diagnose and manage. A 28-year-old woman presented for evaluation of her seizures. Scalp Electroencephalogram (EEG) showed seizures with independent onset over the right posterior and left anterior regions. Positron emission tomography (PET) scans revealed multiple regions of hypometabolism in the brain with maximum decrease in metabolism seen over the left and right precuneus and both occipital lobes. Magnetoencephalography (MEG) revealed epileptogenic dipoles over bilateral precuneus regions. Intracranial EEG revealed seizure onset from the left precuneus and left frontal regions with rapid generalization. She underwent Responsive Neurostimulation System (RNS) implantation targeting the left precuneus and left frontal regions for network modulation. She has had a 90 percent seizure reduction and remains on 2 medications as she continues to follow up in clinic. Posterior quadrant epilepsy remains a challenging condition to manage, and the use of neuromodulation may improve response rates and improve our understanding of these networks. Definite guidelines on location of electrode placement of RNS in such cases remain absent and improved understanding of such seizure networks is expected to improve our ability to target therapeutic nodes accurately to achieve greater seizure control.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49582862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glypican-2 as the Regeneration-Associated Gene (RAG) Glypican-2作为再生相关基因

Journal of experimental neurology Pub Date : 2023-08-16 DOI: 10.33696/neurol.4.076

K. Sakamoto, Yuji Suzuki, K. Kadomatsu

引用次数: 0

The Relationship between Anxiety and Cognition in Stroke Patients: A Cross-Sectional Study 脑卒中患者焦虑与认知关系的横断面研究

Journal of experimental neurology Pub Date : 2023-06-22 DOI: 10.33696/neurol.4.075

Zixiu Zheng, Runluo Song, Yang-yan Song, Yanqing Wang, Yanjun Zhuang, Cong Yu, Jun Xue

{"title":"The Relationship between Anxiety and Cognition in Stroke Patients: A Cross-Sectional Study","authors":"Zixiu Zheng, Runluo Song, Yang-yan Song, Yanqing Wang, Yanjun Zhuang, Cong Yu, Jun Xue","doi":"10.33696/neurol.4.075","DOIUrl":"https://doi.org/10.33696/neurol.4.075","url":null,"abstract":"Background: There is limited evidence on the relationship between anxiety and cognition in stroke patients, and no precise relationship between the two has been indicated.\u0000\u0000Objective: We aimed to explore the precise relationship between anxiety and cognition in Chinese stroke patients.\u0000\u0000Methods: This study was a cross-sectional study, 384 hospitalized stroke patients were assessed with questionnaires and scales, including the Demographic Characteristics Questionnaire, the Hamilton Anxiety Inventory (HAMA), and the Montreal Cognitive Assessment (MoCA).\u0000\u0000Results: Anxiety was present in 55.47% of the 384 patients. Univariate analysis showed that age, gender, marital status, smoking, and alcohol consumption were associated with cognition, and multiple linear regression results showed that HAMA was not independently associated with MoCA after adjusting for potential confounders (β=-0.16, 95% CI: -0.29 to- 0.03), which would be inconsistent with HAMA (subgroup) as a categorical variable (P trend of 0.004) A non-linear relationship was detected between HAMA and MoCA with an inflection point of 9. The effect sizes and confidence intervals to the left and right of the inflection point were -0.54 (-0.78 to -0.30) and 0.02 (-0.14 to -0.17), respectively.\u0000\u0000Conclusion: The relationship between anxiety and cognition is nonlinear. When the HAMA score is less than 9, anxiety and cognition are negatively correlated, and when it is greater than or equal to 9, the cognitive score will no longer decrease and is saturated.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42285663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily Activity Restriction Quantification in Older Population via Using Activity Frequency: Dual Roles in Preventing Falls 利用活动频率量化老年人日常活动限制：预防跌倒的双重作用

Journal of experimental neurology Pub Date : 2023-06-05 DOI: 10.33696/neurol.4.073

Xia Shen, Lin Y. Chen, Jing X. Wang, Yan N. Jiang

{"title":"Daily Activity Restriction Quantification in Older Population via Using Activity Frequency: Dual Roles in Preventing Falls","authors":"Xia Shen, Lin Y. Chen, Jing X. Wang, Yan N. Jiang","doi":"10.33696/neurol.4.073","DOIUrl":"https://doi.org/10.33696/neurol.4.073","url":null,"abstract":"Daily activity restriction is an expected physical behavior aiming to prevent falls in the older population. However, it plays dual roles in preventing falls, both positive and harmful. Therefore, the degree of daily activity restriction is proposed as a critical factor influencing the weight ratio of the positive and negative roles and finally determining the efficacy of fall prevention. Thus, quantification of daily activity restriction is essential to learn its efficacy.\u0000\u0000We proposed using activity frequency to quantify activity restriction and have testified its good sensitivity to discriminate the degree of activity restriction in older populations. We further attempted to link the degree of activity restriction with the degree of fear of falling to estimate the dual roles of activity restriction in preventing falls. Based on it, a new Composite Activity-specific Risk of Falls Scale tool has been developed. It is promising to use for guiding the modification of physical behavior to prevent falls in older populations. However, further studies are required to establish the evidence for its application.","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41990548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0