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Journal of experimental neurology最新文献

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The Jalisco Mutation: Familiar Alzheimer’s Disease in México 哈利斯科州突变:墨西哥人常见的阿尔茨海默病
Journal of experimental neurology Pub Date : 2022-12-28 DOI: 10.33696/neurol.3.066
M. Meraz-Ríos, E. A. Cabrera-Reyes, Mayte-Lizeth Padilla-Cristerna
{"title":"The Jalisco Mutation: Familiar Alzheimer’s Disease in México","authors":"M. Meraz-Ríos, E. A. Cabrera-Reyes, Mayte-Lizeth Padilla-Cristerna","doi":"10.33696/neurol.3.066","DOIUrl":"https://doi.org/10.33696/neurol.3.066","url":null,"abstract":"","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69670590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Induced by Selective Agonist of Serotonin 5-HT1 Receptor – A Case Report 5-羟色胺5-HT1受体选择性激动剂诱导非动脉性前缺血性视神经病变1例
Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.063
{"title":"Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Induced by Selective Agonist of Serotonin 5-HT1 Receptor – A Case Report","authors":"","doi":"10.33696/neurol.3.063","DOIUrl":"https://doi.org/10.33696/neurol.3.063","url":null,"abstract":"","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47558095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics 通过整合eqtl和汇总统计发现神经性厌食症新的候选基因
Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.061
{"title":"Discovery of New Candidate Genes for Anorexia Nervosa through Integration of eQTLs with Summary Statistics","authors":"","doi":"10.33696/neurol.3.061","DOIUrl":"https://doi.org/10.33696/neurol.3.061","url":null,"abstract":"","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49183117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans 反映人类神经和泌尿系统缺陷的啮齿动物腰骶脊髓损伤模型
Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.059
{"title":"A Rodent Lumbosacral Spinal Cord Injury Model Reflecting Neurological and Urological Deficits of Humans","authors":"","doi":"10.33696/neurol.3.059","DOIUrl":"https://doi.org/10.33696/neurol.3.059","url":null,"abstract":"","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45627309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex 神经炎症和小胶质细胞极性:西罗莫司在结节性硬化症小鼠模型中将小胶质细胞极性转变为M2表型
Journal of experimental neurology Pub Date : 2022-12-13 DOI: 10.33696/neurol.3.064
{"title":"Neuroinflammation and Microglial Polarity: Sirolimus Shifts Microglial Polarity to M2 phenotype in a Mouse Model of Tuberous Sclerosis Complex","authors":"","doi":"10.33696/neurol.3.064","DOIUrl":"https://doi.org/10.33696/neurol.3.064","url":null,"abstract":"","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43649467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on Clinical Management with Neurovascular Stents. 神经血管支架临床管理的最新进展。
Journal of experimental neurology Pub Date : 2022-01-01 DOI: 10.33696/neurol.3.062
Danyas Sarathy, Mohammed Elghareeb, Alec Clark, Rebecca Zelmanovich, Brandon Lucke-Wold
{"title":"Update on Clinical Management with Neurovascular Stents.","authors":"Danyas Sarathy, Mohammed Elghareeb, Alec Clark, Rebecca Zelmanovich, Brandon Lucke-Wold","doi":"10.33696/neurol.3.062","DOIUrl":"10.33696/neurol.3.062","url":null,"abstract":"<p><p>Endovascular stenting has continued to evolve given the new trials. Several new stents have recently been developed to address specific purposes. In this focused review, we discuss the concepts of neurointerventional stents and address the clinical implications. Furthermore, each type of stent is discussed with supporting evidence for clinical utility. In the final component, we argue for continued development and utilization.</p>","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"3 2","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10451105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine. 评论：降钙素基因相关肽及其在治疗创伤性脑损伤、蛛网膜下腔出血和相关性偏头痛中的临床用途。
Journal of experimental neurology Pub Date : 2022-01-01
Yusuf Mehkri, Maxwell G Woolridge, Brandon Lucke-Wold
{"title":"Commentary: Calcitonin Gene Related Peptide and Its Clinical Utility for the Treatment of Traumatic Brain Injury, Subarachnoid Hemorrhage and Associated Migraine.","authors":"Yusuf Mehkri, Maxwell G Woolridge, Brandon Lucke-Wold","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":"3 3","pages":"71-74"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10583856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Left Atrial Appendage Occlusion: Where are We Going? 左心耳闭塞:我们要去哪里?
Journal of experimental neurology Pub Date : 2021-12-21 DOI: 10.33696/neurol.2.051
S. Shin, S. Kim, Jai-Wun Park
{"title":"Left Atrial Appendage Occlusion: Where are We Going?","authors":"S. Shin, S. Kim, Jai-Wun Park","doi":"10.33696/neurol.2.051","DOIUrl":"https://doi.org/10.33696/neurol.2.051","url":null,"abstract":"Prevention of ischemic stroke is one of the most important issues in patients with atrial fibrillation (AF). Currently, most patients are managed satisfactorily with oral anticoagulant (OAC) therapy. The remaining patients, who cannot tolerate long-term systemic OAC or who have an excess thrombotic burden that cannot be adequately controlled by OAC alone, require local anti-thrombotic therapy such as left atrial appendage (LAA) mechanical exclusion, either by surgical excision or percutaneous closure device implantation. Since the first percutaneous left atrial appendage occlusion (LAAO) device implantation was performed in 2001, there have been numerous unanswered questions, which might be clarified only after additional experience in this field. Although an enormous number of non-valvular atrial fibrillation (NVAF) patients require thrombo-prophylactic management, which can be either systemic or local management, LAAO has not yet been widely adopted as an alternative to anticoagulant therapy because of the extraordinarily diverse anatomical variation within the LAA as well as the complexity of clinical situations (i.e. relative / absolute contraindication to anticoagulant, high bleeding risk with or without prior major bleeding events, recurrent stroke during proper secondary prevention, comorbidities that increase the bleeding risk or thrombotic risk, and are accompanied by a compromised life expectancy, such as malignancy). The preliminary answer to the question regarding the meaningful destination of LAAO has been carefully discussed in this article. Can LAAO replace OAC?","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46971741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke 机体铁超载是急性缺血性脑卒中脑损伤的决定性因素
Journal of experimental neurology Pub Date : 2021-12-21 DOI: 10.33696/neurol.2.047
J. R. Torrella, R. Rama
{"title":"Body Iron Overload is a Determining Factor in Brain Damage in Acute Ischemic Stroke","authors":"J. R. Torrella, R. Rama","doi":"10.33696/neurol.2.047","DOIUrl":"https://doi.org/10.33696/neurol.2.047","url":null,"abstract":"Stroke is the second largest cause of death worldwide, with a world annual mortality incidence of about 5.5 million people, and it is also the leading cause of disability worldwide with 50% of survivors being chronically disabled [1]. It is estimated that one in four people will experience a stroke in their lifetime [2]. Strokes may be classified into two general types: ischemic and haemorrhagic. Ischemic stroke is caused by a reduction or an interruption of the blood supply to a certain region of the brain due to the obstruction of a blood vessel. In contrast, haemorrhagic stroke occurs due to the rupture of a blood vessel causing bleeding in the brain or in the subarachnoid space [3]. This short communication is centered on ischemic stroke, which is the most prevalent form of stroke worldwide [1].","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46466959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo Neuropathology: Detecting the Neurotoxicity of Candidate Drugs during Early Drug Discovery 体内神经病理学:在早期药物发现中检测候选药物的神经毒性
Journal of experimental neurology Pub Date : 2021-12-21 DOI: 10.33696/neurol.2.052
C. Ferris, P. Kulkarni
{"title":"In vivo Neuropathology: Detecting the Neurotoxicity of Candidate Drugs during Early Drug Discovery","authors":"C. Ferris, P. Kulkarni","doi":"10.33696/neurol.2.052","DOIUrl":"https://doi.org/10.33696/neurol.2.052","url":null,"abstract":"Twenty-five percent of small molecules in drug development for CNS indications fail in clinical trials due to complications with neurotoxicity [1]. Unfortunately, this is not discovered earlier. Indeed, it is very infrequent that a drug is flagged for neurotoxic side effects in early drug discovery (1). The consequences are two-fold: 1) loss of time and money in bringing new drugs to market and, 2) the unwitting exposure of patents in clinical trials to the neurotoxic side effects of what otherwise could be a drug candidate that is effectively treating the problem. Known ahead of time, this could have helped guide the chemistry in the early stages of development to modify the molecule to eliminate the neurotoxicity [2].","PeriodicalId":73744,"journal":{"name":"Journal of experimental neurology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45002531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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