Journal of engineering and science in medical diagnostics and therapy最新文献

{"title":"A Finite Element Based Comparative Study of Lumbosacral Pedicle Screw Fixation and Artificial Disc Replacement","authors":"J. Biswas, Anik Banerjee, N. Mondal, Masud Rana","doi":"10.1115/1.4056953","DOIUrl":"https://doi.org/10.1115/1.4056953","url":null,"abstract":"\u0000 The aim of this is to evaluate the biomechanical performance of double-level semi-rigid pedicle screw fixation and artificial intervertebral disc replacement in lumbar spine. Ti6Al4V and CFR-PEEK material are used for pedicle screw fixation and artificial disc replacement. In the present study, pedicle screw fixation and artificial intervertebral disc replacement are carried out between L3-L4-L5 regions under the application of moment 6,8,10 Nm and range of motion is compared during flexion, extension, and right-left lateral bending. Two level pedicle screw fusion and total disc replacement are developed in the L3-L4-L5 of the lumber spine vertebrae. Carbon fiber reinforced (CFR-PEEK) and Ultra High Molecular Weight Polyethylene (UHMWPE) are considered for the spinal fusion and the core part of the artificial disc respectively. Afterwards, applying the finite element analysis, it is detected that CFR-PEEK rod is able to increase range of motion at the implanted level in comparison to Ti6Al4V rod for both flexion-extension and lateral bending. In case of artificial intervertebral disc replacement hypermobility was observed. Hence, it is significant that rod material with CFR-PEEK is a better alternative for the treatment of degenerative diseases.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75958482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Resonance Frequency and Micro motion to achieve Implant Stability using Vibroacoustic RFA: A Mathematical Model","authors":"Vineet Khened, Kanad Dhok, M. Pradhan, P. Dhatrak","doi":"10.1115/1.4056951","DOIUrl":"https://doi.org/10.1115/1.4056951","url":null,"abstract":"\u0000 Dental implants are surgically implanted into the patient's jaw to replace a missing tooth. The implant should have adequate time to integrate with bone before being subjected to masticatory force to avoid early failure. Resonance Frequency Analysis (RFA) is one of the approaches for determining an implant system's primary stability in terms of micromotion. This research aims to create a two-degree of freedom (dof) mathematical model for dental prostheses based on the vibroacoustic RFA approach. In vibroacoustic system, a loudspeaker or buzzer is used as an input and the displacement of implant is measured using RFA. A sinusoidal force is used which produces a combination of translational and rotational motion of the implant system. While adjusting the input frequency from 4000 to 12000 Hz, is used with the help of MATLAB which later computes the implant system's subsequent micro-motion and resonance frequency. MATLAB is used to visualise the resonance frequency, which is 6658.38 Hz in case of rotational motion and 8138 Hz in translational motion. The micromotion was 1.2692 X 10-11 meters in case of translational motion and 6.91088 X 10-9 radians in case of rotational motion. When there is less micromotion, a higher resonance frequency suggests more excellent osseointegration. For the evaluation of implant stability, a mathematical model is a primary approach which can be implemented to design a stability device using vibroacoustic RFA.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79384971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computational Fluid Dynamics Study of Particle Deposition On Human Lung Dynamic: A Comparison Between the Healthy and Fibrotic Lung","authors":"Carlo Carotenuto, L. Scurani, L. Fontanili, L. Montorsi, M. Milani","doi":"10.1115/1.4056840","DOIUrl":"https://doi.org/10.1115/1.4056840","url":null,"abstract":"\u0000 The lung is the human organ mainly affected by severe coronavirus disease (COVID-19) caused by the novel coronavirus SARS-CoV-2. In this pathology, the dynamic lung function and the respiratory mechanics are compromised, leading to the development of the ARDS (acute respiratory distress syndrome). The resulting damage is the progressive reduction of gas exchange and death in the most critical patients. For these reasons, it is important to study and analyze how this virus adversely affects lung dynamics. The main objective of the present paper is to propose a modeling methods of SARS-CoV-2 virus particles spread in the 23rd generation of lung tree and the mechanical estimation of how a severe stage of Covid-19 characterized by pulmonary fibrosis affects the alveolar sac expansion and hence the breathing capability of the sick person. In this context, the dynamic analysis of the influence of SARS-CoV-2 spread on human lung under real conditions has been shown by means of a numerical approach. Therefore, a multiphase three-dimensional computational fluid dynamics (CFD) study is performed to estimate the Covid-19 virus particles dispersion throughout a simplify model of the 23rd generation of bronchial tree, at the alveolar region. Then, a fully coupled fluid-structure interaction (FSI) with the mesh morphing technique and solid displacement characteristics are used to obtain and evaluate a realistic wall displacement during the expansion of the alveolar sac. A comparison is made between a healthy and a diseased lung. These phases are studied under cyclic steady-state conditions The novelties of this analysis are: firstly, the innovative CFD method proposed in order to model the particles spread inside the alveolar region, and secondly the evaluation of how the presence of Sars-Cov-2 can affect the mechanical properties of the alveolar sac and damage the lung function of a sick person at an advanced stage of infection, such as a person affected by pulmonary fibrosis.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87546451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biaxial Tensile Prestress and Waveguide Effects on Estimates of the Complex Shear Modulus Using Optical-Based Dynamic Elastography in Plate-Like Soft Tissue Phantoms.","authors":"Marta Dore,&nbsp;Aime Luna,&nbsp;Thomas J Royston","doi":"10.1115/1.4056103","DOIUrl":"https://doi.org/10.1115/1.4056103","url":null,"abstract":"<p><p>Dynamic elastography attempts to reconstruct quantitative maps of the viscoelastic properties of biological tissue, properties altered by disease and injury, by noninvasively measuring mechanical wave motion in the tissue. Most reconstruction strategies that have been developed neglect boundary conditions, including quasi-static tensile or compressive loading resulting in a nonzero prestress. Significant prestress is inherent to the functional role of some biological tissues, such as skeletal and cardiac muscle, arterial walls, and the cornea. In the present article a novel configuration, inspired by corneal elastography but generalizable to other applications, is studied. A polymer phantom layer is statically elongated via an in-plane biaxial normal stress while the phantom's response to transverse vibratory excitation is measured. We examine the interplay between biaxial prestress and waveguide effects in this plate-like tissue phantom. Finite static deformations caused by prestressing coupled with waveguide effects lead to results that are predicted by a novel coordinate transformation approach previously used to simplify reconstruction of anisotropic properties. Here, the approach estimates material viscoelastic properties independent of the nonzero prestress conditions without requiring advanced knowledge of those stress conditions.</p>","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"6 1","pages":"011006"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793440/pdf/JESMDT-22-1029_011006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9412825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Fenestrated Balloon Expandable Stent System for the Treatment of Aortoiliac Occlusive Disease.","authors":"John L Cashin,&nbsp;Alex J Wirtz,&nbsp;Guy M Genin,&nbsp;Mohamed Zayed","doi":"10.1115/1.4055877","DOIUrl":"https://doi.org/10.1115/1.4055877","url":null,"abstract":"<p><p>In aortoiliac occlusive disease, atherosclerotic plaques can occlude the distal aortic bifurcation and proximal bilateral iliac artery and thus cause ischemia in the lower extremity. This is typically treated by restoring patency with balloon expandable stents. Stents are typically deployed in a \"kissing stent\" configuration into the bilateral iliac arteries and into the distal aortic bifurcation lumen to restore antegrade arterial flow. However, these stents typically become re-occluded by plaques. To understand the reasons for this and look for solutions, we simulated flow dynamics in the aortic bifurcation in the presence and absence of stents using computational fluid dynamics. Results demonstrated that the kissing stent configuration was associated with high levels of vorticity and flow constriction. These prothrombotic variables were alleviated in an alternative, aortoiliac fenestrated (AIFEN), tapered, and balloon-expandable stent design. Our findings suggest that stent design can be tailored to improve flow fields for aortoiliac stenting.</p>","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":" ","pages":"011004"},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9635567/pdf/jesmdt-22-1015_011004.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40463416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Motion Vision and Neural Efficiency On Target Capture in Basketball Players","authors":"Xianghui Li","doi":"10.1115/1.4056607","DOIUrl":"https://doi.org/10.1115/1.4056607","url":null,"abstract":"\u0000 Basketball players' visual and neurological characteristics may affect their sports performance. In this paper, 20 basketball players and 20 non-athletes received a motion vision test and a neurological efficiency test. The experimental stimulus was to determine whether there was a ball on the picture. The relevant visual data were obtained by an eye tracker. The brain area activity data were obtained by functional magnetic resonance imaging (fMRI). The data were processed and analyzed. The results showed that the reaction time of group A (basketball players) was 526.78 ± 75.36 ms, and the correct rate was 94.12 ± 3.45%, both of which were better than group B (non-athletes). The fixation duration and fixation frequency of group A were 204.77 ± 40.23 ms and 1.67 ± 0.41 times, suggesting good fixation stability, and group A activated fewer brain areas than group B. The experimental results verify that basketball players have better target capture ability and higher neural efficiency while consuming fewer neural resources.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"495 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81040683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finite Element Simulation of Pid-Controlled Bipolar Radiofrequency Ablation of Porcine Spinal Muscle","authors":"H. Kumru, A. Attaluri, V. Gordin, Daniel C Cortes","doi":"10.1115/1.4056516","DOIUrl":"https://doi.org/10.1115/1.4056516","url":null,"abstract":"\u0000 Radiofrequency ablation (RFA) of the medial branch nerve is a widely used therapeutic intervention for back pain originating from the facet joint. However, multifidus denervation is a well-known adverse effect of this RFA procedure. Computational simulations of RFA can be used to design a new multifidus-sparing RFA procedure for facet joint pain. Unfortunately, there is not a computational model available for RFA of porcine spines (a common animal model for the translation of spinal treatments). The objective of this study is to develop and verify a computational model for bipolar radiofrequency ablation of porcine spine muscle. To do this, the electrical and thermal conductivity properties were measured over a temperature range of 20 °C to 90 °C in ex-vivo porcine spinal. A proportional, integral, and derivative (PID) controlled finite element (FE) model was developed and tuned to simulate the ablation process. Finally, tissue temperatures from simulations and experimental ablations were compared. Thermal conductivity values of spinal muscle ranged from 0.33 W/mK to 0.57 W/mK. Similarly, electrical conductivity varied from 0.36 S/m to 1.28 S/m. The tuned PID parameters for temperature-controlled model were Kp=40, Ki=0.01, and Kd=0. A close agreement between experimental measurements of tissue temperature and simulations were observed in the uncertainty range with R-squared values between 0.88 and 0.98. The model developed in this study is a valuable tool for preclinical studies exploring new RFA methods of spinal nerves.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88364399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and Optimization of Crucial Factors Affecting Efficacy of Microwave Ablation","authors":"Shubhamshree Avishek, S. Samantaray","doi":"10.1115/1.4056409","DOIUrl":"https://doi.org/10.1115/1.4056409","url":null,"abstract":"\u0000 Microwave Ablation (MA) has emerged as a better and more promising alternative to medicate the primitive stage of cancer. Major advantages of MA include the organ-specific treatment and the prospect of treating ≥ 3 cm diameter tumors with minimal pain and nominal cost. Past studies suggest that tissue properties and input parameters play a vital role during the MA process. Hence, an in-depth study has been made to inspect the influence of these crucial parameters as follows, applied power, perfusion rate of blood, frequency, thermal conductivity, electrical conductivity, and, relative permittivity on the dimension of ablation zone attained while treating with MA on Lungs. The FEM-based analysis with a numerical approach is taken into account to signify the individual impact of the parameters on the ablation volume. Using the statistical tool, a regression equation was formulated and the data derived from the Taguchi L27 orthogonal array helped to get the maximized ablation zone. The results infer that the applied power has a remarkable effect on the response with a positive correlation. Along with the power, frequency, and blood perfusion rate were also observed to influence the treatment process significantly. The following optimal settings Power3, Frequency3, Blood Perfusion Rate3, Electrical Conductivity3, Thermal Conductivity2, and Relative Permittivity2 were found out along with the maximized ablation volume of 14.35 mm3. The results obtained from the present work would be highly helpful for the radiologist and the clinical practitioners to get pre-treatment data during the initial phase.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88218634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave Ablation Trocar Operated At Dual Tine Dual-frequency: A Numerical Analysis","authors":"Satish Vellavalapalli, R. Repaka","doi":"10.1115/1.4056410","DOIUrl":"https://doi.org/10.1115/1.4056410","url":null,"abstract":"\u0000 Microwave ablation (MWA) is a minimally invasive thermal ablation technique that has the advantages of obtaining high intratumoral temperatures, less treatment time and large ablation region as compared to other thermal ablation techniques. The ablation region obtained during MWA procedure mainly depends on the design and type of the trocar being used. The trocar plays an essential role in the MWA system by governing the energy distribution during tissue ablation. In this study, a novel MWA trocar design has been considered to achieve concentrated ablation region along the tumor's spatial distribution. A dual tine trocar with each tine supplied with energy at different frequencies (2.45 GHz and 6 GHz) has been considered for tumor ablation. Commercially available Finite Element based software has been used (COMSOL-Multiphysics) to analyze the extent of ablation zone. Coupled bioheat and electromagnetic physics interfaces have been utilized. Results showed that the proposed trocar with tines operating at 6 GHz on both the tines leads to a large ablation region (3 cm in diameter) with spherical in shape. Irregularly shaped ablation region can also be achieved by this trocar with tines operating at different frequencies. The minimum time required for complete tumor ablation by the trocar operated at 6 GHz is 4 minutes, followed by 6 minutes for the trocar operated at 2.45 GHz. The proposed trocar can become a part of a better treatment planning system (TPS) based on tumor shape, nearby blood vessel presence, and the trocar's precise insertion.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86015135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Mechanical Responses of a Uniaxially Stretched Neural Fiber Bundle: Theoretical Approach for a Traumatic Loading Condition","authors":"A. Tamura, Junichi Hongu","doi":"10.1115/1.4056304","DOIUrl":"https://doi.org/10.1115/1.4056304","url":null,"abstract":"\u0000 Viscoelasticity of the spinal nerve roots may play a significant role in predicting nerve root damage caused by overall spinal motion. However, only a few studies have investigated the complex mechanical behavior of this tissue. The current study presents a theoretical protocol for predicting mechanical responses of soft biological materials, and this method was used to a uniaxially stretched neural fiber bundle isolated from porcine spinal nerve roots with various loading configurations. Stress relaxation tests were performed to systematically determine a set of parameters dictating the stress decaying process, i.e., a set of relaxation moduli and the corresponding time constants. Based on the obtained experimental and numerical test data, it was confirmed that the proposed method is effective even for the prediction of mechanical response to a cyclic stretch immediately after the ramp-hold test. In addition, an elastic response, i.e., a stress-strain relationship under a high-rate loading regime, was determined analytically. The results demonstrated that instantaneous mechanical responses of neural fiber bundles can be stiffened against very rapid stretch (>10 s-1); however, the fibers are relatively insensitive to moderate loading rates (<1 s-1). The ultimate tensile strength was estimated to be approximately 8 MPa at the structural failure strain (15%). This information will enable the computational assessment of traumatic nerve root injuries sustained during traffic accidents and contact sports.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88860363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}