Journal of engineering and science in medical diagnostics and therapy最新文献

Development and pilot evaluation of a sensor-infused monitoring and training system to prevent pressure injuries in individuals with spinal cord injury. 开发和试点评估传感器注入监测和培训系统，以防止脊髓损伤个体的压力损伤。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2026-01-01 DOI: 10.1115/1.4071026

Jack Janett, Nathan Pineda, Maurizio Macagno, Davide Vigano, Jeffery Wade Rankin

{"title":"Development and pilot evaluation of a sensor-infused monitoring and training system to prevent pressure injuries in individuals with spinal cord injury.","authors":"Jack Janett, Nathan Pineda, Maurizio Macagno, Davide Vigano, Jeffery Wade Rankin","doi":"10.1115/1.4071026","DOIUrl":"10.1115/1.4071026","url":null,"abstract":"Approximately one-third of individuals with spinal cord injury (SCI) experience a pressure injury and complications contribute to a leading cause of death. Currently, there is a lack of adoption and evidence demonstrating the effectiveness of technologies aimed at preventing pressure injuries. This study presents and evaluates a new monitoring and feedback system to facilitate pressure relief activity performance in 22 manual wheelchair users with SCI. After a two-week baseline, participants received pressure injury education, set goals, and were instructed on how to use the system. Data were then collected using the system for 8 months, and a Technology Acceptance Model (TAM) questionnaire was used to assess usability, with 10 participants identified as Responders. Immediately following goal setting and system biofeedback activation, Responders showed a four-fold increase in pressure relief activity (4.48±4.24 vs. 23.37±14.85 s/h, p=0.004) but activity eventually declined to Baseline levels by Month 8 (4.26±5.78 s/h). Recorded sitting time also dropped significantly (5.62±3.30 h/day at Baseline vs. 1.81±2.08 h/day at Months 6-8, p=0.013). Thirty-six out of 40 questionnaire items scored above the acceptability threshold (>5/7). The system demonstrated good acceptability and effectively promoted short-term increases in pressure relief activity. Its greatest value may be as a short-term training tool during rehabilitation or re-training. Future iterations of the system must address limitations associated with promoting long-term adherence.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13366547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148451089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts. 高速三维数字图像相关性和 Schlieren 图像与冲击管加载相结合，用于研究暴露于爆炸物的人体鼓膜的动态响应。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-11-01 Epub Date: 2024-10-23 DOI: 10.1115/1.4066622

Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng

{"title":"High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts.","authors":"Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng","doi":"10.1115/1.4066622","DOIUrl":"10.1115/1.4066622","url":null,"abstract":"Investigating the dynamic response of human tympanic membranes (TMs) exposed to blasts requires full-field-of-view and three-dimensional (3D) methodologies. Our paper introduces a system that combines high-speed 3D digital image correlation (HS 3D-DIC) and Schlieren imaging (HS-SI) with a custom-designed shock tube for generating blast waves. This integrated system allows us to measure TM surface motions under intense transient loading, capturing full-field-of-view shape deformations exceeding 100 μm with a temporal resolution of 10 μs. System characterization encompasses (i) measuring the shock tube's output levels and repeatability, (ii) assessment of the spatial and temporal resolutions of the imaging techniques, and (iii) identification of overall system limitations. Optimizing these factors is crucial for improving the reliability of our system to ensure the accurate measurement of deformations. To assess our shock tube's reliability in generating repeated blast waves, we instrumented it with high-pressure (HP) and high-frequency (HF) pressure sensors along the blast wave pathway to record overpressure waveforms and compared them with Schlieren imaging visualized blast waves. We validate our HS 3D-DIC measured deformations by comparing them with deformations measured using single-point laser Doppler vibrometry (LDV), establishing a comprehensive assessment of the TM's dynamic response and potential fracture mechanics under blast. Finally, we test our approach with 3D-printed TM-like samples and a real cadaveric human TM. This methodology lays the groundwork for further investigations of blast-related auditory damage and the invention of more effective protective and medical solutions.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 4","pages":"041101"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying Real-Time Dynamic Responses and Damage Mechanics of Human Tympanic Membranes Exposed to Blast Waves. 人体鼓膜暴露在冲击波下的实时动态响应和损伤力学的量化。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-11-01 Epub Date: 2025-03-14 DOI: 10.1115/1.4067892

Jonathan Oliveira Luiz, Anahita Alipanahi, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng

{"title":"Quantifying Real-Time Dynamic Responses and Damage Mechanics of Human Tympanic Membranes Exposed to Blast Waves.","authors":"Jonathan Oliveira Luiz, Anahita Alipanahi, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng","doi":"10.1115/1.4067892","DOIUrl":"10.1115/1.4067892","url":null,"abstract":"Understanding the tympanic membrane's (TM, or eardrum) response to high-intensity acoustical events, such as blasts, is crucial for preventing and treating blast-induced auditory injuries. Despite its importance, there remains a gap in methodologies and measurements of the TMs rapid dynamic responses to these events. This study investigates the behavior of human TMs exposed to blasts using a novel system that integrates high-speed quantitative imaging techniques with a custom shock tube (ST). High-speed three-dimensional-digital image correlation (DIC) and high-speed Schlieren imaging techniques are applied in synchronization with high-frequency pressure sensors to quantify generation and propagation of shock wave (SW) and its interaction with the TM during the tests. Additionally, digital microscopy and optical coherence tomography (OCT) are utilized to characterize the TM's morphology pre- and postblast exposure. The full-field high-speed dynamic responses of cadaveric human TMs and their fluid-solid interactions with different levels of blast overpressures are presented, and the rupture of the TMs is described in real-time. These measurements are employed to assess whether the TM behaves as a thin shell under exposure to high acoustical events. The findings from these studies enhance the comprehension of the TMs biomechanics and damage mechanics under harsh conditions, thereby advancing prevention and treatment strategies for blast-induced auditory damage.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 4","pages":"041106"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11979880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infants Sucking Pattern Identification Using Machine-Learned Computational Modeling. 利用机器学习计算模型识别婴儿吮吸模式。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-08-01 Epub Date: 2024-09-30 DOI: 10.1115/1.4066459

Abdullahi Olapojoye, Abhishek Singh, Eri Nishi, Baowei Fei, Aria Nostratinia, Fatemeh Hassanipour

{"title":"Infants Sucking Pattern Identification Using Machine-Learned Computational Modeling.","authors":"Abdullahi Olapojoye, Abhishek Singh, Eri Nishi, Baowei Fei, Aria Nostratinia, Fatemeh Hassanipour","doi":"10.1115/1.4066459","DOIUrl":"10.1115/1.4066459","url":null,"abstract":"Breastfeeding involves a complex coordination of swallowing, breathing, and sucking, with the infant's sucking proficiency being crucial for adequate nutrient intake. However, real-time assessment of milk intake is difficult, and issues with sucking often become apparent after the infant shows signs of nutrient deficiency. Traditional assessments by clinicians rely on the expertise and subjective judgment of healthcare professionals, enabling personalized evaluations. In this research, we introduce a novel approach to identifying sucking patterns by leveraging data collected from infants during breastfeeding sessions. This method utilizes artificial nipple-based sensors to capture the tongue forces exerted by infants, generating valuable clinical data. In the analysis of the collected time-series data, we applied machine-learned computational modeling (MLCM) algorithms to extract pertinent features and identify distinctive sucking patterns. The best-performing model demonstrated an accuracy of 90%, an 80% recall score, a perfect 100% precision score, a 0.90 f1-score, and an area under the curve (AUC) of 0.80. The proposed classification system has the potential to serve as a reliable decision-support tool for clinicians, offering valuable insights into infants' sucking behaviors. By integrating machine learning (ML)-based computational modeling into clinical practice, we aim to enhance the early identification of unhealthy sucking patterns, allowing for timely interventions and pro-active healthcare management.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12536482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145350433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behind Amor Blunt Trauma Lung and Liver Strains From Indenter Loading Via Finite Element Modeling. 基于有限元模型的压头载荷下的肺和肝损伤。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-08-01 Epub Date: 2024-11-21 DOI: 10.1115/1.4066830

Narayan Yoganandan, Karthik Somasundaram, Balaji Harinathan, Karthik Banurekha Devaraj, Alok Shah, Jared Koser, Brian Stemper, Valeta Carol Chancey, B Joseph McEntire

{"title":"Behind Amor Blunt Trauma Lung and Liver Strains From Indenter Loading Via Finite Element Modeling.","authors":"Narayan Yoganandan, Karthik Somasundaram, Balaji Harinathan, Karthik Banurekha Devaraj, Alok Shah, Jared Koser, Brian Stemper, Valeta Carol Chancey, B Joseph McEntire","doi":"10.1115/1.4066830","DOIUrl":"10.1115/1.4066830","url":null,"abstract":"To determine behind armor blunt trauma (BABT) injury criteria, experiments have been conducted by launching blunt projectiles at live swine at velocities up to 65 meters per second (m/s) using one type of indenter design. To ensure the generalizability of the developed injury criteria, additional tests with different indenter designs are needed. The objectives of this study were to evaluate the kinematics and injury parameters from two indenter designs using human body finite element modeling. The simulation matrix consisted of chord and cylindrical shape indenter designs with two different masses of 150 and 230 grams. They were used to impact the liver and lung regions at velocities of 30 and 60 m/s using a human body model. Rib and lung strains from lung impacts and rib strain and liver strain energy densities (SED) from liver impacts were used to evaluate the design variables of mass and shape. Both designs played a role in skeletal and organ injury parameters. Analysis revealed an increased susceptibility for skeletal and organ traumas with the high mass indenter during high velocity impacts. The cylindrical indenter may be protective for organ injuries due to the larger area of loading on the ribcage compared to the chord indenter. Results from the chord indenter may serve as a conservative estimate of injury criteria.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 3","pages":"031009"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142815162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography. 利用弥散磁共振成像和韧带造影术量化跟腱康复患者的筋膜变化

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-08-01 Epub Date: 2024-10-16 DOI: 10.1115/1.4066623

Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes

{"title":"Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography.","authors":"Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes","doi":"10.1115/1.4066623","DOIUrl":"10.1115/1.4066623","url":null,"abstract":"Regardless of the way of treatment, persistent deficits in calf muscles in recovered patients from Achilles tendon rupture (ATR) exist long-term postinjury. Studies on calf muscle changes mostly highlight morphological changes in the calf muscles and Achilles tendon. However, limited attention has been given to fascicular changes. Diffusion tensor imaging (DTI) can provide a better understanding of the characteristics and properties of tissues with organized microstructure. In the current study, we used DTI-derived indices (mean diffusivity (MD), fractional anisotropy (FA), and eigenvalues-λ 1, λ 2, and λ 3) and fiber tractography to better understand the soleus muscle after recovery from ATR by comparing the results of injured legs with healthy ones. Our findings suggest that the standard deviations of measured parameters (FA, MD, and eigenvalues) within the soleus muscle are better predictors of the changes associated with the ATR as compared to the control counterpart for the volumetric region of interest (ROI). Additionally, in four out of five participants, smaller tracts were observed in the injured leg compared to the healthy one, as evidenced by the fiber length distribution of the tracts. Altogether, this study demonstrates the feasibility of the DTI and fiber tractography approaches to quantify the fascicular changes in the individuals recovered from ATR.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 3","pages":"031006"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assistive Technology for Real-Time Fall Prevention during Walking: Evaluation of the Effect of an Intelligent Foot Orthosis 步行时实时预防跌倒的辅助技术：评估智能足部矫形器的效果

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-08-10 DOI: 10.1115/1.4066187

Rieko Yamamoto, S. Itami, Masashi Kawabata, Kohei Morimura, Toshihiko Shiraishi

{"title":"Assistive Technology for Real-Time Fall Prevention during Walking: Evaluation of the Effect of an Intelligent Foot Orthosis","authors":"Rieko Yamamoto, S. Itami, Masashi Kawabata, Kohei Morimura, Toshihiko Shiraishi","doi":"10.1115/1.4066187","DOIUrl":"https://doi.org/10.1115/1.4066187","url":null,"abstract":"\u0000 We present an intelligent foot orthosis (IFO) designed to prevent lateral falls during walking by employing a magnetorheological (MR) fluid brake. This study aims to demonstrate the feasibility of evaluating the effectiveness of the proposed orthosis in fall prevention. Seventeen healthy adults underwent four conditions: (1) without IFO, (2) with IFO and current-OFF, (3) with IFO current-ON, and (4) with IFO and control-ON. Gait was assessed by three-dimensional motion capture and with ground reaction force. Postural changes on the frontal plane were measured, and the mediolateral center of gravity and center of pressure inclination angle (ML COG-COP IA) was calculated. Additionally, tibialis anterior (TA) and peroneus longus (PL) muscle activity during walking were measured using surface electromyography. Results indicate a significant increase in ML COG-COP IA in (3). No significant differences were found in muscle activity between conditions. The study suggests that the posture's deviation from the lateral fall direction in (3) is primarily due to wearing the IFO, emphasizing human postural control over muscle activity. A negative correlation between ML COG-COP IA and TA muscle activity under (4), implies that individuals with lower TA muscle activity may benefit more from IFO fall prevention. In conclusion, the study demonstrates the feasibility of preventing lateral falls in human walking using the proposed orthosis with an MR fluid brake. The general efficacy of the orthosis in lateral fall prevention is suggested, emphasizing the need for further development.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Simple Poc Device for Temperature Control of Multiple Reactions During Recombinase Polymerase Amplification 用于重组酶聚合酶扩增过程中多个反应温度控制的简单 Poc 装置

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-26 DOI: 10.1115/1.4066055

Aubrey Schultz, Shannon Servoss, Robert Beitle

{"title":"A Simple Poc Device for Temperature Control of Multiple Reactions During Recombinase Polymerase Amplification","authors":"Aubrey Schultz, Shannon Servoss, Robert Beitle","doi":"10.1115/1.4066055","DOIUrl":"https://doi.org/10.1115/1.4066055","url":null,"abstract":"\u0000 For individuals with infectious diseases, early and accurate diagnosis is critical. A rapid diagnosis allows for prompt and effective treatment and increases the chance of a full recovery without complications. Additionally, when containing a wide-scale infectious disease outbreak, circumstances are significantly improved by the ability to test the populace frequently, swiftly, and affordably. Regarding specificity and sensitivity, nucleic acid amplification tests (NAAT) are one of the best options for diagnosing infectious diseases. Historically, polymerase chain reaction (PCR) has been used, but complex thermocycling and complicated PCR protocols have often limited PCR to clinical settings. Due to increased simplicity, the isothermal NAAT recombinase polymerase amplification (RPA) has the potential to deliver reliable POC diagnostics in low-resource settings. When designing POC devices for isothermal NAATs, creating isothermal temperature conditions is perhaps the most significant challenge. This work presents a flexible and robust device capable of incubating 3 RPA reactions for simultaneous amplification in conditions conducive to POC testing. The device costs ~$ 60 USD to construct and is easy to assemble. A battery-powered polyimide thin-film resistive heater provides energy, and the device only requires power for a fraction of the total incubation time. The device uses a phase change material (PCM) to regulate temperature to avoid the complexity of a microcontroller. RPA reactions were successfully incubated in 30 minutes using the device.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"42 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auxetic Structure Inspired Microneedle Arrays for Minimally Invasive Drug Delivery 用于微创给药的磁性结构启发微针阵列

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-20 DOI: 10.1115/1.4066007

Maher Amer, Christina Fisher, Georgia Small, Blake Bullock, Vero Salinas, Jaden Langford

引用次数: 0

Hemodynamics of Circle of Willis Having Hypoplastic/Stenotic Anterior Cerebral Artery A1 Segment 大脑前动脉 A1 段发育不良/狭窄的威利斯环的血液动力学特征

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-20 DOI: 10.1115/1.4066008

Harikrishna M. Menon, Tondup Dolkar, Jayanand B Sudhir, Shine Sr

{"title":"Hemodynamics of Circle of Willis Having Hypoplastic/Stenotic Anterior Cerebral Artery A1 Segment","authors":"Harikrishna M. Menon, Tondup Dolkar, Jayanand B Sudhir, Shine Sr","doi":"10.1115/1.4066008","DOIUrl":"https://doi.org/10.1115/1.4066008","url":null,"abstract":"\u0000 This study utilizes computational tools to analyze the hemodynamic effects of a hypoplastic/stenotic A1 segment in the Anterior Cerebral Artery (ACA) on the Circle of Willis (CoW). The objective is to investigate how variations in ACA A1 diameter affect flow dynamics, wall shear stress (WSS), and the initiation of aneurysms within the CoW. An idealized CoW geometry is employed, incorporating hypoplastic ACA A1 segments with reductions of 25%, 50%, 75%, and 100% in diameter and a 50% constriction representing stenosis. A 3D computational fluid dynamics (CFD) model explores flow dynamics and WSS distribution. The computational methodology is validated against experimental data from existing literature. The study demonstrates the resilience of overall brain perfusion despite a hypoplastic ACA A1 segment. Significant alterations and diversions in flow, particularly at the ACoM-ACA junction, are observed under varying degrees of hypoplasticity. Analysis of radial velocity profiles reveals asymmetry in flow distribution, exacerbating risks of arterial diseases such as atherosclerosis and thrombosis. Distinct patterns of WSS distribution during peak systole in the ACA A2 segment highlight the influence of hypoplasticity on vascular health, with implications for structural aberrations and aneurysm formation, particularly in the Posterior Cerebral Artery (PCA). A comparison study of rigid wall cases with elastic walls using a fluid-structure interaction (FSI) model is also done to understand the applicability of FSI. Insights gained from this research contribute to comprehending CoW anomalies' pathophysiology and offer guidance for developing effective treatment strategies.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"33 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0