Journal of engineering and science in medical diagnostics and therapy最新文献

High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts. 高速三维数字图像相关性和 Schlieren 图像与冲击管加载相结合，用于研究暴露于爆炸物的人体鼓膜的动态响应。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-11-01 Epub Date: 2024-10-23 DOI: 10.1115/1.4066622

Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng

{"title":"High-Speed Three-Dimensional-Digital Image Correlation and Schlieren Imaging Integrated With Shock Tube Loading for Investigating Dynamic Response of Human Tympanic Membrane Exposed to Blasts.","authors":"Anahita Alipanahi, Jonathan Oliveira Luiz, John J Rosowski, Cosme Furlong, Jeffrey Tao Cheng","doi":"10.1115/1.4066622","DOIUrl":"https://doi.org/10.1115/1.4066622","url":null,"abstract":"Investigating the dynamic response of human tympanic membranes (TMs) exposed to blasts requires full-field-of-view and three-dimensional (3D) methodologies. Our paper introduces a system that combines high-speed 3D digital image correlation (HS 3D-DIC) and Schlieren imaging (HS-SI) with a custom-designed shock tube for generating blast waves. This integrated system allows us to measure TM surface motions under intense transient loading, capturing full-field-of-view shape deformations exceeding 100 μm with a temporal resolution of 10 μs. System characterization encompasses (i) measuring the shock tube's output levels and repeatability, (ii) assessment of the spatial and temporal resolutions of the imaging techniques, and (iii) identification of overall system limitations. Optimizing these factors is crucial for improving the reliability of our system to ensure the accurate measurement of deformations. To assess our shock tube's reliability in generating repeated blast waves, we instrumented it with high-pressure (HP) and high-frequency (HF) pressure sensors along the blast wave pathway to record overpressure waveforms and compared them with Schlieren imaging visualized blast waves. We validate our HS 3D-DIC measured deformations by comparing them with deformations measured using single-point laser Doppler vibrometry (LDV), establishing a comprehensive assessment of the TM's dynamic response and potential fracture mechanics under blast. Finally, we test our approach with 3D-printed TM-like samples and a real cadaveric human TM. This methodology lays the groundwork for further investigations of blast-related auditory damage and the invention of more effective protective and medical solutions.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 4","pages":"041101"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography. 利用弥散磁共振成像和韧带造影术量化跟腱康复患者的筋膜变化

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2025-08-01 Epub Date: 2024-10-16 DOI: 10.1115/1.4066623

Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes

{"title":"Quantifying the Fascicular Changes in Recovered Achilles Tendon Patients Using Diffusion Magnetic Resonance Imaging and Tractography.","authors":"Shabnam Rahimnezhad, Tanzil M Arefin, Xiaoxiao Bai, Thomas Neuberger, Daniel Cortes","doi":"10.1115/1.4066623","DOIUrl":"https://doi.org/10.1115/1.4066623","url":null,"abstract":"Regardless of the way of treatment, persistent deficits in calf muscles in recovered patients from Achilles tendon rupture (ATR) exist long-term postinjury. Studies on calf muscle changes mostly highlight morphological changes in the calf muscles and Achilles tendon. However, limited attention has been given to fascicular changes. Diffusion tensor imaging (DTI) can provide a better understanding of the characteristics and properties of tissues with organized microstructure. In the current study, we used DTI-derived indices (mean diffusivity (MD), fractional anisotropy (FA), and eigenvalues-λ 1, λ 2, and λ 3) and fiber tractography to better understand the soleus muscle after recovery from ATR by comparing the results of injured legs with healthy ones. Our findings suggest that the standard deviations of measured parameters (FA, MD, and eigenvalues) within the soleus muscle are better predictors of the changes associated with the ATR as compared to the control counterpart for the volumetric region of interest (ROI). Additionally, in four out of five participants, smaller tracts were observed in the injured leg compared to the healthy one, as evidenced by the fiber length distribution of the tracts. Altogether, this study demonstrates the feasibility of the DTI and fiber tractography approaches to quantify the fascicular changes in the individuals recovered from ATR.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"8 3","pages":"031006"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11515863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assistive Technology for Real-Time Fall Prevention during Walking: Evaluation of the Effect of an Intelligent Foot Orthosis 步行时实时预防跌倒的辅助技术：评估智能足部矫形器的效果

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-08-10 DOI: 10.1115/1.4066187

Rieko Yamamoto, S. Itami, Masashi Kawabata, Kohei Morimura, Toshihiko Shiraishi

{"title":"Assistive Technology for Real-Time Fall Prevention during Walking: Evaluation of the Effect of an Intelligent Foot Orthosis","authors":"Rieko Yamamoto, S. Itami, Masashi Kawabata, Kohei Morimura, Toshihiko Shiraishi","doi":"10.1115/1.4066187","DOIUrl":"https://doi.org/10.1115/1.4066187","url":null,"abstract":"\u0000 We present an intelligent foot orthosis (IFO) designed to prevent lateral falls during walking by employing a magnetorheological (MR) fluid brake. This study aims to demonstrate the feasibility of evaluating the effectiveness of the proposed orthosis in fall prevention. Seventeen healthy adults underwent four conditions: (1) without IFO, (2) with IFO and current-OFF, (3) with IFO current-ON, and (4) with IFO and control-ON. Gait was assessed by three-dimensional motion capture and with ground reaction force. Postural changes on the frontal plane were measured, and the mediolateral center of gravity and center of pressure inclination angle (ML COG-COP IA) was calculated. Additionally, tibialis anterior (TA) and peroneus longus (PL) muscle activity during walking were measured using surface electromyography. Results indicate a significant increase in ML COG-COP IA in (3). No significant differences were found in muscle activity between conditions. The study suggests that the posture's deviation from the lateral fall direction in (3) is primarily due to wearing the IFO, emphasizing human postural control over muscle activity. A negative correlation between ML COG-COP IA and TA muscle activity under (4), implies that individuals with lower TA muscle activity may benefit more from IFO fall prevention. In conclusion, the study demonstrates the feasibility of preventing lateral falls in human walking using the proposed orthosis with an MR fluid brake. The general efficacy of the orthosis in lateral fall prevention is suggested, emphasizing the need for further development.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Simple Poc Device for Temperature Control of Multiple Reactions During Recombinase Polymerase Amplification 用于重组酶聚合酶扩增过程中多个反应温度控制的简单 Poc 装置

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-26 DOI: 10.1115/1.4066055

Aubrey Schultz, Shannon Servoss, Robert Beitle

{"title":"A Simple Poc Device for Temperature Control of Multiple Reactions During Recombinase Polymerase Amplification","authors":"Aubrey Schultz, Shannon Servoss, Robert Beitle","doi":"10.1115/1.4066055","DOIUrl":"https://doi.org/10.1115/1.4066055","url":null,"abstract":"\u0000 For individuals with infectious diseases, early and accurate diagnosis is critical. A rapid diagnosis allows for prompt and effective treatment and increases the chance of a full recovery without complications. Additionally, when containing a wide-scale infectious disease outbreak, circumstances are significantly improved by the ability to test the populace frequently, swiftly, and affordably. Regarding specificity and sensitivity, nucleic acid amplification tests (NAAT) are one of the best options for diagnosing infectious diseases. Historically, polymerase chain reaction (PCR) has been used, but complex thermocycling and complicated PCR protocols have often limited PCR to clinical settings. Due to increased simplicity, the isothermal NAAT recombinase polymerase amplification (RPA) has the potential to deliver reliable POC diagnostics in low-resource settings. When designing POC devices for isothermal NAATs, creating isothermal temperature conditions is perhaps the most significant challenge. This work presents a flexible and robust device capable of incubating 3 RPA reactions for simultaneous amplification in conditions conducive to POC testing. The device costs ~$ 60 USD to construct and is easy to assemble. A battery-powered polyimide thin-film resistive heater provides energy, and the device only requires power for a fraction of the total incubation time. The device uses a phase change material (PCM) to regulate temperature to avoid the complexity of a microcontroller. RPA reactions were successfully incubated in 30 minutes using the device.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"42 29","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141800075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auxetic Structure Inspired Microneedle Arrays for Minimally Invasive Drug Delivery 用于微创给药的磁性结构启发微针阵列

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-20 DOI: 10.1115/1.4066007

Maher Amer, Christina Fisher, Georgia Small, Blake Bullock, Vero Salinas, Jaden Langford

引用次数: 0

Hemodynamics of Circle of Willis Having Hypoplastic/Stenotic Anterior Cerebral Artery A1 Segment 大脑前动脉 A1 段发育不良/狭窄的威利斯环的血液动力学特征

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-20 DOI: 10.1115/1.4066008

Harikrishna M. Menon, Tondup Dolkar, Jayanand B Sudhir, Shine Sr

{"title":"Hemodynamics of Circle of Willis Having Hypoplastic/Stenotic Anterior Cerebral Artery A1 Segment","authors":"Harikrishna M. Menon, Tondup Dolkar, Jayanand B Sudhir, Shine Sr","doi":"10.1115/1.4066008","DOIUrl":"https://doi.org/10.1115/1.4066008","url":null,"abstract":"\u0000 This study utilizes computational tools to analyze the hemodynamic effects of a hypoplastic/stenotic A1 segment in the Anterior Cerebral Artery (ACA) on the Circle of Willis (CoW). The objective is to investigate how variations in ACA A1 diameter affect flow dynamics, wall shear stress (WSS), and the initiation of aneurysms within the CoW. An idealized CoW geometry is employed, incorporating hypoplastic ACA A1 segments with reductions of 25%, 50%, 75%, and 100% in diameter and a 50% constriction representing stenosis. A 3D computational fluid dynamics (CFD) model explores flow dynamics and WSS distribution. The computational methodology is validated against experimental data from existing literature. The study demonstrates the resilience of overall brain perfusion despite a hypoplastic ACA A1 segment. Significant alterations and diversions in flow, particularly at the ACoM-ACA junction, are observed under varying degrees of hypoplasticity. Analysis of radial velocity profiles reveals asymmetry in flow distribution, exacerbating risks of arterial diseases such as atherosclerosis and thrombosis. Distinct patterns of WSS distribution during peak systole in the ACA A2 segment highlight the influence of hypoplasticity on vascular health, with implications for structural aberrations and aneurysm formation, particularly in the Posterior Cerebral Artery (PCA). A comparison study of rigid wall cases with elastic walls using a fluid-structure interaction (FSI) model is also done to understand the applicability of FSI. Insights gained from this research contribute to comprehending CoW anomalies' pathophysiology and offer guidance for developing effective treatment strategies.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"33 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141819690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reliability Test of Mobile Embedded Accelerometers and Gyroscopes with the Goal of Measuring Postural Stability for People with Parkinson's Disease 以测量帕金森病患者姿势稳定性为目标的移动嵌入式加速计和陀螺仪可靠性测试

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-07-01 DOI: 10.1115/1.4065860

Matthew Thelen, Alexis Meeker, Fardeen Mazumder, Mariam Tabbah, Linda Zhu, Charlotte Tang, Nathaniel S. Miller

{"title":"Reliability Test of Mobile Embedded Accelerometers and Gyroscopes with the Goal of Measuring Postural Stability for People with Parkinson's Disease","authors":"Matthew Thelen, Alexis Meeker, Fardeen Mazumder, Mariam Tabbah, Linda Zhu, Charlotte Tang, Nathaniel S. Miller","doi":"10.1115/1.4065860","DOIUrl":"https://doi.org/10.1115/1.4065860","url":null,"abstract":"\u0000 Parkinson's Disease (PD) is the second most common neurodegenerative disease in the United States. The cardinal symptoms of PD are tremor, rigidity, slowed movement, and impaired balance. These symptoms often interfere with the daily activities of people with Parkinson's (PwPD) and negatively affect quality of life (QoL). Therefore, monitoring PD symptoms is essential for clinical evaluations and adjusting medication to help maintain QoL for PwPD. We are developing a mobile app to conduct at-home PD symptom monitoring to provide more timely, frequent, and accurate measurements of PD symptoms. While the tremor and finger-tapping results collected in the mobile app have been discussed in previous publications, this paper focuses on the design and evaluation of postural stability tests in the app and validating the reliability of the embedded accelerometers and gyroscopes in smartphones. During the test, a shaker was employed to provide vibration in amplitude and frequency ranges similar to human postural stability signals, and both the accelerometer and gyroscope measurements were evaluated. We used signal processing algorithms to extract postural stability factors, such as the root mean square (RMS) value, the derivative of acceleration, frequency factors, etc. for the accelerations, and the ranges and RMS for the angular velocity. Our findings show that smartphone devices have good consistency over multiple trials and between devices, and motion patterns achieved from multiple data points are reliable for postural stability analysis.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"21 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomechanical Analysis of Orthodontic Miniscrew-Assisted Rapid Palatal Expansion On Dental and Bone Tissues: A Finite-Element Study 正畸微型螺钉辅助快速腭扩展对牙齿和骨组织的生物力学分析：有限元研究

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-05-24 DOI: 10.1115/1.4065589

Egon Mamboleo, Abdelhak Ouldyerou, Khaled Alsharif, Peter Ngan, A. Merdji, Sandipan Roy, O. Mukdadi

{"title":"Biomechanical Analysis of Orthodontic Miniscrew-Assisted Rapid Palatal Expansion On Dental and Bone Tissues: A Finite-Element Study","authors":"Egon Mamboleo, Abdelhak Ouldyerou, Khaled Alsharif, Peter Ngan, A. Merdji, Sandipan Roy, O. Mukdadi","doi":"10.1115/1.4065589","DOIUrl":"https://doi.org/10.1115/1.4065589","url":null,"abstract":"\u0000 This study aims to delineate the biomechanical responses in both soft and hard tissues, alongside the interactions within the surrounding bone of a human skull subjected to clinical loadings generated by a miniscrew-assisted rapid palatal expansion (MARPE) device. Cone-beam computed tomography (CBCT) scans of a 20-year-old female skull were segmented. The skull bones were meticulously modeled to reconstruct a comprehensive 3D model for finite-element analysis (FEA). A displacement of 0.125 mm was applied on each side (0.25 mm total) of the MARPE device to simulate one complete turn of the jackscrew. The outcomes revealed that the miniscrews experienced a maximum equivalent von Mises stress of 264.91 MPa. Notably, the separation of the midpalatal suture exhibited a quasi-parallel deformation with an average displacement of 0.247 mm and a standard deviation of 0.00667 mm. The ratio of the rotational angle to the lateral displacement of the zygomaticomaxillary complex was 0.6436 degree/mm. No Fracture of miniscrews was observed during the activation of one turn per day.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"2 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design of a Device to Ease and Improve the Diagnosis of Popliteal Artery Entrapment Syndrome (paes) 设计一种设备以简化和改进腘动脉闭锁综合征的诊断 (paes)

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-05-24 DOI: 10.1115/1.4065588

Emma Rutherford, Wenhao Xu, Kiet Vu, Claudia Lozano, Alexandra Lee, Paige Dzenutis, Arriyan Dowlatshahi, Anthony Pennes, Jay Connor, Alexander Slocum

引用次数: 0

Comparison of Load-Sharing Responses Between Graded Posterior Cervical Foraminotomy and Conventional Fusion Using Finite Element Modeling. 应用有限元模型比较分级颈后切口和常规融合的负荷分担反应。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2024-05-01 Epub Date: 2023-10-09 DOI: 10.1115/1.4063465

Narayan Yoganandan, Hoon Choi, Yuvaraj Purushothaman, Aditya Vedantam, Balaji Harinathan, Anjishnu Banerjee

{"title":"Comparison of Load-Sharing Responses Between Graded Posterior Cervical Foraminotomy and Conventional Fusion Using Finite Element Modeling.","authors":"Narayan Yoganandan, Hoon Choi, Yuvaraj Purushothaman, Aditya Vedantam, Balaji Harinathan, Anjishnu Banerjee","doi":"10.1115/1.4063465","DOIUrl":"10.1115/1.4063465","url":null,"abstract":"Following the diagnosis of unilateral cervical radiculopathy and need for surgical intervention, anterior cervical diskectomy and fusion (conventional fusion) and posterior cervical foraminotomy are common options. Although patient outcomes may be similar between the two procedures, their biomechanical effects have not been fully compared using a head-to-head approach, particularly, in relation to the amount of facet resection and internal load-sharing between spinal segments and components. The objective of this investigation was to compare load-sharing between conventional fusion and graded foraminotomy facet resections under physiological loading. A validated finite element model of the cervical spinal column was used in the study. The intact spine was modified to simulate the two procedures at the C5-C6 spinal segment. Flexion, extension, and lateral bending loads were applied to the intact, graded foraminotomy, and conventional fusion spines. Load-sharing was determined using range of motion data at the C5-C6 and immediate adjacent segments, facet loads at the three segments, and disk pressures at the adjacent segments. Results were normalized with respect to the intact spine to compare surgical options. Conventional fusion leads to increased motion, pressure, and facet loads at adjacent segments. Foraminotomy leads to increased motion and anterior loading at the index level, and motions decrease at adjacent levels. In extension, the left facet load decreases after foraminotomy. Recognizing that foraminotomy is a motion preserving alternative to conventional fusion, this study highlights various intrinsic biomechanical factors and potential instability issues with more than one-half facet resection.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"7 2","pages":"021006"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10583278/pdf/jesmdt-23-1042_021006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49685828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0