Journal of engineering and science in medical diagnostics and therapy最新文献_第10页

Axial Wall Displacement At the Common Carotid Artery is Associated with the Lamb Waves 颈总动脉轴壁位移与兰姆波有关

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-11-16 DOI: 10.1115/1.4056267

Z. Hao, Md. Mahfuzur Rahman, J. Au, Chloe E Athaide, L. Jutlah

{"title":"Axial Wall Displacement At the Common Carotid Artery is Associated with the Lamb Waves","authors":"Z. Hao, Md. Mahfuzur Rahman, J. Au, Chloe E Athaide, L. Jutlah","doi":"10.1115/1.4056267","DOIUrl":"https://doi.org/10.1115/1.4056267","url":null,"abstract":"\u0000 As compared with its radial wall displacement, axial wall displacement at the common carotid artery (CCA) carries independent clinical values, but its physical mechanisms are unclear. This study aims to investigate whether axial wall displacement at the CCA is solely from Young waves. A pulse wave propagation theory is utilized to identify two types of waves, Young waves and Lamb waves, in an artery, and identifies two sources for axial wall displacement, wall shear stress and radial wall displacement gradient with a factor of the difference between axial and circumferential initial tension, which reveals the influence of axial initial tension on the waveform of axial wall displacement. Theoretical expressions are derived for calculating the waveforms of axial wall displacement and its two sources in the Young waves. With the measured pulsatile pressure and blood velocity at the CA of three healthy adults as the inputs, the waveforms of axial wall displacement in the Young waves are calculated at different values of axial initial tension, and are found to greatly differ from their measured counterparts. As such, the Lamb waves may contribute to axial wall displacement at the CCA and the associated physical and physiological implications are discussed. Given the clinical values of axial wall displacement at the CCA, the Lamb waves may play a non-negligible role in determining arterial health and needs to be further studied for a comprehensive assessment of arterial wall mechanics.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81444222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-Objective Optimal Regulation of Glucose Concentration in Type I Diabetes Mellitus 1型糖尿病血糖浓度的多目标优化调控

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-11-08 DOI: 10.1115/1.4056176

Raya Abushaker, Y. Sardahi, Ahmad M. Alshorman

{"title":"Multi-Objective Optimal Regulation of Glucose Concentration in Type I Diabetes Mellitus","authors":"Raya Abushaker, Y. Sardahi, Ahmad M. Alshorman","doi":"10.1115/1.4056176","DOIUrl":"https://doi.org/10.1115/1.4056176","url":null,"abstract":"\u0000 Type I diabetes is a chronic disease in which insulin is not adequately produced by the pancreatic β-cells, which leads to a high glucose concentration. In practice, external Insulin delivery is the only method to deal with this disease. To this end, a multi-objective optimal control for insulin delivery is introduced in this paper. Three conflicting objectives are considered: minimizing the risk of hypoglycemia and hyperglycemia, and reducing the amount of injected insulin. These objectives are simultaneously minimized while tuning the closed-loop system parameters that include the design details of the linear-quadratic regulator(LQR) and estimator speed of convergence. The lower and upper bounds of the LQR setup parameters are determined by Bryson's rule taking into account the nominal glucose range (70 – 160 mg/dL) and maximum and minimum pump infusion rates (0.0024 –15 mU/min). The lower and upper bounds of the estimator convergence speed are chosen such that the estimator is faster than the fastest mode of the closed-loop system. For computer simulations, Bergman's minimal model, which is one of the commonly used models, is employed to simulate glucose-insulin dynamics in Type-I diabetic patients. The non-dominated sorting genetic algorithm (NSGA-II) solves the optimization problem, one of the widely used algorithms in solving multi-objective optimization problems (MOPs). The optimal solutions in terms of the Pareto set and its image, the Pareto front, are obtained and analyzed. The results show that the MOP solution introduces many optimal options from which the decision-maker can choose to implement. Furthermore, under high initial glucose levels, parametric variations of Bergman's model, and external disturbance; the optimal control performance is tested to show that the system can bring glucose levels quickly to the desired value regardless of high initial glucose concentrations, can efficiently work for different patients, and is robust against irregular snacks or meals.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77541735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender Differences in Cervical Spine Motions and Loads With Head Supported Mass Using Finite Element Models. 基于有限元模型的颈椎运动和头部承重的性别差异。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-11-01 Epub Date: 2022-07-07 DOI: 10.1115/1.4054856

Yuvaraj Purushothaman, Narayan Yoganandan

{"title":"Gender Differences in Cervical Spine Motions and Loads With Head Supported Mass Using Finite Element Models.","authors":"Yuvaraj Purushothaman, Narayan Yoganandan","doi":"10.1115/1.4054856","DOIUrl":"10.1115/1.4054856","url":null,"abstract":"While many studies have been conducted to delineate the role of gender in rear impact via experiments, clinical investigations, modeling, and epidemiological research, the effect of the added head mass on segmental motions has received less attention. The objective of the study is to determine the role of the head supported mass on the segmental motions and loads on the cervical spinal column from rear impact loading. The study used finite element modeling. The model was subjected to mesh convergence studies. It was validated with human cadaver experimental data by applying the rear impact acceleration pulse to the base of the spine. At all levels of the subaxial spinal column, a comparison was made between male and female spines and with and without the use of an army combat helmet. For this purpose, segmental motions, forces, and bending moments were used as biomechanical parameters. Results showed that female spines responded with increased motions than males, and the presence of a helmet increased motions and loads in males and female spines at all levels. Numerical data are given. Head supported mass affects spine responses at all levels. The present computational modeling study, from one geometry for the male spine and one geometry for the female spine (limitations are addressed in the paper), provided insights into the mechanisms of the internal load transfer with the presence of head supported mass, prevalent in certain civilian occupations and active-duty Service members in the military.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"5 4","pages":"041004"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9341196/pdf/jesmdt-22-1001_041004.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40454224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies. 机械通气过程中肺结构和功能异质性的评估:方法综述。

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-11-01 Epub Date: 2022-05-11 DOI: 10.1115/1.4054386

Jacob Herrmann, Michaela Kollisch-Singule, Joshua Satalin, Gary F Nieman, David W Kaczka

{"title":"Assessment of Heterogeneity in Lung Structure and Function During Mechanical Ventilation: A Review of Methodologies.","authors":"Jacob Herrmann, Michaela Kollisch-Singule, Joshua Satalin, Gary F Nieman, David W Kaczka","doi":"10.1115/1.4054386","DOIUrl":"https://doi.org/10.1115/1.4054386","url":null,"abstract":"The mammalian lung is characterized by heterogeneity in both its structure and function, by incorporating an asymmetric branching airway tree optimized for maintenance of efficient ventilation, perfusion, and gas exchange. Despite potential benefits of naturally occurring heterogeneity in the lungs, there may also be detrimental effects arising from pathologic processes, which may result in deficiencies in gas transport and exchange. Regardless of etiology, pathologic heterogeneity results in the maldistribution of regional ventilation and perfusion, impairments in gas exchange, and increased work of breathing. In extreme situations, heterogeneity may result in respiratory failure, necessitating support with a mechanical ventilator. This review will present a summary of measurement techniques for assessing and quantifying heterogeneity in respiratory system structure and function during mechanical ventilation. These methods have been grouped according to four broad categories: (1) inverse modeling of heterogeneous mechanical function; (2) capnography and washout techniques to measure heterogeneity of gas transport; (3) measurements of heterogeneous deformation on the surface of the lung; and finally (4) imaging techniques used to observe spatially-distributed ventilation or regional deformation. Each technique varies with regard to spatial and temporal resolution, degrees of invasiveness, risks posed to patients, as well as suitability for clinical implementation. Nonetheless, each technique provides a unique perspective on the manifestations and consequences of mechanical heterogeneity in the diseased lung.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"5 4","pages":"040801"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9132008/pdf/jesmdt-21-1060_040801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40520191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gesture Recognition and Master-slave Control of a Manipulator Based On Semg and CNN-GRU 基于Semg和CNN-GRU的机械手手势识别与主从控制

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-10-30 DOI: 10.1115/1.4056325

Zhaojie Ge, Zhile Wu, Xu Han, Ping Zhao

引用次数: 3

Matrix-Patterned Micromarkers for Tracking Local Contractile Movements of Myotubes Cultured on Thin-Film Scaffold 基质模式微标记跟踪薄膜支架上肌管局部收缩运动

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-10-30 DOI: 10.1115/1.4056779

S. Hashimoto

引用次数: 1

Molecular Mechanisms Underlying the Effect of Paeoniae Radix Rubra On Sepsis-Induced Coagulopathy: A Network Pharmacology and Molecular Docking Approach 赤芍抗脓毒症凝血功能的分子机制:网络药理学和分子对接方法

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-10-28 DOI: 10.1115/1.4056104

Shan Gao, Dongsheng Wang

{"title":"Molecular Mechanisms Underlying the Effect of Paeoniae Radix Rubra On Sepsis-Induced Coagulopathy: A Network Pharmacology and Molecular Docking Approach","authors":"Shan Gao, Dongsheng Wang","doi":"10.1115/1.4056104","DOIUrl":"https://doi.org/10.1115/1.4056104","url":null,"abstract":"\u0000 To investigate the effective components and underlying mechanism of Paeoniae radix rubra (PRR) in treating sepsis-induced coagulopathy (SIC) on the basis of network pharmacology and molecular docking approaches. At present, no therapeutic agent has been approved for the treatment of SIC. Identifying drugs for SIC from Chinese medicine is an encouraging research direction. The predicted targets and effective components of PRR were identified by analysis of the TCMSP database. Bioinformatics databases were employed to identify the disease targets of SIC. These key targets were then uploaded to the STRING database to generate protein-protein interaction networks. The ORG package in R v4.1.2 software was applied for functional and pathway enrichment analyses of the key targets. Finally, discovery studio software was used to perform docking analyses of key targets and effective components. Nine chemically active components and eighty-four common targets associated with drugs and SIC were identified. PPI network analysis identified several key targets. Further analysis identified enrichment in several signaling pathways; these changes could exert influence on a number of biological processes, including responses to xenobiotic stimuli, oxidative stress, molecules of bacterial origin, thus playing an anti-SIC pharmacological role. According to molecular docking results, these key targets had strong binding affinity to the active components. PRR can contribute to SIC by medicating core target genes (e.g., CASP3, PTGS2, TP53, AKT1, MMP9, TNF, JUN, IL6, and CXCL8), and regulating multiple key pathways (e.g., the Lipid and atherosclerosis pathway).","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"210 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75470827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obstacle Avoidance for Omnidirectional Mobile Robot Using SLAM 基于SLAM的全向移动机器人避障研究

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-09-21 DOI: 10.1115/1.4055689

V. Nandikolla, Bryan Ghoslin

{"title":"Obstacle Avoidance for Omnidirectional Mobile Robot Using SLAM","authors":"V. Nandikolla, Bryan Ghoslin","doi":"10.1115/1.4055689","DOIUrl":"https://doi.org/10.1115/1.4055689","url":null,"abstract":"\u0000 In the field of mobile robotics, Simultaneous Localization and Mapping (SLAM) is an algorithmic approach to the computational problem of creating and updating a map of an environment while simultaneously keeping track of where the robot is within the environment. Applications of a SLAM algorithm are important for autonomous mobile systems to traverse an environment while avoiding obstacles and accurately achieving designated goal destinations. This paper presents the design of a SLAM-driven controller for a semi-autonomous omnidirectional mobile robot. Input to the system comes from a Brain Computer Interface in the form of simple driving commands or a goal destination as decided by the user. Due to latency issues of reacting and responding in real time, the system must safely navigate following the last given commands until it runs out of free space, reaches a goal designation, or receives a new command. The robotic system utilizes a three-wheeled robot kit with an upgraded sensor system. The Intel RealSense Depth Camera D435 and two lidar sensors are utilized to construct a full 360° field of view. The SLAM algorithm and system controllers are developed using the Robot Operating System (ROS). The controllers are developed and tested within Gazebo, which is a physics simulation engine utilized for rapid prototyping. Testing was performed to validate controller performance when given varying commands as well as performing long distance path planning and obstacle avoidance. The system was often capable of achieving its goal destinations with a small error of around 3% or less though the error was found to increase with the more commands the system processed.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89588208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relations of Radial Vibration of the Arterial Wall to Pulsatile Parameters in Blood Flow for Extraction of Arterial Indices 动脉壁径向振动与血流脉动参数的关系，用于提取动脉指标

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-08-30 DOI: 10.1115/1.4055390

Z. Hao

{"title":"Relations of Radial Vibration of the Arterial Wall to Pulsatile Parameters in Blood Flow for Extraction of Arterial Indices","authors":"Z. Hao","doi":"10.1115/1.4055390","DOIUrl":"https://doi.org/10.1115/1.4055390","url":null,"abstract":"\u0000 Given the wide utility of radial vibration of the arterial wall for clinical values, this paper presents a theoretical study on the relations of radial vibration of the arterial wall to pulsatile parameters in blood flow. Pulse wave propagation in an artery is formulated as a combination of the governing equations of blood flow and the arterial wall and no-slip conditions at the blood-wall interface, and is analyzed to obtain the wave velocity and the theoretical expressions for blood flow rate and radial wall displacement in terms of pulsatile pressure. With the harmonics of a pulse signal, theoretical relations of radial vibration of the arterial wall to pulsatile parameters in blood flow are derived under two conditions: without and with wave reflection. These theoretical relations identify the assumptions for the simplified relations employed in the utility of radial vibration of the arterial wall for clinical values. With the arterial wall treated as a unit-mass vibration system, these simplified relations are utilized for extraction of arterial indices from radial vibration of the arterial wall. Other applications of such relations for clinical values are discussed, and the interaction between the arterial wall and blood flow is further revealed from the perspective of energy and 1D wave equations. With harmonics and wave reflection considered, the derived theoretical expressions for radial wall vibration, pulsatile parameters in blood flow, and the relations between them provide a theoretical guidance for improving their interpretation for clinical values with clearly-defined physiological implications and assumptions.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83068496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Numerical Modelling of Conical-Shaped Bone Marrow Biopsy Needle Into Multilayer Iliac Crest Model 锥形骨髓活检针在多层髂骨模型中的数值模拟

Journal of engineering and science in medical diagnostics and therapy Pub Date : 2022-08-12 DOI: 10.1115/1.4055221

R. Nadda, R. Repaka, A. Sahani

{"title":"Numerical Modelling of Conical-Shaped Bone Marrow Biopsy Needle Into Multilayer Iliac Crest Model","authors":"R. Nadda, R. Repaka, A. Sahani","doi":"10.1115/1.4055221","DOIUrl":"https://doi.org/10.1115/1.4055221","url":null,"abstract":"\u0000 Bone marrow biopsy (BMB) is a standard technique used in various therapies, research, diagnosis, and prognosis. The extensive forces during biopsy result in unnecessary stress concentrations that are primarily hazardous to weak end bones. To enhance protection and to better identify the risks of bone biopsy, it is essential to understand and predict the interaction of needles with multiple layers of skin and bone. The present investigation aimed to find out the numerical evaluation of forces involved in the insertion and extraction of the needle into multilayer iliac crest model. The insertion and extraction forces have been studied at different diameters of biopsy needles up to a depth of 15.35 mm and insertion speeds in the range of 1 mm/sec - 10 mm/sec. The results showed that the insertion and extraction forces vary according to the needle diameter and relative velocity among the needle and tissue layers. A linear force vs. depth relationship has been obtained in the preliminary phase, and as the depth of insertion increases, the forces increase non-linearly. At the end phase of penetration, the forces augmented more rapidly at a low insertion rate compared to the high insertion rate.","PeriodicalId":73734,"journal":{"name":"Journal of engineering and science in medical diagnostics and therapy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83222451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3