Journal of dentistry (Shiraz, Iran)最新文献

{"title":"Comparison of Mast Cell Count in Oral Epithelial Dysplasia and Squamous Cell Carcinoma.","authors":"Saede Atarbashi-Moghadam, Maral Niazmand, Shahla Vafadar, Sanaz Gholami Toghchi","doi":"10.30476/dentjods.2024.99652.2164","DOIUrl":"10.30476/dentjods.2024.99652.2164","url":null,"abstract":"<p><strong>Statement of the problem: </strong>Squamous cell carcinomas (SCCs) and premalignant disorders such as leukoplakia are common oral cavity lesions. Although these lesions are epithelial in nature, they are also associated with juxta-epithelial chronic inflammation. Mast cells play a significant role in inflammation initiation and propagation.</p><p><strong>Purpose: </strong>Previous studies have yielded conflicting results in this field. Therefore, this research aimed to assess the number of mast cells in oral SCC and dysplastic leukoplakia and explore their possible role in these lesions.</p><p><strong>Materials and method: </strong>In this retrospective cross-sectional study, sixty-three archival cases, including 22 OSCCs, 28 dysplastic leukoplakias as epithelial dysplasia (ED), and 13 normal oral mucosal tissues, were examined for mast cells, using toluidine blue staining. Hotspot areas were identified at 10× magnification and mast cells were counted in 5 fields at 40× magnification. The average cell numbers were calculated, and the severity of inflammation was scored. Statistical analysis was performed using SPSS statistical software 20, including One-way ANOVA, Two-way ANOVA, paired-t test, and independent t-test. <i>p</i> Value < 0.05 was considered significant.</p><p><strong>Results: </strong>Among the 51 pathologic lesions, 54.9% were males and 45.1% were females, with a mean age of 56.34±15.35 years. The most common locations were the tongue and buccal mucosa. The mast cell count was significantly lower in SCC compared to ED (<i>p</i>= 0.009). There was no correlation between mast cell count and inflammation score (<i>p</i>= 0.345).</p><p><strong>Conclusion: </strong>In this study, the mast cell count was higher in ED compared to OSCC, suggesting an increase in these cells during the pre-malignant stages. However, the number of mast cells decreased after connective tissue invasion and microenvironmental changes occurred.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 4","pages":"369-373"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142878800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, CBCT and Histological Analysis of a Florid Cemento-Osseous Dysplasia with Co-Occurrence of Simple Bone Cyst in the Mandible: A Case Report.","authors":"Antoine Berberi","doi":"10.30476/dentjods.2024.101163.2276","DOIUrl":"10.30476/dentjods.2024.101163.2276","url":null,"abstract":"<p><p>Cemento-osseous dysplasia (COD) is classified, by the World Health Organization as a benign fibro-osseous lesion related to the tooth and periapical area of the jaws and is considered as a benign reactive process appearing from the apical periodontium in close relation with the apices of teeth. Usually, it is asymptomatic, discovered accidentally, and affecting particularly middle-aged African women. There are four subtypes distinguished of the lesion: periapical (PCOD), focal (FCOD), florid (FLCOD) and familial florid cemento-osseous dysplasia (FFLCOD). Pseudocysts found in the jaws go by various names, including solitary bone cyst, traumatic bone cyst, or simple bone cyst (SBC). These two pathologies have been reported separately; however, their co-occurrence remains rare and the first case of FLCOD with co-occurrence of SBC was reported by Melrose <i>et al</i>. in 1976 and later a few cases been reported in the literature. The aim of this report is to describe a case of a 46-year-old oriental female diagnosed with FLCOD with co-occurrence of SBC. Under local analgesia, a surgical exploration of the cyst was performed. In addition, a biopsy with a trephine was done in the region of missing right first mandibular molar. Based on the patient clinical, radiographic, and histological findings, a diagnosis of FLCOD was made in co-occurrence with a mandibular SBC. An examination of another female family member unveils a distinctive case, and the familial factor has been ruled out. No further treatment was planned and only follow-up was suggested.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"278-287"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Clivus Length and Angle with Chronological Age, Gender, Sagittal Growth Pattern of the Jaws, and Skeletal Maturation Using Lateral Cephalometry.","authors":"Maryam Hedayatian, Saeed Azarbayejani, Alireza Omrani, Shahab Etemadi Borujeni","doi":"10.30476/dentjods.2023.98275.2065","DOIUrl":"10.30476/dentjods.2023.98275.2065","url":null,"abstract":"<p><strong>Statement of the problem: </strong>Determination of remaining growth potential of patients is the most important factor in orthodontic treatment.</p><p><strong>Purpose: </strong>This study aimed to assess the correlation of clivus length and angle with age, gender, sagittal growth pattern of the jaws, and skeletal maturation using lateral cephalometry.</p><p><strong>Materials and method: </strong>This cross-sectional study was conducted on 390 lateral cephalograms (Vatech, paX-i3D Green, South Korea) of patients aged 6 to 25 years. The patients were assigned to three groups of skeletal class I, II, III (n=130) with equal gender distribution. The clivus length and angle, Welcher angle, maxillary and mandibular effective length, sella turcica to Nasion (SN), and the angles between SN and point A (SNA), between SN and point B (SNB), and between NA and NB (ANB )were measured. Correlations of variables with age and gender, and cervical vertebral maturation stage (CVMS) were analyzed using the Pearson and Spearman's correlation tests, independent t-test, and one-way ANOVA at 0.05 level of significance.</p><p><strong>Results: </strong>Clivus length had a significant correlation with SNA (r= 0.103, <i>p</i>= 0.042), SNB (r= 0.108, <i>p</i>= 0.033), maxillary (r= 0.547, <i>p</i>< 0.001) and mandibular (r= 0.589, <i>p</i>< 0.001) effective lengths, SN length (r= 0.586, <i>p</i>< 0.001), and CVMS (r= 0.697, <i>p</i>< 0.001). Clivus angle had a significant correlation with SNA (r= 0.105, <i>p</i>= 0.039), SNB (r= 0.155, <i>p</i>= 0.002), maxillary (r= 0.507, <i>p</i>< 0.001) and mandibular (r= 0.596, <i>p</i>= 0.001) effective lengths, SN length (r= 0.566, <i>p</i>< 0.001), and CVMS (r= 0.699, <i>p</i>< 0.001). The mean clivus length (<i>p</i>= 0.006) and angle (<i>p</i>= 0.002) were significantly higher in males, and had a significant correlation with age (r= 0.636 and r= 0.718, <i>p</i>< 0.001). The mean clivus length and angle were not significantly different in class I, II, III (<i>p</i>> 0.05).</p><p><strong>Conclusion: </strong>All parameters were greater in males, and increased with age (except Welcher angle). Clivus length and angle had significant correlations with position of both jaws but not with sagittal relationship.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"251-261"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Rate, Biomechanical Complications, and Patient Satisfaction of Implant-Supported FRC Full-Arch Prostheses: A Retrospective Study with Follow up of 5 Years.","authors":"Daniel Hernández-González, Mauro Marincola, Antonio Díaz-Caballero, Alfredo Passaretti, Andrea Cicconetti","doi":"10.30476/dentjods.2023.98022.2047","DOIUrl":"10.30476/dentjods.2023.98022.2047","url":null,"abstract":"<p><strong>Statement of the problem: </strong>The satisfaction of patients with dentures on implants has different points of view that become fundamental aspects for the development of research on the quality of life of these patients, the eventual biomechanical complications to which these prostheses and implants can be subjected, and design considerations for cantilever extensions.</p><p><strong>Purpose: </strong>The objective of research was to assess the implants and prosthesis survival rates, biomechanical complications relative to the length of the distal extensions (cantilevers), and the satisfaction of the patients with a fixed implant-supported full-arch fiber-reinforced composites prosthesis.</p><p><strong>Materials and method: </strong>A retrospective clinical and radiographic cohort study was developed. Clinical records of a selected cohort were analyzed according to inclusion and exclusion criteria. Data on a patient who underwent to fixed implant-supported full-arch fiber-reinforced composites prosthesis at least of five years of function were collected. Data analysis was performed using Kaplan-Meier curves and Fisher's Exact Test. P values less than 0.05 were considered statistically significant.</p><p><strong>Results: </strong>After insertion, 1 of 29 prostheses failed, the overall prosthetic survival rate observed at 5 years was 96.5%. Of the 120 implants placed in 28 patients, only 4 patients experienced loss of an implant during the 5 years of observation; the implant survival rate throughout the observation period was 86.2%. Distal extension seems to negatively affect the prognosis of implant-supported rehabilitation. Regarding the level of satisfaction of the patient with the prosthesis, none reported being uncomfortable or dissatisfied neither with their appearance nor with the taste of food throughout the studied period.</p><p><strong>Conclusion: </strong>No relevant associations were found between the variables involved. The study found the improvement in quality of life following the installation of fixed rehabilitation on the patients. Once the potential benefits of patients are obtained, controlled clinical trials are encouraged.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"268-274"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive Impact of Mitochondria-Targeting Antibiotics for Cancer Stem Cells of Oral Squamous Cell Carcinoma: Proposal for a Novel Approach in Resistant Cases.","authors":"Mohammad Amin Amiri, Hesam Abbasi, Shahram Hamedani, Hossein Daneste","doi":"10.30476/dentjods.2024.102852.2397","DOIUrl":"10.30476/dentjods.2024.102852.2397","url":null,"abstract":"","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"190-191"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452599/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Mucosamin Spray as an Adjunct for Prevention of Oral Mucositis in Children under Chemotherapy: A Two-Center Randomized Clinical Trial.","authors":"Fatemeh Ghoroubi, Mandana Alamdari Mahd, Azim Mehrvar, Bibi Shahin Shamsian, Sara Tavassoli-Hojjati","doi":"10.30476/dentjods.2023.98910.2116","DOIUrl":"10.30476/dentjods.2023.98910.2116","url":null,"abstract":"<p><strong>Statement of the problem: </strong>Chemotherapy-induced mucositis is the most common complication during cancer treatment. This complication can lead to pain, increased risk of infection and malnutrition. Therefore, it is important to find a solution to reduce the severity and duration of side effects.</p><p><strong>Purpose: </strong>This study aimed to assess the efficacy of Mucosamin spray as an adjunct for prevention of oral mucositis in children under chemotherapy.</p><p><strong>Materials and method: </strong>This parallel-design clinical trial evaluated 48 patients aged 5 to 15 years with leukemia and lymphoma presenting to the Hematology Department of Mofid and Mahak Hospitals. The patients were randomly divided into two groups (n=24). Before starting chemotherapy, all patients received oral hygiene instructions (toothbrushing without flossing). Patients in both groups were requested to use a mouthwash composed of nystatin, aluminum-magnesium hydroxide suspension (aluminum MgS), and diphenhydramine for 1 min every morning on a daily basis starting the day before treatment. Patients in the intervention group were also requested to spray their entire oral mucosa with Mucosamin spray 3 times a day in addition to using the mouthwash. Patients were requested to refrain from eating and drinking for 1h after spraying. The patients were clinically examined by a senior dental student once every other day for 20 days regarding the occurrence, severity, and duration of oral mucositis. Data were analyzed using the Chi-square and Mann-Whitney tests, Kaplan-Meier survival analysis, and log rank test.</p><p><strong>Results: </strong>No significant difference was noted between the two groups in the incidence, severity, or time of development of mucositis (<i>p</i>> 0.05). The 7-day non-recovery percentage was 72.7% (SE= 13.4) and 25.0% (SE= 15.3) in the control and test groups, respectively, indicating shorter duration (faster healing) of mucositis in the intervention group (<i>p</i>= 0.01).</p><p><strong>Conclusion: </strong>Within the limitations of this study, it seems that prophylactic application of Mucosamin spray can shorten the course of oral mucositis, in case of its occurrence.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"243-250"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bond Strength Evaluation of Ceramic Restorations with Immediate Dentin Sealing: A Systematic Review and Meta-Analysis.","authors":"Pooran Samimi, Pedram Iranmanesh, Maryam Khoroushi, Mohammad Hossein Kafi, Niloufar Jafari","doi":"10.30476/dentjods.2023.97057.1986","DOIUrl":"10.30476/dentjods.2023.97057.1986","url":null,"abstract":"<p><strong>Statement of the problem: </strong>Immediate dentin sealing (IDS) was introduced to overcome the disadvantages of delayed dentin sealing like pollution of dentin tubules, microleakage, and bond strength destruction over time. The effect of IDS on the bond strength of indirect restorations is still debatable.</p><p><strong>Purpose: </strong>This study was conducted to determine the effect of IDS on the bond strength of ceramic restorations to dentin.</p><p><strong>Materials and method: </strong>In this systematic review and meta-analysis, the study protocol was registered on the PROSPERO database under the registration number CRD420202014 27. MEDLINE (PubMed), Web of Science, Scopus, and ProQuest databases were searched until January 2021 and updated in January 2022. Worldcat.org and Opengrey.eu, ProQuest dissertation and thesis, and Google Scholar were searched to explore the grey literature. The <i>in vitro</i> studies evaluating the bond strength of ceramic restoration to dentin with and without IDS were included. Seven criteria were assessed to evaluate the risk of bias in the study. Statistical analyses were conducted using RevMan 5.3. The inverse variance method was used to determine the mean difference of micro-tensile bond strength (µTBS) and shear bond strength (SBS).</p><p><strong>Results: </strong>A total of 10 studies (20 datasets) were included in the meta-analysis. Regarding the µTBS analysis, IDS had a significantly higher bond strength than Delayed Dentin Sealing (DDS) (MD:1.16, 95%CI:0.28_2.03, I²=0%). However, no significant difference was found between them in the SBS analysis (MD:0.25, 95%CI: -0.56-1.06, I²=96%). All studies were categorized to have a moderate or high risk of bias.</p><p><strong>Conclusion: </strong>Most <i>in vitro</i> evidence showed favorable results for the effect of IDS on the bond strength and durability of indirect restorations. The adhesive system and the type of ceramic and its treatment before cementation are determining factors. Due to the heterogeneity of the outcomes and studies with a moderate/high risk of bias, the quality of the evidence was low.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"192-202"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of the Accuracy of Electronic Apex Locator and Digital Radiography for Working Length Determination in Primary Teeth: A Systematic Review.","authors":"Ishita Agrawal, Farhin Katge, Sanmati Pol, Devendra Patil, Vamsi Krishna Chimata, Debapriya Pradhan","doi":"10.30476/dentjods.2023.97323.2006","DOIUrl":"10.30476/dentjods.2023.97323.2006","url":null,"abstract":"<p><strong>Statement of the problem: </strong>It is challenging to perform a pulpectomy procedure in primary tooth because of its physiological root resorption and variation in root morphology. Working length measurement is considered to be one of the critical steps, as it determines the extent of obturation and apical seal.</p><p><strong>Purpose: </strong>To compare the accuracy of electronic apex locator (EAL) and digital radiography (DR) for working length determination in primary teeth.</p><p><strong>Materials and method: </strong>In this systematic review, electronic databases and grey literature were searched from 1st January 2005 to 1^st January 2023 for randomized control trial, non- randomized control trial, <i>in vitro</i> studies, <i>ex vivo</i> studies that compared accuracy of EAL and DR in primary teeth. Two reviewers independently identified studies, retrieved data, and assessed risk of bias using the revised and validated MINORS (methodological index for non-randomized studies) criteria.</p><p><strong>Results: </strong>Ten studies were included in qualitative analysis. Seven out of ten studies showed low risk of bias whereas other three studies showed high risk of bias. In view of methodological heterogeneity of the findings, a meta-analysis was not conducted.</p><p><strong>Conclusion: </strong>Available evidence suggests a moderate quality of evidence in this systematic review. Analyzing the ten studies included in this systematic review, the majority of studies showed statistically insignificant difference between EAL and DR. However, EAL was closer to actual WL as compared to DR. Based on the evidence that is currently available; EAL can be considered as an alternative for working length measurement in primary teeth.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"203-214"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholesterol Granuloma of the Lower Lip: Report of a Rare Case.","authors":"Sorena Fardisi, Sara Amanpour","doi":"10.30476/dentjods.2024.100683.2242","DOIUrl":"10.30476/dentjods.2024.100683.2242","url":null,"abstract":"<p><p>Cholesterol granuloma is the result of foreign body type response to the deposition of cholesterol crystals in the tissues. It is usually associated with chronic middle ear diseases and the middle ear and mastoid antrum are the most common location for this lesion. Histopathological findings are accumulation of cholesterol clefts, ghost cells, chronic inflammatory cells, and giant cells in a fibrous granulation tissue. Cases of cholesterol granuloma have been recently reported in the jaws but still they are few in the literature of dentistry. This article presents a unique case of cholesterol granuloma occurring in the lower lip secondary to a history of trauma.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"275-277"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of <i>Dracocephalum Moldavica</i> Essential Oil with Chlorhexidine on Cariogenic Bacteria.","authors":"Bahareh Nazemisalman, MScD Seyede Solmaz Taheri, Fatemeh Heydari, Alireza Yazdinezhad, Fakhri Haghi, Mahsa Shabouei Jam, Samira Basir Shabestari","doi":"10.30476/dentjods.2023.97602.2020","DOIUrl":"10.30476/dentjods.2023.97602.2020","url":null,"abstract":"<p><strong>Statement of the problem: </strong>Dental caries and periodontal disease are the most common oral problems. Chemical antibacterial agents often have side effects; thus, researchers have long been in search for organic and herbal products to prevent dental caries and periodontal disease.</p><p><strong>Purpose: </strong>The present study has aimed to assess the effects of <i>Dracocephalum moldavica</i> essential oil on <i>Streptococcus mutans</i>, <i>Streptococcus salivarius</i>, <i>Streptococcus sobrinus</i>, and <i>Lactobacillus acidophilus</i> compared to Chlorhexidine (CHX).</p><p><strong>Materials and method: </strong>In this <i>in vitro</i> study, the plants were collected from Zanjan Province, Iran. Analysis of the essential oil was carried out by gas chromatography/mass chromatography. Micro-broth dilution and disc diffusion methods were used for assessment of the antimicrobial activity, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated.</p><p><strong>Results: </strong>The mean diameter of the growth inhibition zones in the well plate method for <i>Dracocephalum moldavica</i> showed that it had greater antimicrobial activity against <i>Lactobacillus acidophilus</i> than others (<i>p</i> Value= 0.01). Furthermore, <i>Dracocephalum moldavica</i> had higher antimicrobial activity than CHX. The results of MIC and MBC showed that <i>Dracocephalum moldavica</i> had lower antibacterial activity than CHX.</p><p><strong>Conclusion: </strong><i>Dracocephalum moldavica</i> essential oil demonstrated antibacterial properties against cariogenic bacteria. Given that other favorable properties of these essential oils are confirmed, they may be suitable for use as antibacterial agents in the formulation of oral healthcare products.</p>","PeriodicalId":73702,"journal":{"name":"Journal of dentistry (Shiraz, Iran)","volume":"25 3","pages":"223-228"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11452596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142382653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}