Advances in neurobiology最新文献_第7页

Microglia and Sleep Disorders. 小胶质细胞与睡眠障碍

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-55529-9_20

Katherine Picard, Kira Dolhan, Jyoti J Watters, Marie-Ève Tremblay

引用次数: 0

Microglia Colonization Associated with Angiogenesis and Neural Cell Development. 小胶质细胞定植与血管生成和神经细胞发育有关

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-55529-9_10

G Jean Harry

引用次数: 0

Astrocyte Development in the Rodent. 啮齿动物的星形胶质细胞发育

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-64839-7_3

Yajun Xie, Corey C Harwell, A Denise R Garcia

{"title":"Astrocyte Development in the Rodent.","authors":"Yajun Xie, Corey C Harwell, A Denise R Garcia","doi":"10.1007/978-3-031-64839-7_3","DOIUrl":"10.1007/978-3-031-64839-7_3","url":null,"abstract":"Astrocytes have gained increasing recognition as key elements of a broad array of nervous system functions. These include essential roles in synapse formation and elimination, synaptic modulation, maintenance of the blood-brain barrier, energetic support, and neural repair after injury or disease of the nervous system. Nevertheless, our understanding of mechanisms underlying astrocyte development and maturation remains far behind that of neurons and oligodendrocytes. Early efforts to understand astrocyte development focused primarily on their specification from embryonic progenitors and the molecular mechanisms driving the switch from neuron to glial production. Considerably, less is known about postnatal stages of astrocyte development, the period during which they are predominantly generated and mature. Notably, this period is coincident with synapse formation and the emergence of nascent neural circuits. Thus, a greater understanding of astrocyte development is likely to shed new light on the formation and maturation of synapses and circuits. Here, we highlight key foundational principles of embryonic and postnatal astrocyte development, focusing largely on what is known from rodent studies.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"39 ","pages":"51-67"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health and Disease. 小胶质细胞的结构和功能体内成像及其在健康和疾病中的应用进展。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-55529-9_5

Alexis Crockett, Martin Fuhrmann, Olga Garaschuk, Dimitrios Davalos

{"title":"Progress in Structural and Functional In Vivo Imaging of Microglia and Their Application in Health and Disease.","authors":"Alexis Crockett, Martin Fuhrmann, Olga Garaschuk, Dimitrios Davalos","doi":"10.1007/978-3-031-55529-9_5","DOIUrl":"https://doi.org/10.1007/978-3-031-55529-9_5","url":null,"abstract":"The first line of defense for the central nervous system (CNS) against injury or disease is provided by microglia. Microglia were long believed to stay in a dormant/resting state, reacting only to injury or disease. This view changed dramatically with the development of modern imaging techniques that allowed the study of microglial behavior in the intact brain over time, to reveal the dynamic nature of their responses. Over the past two decades, in vivo imaging using multiphoton microscopy has revealed numerous new functions of microglia in the developing, adult, aged, injured, and diseased CNS. As the most dynamic cells in the brain, microglia continuously contact all structures and cell types, such as glial and vascular cells, neuronal cell bodies, axons, dendrites, and dendritic spines, and are believed to play a central role in sculpting neuronal networks throughout life. Following trauma, or in neurodegenerative or neuroinflammatory diseases, microglial responses range from protective to harmful, underscoring the need to better understand their diverse roles and states in different pathological conditions. In this chapter, we introduce multiphoton microscopy and discuss recent advances in structural and functional imaging technologies that have expanded our toolbox to study microglial states and behaviors in new ways and depths. We also discuss relevant mouse models available for in vivo imaging studies of microglia and review how such studies are constantly refining our understanding of the multifaceted role of microglia in the healthy and diseased CNS.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"37 ","pages":"65-80"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroimaging Correlates of Functional Outcome Following Pediatric TBI. 小儿创伤性脑损伤后功能结果的神经影像学相关性

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69832-3_3

Emily L Dennis, Finian Keleher, Brenda Bartnik-Olson

引用次数: 0

Rodent Models for ASD Biomarker Development. 开发 ASD 生物标记物的啮齿动物模型。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_8

Henry H C Lee, Mustafa Sahin

引用次数: 0

Structural Brain Imaging Biomarkers of Autism Spectrum Disorder. 自闭症谱系障碍的脑结构成像生物标志物。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-69491-2_17

David G Amaral, Derek Sayre Andrews, Christine Wu Nordahl

引用次数: 0

The Roles of Endogenous Opioids in Placebo and Nocebo Effects: From Pain to Performance to Prozac. 内源性阿片类药物在安慰剂和安慰剂效应中的作用：从疼痛到表现再到百忧解

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_10

Patrick L Kerr, John M Gregg

引用次数: 0

Depression, Cancer, Inflammation, and Endogenous Opioids: Pathogenic Relationships and Therapeutic Options. 抑郁症、癌症、炎症和内源性阿片类药物：致病关系与治疗方案》。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_21

Jennifer Hancock, Cristian Sirbu, Patrick L Kerr

引用次数: 0

Endorphins, Sexuality, and Reproduction. 内啡肽、性和生殖。

Advances in neurobiology Pub Date : 2024-01-01 DOI: 10.1007/978-3-031-45493-6_20

Marjan Khajehei

{"title":"Endorphins, Sexuality, and Reproduction.","authors":"Marjan Khajehei","doi":"10.1007/978-3-031-45493-6_20","DOIUrl":"10.1007/978-3-031-45493-6_20","url":null,"abstract":"Beta-endorphin is secreted from the hypothalamus and pituitary in both mother and newborn. The placenta produces numerous pituitary hormones from the third month of pregnancy, one of which is βE. It has been suggested that βE has a role in the appetitive and precopulatory phase of sexual behavior in animals. An increase in endorphin levels during sexual activity in humans may contribute to attachment and bonding between partners, but contradictory reports in the literature question the association between sexuality and βE levels. The level of βE also increases during pregnancy, rises in early labor, peaks in late labor, and drops in the postpartum period. This fluctuation provides natural analgesia, raises the pain threshold, decreases the sensation of pain, or suppresses pain, and decreases fear levels during labor and birth. Beta-endorphin also protects the fetus from hypoxia during labor and birth and potential neural damage by aiding blood flow to the brain under hypoxic conditions. It has been suggested that a variety of pharmacologic and nonpharmacologic complementary therapies, when used in pregnancy, labor, and birth, activate the opioid receptors in the CNS and alter the sensation of pain during labor and birth, affect the mother-child attachment and affect sexual function. These studies report contradictory results that will be discussed in this chapter.","PeriodicalId":7360,"journal":{"name":"Advances in neurobiology","volume":"35 ","pages":"397-433"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141316484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0