Journal of Alzheimer's disease reports最新文献

筛选
英文 中文
A surgical therapy for Alzheimer's disease with lymphaticovenular anastomosis. 淋巴-小静脉吻合术治疗阿尔茨海默病。
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-10-03 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251384244
Xiwen Ma, Feiyun Wang, Guiqing Wang, Meiying Zhao, Youmao Zheng, Yintao Guo, Jingheng Wu, Yuntao Liu, Yulin Liu, Guinv He, Lixuan Ren, Zhenping Gong, Jingxin Wang, Li Chen, Shoukui Hu, Qinjun Chu, Zhengkai Li, Jing Wu, Runtao Li, Xiaojie Zhang, Qian Shi, Hongkai Lian, Jianping Ye
{"title":"A surgical therapy for Alzheimer's disease with lymphaticovenular anastomosis.","authors":"Xiwen Ma, Feiyun Wang, Guiqing Wang, Meiying Zhao, Youmao Zheng, Yintao Guo, Jingheng Wu, Yuntao Liu, Yulin Liu, Guinv He, Lixuan Ren, Zhenping Gong, Jingxin Wang, Li Chen, Shoukui Hu, Qinjun Chu, Zhengkai Li, Jing Wu, Runtao Li, Xiaojie Zhang, Qian Shi, Hongkai Lian, Jianping Ye","doi":"10.1177/25424823251384244","DOIUrl":"10.1177/25424823251384244","url":null,"abstract":"<p><strong>Background: </strong>Deep cervical lymphaticovenular anastomosis (dcLVA) surgery is able to control aging-associated Alzheimer's disease in patients. However, the efficacy rate remains unknown.</p><p><strong>Objective: </strong>This study is designed to test the surgery efficacy in the treatment of mild-to-moderate AD patients.</p><p><strong>Methods: </strong>This is a single-center retrospective study of dcLVA treatment of mild-to-moderate AD for 3 months. A total of 41 patients received the surgery, in which lymph vessels and lymph nodes in the district III of cervical area were identified using indocyanine fluorescence dye. The afferent lymphatics of the obstructed lymph nodes were connected to the jugular vein to fix the lymphatic blockage under a fluorescent microscope. The efficacy rate was examined at 3-month post-surgery by clinical scores and biomarkers.</p><p><strong>Results: </strong>Lymph flow obstruction was observed on both sides of cervical area in the AD patients. The obstruction was successfully resolved through the surgery, and AD progression was attenuated or even reversed in the patients according to improvement in the scales of MMSE, ADL, NPI, CDR-SB, and CGI-EI. The average effectiveness rate was 50% by the CDR-SB score improvement. The efficacy was higher with shorter disease duration but not influenced by age and <i>APOE4</i> genotype. Aβ<sub>42/40</sub> ratio and p-tau181 were improved in more than 67% patients. There were 2 cases of mild adverse reactions that were controlled immediately by regular treatments.</p><p><strong>Conclusions: </strong>The data demonstrate that dcLVA surgery is an effective and safe therapy for AD in mild-to-moderate patients with 50% efficacy rate as measured by improvement of the CDR-SB score.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251384244"},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statins, cholesterol and cognition at the time of Alzheimer's disease diagnosis: A cross-sectional study from the Swedish registry for cognitive/dementia disorders. 他汀类药物、胆固醇和阿尔茨海默病诊断时的认知:来自瑞典认知/痴呆障碍登记处的横断面研究
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-10-03 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251385903
Bojana Petek, Minjia Mo, Hong Xu, Jakob Norgren, Minh Tuan Hoang, Marta Villa-Lopez, Henrike Häbel, Julianna Kele, Luana Naia, Silvia Maioli, Joana B Pereira, Milica Gregorič Kramberger, Bengt Winblad, Maria Eriksdotter, Juan-Jesus Carrero, Sara Garcia-Ptacek
{"title":"Statins, cholesterol and cognition at the time of Alzheimer's disease diagnosis: A cross-sectional study from the Swedish registry for cognitive/dementia disorders.","authors":"Bojana Petek, Minjia Mo, Hong Xu, Jakob Norgren, Minh Tuan Hoang, Marta Villa-Lopez, Henrike Häbel, Julianna Kele, Luana Naia, Silvia Maioli, Joana B Pereira, Milica Gregorič Kramberger, Bengt Winblad, Maria Eriksdotter, Juan-Jesus Carrero, Sara Garcia-Ptacek","doi":"10.1177/25424823251385903","DOIUrl":"10.1177/25424823251385903","url":null,"abstract":"<p><strong>Background: </strong>Evidence suggests statins may influence cognition in Alzheimer's disease (AD), but specific use patterns in AD patients remain unclear.</p><p><strong>Objective: </strong>To identify factors influencing statin use in AD and explore associations between statins, cholesterol, and cognition, evaluated with Mini-Mental State Examination (MMSE) at dementia diagnosis.</p><p><strong>Methods: </strong>A cross-sectional study using data from the Swedish Registry for Dementia and Cognitive Disorders (SveDem) and Stockholm Creatinine Measurements (SCREAM) from 2007 to 2018. Multivariable logistic regression examined associations between baseline characteristics and statin use, while linear regression analyzed relationships between statins, cholesterol levels, and MMSE scores.</p><p><strong>Results: </strong>We included 3074 AD patients (mean age 78.1 years; 59.4% women), of whom 1028 used statins (79.6% simvastatin, 20.4% atorvastatin). Patients with diabetes mellitus, ischemic heart disease, or stroke had greater odds of receiving statins. Older patients had slightly lower odds of receiving any statin at baseline (simvastatin use OR 0.98, 95% CI 0.97-0.99). Simvastatin users had 0.53 points higher MMSE on average at baseline compared to non-users of statins (se 0.23, p = 0.021). Higher low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) levels were associated with higher MMSE in non-users of statins, but not in statin users.</p><p><strong>Conclusions: </strong>Younger AD patients and those with cardiovascular disease were more likely to use statins. Simvastatin use was linked to higher cognitive scores at diagnosis. In non-users, higher LDL-C, TC, and HDL-C levels correlated with better baseline cognitive scores. Longitudinal studies are needed to investigate the effects of statins on cognitive decline in AD.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251385903"},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary study on the feasibility of virtual reality-based cognitive training on patients with mild to moderate Alzheimer's disease. 基于虚拟现实的认知训练对轻中度阿尔茨海默病患者可行性的初步研究。
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-10-03 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251385901
HyeWon Jeong, Dongha Kang, Jung-Eun Kim, Jiyun Lim, Ho-Won Lee
{"title":"Preliminary study on the feasibility of virtual reality-based cognitive training on patients with mild to moderate Alzheimer's disease.","authors":"HyeWon Jeong, Dongha Kang, Jung-Eun Kim, Jiyun Lim, Ho-Won Lee","doi":"10.1177/25424823251385901","DOIUrl":"10.1177/25424823251385901","url":null,"abstract":"<p><strong>Background: </strong>Alzheimer's disease (AD) is a neurodegenerative disease that causes a decline in cognitive functions, considerably affecting a patient's life. Recently, virtual reality (VR) technology has emerged as a new tool used in the cognitive training of patients with AD.</p><p><strong>Objective: </strong>This study aimed to investigate the safety, feasibility, and clinical efficacy of VR-based cognitive training for patients with mild to moderate AD.</p><p><strong>Methods: </strong>Thirteen participants diagnosed with mild to moderate AD underwent VR training sessions by using the MentiTree software. Each session was conducted for 30 min twice a week for 9 weeks (total of 540 min). Cognitive functions were assessed before and after the intervention.</p><p><strong>Results: </strong>Although 1 of the 13 participants experienced adverse effects, the 9-week cognitive training was well tolerated and had a high feasibility of 93%±24.65%. A tendency toward improvement was observed in the visual recognition memory of the participants (p = 0.034), but other domains did not significantly change.</p><p><strong>Conclusions: </strong>VR-based cognitive training is safely accepted by patients with mild to moderate AD. The potential of VR in AD treatment should be further explored using a randomized control group.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251385901"},"PeriodicalIF":2.8,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KIAA0319 modulates Alzheimer's disease risk through PMM2 regulation: Evidence from integrated pQTL-mediation and transcriptomic analyses. KIAA0319通过PMM2调节阿尔茨海默病风险:来自综合pqtl介导和转录组学分析的证据
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251384245
Peng Wen, Chong Han, Hongxin Zhao, Shengtao Yao, Huan Chen
{"title":"KIAA0319 modulates Alzheimer's disease risk through PMM2 regulation: Evidence from integrated pQTL-mediation and transcriptomic analyses.","authors":"Peng Wen, Chong Han, Hongxin Zhao, Shengtao Yao, Huan Chen","doi":"10.1177/25424823251384245","DOIUrl":"10.1177/25424823251384245","url":null,"abstract":"<p><strong>Background: </strong>Genome-wide studies have identified multiple risk genes for Alzheimer's disease (AD), yet the causal protein interactions and pathways driving AD pathogenesis remain unclear.</p><p><strong>Objective: </strong>This study aimed to assess the causal relationships between plasma proteins and AD risk, and to delineate protein-mediated regulatory pathways involved in AD pathogenesis.</p><p><strong>Methods: </strong>We assessed the causal relationships between plasma proteins and AD risk using protein quantitative trait loci (pQTL) data from two large-scale resources: the UK Biobank Pharma Proteomics Project (UKB-PPP) and deCODE genetics. These data were integrated with genome-wide association studies (GWAS) on AD. We applied two-sample Mendelian randomization (MR), followed by two-step MR and mediation analyses, to delineate causal regulatory pathways and quantify mediating effects of proteins in AD pathogenesis. To further provide supporting evidence, we analyzed transcriptomic data from postmortem AD brain tissues (GSE33000, Gene Expression Omnibus) and conducted differential expression analyses.</p><p><strong>Results: </strong>In the UK Biobank cohort, seven upstream proteins showed causal associations with six downstream proteins in the deCODE cohort, which in turn influenced AD risk through both positive and negative regulatory effects (p < 0.05). Transcriptomic analysis demonstrated significant downregulation of <i>KIAA0319</i> in AD patients (p < 0.0001). These findings were consistent with our mediation analysis, which indicated that reduced KIAA0319 expression adversely affected PMM2 and thereby increased AD risk (mediation effect: 13.37%, 95% CI: 1.68%-25.06%, p < 0.05).</p><p><strong>Conclusions: </strong>This integrative analysis uncovered a novel KIAA0319-PMM2 regulatory axis implicated in AD pathogenesis. Both proteins represent potential therapeutic targets for future AD interventions.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251384245"},"PeriodicalIF":2.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480830/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visual art therapy for cognitive and emotional enhancement in aging and dementia: A structured narrative review. 视觉艺术疗法对认知和情感增强的衰老和痴呆:一个结构化的叙事回顾。
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-29 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251383728
Yulong Zhao, Ting Li, Huimin Wang, Chunxia Li
{"title":"Visual art therapy for cognitive and emotional enhancement in aging and dementia: A structured narrative review.","authors":"Yulong Zhao, Ting Li, Huimin Wang, Chunxia Li","doi":"10.1177/25424823251383728","DOIUrl":"10.1177/25424823251383728","url":null,"abstract":"<p><p>Visual art therapy is an emerging non-pharmacological intervention that integrates mental health and human services to enhance cognitive functions. It has shown promising results in supporting cognitive performance among healthy elderly individuals, those with mild cognitive impairment (MCI), and individuals with mild to moderate dementia, particularly Alzheimer's disease (AD). Given the limitations of current pharmacological treatments for dementia, visual art therapy presents an accessible, engaging alternative that fosters cognitive, sensory, and emotional stimulation-potentially contributing to neuroplastic changes in the aging brain. Here, we review recent applications of visual art therapy for these populations, particularly focusing on AD. The review highlights the significant impact of visual art therapy on cognitive function, summarizing the main approaches used and exploring mechanisms of cognitive enhancement, which may involve alterations in brain structure, neuroplasticity, and the promotion of sensory system neuroplasticity, particularly in audition and vision. It also discusses enhancements in functional connectivity within the default mode network. Future research should investigate optimal art therapy methods, scientific evaluation and quantitative analysis, explore integration with other non-pharmacological interventions, and pursue interdisciplinary investigation of art therapy mechanisms through neuroimaging. This review offers new insights into the empirical evidence supporting the use of visual art therapy for improving cognitive function in both healthy elderly individuals and dementia patients, explores potential neurobiological mechanisms underlying its cognitive benefits, and identifies current gaps and future directions for interdisciplinary research and clinical application, thereby fostering further research and application to address cognitive decline.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251383728"},"PeriodicalIF":2.8,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12480809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue-based assay-confirmed, antibody-negative autoimmune encephalitis responsive to low-dose rituximab in an elderly patient. 基于组织的检测证实,抗体阴性的自身免疫性脑炎对低剂量利妥昔单抗有反应。
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-26 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251383524
Lin Han, Chuan Li, Lin Li, Dan Yao, Yunfeng Hao, Chao Zhao, Xuan Zhou, Ying Li, Yuting Dang, Rong Zhang, Wenping Zhu, Shuyu Liu, Lan Gao, Ying Du, Wei Zhang
{"title":"Tissue-based assay-confirmed, antibody-negative autoimmune encephalitis responsive to low-dose rituximab in an elderly patient.","authors":"Lin Han, Chuan Li, Lin Li, Dan Yao, Yunfeng Hao, Chao Zhao, Xuan Zhou, Ying Li, Yuting Dang, Rong Zhang, Wenping Zhu, Shuyu Liu, Lan Gao, Ying Du, Wei Zhang","doi":"10.1177/25424823251383524","DOIUrl":"10.1177/25424823251383524","url":null,"abstract":"<p><p>Antibody-negative Autoimmune encephalitis (AE) presents a diagnostic challenge, requiring a high index of clinical suspicion and comprehensive evaluation. We report a 66-year-old man presenting with a seizure accompanied by progressive cognitive decline over several days. Despite the presence of hallmark symptoms and suggestive imaging, the patient was initially misdiagnosed, delaying timely immunotherapy. The diagnosis of antibody-negative AE was made based on clinical criteria, including consistent serological and cerebrospinal fluid (CSF) analyses (negative for known autoimmune and paraneoplastic antibodies), alongside a positive tissue-based assay (TBA), cranial MRI findings, and peripheral blood B-cell profiling. The patient responded well to immunotherapy with a low-dose sequential rituximab regimen, demonstrating clinical improvement and halting disease progression. This case highlights the importance of adhering to diagnostic criteria for AE and integrating TBA into the diagnostic workflow for antibody-negative AE.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251383524"},"PeriodicalIF":2.8,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12475340/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regular monitoring of SARS-CoV-2 carriage and antibody levels against the virus helped maintain social interactions for Alzheimer's disease residents in a Belgian nursing home during the pandemic. 在大流行期间,定期监测SARS-CoV-2携带情况和针对该病毒的抗体水平有助于维持比利时一家养老院阿尔茨海默病患者的社会交往。
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-23 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251377732
Amandine Tytgat, Anh Nguyet Diep, Florence Flamme, Marie-Cécile Dupas, Jean Artois, Martine Fory, Margaux Dandoy, Frédérique Damseaux, Mutien-Marie Garigliany, Daniel Desmecht, Marie-Pierre Hayette, Catherine Sabatel, Michaël Artisien, Sophie Brasseur, Yves van Laethem, Charlotte Martin, Clotilde Visée, Anne-Catherine Gérard, Anne-Françoise Donneau, Laurent Gillet, Patricia Kirkove, Fabrice Bureau, Laurence Fiévez
{"title":"Regular monitoring of SARS-CoV-2 carriage and antibody levels against the virus helped maintain social interactions for Alzheimer's disease residents in a Belgian nursing home during the pandemic.","authors":"Amandine Tytgat, Anh Nguyet Diep, Florence Flamme, Marie-Cécile Dupas, Jean Artois, Martine Fory, Margaux Dandoy, Frédérique Damseaux, Mutien-Marie Garigliany, Daniel Desmecht, Marie-Pierre Hayette, Catherine Sabatel, Michaël Artisien, Sophie Brasseur, Yves van Laethem, Charlotte Martin, Clotilde Visée, Anne-Catherine Gérard, Anne-Françoise Donneau, Laurent Gillet, Patricia Kirkove, Fabrice Bureau, Laurence Fiévez","doi":"10.1177/25424823251377732","DOIUrl":"10.1177/25424823251377732","url":null,"abstract":"<p><strong>Background: </strong>People suffering from Alzheimer's disease and related disorders (ADRD) were severely impacted by the COVID-19 pandemic, both physically and mentally.</p><p><strong>Objective: </strong>This one-year study aimed to implement a protocol for controlling the spread of SARS-CoV-2 in a Belgian nursing home hosting exclusively patients suffering from ADRD, while minimizing pandemic-associated constraints.</p><p><strong>Methods: </strong>After confirming the absence of positive cases in the nursing home and the development of a proper immunity against SARS-CoV-2, the staff members enrolled in the study were allowed to remove their mask. Then, a weekly non-invasive saliva RT-qPCR testing for SARS-CoV-2 detection was implemented to detect cases among the staff and residents. A monthly serological monitoring was set up to follow the levels of neutralizing and IgG antibodies against SARS-CoV-2.</p><p><strong>Results: </strong>Three waves of COVID-19 infection were observed and quickly contained thanks to an effective quarantine policy. We confirmed the stronger humoral response developed by people infected before primo-vaccination compared to naïve-vaccinated ones and the weaker immune response of elderly individuals compared to younger participants, a difference abolished by booster. In parallel, we showed that ADRD people were able to develop a similar humoral response to SARS-CoV-2 vaccination or infection to that of people of similar age not suffering from these diseases.</p><p><strong>Conclusions: </strong>We show that a strict protocol aimed at early case detection and anti-SARS-CoV-2 immunity follow-up has enabled ADRD residents from a Belgian nursing home to maintain social interactions thanks to the ability of study participants to remove masks, while minimizing the risk of infection.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251377732"},"PeriodicalIF":2.8,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neurofilament light (NfL) chain levels predict clinical decline in Alzheimer's disease: A systematic review and meta-analysis. 神经丝光(NfL)链水平预测阿尔茨海默病的临床衰退:一项系统回顾和荟萃分析
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-22 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251379878
Kim Thomas, Paul Spin, Nikita Sir, Kevin Hou, Nicholas J Ashton, Henrik Zetterberg, Sonya Miller, Carol Pringle, Richard Stefanacci, Claude M Wischik, Serge Gauthier
{"title":"Neurofilament light (NfL) chain levels predict clinical decline in Alzheimer's disease: A systematic review and meta-analysis.","authors":"Kim Thomas, Paul Spin, Nikita Sir, Kevin Hou, Nicholas J Ashton, Henrik Zetterberg, Sonya Miller, Carol Pringle, Richard Stefanacci, Claude M Wischik, Serge Gauthier","doi":"10.1177/25424823251379878","DOIUrl":"10.1177/25424823251379878","url":null,"abstract":"<p><strong>Background: </strong>Regulatory approval of new investigational Alzheimer's disease (AD) therapies could be accelerated if reasonably likely surrogate endpoints could be used. Neurofilament light chain (NfL) has potential utility as a prognostic biomarker of neurodegeneration in AD.</p><p><strong>Objective: </strong>To synthesize available evidence on the relationship between baseline NfL levels and longitudinal clinical decline.</p><p><strong>Methods: </strong>A systematic literature review identified 19 eligible studies, contributing 37 longitudinal statistical models evaluating the association between baseline NfL (plasma or cerebrospinal fluid [CSF]) with subsequent clinical decline based on validated clinical scales including Mini-Mental State Examination (MMSE), Alzheimer's Disease Assessment Scale-Cognitive Subscale, and Clinical Dementia Rating. Results were pooled via meta-analysis, using partial correlation coefficients (PCC), separately for patient sub-groups (mild cognitive impairment, AD or combined).</p><p><strong>Results: </strong>Across the AD continuum, higher baseline NfL levels were consistently associated with greater cognitive and global clinical decline in most analyses. This pattern was consistent for both plasma (pooled PCC = -0.17 [95% CI = -0.22, -0.12] for MMSE, any AD population) and CSF NfL (pooled PCC = -0.14 [95% CI = -0.24, -0.04] for MMSE, any AD population). The strength of association across multiple clinical endpoints and populations, measured by absolute value of pooled PCC, ranged from 0.13 to 0.25.</p><p><strong>Conclusions: </strong>The results support the utility of NfL as a predictive biomarker for progression of clinical decline in AD patients.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251379878"},"PeriodicalIF":2.8,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145152040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Progesterone induction of tau phosphorylation during the differentiation of human embryonic stem cells into neuroectodermal rosettes. 黄体酮诱导人胚胎干细胞向神经外胚层莲座分化过程中的tau磷酸化。
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-17 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251370643
Prashob Porayette, Maria M Kaltcheva, George Perry, Tracy Butler, Sivan Vadakkadath Meethal, Craig S Atwood
{"title":"Progesterone induction of tau phosphorylation during the differentiation of human embryonic stem cells into neuroectodermal rosettes.","authors":"Prashob Porayette, Maria M Kaltcheva, George Perry, Tracy Butler, Sivan Vadakkadath Meethal, Craig S Atwood","doi":"10.1177/25424823251370643","DOIUrl":"10.1177/25424823251370643","url":null,"abstract":"<p><strong>Background: </strong>Tau phosphorylation is associated with neuronal division and differentiation in the fetal brain, in neuroblastoma cells, in the hibernating brains of ground squirrels and black bears, and in post-mitotic neurons in the Alzheimer's disease (AD) brain. The disassembly of the rigid microtubule structure of neurons for neuronal division and neurite remodeling requires the removal of the microtubule stabilizing protein tau via its phosphorylation.</p><p><strong>Objective: </strong>To determine if tau phosphorylation is required during neural embryogenesis.</p><p><strong>Methods: </strong>Using an <i>in vitro</i> human model of early embryonic development, human embryonic stem cells (hESC) were differentiated into embryoid bodies (EBs; akin to an early blastocyst) and then into neuroectodermal rosettes (akin to a rudimentary neural tube containing neuroectodermal precursor cells) upon treatment with progesterone. The neuroectodermal rosettes were then treated with and without LiCl (Cdk5 inhibitor) or roscovitine (GSK-3β inhibitor) and assayed for the expression of tau, P-tau, nestin (an early marker of neurogenesis), Cdk5 and GSK-3β.</p><p><strong>Results: </strong>Tau was not expressed in hESC, but tau expression and its phosphorylation increase upon progesterone-induced differentiation of hESC into neuroectodermal rosettes. Both Cdk5 and GSK-3β, enzymes associated with tau phosphorylation, were expressed in hESCs, EBs, and neuroectodermal rosettes. The GSK-3β inhibitor LiCl, but not the Cdk-5 inhibitor roscovitine, prevented tau phosphorylation and nestin expression and the formation of neuroectodermal precursor cells.</p><p><strong>Conclusions: </strong>These preliminary results suggest that progesterone induces tau expression and its phosphorylation during the differentiation of neuroectodermal rosettes from hESC and suggest that tau and its phosphorylation is obligatory for neuronal precursor cell mitosis. The parallels between neural embryogenesis and neurodegeneration are discussed in the context of tau phosphorylation and the aberrant re-entry of neurons into the cell cycle in AD.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251370643"},"PeriodicalIF":2.8,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145115128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrating repetitive transcranial magnetic stimulation and Mediterranean diet for cognitive and anxiety improvement in early Alzheimer's disease: A case report and literature review. 整合重复性经颅磁刺激和地中海饮食对早期阿尔茨海默病的认知和焦虑改善:一个病例报告和文献综述
IF 2.8
Journal of Alzheimer's disease reports Pub Date : 2025-09-16 eCollection Date: 2025-01-01 DOI: 10.1177/25424823251377988
Yumei Liu, Lin Zhu, Zian Pei, Zhifan Zhou, Xiaolin Su, Huixia Ren, Shuhan Fan, Xiaoyong Lan, Chongyuan Lian, Xue Shi, Yi Guo
{"title":"Integrating repetitive transcranial magnetic stimulation and Mediterranean diet for cognitive and anxiety improvement in early Alzheimer's disease: A case report and literature review.","authors":"Yumei Liu, Lin Zhu, Zian Pei, Zhifan Zhou, Xiaolin Su, Huixia Ren, Shuhan Fan, Xiaoyong Lan, Chongyuan Lian, Xue Shi, Yi Guo","doi":"10.1177/25424823251377988","DOIUrl":"10.1177/25424823251377988","url":null,"abstract":"<p><p>A 52-year-old male with early-stage Alzheimer's disease and long-standing anxiety received 30 repetitive transcranial magnetic stimulation sessions over 8 months and 20-month Mediterranean diet intervention. Neuropsychological assessments [Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Clinical Dementia Rating, Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), Pittsburgh Sleep Quality Index) and resting-state electroencephalogram (rsEEG) were conducted at baseline, during treatment, and at 6-month follow-up. After treatment, MoCA and MMSE scores improved by 6 and 5 points; HAMA and HAMD scores declined by 7 and 3 points. rsEEG showed progressive increases in individual alpha peak frequency (8.69 to 10.22 Hz), enhancement of alpha power, and reduction in theta power. Cerebrospinal fluid amyloid-β<sub>42</sub> levels also normalized. The patient reported marked mental well-being.</p>","PeriodicalId":73594,"journal":{"name":"Journal of Alzheimer's disease reports","volume":"9 ","pages":"25424823251377988"},"PeriodicalIF":2.8,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441292/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信