Integrating repetitive transcranial magnetic stimulation and Mediterranean diet for cognitive and anxiety improvement in early Alzheimer's disease: A case report and literature review.

IF 2.8 Q2 NEUROSCIENCES

Journal of Alzheimer's disease reports Pub Date : 2025-09-16 eCollection Date: 2025-01-01 DOI:10.1177/25424823251377988

Yumei Liu, Lin Zhu, Zian Pei, Zhifan Zhou, Xiaolin Su, Huixia Ren, Shuhan Fan, Xiaoyong Lan, Chongyuan Lian, Xue Shi, Yi Guo

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Abstract

A 52-year-old male with early-stage Alzheimer's disease and long-standing anxiety received 30 repetitive transcranial magnetic stimulation sessions over 8 months and 20-month Mediterranean diet intervention. Neuropsychological assessments [Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), Clinical Dementia Rating, Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), Pittsburgh Sleep Quality Index) and resting-state electroencephalogram (rsEEG) were conducted at baseline, during treatment, and at 6-month follow-up. After treatment, MoCA and MMSE scores improved by 6 and 5 points; HAMA and HAMD scores declined by 7 and 3 points. rsEEG showed progressive increases in individual alpha peak frequency (8.69 to 10.22 Hz), enhancement of alpha power, and reduction in theta power. Cerebrospinal fluid amyloid-β₄₂ levels also normalized. The patient reported marked mental well-being.

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整合重复性经颅磁刺激和地中海饮食对早期阿尔茨海默病的认知和焦虑改善：一个病例报告和文献综述

一名患有早期阿尔茨海默病和长期焦虑的52岁男性患者接受了30次重复经颅磁刺激，为期8个月和20个月的地中海饮食干预。神经心理学评估[蒙特利尔认知评估（MoCA），迷你精神状态检查（MMSE），临床痴呆评分，汉密尔顿焦虑评分量表（HAMA），汉密尔顿抑郁评分量表（HAMD），匹兹堡睡眠质量指数]和静息状态脑电图（rsEEG）在基线，治疗期间和6个月随访时进行。治疗后MoCA、MMSE评分分别提高6分、5分；HAMA和HAMD分别下降了7分和3分。rsEEG显示个体α峰频率逐渐增加（8.69 ~ 10.22 Hz）， α功率增强，θ功率降低。脑脊液淀粉样蛋白-β42水平也恢复正常。病人报告说他的精神很健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's disease reports

CiteScore

2.80

自引率

0.00%

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