JMM case reports最新文献_第8页

HIV positive patient with GBS-like syndrome. HIV阳性的gbs样综合征患者。

JMM case reports Pub Date : 2017-08-01 DOI: 10.1099/jmmcr.0.005107

Samantha J Shepherd, Heather Black, Emma C Thomson, Rory N Gunson

{"title":"HIV positive patient with GBS-like syndrome.","authors":"Samantha J Shepherd, Heather Black, Emma C Thomson, Rory N Gunson","doi":"10.1099/jmmcr.0.005107","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005107","url":null,"abstract":"Introduction. Guillain-Barré Syndrome (GBS) is an acute demyelinating polyneuropathy which can occur post-infection. Criteria of diagnosis of GBS include areflexia with progressive bilateral weakness in arms and legs. GBS can lead to severe respiratory and cardiac complications. The fatality rate can be up to 5 % in patients, depending on the severity of the symptoms. HIV can cause a range of neurological disorders including, on rare occasions, GBS. GBS can occur at any stage of HIV infection, highlighting the complexity of diagnosis of GBS within HIV patients. Case presentation. A 57 year old female with lumbar back pain radiating to the legs, poor mobility and tiredness, with reports of a viral-like illness four days previously, was initially diagnosed with a lower respiratory tract infection and discharged. Seventeen days later the patient was readmitted to hospital with progressive lower and upper limb weakness, areflexia and sensory loss. She was diagnosed with GBS and was unexpectedly discovered to be HIV-positive. HIV avidity was low indicating a recently acquired HIV infection. The patient was treated with intravenous immunoglobulin for five days for the GBS and commenced antriretrovirals for HIV. The patient was discharge from hospital 53 days after admission with walking aids and regular physiotherapy follow-up.Conclusion: . This case highlighted the need for all clinicians to be aware that patients with symptoms of GBS, regardless of clinical history should be offered an HIV test. GBS can be the first sign a patient is HIV-positive.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 8","pages":"e005107"},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1099/jmmcr.0.005107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9944427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Sinister seafood: bacteraemia secondary to non-O1/O139 Vibrio cholerae infection. 险恶的海鲜:继发于非o1 /O139霍乱弧菌感染的菌血症。

JMM case reports Pub Date : 2017-07-05 eCollection Date: 2017-07-01 DOI: 10.1099/jmmcr.0.005103

Maxime J Billick, Philip W Lam, Isaac I Bogoch

{"title":"Sinister seafood: bacteraemia secondary to non-O1/O139 Vibrio cholerae infection.","authors":"Maxime J Billick, Philip W Lam, Isaac I Bogoch","doi":"10.1099/jmmcr.0.005103","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005103","url":null,"abstract":"Introduction.Vibrio species are curved, motile Gram-negative bacilli found in estuarine and marine environments, and are known to cause to gastroenteritis, skin and soft tissue infections, and septicaemia. While not responsible for cholera epidemics, non-O1/O139 Vibrio cholerae (NOVC) is increasingly reported as a cause of gastroenteritis. Case presentation. A 66-year-old man presented to an emergency department with a 1 week history of epigastric pain, emesis and fever. Blood cultures drawn on admission initially demonstrated Gram-negative bacilli, and ultimately grew NOVC, which was later confirmed by matrix-assisted laser desorption ionization-time of flight MS. Subsequent history revealed that the patient had eaten fish and seafood prior to falling ill. He was treated with intravenous ceftriaxone and oral doxycycline while admitted, and oral ciprofloxacin and doxycycline upon discharge. His bacteraemia was believed to be secondary to altered gut anatomy from prior surgery and proton-pump inhibitor use. Conclusion. Risk factors for NOVC bacteraemia include cirrhosis, immunosuppression and other forms of liver disease. Cases are often linked to a history of seafood ingestion when water temperatures rise, enabling Vibrio species to proliferate. While the optimal management of NOVC bacteraemia is unclear, a combination of a third-generation cephalosporin with a tetracycline has been suggested. Physicians should maintain a high index of suspicion for this pathogen when evaluating ill patients with a history of liver disease and seafood ingestion.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 7","pages":"e005103"},"PeriodicalIF":0.0,"publicationDate":"2017-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Marked peripheral eosinophilia due to prolonged administration of posaconazole. 由于长期服用泊沙康唑导致明显的外周嗜酸性粒细胞增多。

JMM case reports Pub Date : 2017-06-30 eCollection Date: 2017-06-01 DOI: 10.1099/jmmcr.0.005100

Maher Alharbi, Rae-Kiran Jhinger, Terence Wuerz, Andrew Walkty

{"title":"Marked peripheral eosinophilia due to prolonged administration of posaconazole.","authors":"Maher Alharbi, Rae-Kiran Jhinger, Terence Wuerz, Andrew Walkty","doi":"10.1099/jmmcr.0.005100","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005100","url":null,"abstract":"Introduction. Posaconazole is a triazole antifungal that is used in the treatment of a variety of fungal infections, as well as in the management of mucormycosis (on an off-label basis). Eosinophilia associated with exposure to azole antifungals has been described rarely in the literature. Case presentation. A 31-year-old male on peritoneal dialysis (PD) for end-stage renal disease, secondary to diabetic nephropathy, presented to hospital with abdominal pain after a trip to St Lucia. He was taken to the operating room, where the PD catheter was removed and an abdominal-wall abscess was debrided. Rhizopus species was recovered on culture of the abdominal-wall tissue, and the patient was started on amphotericin B deoxycholate. He was subsequently stepped down to posaconazole, for a planned treatment duration of 12 months. Approximately 43 days after the initiation of posaconazole, it was noted that his peripheral eosinophil count started to rise. No other cause for the eosinophilia was identified. Posaconazole was discontinued, and the patient's eosinophil count began to drop 2 days later. The temporal association of eosinophilia following initiation of posaconazole and the subsequent improvement after drug discontinuation suggests a probable causal relationship. Conclusion. At the time of writing, there have been only two other published cases of azole-associated peripheral eosinophilia. In reporting this case, we hope to increase health-care provider awareness of this rare adverse event. For patients receiving prolonged therapy with posaconazole, periodic monitoring of the complete blood count with differential may be considered.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 6","pages":"e005100"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Rash and hepatosplenomegaly in a newborn. 新生儿皮疹和肝脾肿大。

JMM case reports Pub Date : 2017-06-30 eCollection Date: 2017-06-01 DOI: 10.1099/jmmcr.0.005098

Eimear Kitt, Rebecca M May, Andrew P Steenhoff

{"title":"Rash and hepatosplenomegaly in a newborn.","authors":"Eimear Kitt, Rebecca M May, Andrew P Steenhoff","doi":"10.1099/jmmcr.0.005098","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005098","url":null,"abstract":"A newborn male infant, with an estimated gestational age of 35weeks, was born via spontaneous vaginal delivery to a 28year-old mother, who presented in active labour with a macular rash on her hands and feet noted at the time of delivery, as shown in Fig. 1(c–e). Maternal history was significant for illicit drug use and scant prenatal care, without thorough serological evaluation performed prior to delivery. Physical examination at birth revealed a small-for-gestational-age infant in moderate respiratory distress. He had a distended abdomen with hepatosplenomegaly. Dermatological examination demonstrated dry flaky skin throughout and some scattered petechiae. Laboratory evaluation was notable for haemoglobin of 13.3 g dl , leukocytosis of 81 000 μl 1 (55% segmented neutrophils, 19% monocytes, 21% lymphocytes, 1% bands and 2% eosinophils) and thrombocytopenia of 15 000 μl 1 . The C-reactive protein level was markedly elevated at 47.8mg l . Liver function tests unearthed a transaminitis and significant hyperbilirubinaemia at time of birth, which subsequently peaked at 16.6 μmol l 1 (direct 9.9, indirect 6.2). Radiographs of extremities revealed a ‘somewhat serrated appearance of proximal femoral and humeral metaphyses’. Brain imaging with head ultrasound was normal. Abdominal ultrasound confirmed enlargement of the liver. Treatment was started for a suspected congenital infection – confirmed based on the images of the placental tissue (Fig. 1a, b). He received two platelet transfusions, one red blood cell transfusion and was started on ursodiol for treatment of conjugated hyperbilirubinaemia, at a dose of 8 mg kg 1 divided twice daily. He responded to treatment and was well when discharged home at 2 weeks of life.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 6","pages":"e005098"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A case of Exophiala dermatitidis infection in a child after allogeneic stem cell transplantation: case report and literature review of paediatric cases. 异基因干细胞移植后儿童外表皮皮炎感染1例:儿科病例报告及文献复习。

JMM case reports Pub Date : 2017-06-26 eCollection Date: 2017-06-01 DOI: 10.1099/jmmcr.0.005102

Dominika Tanuskova, Julia Horakova, Darina Buzassyova, Miroslava Poczova, Ivana Bodova, Peter Svec, Alica Chocholova, Jaroslava Adamcakova, Tomas Sykora, Miroslava Pozdechova, Lucia Geczova, Alexandra Kolenova

{"title":"A case of Exophiala dermatitidis infection in a child after allogeneic stem cell transplantation: case report and literature review of paediatric cases.","authors":"Dominika Tanuskova, Julia Horakova, Darina Buzassyova, Miroslava Poczova, Ivana Bodova, Peter Svec, Alica Chocholova, Jaroslava Adamcakova, Tomas Sykora, Miroslava Pozdechova, Lucia Geczova, Alexandra Kolenova","doi":"10.1099/jmmcr.0.005102","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005102","url":null,"abstract":"Introduction.Exophiala dermatitidisis a relatively common environmental black yeast with worldwide distribution and is a rare cause of fungal infection, mostly in patients with certain predisposing factors. Due to the rarity of the infection, little is known about the specific predisposing factors, way of infection or treatment. Case presentation. Here, we report what is to our knowledge the first case of E. dermatitidis infection in a child after allogeneic stem cell transplantation. We also review all paediatric cases reported in the literature since 1993. Conclusion. This is, to our knowledge, the first reported case of E. dermatitidis infection in a child after allogeneic stem cell transplantation. This report should increase the awareness of E. dermatitidis in immunocompromised paediatric patients, particularly after stem cell transplantation.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 6","pages":"e005102"},"PeriodicalIF":0.0,"publicationDate":"2017-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cutaneous fungal infection in an immunocompromised host. 免疫力低下人群的皮肤真菌感染。

JMM case reports Pub Date : 2017-06-21 eCollection Date: 2017-06-01 DOI: 10.1099/jmmcr.0.005101

David Sotello, Mark Cappel, Tamara Huff, Diana Meza, Salvador Alvarez, Claudia R Libertin

引用次数: 0

Acute diarrhoea due to a Shiga toxin 2e-producing Escherichia coli O8 : H19. 由产志贺毒素2的大肠杆菌O8: H19引起的急性腹泻。

JMM case reports Pub Date : 2017-06-14 eCollection Date: 2017-06-01 DOI: 10.1099/jmmcr.0.005099

Angela Saupe, Birgit Edel, Wolfgang Pfister, Bettina Löffler, Ralf Ehricht, Jürgen Rödel

引用次数: 10

First case of human peritoneal cysticercosis mimicking peritoneal carcinosis: necessity of laparoscopy and histologic assessment for the correct diagnosis. 模拟腹膜癌的人腹膜囊虫病第1例:腹腔镜检查的必要性和正确诊断的组织学评估。

JMM case reports Pub Date : 2017-06-08 eCollection Date: 2017-06-01 DOI: 10.1099/jmmcr.0.005097

Martina Rudelius, Klaus Brehm, Martin Poelcher, Christoph Spinner, Andreas Rosenwald, Clarissa Prazeres da Costa

{"title":"First case of human peritoneal cysticercosis mimicking peritoneal carcinosis: necessity of laparoscopy and histologic assessment for the correct diagnosis.","authors":"Martina Rudelius, Klaus Brehm, Martin Poelcher, Christoph Spinner, Andreas Rosenwald, Clarissa Prazeres da Costa","doi":"10.1099/jmmcr.0.005097","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005097","url":null,"abstract":"Introduction. Correct diagnosis of peritoneal infectious disease can be extremely difficult due to non-specific clinical features. Thus, careful assessment with thorough histopathological work-up is essential. Here, we report the first case of human peritoneal cysticercosis mimicking peritoneal carcinosis. Case presentation. The patient presented with recurring ascites and a tumour in the Douglas cavity accompanied by elevated tumour markers. There were no signs of systemic infection. On laparoscopy, the tumour was resected completely. Histology revealed a granulomatous reaction and a diagnosis suspicious of tuberculosis was made. Only after additional sections, avital cestode-fragments were visible and Taenia martis DNA was detected. Further staging by computerized tomography scan of the lung and brain turned out negative and the patient recovered quickly. Conclusion. Laparoscopy and histopathological examination can be extremely helpful for correct diagnosis and management in uncertain recurrent ascites. This case clearly demonstrates that orphan infectious diseases should also be considered. Only complete histopathological examination with serial sections and additional molecular testing can lead to the appropriate diagnosis.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 6","pages":"e005097"},"PeriodicalIF":0.0,"publicationDate":"2017-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

A case of Vibrio vulnificus infection complicated with fulminant purpura: gene and biotype analysis of the pathogen. 创伤弧菌感染并发暴发性紫癜1例:病原菌基因及生物型分析。

JMM case reports Pub Date : 2017-05-19 eCollection Date: 2017-05-01 DOI: 10.1099/jmmcr.0.005096

Masatoshi Hori, Akifumi Nakayama, Daisuke Kitagawa, Hidetada Fukushima, Hideki Asai, Yasuyuki Kawai, Kazuo Okuchi

{"title":"A case of Vibrio vulnificus infection complicated with fulminant purpura: gene and biotype analysis of the pathogen.","authors":"Masatoshi Hori, Akifumi Nakayama, Daisuke Kitagawa, Hidetada Fukushima, Hideki Asai, Yasuyuki Kawai, Kazuo Okuchi","doi":"10.1099/jmmcr.0.005096","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005096","url":null,"abstract":"Introduction.Vibrio vulnificus (V. vulnificus) causes a severe infection that develops in the compromised host. Its pathophysiology is classified into three types: (1) primary septicaemia, (2) gastrointestinal illness pattern and (3) wound infection pattern. Of these, primary septicaemia is critical. V. vulnificus can be classified into three biotypes and two genotypes and its pathogenicity is type-dependent. Case presentation. A 47-year-old man presented to a local hospital with chief complaints of fever, bilateral lower limb pain and diarrhoea. He had no history of foreign travel or known medical problems. He was in septic shock and developed fulminant purpura within 24 h of the onset. High-dose vasopressor and antibiotic administration failed to alter his status and he died 3 days after the onset of symptoms. V. vulnificus was isolated from blood, skin and nasal discharge cultures. Biotype and gene analysis of the microbe isolated identified it as Biotype 3, mainly reported in Israel in wound infections, and Genotype E, implicating an environmental isolate. These typing analyses indicated that the microbe isolated could be classified as a type with low pathogenicity. Conclusion. This case highlighted that Biotype 3 and Genotype E can also cause primary septicaemia. Although the majority of reports on Biotype 3 have been from the Middle East, this experience with the present case provided evidence that the habitat of Biotype 3 V. vulnificus has been extending to East Asia as well.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 5","pages":"e005096"},"PeriodicalIF":0.0,"publicationDate":"2017-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Lower extremity mycotic aneurysm in a patient with Listeria monocytogenes - associated prosthetic valve endocarditis. 单核增生李斯特菌相关人工瓣膜心内膜炎患者下肢真菌性动脉瘤1例。

JMM case reports Pub Date : 2017-05-09 eCollection Date: 2017-05-01 DOI: 10.1099/jmmcr.0.005095

Elham Rahmati, P Jan Geiseler, Rosemary C She

{"title":"Lower extremity mycotic aneurysm in a patient with Listeria monocytogenes - associated prosthetic valve endocarditis.","authors":"Elham Rahmati, P Jan Geiseler, Rosemary C She","doi":"10.1099/jmmcr.0.005095","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005095","url":null,"abstract":"Introduction.Listeria monocytogenes is a rare etiology of infectious endocarditis with only 30 cases of prosthetic valve and about twice as many native valve infections described in the literature. We describe an unusual presentation of an endovascular embolic phenomenon with associated lower extremity mycotic aneurysm due to Listeria monocytogenes prosthetic aortic valve and aortic endograft infection. Case presentation. This is a case of an elderly gentleman with prior history of bioprosthetic aortic valve placement and aortic arch repair who was admitted with several weeks of constitutional symptoms and left lower leg pain. Diagnostic work-up was consistent with thrombosed popliteal artery aneurysm. Blood cultures were positive for Listeria monocytogenes. A transesophageal echocardiogram revealed vegetation on the bioprosthetic valve. The patient underwent arterial bypass and ligation of the aneurysm as well as redoing of his aortic valve and aortic graft replacement. Histopathology of the aortic valve was remarkable for acute inflammation and Gram-positive coccobacilli and bacilli occupying intracellular spaces. The results of broad-range bacterial 16S rRNA PCR and sequence analysis of unfixed aortic valve tissue confirmed detection of L. monocytogenes. Conclusion. Infective endocarditis attributable to species of the genus Listeriais a rare entity. As such, there are no specific guidelines for treatment of Listeria monocytogenesendocarditis. However, combination of penicillin or ampicillin with gentamicin is the most acceptable approach described in the literature. Our patient was treated with ampicillin and gentamicin for 6 weeks followed by life-long amoxicillin suppression therapy. The patient remained asymptomatic at a 6 months follow up visit.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 5","pages":"e005095"},"PeriodicalIF":0.0,"publicationDate":"2017-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35603171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3