JMM case reports最新文献_第9页

Aeromonas species endogenous endophthalmitis. 气单胞菌属内源性眼内炎。

JMM case reports Pub Date : 2017-05-04 eCollection Date: 2017-05-01 DOI: 10.1099/jmmcr.0.005094

Laura Ryan, Gareth Higgins, Maeve Doyle

引用次数: 6

16S rRNA deep sequencing identifies Actinotignum schaalii as the major component of a polymicrobial intra-abdominal infection and implicates a urinary source. 16S rRNA深度测序鉴定沙利放线菌是多微生物腹腔感染的主要成分，并暗示其泌尿源。

JMM case reports Pub Date : 2017-05-03 eCollection Date: 2017-05-01 DOI: 10.1099/jmmcr.0.005091

Andrew Bryan, Lindsey M Kirkpatrick, John J Manaloor, Stephen J Salipante

{"title":"16S rRNA deep sequencing identifies Actinotignum schaalii as the major component of a polymicrobial intra-abdominal infection and implicates a urinary source.","authors":"Andrew Bryan, Lindsey M Kirkpatrick, John J Manaloor, Stephen J Salipante","doi":"10.1099/jmmcr.0.005091","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005091","url":null,"abstract":"Introduction. It can be difficult to catalogue the individual organisms comprising polymicrobial patient infections, both because conventional clinical microbiological culture does not facilitate the isolation and enumeration of all members of a complex microbial community, and because fastidious organisms may be mixed with organisms that grow rapidly in vitro. Empiric antimicrobial treatment is frequently employed based on the anatomical site and the suspected source of the infection, especially when an appropriately collected surgical specimen is not obtained. Case presentation. We present a case of an intra-abdominal infection in a patient with complex anatomy and recurrent urinary tract infections. Imaging did not reveal a clear source of infection, no growth was obtained from urine cultures and initial abdominal fluid cultures were also negative. In contrast, 16S rRNA deep sequencing of abdominal fluid samples revealed mixed bacterial populations with abundant anaerobes, including Actinotignum schaalii (Actinobaculum schaalii). Ultimately, only Enterobacter cloacae complex and meticillin-resistant Staphylococcus aureus, both of which were identified by sequencing, were recovered by culture. Conclusion. The clinical application of 16S rRNA deep sequencing can more comprehensively and accurately define the organisms present in an individual patient's polymicrobial infection than conventional microbiological culture, detecting species that are not recovered under standard culture conditions or that are otherwise unexpected. These results can facilitate effective antimicrobial stewardship and help elucidate the possible origins of infections.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 5","pages":"e005091"},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35446418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Streptococcus suis serotype 9 endocarditis and subsequent severe meningitis in a growing pig despite specific bactericidal humoral immunity. 猪链球菌血清9型心内膜炎和随后的严重脑膜炎，尽管有特定的杀菌体液免疫。

JMM case reports Pub Date : 2017-05-03 eCollection Date: 2017-05-01 DOI: 10.1099/jmmcr.0.005093

Karoline Rieckmann, Kristin Müller, Annette Moter, Christoph G Baums, Anna Seydel

{"title":"Streptococcus suis serotype 9 endocarditis and subsequent severe meningitis in a growing pig despite specific bactericidal humoral immunity.","authors":"Karoline Rieckmann, Kristin Müller, Annette Moter, Christoph G Baums, Anna Seydel","doi":"10.1099/jmmcr.0.005093","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005093","url":null,"abstract":"Introduction: . Meningitis and endocarditis are common pathologies of Streptococcussuis infections in pigs and humans. S. suis serotype 9 strains contribute substantially to health problems in European pig production, and immune prophylaxis against this serotype is very difficult.Case presentation: . We report the clinical course and histopathological picture of a 10-week-old growing pig following experimental intravenous infection with S. suis serotype 9. The piglet showed rapid onset of severe clinical signs of meningitis 11 days post-intravenous challenge following prime-booster vaccination. Histopathological findings revealed a diffuse fibrinosuppurative leptomeningitis. Additionally, a polyphasic endocarditis valvularis thromboticans with numerous bacterial colonies was diagnosed. Bacteriological culture of the brain and the mitral valve confirmed association with the challenge strain. However, virulent serotype 2 and 9 strains were killed in the blood of this piglet ex vivo prior experimental infection.Conclusion: . Endocarditis induced by S. suis infection might develop and persist despite the presence of high specific bactericidal activity in the blood. Severe leptomeningitis is a putative sequela of such an endocarditis.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 5","pages":"e005093"},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1099/jmmcr.0.005093","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35446419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

A case of polymicrobial anaerobic spondylodiscitis due to Parvimonas micra and Fusobacterium nucleatum. 一例由小花伞菌和核酸镰刀菌引起的多微生物厌氧性脊椎盘炎。

JMM case reports Pub Date : 2017-04-26 eCollection Date: 2017-04-01 DOI: 10.1099/jmmcr.0.005092

Leanne M Cleaver, Shara Palanivel, Damien Mack, Simon Warren

{"title":"A case of polymicrobial anaerobic spondylodiscitis due to Parvimonas micra and Fusobacterium nucleatum.","authors":"Leanne M Cleaver, Shara Palanivel, Damien Mack, Simon Warren","doi":"10.1099/jmmcr.0.005092","DOIUrl":"10.1099/jmmcr.0.005092","url":null,"abstract":"Introduction. Here, we present a case of polymicrobial anaerobic spondylodiscitis. Case Presentation. A forty-five year-old female patient was referred to a specialist orthopaedic hospital with an eight week history of back pain without fevers. X-ray imaging and magnetic resonance imaging showed acute osteomyelitis of the twelfth thoracic and first lumbar vertebrae. Prolonged enrichment cultures grew Parvimonas micra and Fusobacterium nucleatum, identified by matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS). The patient was successfully treated with six weeks of intravenous ertapenem and oral clindamycin. Conclusion. Anaerobic discitis is rare, and polymicrobial discitis is rarer still. A PubMed literature review revealed only seven cases of F. nucleatum discitis and only twelve cases of P. micra discitis; this includes only one other reported case of a polymicrobial discitis due to infection with both anaerobes. We emphasise the importance of prolonging enrichment culture and the use of fast yet accurate identification of anaerobes using MALDI-ToF MS in these infections.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 4","pages":"e005092"},"PeriodicalIF":0.0,"publicationDate":"2017-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35446417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral vasculitis and intracranial multiple aneurysms in a child with Lyme neuroborreliosis. 莱姆病儿童的脑血管炎和颅内多发动脉瘤。

JMM case reports Pub Date : 2017-04-21 eCollection Date: 2017-04-01 DOI: 10.1099/jmmcr.0.005090

Elisa Kortela, Jukka Hytönen, Jussi Numminen, Margit Overmyer, Harri Saxen, Jarmo Oksi

{"title":"Cerebral vasculitis and intracranial multiple aneurysms in a child with Lyme neuroborreliosis.","authors":"Elisa Kortela, Jukka Hytönen, Jussi Numminen, Margit Overmyer, Harri Saxen, Jarmo Oksi","doi":"10.1099/jmmcr.0.005090","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005090","url":null,"abstract":"Introduction. Lyme borreliosis is a multisystem tick-borne disease caused by Borrelia burgdorferi. Neurological manifestations are reported in up to 15 % of adult patients with Lyme disease, while the frequency among children is higher. The most common manifestations are painful radiculopathy, facial nerve paresis and lymphocytic meningitis. Epileptic seizures and cerebral vasculitis with stroke or aneurysms are very rare complications. Case presentation. We describe a paediatric patient with sensorineural auditory dysfunction, headache, fatigue and epileptic seizures as sequelae of meningoencephalitis/Lyme neuroborreliosis (LNB) caused by B. burgdorferi. Brain magnetic resonance imaging revealed widespread enhancement of the leptomeninges, cranial nerves and artery walls compatible with vasculitis and disturbances in cerebrospinal fluid (CSF) circulation. The patient was treated with ceftriaxone for 2 weeks. Two years later, the patient had an ischemic stroke. Brain magnetic resonance angiography revealed multiple aneurysms, which were not present previously. The largest aneurysm was operated rapidly. The patient was treated with another course of intravenous ceftriaxone for 4 weeks and pulse therapy with corticosteroids. He recovered well.Conclusion: . This unique case demonstrates complications of LNB that can result in serious morbidity or even mortality. Lumbar puncture and analysis should be considered for paediatric patients with epileptic seizures or cerebrovascular events living in a Lyme borreliosis endemic area.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 4","pages":"e005090"},"PeriodicalIF":0.0,"publicationDate":"2017-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630958/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35446416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An unusual cutaneous infection caused by Mycobacterium marinum. 由海洋分枝杆菌引起的一种不寻常的皮肤感染。

JMM case reports Pub Date : 2017-04-12 eCollection Date: 2017-04-01 DOI: 10.1099/jmmcr.0.005088

Federica Veronese, Elisa Zavattaro, Pamela Farinelli, Enrico Colombo, Paola Savoia

{"title":"An unusual cutaneous infection caused by Mycobacterium marinum.","authors":"Federica Veronese, Elisa Zavattaro, Pamela Farinelli, Enrico Colombo, Paola Savoia","doi":"10.1099/jmmcr.0.005088","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005088","url":null,"abstract":"Introduction.Mycobacterium marinum is a non-tubercular mycobacterium residing in fresh or salt water (in tropical or temperate areas); it is a fish and human pathogen, and in immunocompromised patients can cause severe cutaneous and subcutaneous infections. Case presentation. A 46-year-old white man who underwent immunosuppressive therapy was admitted to our department in May 2016 for skin lesions previously diagnosed as 'unusual erysipelas'. We rejected the hypothesis of erysipelas, due to the clinical features, and our diagnostic hypotheses were oriented towards sporotrichosis, atypical mycobacteriosis, cutaneous tuberculosis and cutaneous sarcoidosis. Histological examination performed after a skin biopsy was compatible with a diagnosis of sporotrichosis. However, PCR performed on fresh tissue demonstrated the presence of M. marinum. Conclusion. The case reported is interesting for the unusual clinical localization and modality of infection. The patient became infected by contact with contaminated remains or in the sea, in a geographical area not endemic for M. marinum. The previous state of immunosuppression favoured infection; however, the presence of M. marinum in this area suggests a possible tropicalization of the water of the Mediterranean Sea. To our knowledge, this case is the only one reported in the literature with this modality of infection and in that geographical area.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 4","pages":"e005088"},"PeriodicalIF":0.0,"publicationDate":"2017-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35446414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

First report of fatal disseminated microsporidiosis in two inland bearded dragons Pogona vitticeps in Japan. 首次报告日本两只内陆胡须龙（Pogona vitticeps）感染致命的播散性微孢子虫病。

JMM case reports Pub Date : 2017-04-12 eCollection Date: 2017-04-01 DOI: 10.1099/jmmcr.0.005089

Kojiro Shibasaki, Toshihiro Tokiwa, Akihiro Sukegawa, Hirotaka Kondo, Kenichi Tamukai, Yumiko Haga, Kazunori Ike

{"title":"First report of fatal disseminated microsporidiosis in two inland bearded dragons Pogona vitticeps in Japan.","authors":"Kojiro Shibasaki, Toshihiro Tokiwa, Akihiro Sukegawa, Hirotaka Kondo, Kenichi Tamukai, Yumiko Haga, Kazunori Ike","doi":"10.1099/jmmcr.0.005089","DOIUrl":"10.1099/jmmcr.0.005089","url":null,"abstract":"Introduction.Encephalitozoon pogonae is a newly described pathogen belonging to the phylum Microsporidia. In Austria and the USA, this species has been isolated from fatal and disseminated cases of captive-bred inland bearded dragons. Here, we report the case of fatal disseminated microsporidiosis caused by E. pogonae in two bearded dragons in Japan. Case Presentation. The two lizards from different private households in Tokyo, Japan, had been brought to an animal hospital for examination. In both cases, the animal presented with a history of weight loss for several weeks. There were no improvements in clinical symptoms and the lizards deteriorated and finally died. Histopathological examination demonstrated necrotizing granulomatous inflammation attributed to disseminated microsporidian infection. Nucleotide sequencing of the nuclear ribosomal internal transcribed spacer region identified the microsporidian as E. pogonae with sequence identity of 100 %. Conclusion. We report the first case, to our knowledge, of disseminated microsporidiosis caused by E. pogonae in inland bearded dragons in Japan. Although it is difficult to diagnose prenatally since the signs are nonspecific, the disease should be considered in the differential diagnosis of chronic infections that do not respond to antibiotics.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 4","pages":"e005089"},"PeriodicalIF":0.0,"publicationDate":"2017-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35446415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner. 西伯利亚哈士奇犬主人的一种新型假中间葡萄球菌引起的皮肤感染。

JMM case reports Pub Date : 2017-03-20 eCollection Date: 2017-03-01 DOI: 10.1099/jmmcr.0.005087

Andrew R Robb, Elizabeth D Wright, Adele M E Foster, Robert Walker, Colin Malone

{"title":"Skin infection caused by a novel strain of Staphylococcus pseudintermedius in a Siberian husky dog owner.","authors":"Andrew R Robb, Elizabeth D Wright, Adele M E Foster, Robert Walker, Colin Malone","doi":"10.1099/jmmcr.0.005087","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005087","url":null,"abstract":"Introduction.Staphylococcus pseudintermedius, an opportunistic pathogen of dogs and cats, is rarely reported to cause infection in humans. Here, we describe a case of severe skin infection caused by S. pseudintermedius, in a 47-year-old male, a dog owner; to the best of our knowledge, this is the first such case reported from Scotland. Case presentation. The patient presented with a short history of a severe ecthyma-like lesion on his forehead, with smaller lesions on his abdomen and legs. Bacterial culture revealed Clostridium perfringens, thought to be colonizing the wound, and a Staphylococcus species, identified as S. pseudintermedius by matrix-assisted laser desorption/ionization-time of flight MS and confirmed by molecular methods using a PCR-RFLP approach. The patient was treated with flucloxacillin, penicillin V and Fucibet cream, and recovered fully. Zoonotic infection was considered likely; however, screening swabs from his dogs grew S. pseudintermedius of a different clonal type. Both patient and dog strains carried Staphylococcus intermedius exfoliative toxin and leucocidin I, closely related to Panton-Valentine leucocidin, possibly contributing to the severity of the infection. S pseudintermedius, although coagulase positive, is normally negative by rapid slide clumping and latex agglutination tests routinely used to identify Staphylococcus aureus. Hence, S. pseudintermedius may easily be misidentified as a coagulase-negative staphylococcus and considered insignificant. Conclusion. This is, to the best of our knowledge, the first reported case of a human S. pseudintermedius infection in Scotland. Zoonotic transmission of S. pseudintermedius between pets and owners has been shown. However, in this case zoonosis could not be confirmed.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 3","pages":"jmmcr005087"},"PeriodicalIF":0.0,"publicationDate":"2017-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5382809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35130434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

A cardiac implantable device infection by Raoultella planticola in an immunocompromized patient. 免疫功能低下患者的心脏植入式装置感染。

JMM case reports Pub Date : 2017-02-28 eCollection Date: 2017-02-01 DOI: 10.1099/jmmcr.0.005080

Chandra Adjodah, Chistophe D'Ivernois, David Leyssene, Jean-Baptiste Berneau, Yann Hemery

{"title":"A cardiac implantable device infection by Raoultella planticola in an immunocompromized patient.","authors":"Chandra Adjodah, Chistophe D'Ivernois, David Leyssene, Jean-Baptiste Berneau, Yann Hemery","doi":"10.1099/jmmcr.0.005080","DOIUrl":"https://doi.org/10.1099/jmmcr.0.005080","url":null,"abstract":"Introduction. Infection of cardiac implantable electronic devices is a severe condition associated with high mortality, particularly in patients who are dependent upon heart-pacing devices. Staphylococci are found in 70 % of reported cases. Case presentation. We report the case of a cardiac-pacemaker infection in a 79-year-old man, cumulating a history of rheumatoid arthritis treated by corticosteroids and methotrexate by a recently identified micro-organism: Raoultella planticola. He presented local signs of infection on his VVI pacemaker implantation site and underwent urgent pocket device replacement under cefamandole antibioprophylaxis. On incision thick pus oozed out. It was necessary to perform a complete hardware extraction comprising the pulse generator and the ancient lead. Pus was inoculated into aerobic and anaerobic culture vials and Gram staining unveiled Gram-negative rods. Microbiology analysis identified the organism as R. planticola. A new pacing device was inserted on the contrlateral pectoral region. Ciprofloxacin enabled full recovery. A literature review concerning this pathogen revealed that it is involved in severe infections such as bloodstream infections, peritonitis, cellulitis, pneumonia and lung abscesses, and urinary tract infections. In these case reports, underlying co-morbidities were identified such as solid active neoplasia, recent chemotherapy, corticosteroids, solid-organ-recipient patients and recent open surgery. Conclusion.R. planticola is a serious emerging pathogen and contributes to the burden of various infectious conditions. Its pathogenicity and occurrence should be known by clinicians and a high level of awareness is necessary to precisely identify it provide the correct antibiotic regimen.","PeriodicalId":73559,"journal":{"name":"JMM case reports","volume":"4 2","pages":"e005080"},"PeriodicalIF":0.0,"publicationDate":"2017-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5361635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34860843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Successful treatment of Listeria monocytogenes prosthetic valve endocarditis using rifampicin and benzylpenicillin in combination with valve replacement. 利福平、青霉素联合瓣膜置换术成功治疗单核增生李斯特菌人工瓣膜心内膜炎。

JMM case reports Pub Date : 2017-02-28 eCollection Date: 2017-02-01 DOI: 10.1099/jmmcr.0.005085

Tasnim Hasan, William Chik, Sharon Chen, Jen Kok

引用次数: 7