Leanne M Cleaver, Shara Palanivel, Damien Mack, Simon Warren
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引用次数: 0
摘要
导言。我们在此介绍一例多微生物厌氧性脊椎盘炎病例。病例介绍。一名四十五岁的女性患者因背部疼痛八周,无发烧症状,被转诊至骨科专科医院。X 射线成像和磁共振成像显示第十二胸椎和第一腰椎有急性骨髓炎。经过长时间的富集培养,培养出了微小副杆菌和核分枝杆菌,并通过基质辅助激光解吸电离飞行时间(MALDI-ToF)质谱(MS)进行了鉴定。患者接受了为期六周的静脉注射厄他培南和口服克林霉素的治疗,并取得了成功。结论:厌氧性椎间盘炎非常罕见。厌氧菌性椎间盘炎非常罕见,而多菌性椎间盘炎则更为罕见。PubMed 文献综述显示,仅有 7 例核不动杆菌椎间盘炎病例和 12 例小核不动杆菌椎间盘炎病例;其中仅有一例因同时感染两种厌氧菌而导致多菌性椎间盘炎的报道。我们强调在这些感染中延长富集培养时间和使用 MALDI-ToF MS 快速而准确地鉴定厌氧菌的重要性。
A case of polymicrobial anaerobic spondylodiscitis due to Parvimonas micra and Fusobacterium nucleatum.
Introduction. Here, we present a case of polymicrobial anaerobic spondylodiscitis. Case Presentation. A forty-five year-old female patient was referred to a specialist orthopaedic hospital with an eight week history of back pain without fevers. X-ray imaging and magnetic resonance imaging showed acute osteomyelitis of the twelfth thoracic and first lumbar vertebrae. Prolonged enrichment cultures grew Parvimonas micra and Fusobacterium nucleatum, identified by matrix-assisted laser desorption ionisation-time of flight (MALDI-ToF) mass spectrometry (MS). The patient was successfully treated with six weeks of intravenous ertapenem and oral clindamycin. Conclusion. Anaerobic discitis is rare, and polymicrobial discitis is rarer still. A PubMed literature review revealed only seven cases of F. nucleatum discitis and only twelve cases of P. micra discitis; this includes only one other reported case of a polymicrobial discitis due to infection with both anaerobes. We emphasise the importance of prolonging enrichment culture and the use of fast yet accurate identification of anaerobes using MALDI-ToF MS in these infections.