JADA foundational science最新文献

{"title":"A combination treatment of low-dose dexamethasone and aspirin-triggered resolvin D1 reduces Sjögren syndrome–like features in a mouse model","authors":"Harim Tavares dos Santos DDS, PhD ,&nbsp;Frank Maslow BS ,&nbsp;Kihoon Nam PhD ,&nbsp;Bryan Trump DDS ,&nbsp;Gary A. Weisman PhD ,&nbsp;Olga J. Baker DDS, PhD","doi":"10.1016/j.jfscie.2022.100016","DOIUrl":"10.1016/j.jfscie.2022.100016","url":null,"abstract":"<div><h3>Background</h3><p>Sjögren syndrome (SS) is an autoimmune disease characterized by lymphocytic infiltration and diminished secretory function of the salivary glands. Dexamethasone (DEX) resolves dry mouth and lymphocytic infiltration; however, this treatment is difficult to maintain because of multiple adverse effects (eg, osteoporosis and skin thinning); likewise, aspirin-triggered resolvin D1 (AT-RvD1) increases saliva secretion but cannot eliminate lymphocytic infiltration. Previous studies showed that a combination of low-dose DEX with AT-RvD1 before disease onset prevents SS-like features in a mouse model; however, this is not clinically practical because there are no reliable indicators of SS before disease onset. Therefore, the authors applied the combined treatment at disease onset to show its efficacy and comparative lack of adverse effects, so that it may reasonably be maintained over a patient’s lifetime.</p></div><div><h3>Methods</h3><p>NOD/ShiLtJ mice were treated with ethanol (vehicle control), high-dose DEX alone, AT-RvD1 alone, or a combination of low-dose DEX with AT-RvD1 at disease onset for 8 weeks. Then saliva flow rates were measured, and submandibular glands were harvested for histologic analyses.</p></div><div><h3>Results</h3><p>A combined treatment of low-dose DEX with AT-RvD1 significantly decreased mast cell degranulation and lymphocytic infiltration, increased saliva secretion, and restored apical aquaporin-5 expression in submandibular glands of NOD/ShiLtJ mice.</p></div><div><h3>Conclusions</h3><p>Low-dose DEX combined with AT-RvD1 reduces the severity of SS-like manifestation and prevents the development of advanced and potentially irreversible damage, all in a form that can reasonably be administered indefinitely without the need to cease treatment because of secondary effects.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":"Article 100016"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6b/14/nihms-1926175.PMC10448398.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10459157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive dental materials","authors":"Jack L. Ferracane PhD ,&nbsp;Sharanbir K. Sidhu BDS, MSc, PhD ,&nbsp;Mary Anne S. Melo DDS, MSc, PhD, FADM ,&nbsp;In-Sung Luke Yeo DDS, MSD, PhD ,&nbsp;Anibal Diogenes DDS, MS, PhD ,&nbsp;Brian W. Darvell DSc","doi":"10.1016/j.jfscie.2023.100022","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100022","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico study of hyposalivation and sugar exposure on biofilm dysbiosis","authors":"David Head PhD ,&nbsp;Philip D. Marsh PhD ,&nbsp;Deirde Devine PhD ,&nbsp;Livia M.A. Tenuta DDS, MS, PhD","doi":"10.1016/j.jfscie.2022.100019","DOIUrl":"10.1016/j.jfscie.2022.100019","url":null,"abstract":"<div><h3>Background</h3><p>Dental caries develops under actively sugar-fermenting dental biofilms, but the most successful control methods available only target mineral loss. Reduced salivary flow rates (hyposalivation) significantly exacerbate caries progression by lessening sugar and acid clearance near tooth surfaces. Maintaining dental biofilm symbiosis (health) under hyposalivation requires knowledge of the impact of acid inhibition under given dietary regimens.</p></div><div><h3>Methods</h3><p>An individual-based mathematical model was used to predict biofilm dysbiosis under normal or hyposalivatory conditions by regulating the frequency of sugar intake and inhibiting microbial glycolysis, reducing the acid challenge to the tooth mineral. The impact of pH-dependent (stronger inhibition at lower pH [eg, fluoride]) and pH-independent (general percentage reduction in acid production) strategies on pH near the tooth surface during sugar intake, and the corresponding compositional changes in the biofilm, were quantified.</p></div><div><h3>Results</h3><p>Under normal saliva flow, reducing the frequency of sugar intake and increasing the inhibition of acid production by pH-dependent or pH-independent strategies could prevent bacterial dysbiosis and prevent the biofilm from having a caries-associated (dysbiotic) to a health-associated (symbiotic) composition. However, under hyposalivatory conditions, dysbiosis occurred beyond 2 sugar intakes per day, and the degree of inhibition of glycolysis required to prevent dysbiosis was not feasible with available therapeutics.</p></div><div><h3>Conclusions</h3><p>Model data predict that to counteract the drastic effect of hyposalivation on biofilm dysbiosis, it will be essential to significantly reduce the frequency of fermentable sugar intake and any direct inhibition of bacterial metabolism.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":"Article 100019"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46203290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular systems architecture of host-microbiome interactions in periodontitis","authors":"V.A. Shiva Ayyadurai PhD ,&nbsp;Prabhakar Deonikar PhD ,&nbsp;Philip Stashenko DMD, PhD","doi":"10.1016/j.jfscie.2023.100026","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100026","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of carbonate removal and demineralization inhibition in primary teeth using a 9.3-μm carbon dioxide laser","authors":"Ali Badreddine PhD ,&nbsp;Vijayashankar Ramareddy PhD ,&nbsp;Charles Kerbage PhD","doi":"10.1016/j.jfscie.2022.100017","DOIUrl":"https://doi.org/10.1016/j.jfscie.2022.100017","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49775943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of vertical load and speed on toothbrush stiffness measurements","authors":"Ashley N. Bowers MS ,&nbsp;Christina M. Tyrakowski PhD ,&nbsp;Jamie Spomer PhD ,&nbsp;Prerna Gopal BDS, PhD","doi":"10.1016/j.jfscie.2023.100023","DOIUrl":"10.1016/j.jfscie.2023.100023","url":null,"abstract":"<div><h3>Background</h3><p>Dental abrasion can be caused by aggressive brushing or using a toothbrush with stiff bristles. Because this damage to the oral cavity is irreversible, prevention is ideal. The international standards for testing toothbrushes for safety and efficacy are International Organization for Standardization (ISO) 22254, ISO 20126, and ISO 20127. American National Standards (ANSI)/American Dental Association (ADA) 119 is an adoption of ISO 22254 and ISO 20126 for manual toothbrushes, and ANSI/ADA 120 is an adoption of ISO 20127 for powered toothbrushes. ISO 22254 contains a test method for the resistance of the tufted portion to deflection, from which toothbrush stiffness is calculated. Key variables of this test method, such as changing the vertical load (VL) applied to the tufted portion of the brush head during testing and changing the velocity of the brushing table of the toothbrush stiffness test machine, were examined.</p></div><div><h3>Methods</h3><p>Twenty-eight different manual (n = 5) and powered (n = 23) toothbrushes were tested with modification according to the resistance to deflection method in ANSI/ADA 119. The means of the stiffness values at each VL or brushing table velocity for each toothbrush were compared using 2-sample <em>t</em> tests.</p></div><div><h3>Results</h3><p>Most of the toothbrush stiffness values were statistically significantly different at different VLs. However, most toothbrush stiffness values exhibited no statistical differences between the 2 velocities tested.</p></div><div><h3>Conclusions</h3><p>Most modern toothbrushes cannot withstand the VL required in the ANSI/ADA standard. The VL used for testing significantly affects stiffness measurements, whereas the velocity of the brushing table during testing did not significantly affect the stiffness values obtained.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":"Article 100023"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44249486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the risk of <i>Enterococcus faecalis</i> cross-contamination of gutta-percha cartridges.","authors":"Whitney A Smith, Carissa A Hutchison, Rodney V Scott, Susan E Hinman, Nancy H Osborne, Nicholas J Hamlin, Kristi L Frank","doi":"10.1016/j.jfscie.2023.100021","DOIUrl":"10.1016/j.jfscie.2023.100021","url":null,"abstract":"<p><strong>Background: </strong>Gutta-percha (GP) cartridges are intended for a single patient and are not considered sterile. Providers may use these cartridges in multiple canals of a single tooth or multiple teeth on the same patient without disinfection between uses, creating the potential for bacteria to be transferred between canal systems. <i>Enterococcus faecalis</i> is a hardy bacterial species often isolated from failed root canal treatments. This study tested if GP cartridges have the potential to cross-contaminate root canals with <i>E. faecalis</i>. Methods for GP cartridge disinfection were also evaluated.</p><p><strong>Methods: </strong>Twenty-three-gauge medium-body GP cartridges placed in an obturation unit were purposefully contaminated with 1 of 3 concentrations of <i>E. faecalis</i> strain OG1RF. Contaminated cartridges were either (1) wiped with an alcohol swab, (2) heated with GP extrusion while in the bacterial culture, (3) heated with GP extrusion while in the bacterial culture and then wiped with an alcohol swab, or (4) not disinfected after removal from the bacterial culture (control). Bacteria were dislodged into a fresh medium by sonication, and the number of viable bacteria recovered from the tips was measured.</p><p><strong>Results: </strong>Viable cultures of <i>E. faecalis</i> could not be recovered consistently from tips in the control and disinfection treatment conditions.</p><p><strong>Conclusions: </strong>Cross-contamination of root canals with <i>E. faecalis</i> with the GP cartridge is unlikely.</p>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12345616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Show me “Bioactive!”","authors":"Jack L. Ferracane PhD","doi":"10.1016/j.jfscie.2023.100027","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100027","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ease of use in accessing electronic dental records with a touchless interface compared with a conventional mouse","authors":"Tudor Ilies BS ,&nbsp;Nicholas Camic DMD ,&nbsp;Aditya Tadinada DDS, MDentSci","doi":"10.1016/j.jfscie.2023.100024","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100024","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The growth and dissolution of sodium fluoride hopper crystals","authors":"Alexis N. Frigyes BS, MS ,&nbsp;Jacqueline Holdren ,&nbsp;William A. McHale BS ,&nbsp;Mark A. Latta BS, MS, DMD ,&nbsp;Stephen M. Gross BS, PhD","doi":"10.1016/j.jfscie.2022.100020","DOIUrl":"https://doi.org/10.1016/j.jfscie.2022.100020","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"2 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49783714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}