JADA foundational science最新文献

{"title":"Pooling individual samples","authors":"Carissa Comnick MS , Cristina de Mattos Pimenta Vidal DDS, MS, PhD , Xian Jin Xie PhD","doi":"10.1016/j.jfscie.2022.100005","DOIUrl":"10.1016/j.jfscie.2022.100005","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100005"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X22000019/pdfft?md5=dac25407347df5720a6f40f1079319b7&pid=1-s2.0-S2772414X22000019-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative evaluation of the metallic artifact generated by a ceramic dental implant and a titanium dental implant imaged on cone-beam computed tomographic scans","authors":"Emma K. Warren BS ,&nbsp;Anusha Vaddi MDS ,&nbsp;Aditya Tadinada MDS","doi":"10.1016/j.jfscie.2022.100007","DOIUrl":"10.1016/j.jfscie.2022.100007","url":null,"abstract":"<div><h3>Background</h3><p>Dental implants are becoming the treatment of choice for restoring edentulous sites. Dental implants are typically made of a titanium alloy, and this produces a metallic artifact that obscures adjacent anatomy when imaged using x-radiation, specifically on cone-beam computed tomographic (CBCT) scans. This artifact makes it challenging to evaluate peri-implant bone levels and any associated pathology. It was hypothesized that the introduction of ceramic implants would help in overcoming this challenge due to the nature and composition of the ceramic. The objective of this study was to compare the metallic artifact produced by ceramic and titanium dental implants when imaged with CBCT.</p></div><div><h3>Methods</h3><p>Dental implants were placed in the edentulous sites of 2 dry human skulls, and CBCT scans with a standard 360° acquisition and a low-dose 180° acquisition were obtained. The metallic artifact generated by the implants was measured quantitatively using pixel intensity values and qualitatively using a modified Likert scale.</p></div><div><h3>Results</h3><p>Average pixel intensity values, by gnathic region, ranged from 123.5 through 507 for titanium implants and 500 through 1,088.5 for ceramic implants. Qualitative analysis showed that ceramic implants produced more metallic artifact than titanium implants. Intraoperator and interoperator reliabilities assessed using Cronbach α showed consistency for both qualitative and quantitative analyses.</p></div><div><h3>Conclusion</h3><p>Ceramic dental implants produced significantly more metallic artifact when imaged on CBCT scans than titanium implants.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100007"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X22000032/pdfft?md5=ce0a0ae2a4df6351805076ef6948aadb&pid=1-s2.0-S2772414X22000032-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton pump inhibitors are associated with reduced periodontal disease severity","authors":"Paul A. Herrmann DDS ,&nbsp;Robert E. Cohen DDS, MS, PhD ,&nbsp;Lisa M. Yerke DDS, MS","doi":"10.1016/j.jfscie.2022.100011","DOIUrl":"10.1016/j.jfscie.2022.100011","url":null,"abstract":"<div><h3>Background</h3><p>Proton pump inhibitors (PPIs), such as omeprazole, esomeprazole, and pantoprazole, are frequently prescribed to treat acid-related gastrointestinal diseases. PPIs inhibit the hydrogen potassium–adenosine triphosphatase proton pump in gastric parietal cells, decreasing acid release. However, PPIs also affect bone metabolism by altering mineralization and resorption rates and inducing changes in the gastrointestinal microbiota. Therefore, the authors assessed whether PPIs also might be associated with periodontal pathogenesis.</p></div><div><h3>Methods</h3><p>Medical and dental records (N = 1,017) of patients seeking treatment at the School of Dental Medicine at the State University of New York, University at Buffalo Postgraduate Periodontics Clinic (2010-2017) were reviewed to obtain periodontal status, medication history, systemic diseases and conditions, and demographic information. Patients who received a diagnosis of generalized periodontitis stages III through IV, grades B through C were further assessed in this study (n = 518).</p></div><div><h3>Results</h3><p>A statistically significant inverse relationship was found between the use of PPIs and the percentage of teeth with 6 mm or greater probing depths. That relationship persisted after adjusting for diabetes, smoking, and the presence of systemic factors. The prevalence of pocket depths 6 mm or greater was 13.1% in patients taking PPIs vs 19.9% in patients not taking PPIs (group difference, 6.8%; 34.2% decrease; 95% CI, 2.1% to 11.6%; <em>P</em> = .006). There were no statistically significant differences in oral hygiene efficacy or age in the PPI vs non-PPI groups (<em>P</em> &gt; .05), implying that either potentially confounding factor did not influence the observed results.</p></div><div><h3>Conclusions</h3><p>The use of PPIs is associated with less severe periodontal disease.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100011"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X2200007X/pdfft?md5=ffe626ab0d6f6cd13599b7428bdcd79f&pid=1-s2.0-S2772414X2200007X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofilm disruption and bactericidal activity of aqueous ozone coupled with ultrasonic dental scaling","authors":"Kevin C. Failor PhD ,&nbsp;Bruce Silver DMD ,&nbsp;Westin Yu BS ,&nbsp;Jason E. Heindl PhD","doi":"10.1016/j.jfscie.2021.100003","DOIUrl":"10.1016/j.jfscie.2021.100003","url":null,"abstract":"<div><h3>Background</h3><p>The COVID-19 pandemic has heightened the awareness of a common hazard encountered in the dental clinic: aerosol transmission of pathogens. Treatment of sources of infection before or during dental procedures is one means of decreasing pathogen load and aerosol transmission.</p></div><div><h3>Methods</h3><p>An ultrasonic scaler supplied with aqueous ozone was used to examine the effect of its viability on planktonic cultures and biofilms formed by 2 model bacteria: <em>Rothia mucilaginosa</em> and <em>Escherichia coli</em>.</p></div><div><h3>Results</h3><p>Both organisms showed susceptibility to aqueous ozone alone (97% and 99.5% lethality, respectively). When combined with manual scaling using an ultrasonic scaler, a greater than 99% reduction in colony-forming units (CFUs)/mL could be reached with an aqueous ozone concentration of approximately 2 mg/L (<em>R. mucilaginosa</em>) or 0.75 mg/L (<em>E. coli</em>) after 5 through 6 seconds of scaling.</p></div><div><h3>Conclusions</h3><p>Aqueous ozone coupled with ultrasonic scaling exhibited a higher efficiency of microbial kill than either method used alone<strong><em>.</em></strong> Both gram-positive and gram-negative species were affected by this treatment. Studies on other oral microbiota constituents, including fungi and viruses, will provide information on the efficacy of this method on a greater biological scale. Studies to verify concomitant reduction of microbial load in dispersed aerosols in clinical settings should be completed to support practical applications of this treatment.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100003"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8820975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10267378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of silver diamine fluoride on the remineralization of early enamel carious lesions under pH-cycling conditions","authors":"Parand Sorkhdini DVM, PhD ,&nbsp;Yasmi O. Crystal DMD, MSc, FAAPD ,&nbsp;Qing Tang MS ,&nbsp;Frank Lippert PhD","doi":"10.1016/j.jfscie.2022.100006","DOIUrl":"10.1016/j.jfscie.2022.100006","url":null,"abstract":"<div><h3>Background</h3><p>This study explored the in vitro anticaries efficacy of silver diamine fluoride (SDF) in remineralizing early enamel carious lesions.</p></div><div><h3>Methods</h3><p>Lesions were created in human enamel specimens, which were divided into 5 groups (n = 36): SDF (38%), SDF and potassium iodide (SDF and KI), potassium fluoride (KF), silver nitrate (AgNO₃), and deionized water (DIW). Treatments were applied once. Groups were divided into 2 subgroups (n = 18), pH cycled for 5 days with twice-daily treatments with either fluoride or DIW. Vickers hardness number measurements were conducted at each stage. Data were analyzed using a 2-way analysis of variance.</p></div><div><h3>Results</h3><p>The 2-way analysis of variance for ΔVickers hardness number was significant (<em>P</em> &lt; .0001). In both pH-cycling models (with or without fluoride), SDF, SDF and KI, and KF promoted more remineralization than AgNO₃ and DIW (<em>P</em> &lt; .0001). In the presence of twice-daily fluoride treatments, there was no difference between SDF, SDF and KI, and KF (<em>P</em> = .4577). However, in the absence of fluoride treatments, SDF promoted more remineralization than SDF and KI and KF (<em>P</em> &lt; .0001). There were no differences between SDF and KI and KF (<em>P</em> = .4577 and <em>P</em> = .2156; pH-cycling models with and without fluoride, respectively) and AgNO₃ vs DIW (<em>P</em> = .6553 and <em>P</em> = .1194).</p></div><div><h3>Conclusion</h3><p>With the copresence of fluoride, SDF and SDF and KI equally promote remineralization of enamel lesions. KI impairs SDF-related remineralization in the absence of fluoride treatments.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100006"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X22000020/pdfft?md5=c2e01d378799ad70870bf986aa1a389d&pid=1-s2.0-S2772414X22000020-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of abutment screw preload and preload simulation techniques on dental implant lifetime","authors":"Megha Satpathy BS ,&nbsp;Rose M. Jose MS ,&nbsp;Yuanyuan Duan MS, PhD ,&nbsp;Jason A. Griggs PhD","doi":"10.1016/j.jfscie.2022.100010","DOIUrl":"10.1016/j.jfscie.2022.100010","url":null,"abstract":"<div><h3>Background</h3><p>This study aimed to investigate how the predicted implant fatigue lifetime is affected by the loss of connector screw preload and the finite element analysis method used to simulate preload.</p></div><div><h3>Methods</h3><p>A dental implant assembly (DI1, Biomet-3i external hex; Zimmer Biomet) was scanned using microcomputed tomography and measured using Mimics software (Materialise) and an optical microscope. Digital replicas were constructed using SolidWorks software (Dassault Systèmes). The material properties were assigned in Abaqus (Dassault Systèmes). An external load was applied at 30° off-axial loading. Eight levels of connector screw preload (range, 0-32 Ncm) were simulated for DI1. This assembly and an additional model (DI2) having a longer and narrower screw were compared regarding their fatigue limits (using fe-safe software [Dassault Systèmes]) for 2 preloading methods: (1) adding preload torque or (2) adding bolt axial tension.</p></div><div><h3>Results</h3><p>The maximum von Mises stresses of DI1 (on the connector screw threads) with and without preload were 439.90 MPa and 587.90 MPa. The predicted fatigue limit was the same for preloads from 100% through 80% of the manufacturer’s recommendation and dropped precipitously between 80% and 70% preload. Adding a preload torque on the screw resulted in a more uniform stress distribution on the screw compared with bolt axial tension, especially for DI2, which had a longer and narrower screw than DI1.</p></div><div><h3>Conclusions</h3><p>A substantial loss of preload can be accommodated without compromising the fatigue resistance of this dental implant. Computer models should be constructed using torque instead of a bolt axial tension.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100010"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9873498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10583860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Science is organized knowledge","authors":"Jack L. Ferracane PhD","doi":"10.1016/j.jfscie.2021.100001","DOIUrl":"10.1016/j.jfscie.2021.100001","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100001"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X21000013/pdfft?md5=6447ff0e617e1cc695a01cf33cb0daa7&pid=1-s2.0-S2772414X21000013-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The erosive potential of sugar-free waters on cervical dentin","authors":"Scott D. Eckhart DDS, MPH, MS, CPH ,&nbsp;John A. Brewster DDS, MS ,&nbsp;Denice C. Curtis DDS, MPH, DHS","doi":"10.1016/j.jfscie.2022.100009","DOIUrl":"10.1016/j.jfscie.2022.100009","url":null,"abstract":"<div><h3>Background</h3><p>It has been well-documented that highly acidic beverages containing sugar are capable of dental erosion. As dentin has a lower critical pH, it is more susceptible than enamel to erosion. This study aimed to examine the effect of sugar-free water beverages on the erosion of cervical dentin.</p></div><div><h3>Methods</h3><p>Eight beverages were selected, including a positive control and negative control. For each beverage, the pH (n = 5) and total acidity (n = 3) were determined with a digital pH meter. Freshly extracted human premolars were sectioned to create cervical dentin specimens (n = 48). Specimens were imaged using laser profilometry before and after the specimens were challenged with beverages for 24 hours. The 3-dimensional before and after scans were evaluated to determine the change in surface volume, erosion depth, and surface roughness. The data were analyzed with a Kruskal-Wallis with Dunn post hoc test (α = 0.05).</p></div><div><h3>Results</h3><p>The pH of all samples was less than 5.5, except for the negative control. Noncarbonated waters required significantly less base to neutralize the acid than carbonated beverages. A significant difference was realized through profilometry between the carbonated and noncarbonated beverages, with the former displaying increased volume loss, greater depth, and an amplified change in surface roughness.</p></div><div><h3>Conclusion</h3><p>Within the limitations of this study, carbonated beverages have greater potential to cause dentinal erosion. The low total acidity of the noncarbonated waters makes them more likely to be buffered in the oral environment than beverages with carbonation or higher total acidity.</p></div>","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 ","pages":"Article 100009"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772414X22000056/pdfft?md5=1677f439e174dfc479ef7f7bb0f7e115&pid=1-s2.0-S2772414X22000056-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Show me “Bioactive!”","authors":"J. Ferracane","doi":"10.1016/j.jfscie.2023.100027","DOIUrl":"https://doi.org/10.1016/j.jfscie.2023.100027","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survey of the mechanical and physical behaviors of yttria-stabilized zirconia from multiple dental laboratories","authors":"Yifeng Liao, Max Gruber, Henry Lukic, Jim McLees, Si Chen, A. Boghosian, S. Megremis","doi":"10.1016/j.jfscie.2022.100018","DOIUrl":"https://doi.org/10.1016/j.jfscie.2022.100018","url":null,"abstract":"","PeriodicalId":73530,"journal":{"name":"JADA foundational science","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54466304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}