iRadiology最新文献

{"title":"A canine acute coronary occlusion model using thrombus implantation by percutaneous coronary intervention","authors":"Ting Ma,&nbsp;Ling Jie Yang,&nbsp;Yanqiu Zhang,&nbsp;Alimina Awen,&nbsp;Lina Guan,&nbsp;Yuming Mu","doi":"10.1002/ird3.38","DOIUrl":"10.1002/ird3.38","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To establish an acute canine coronary artery occlusion model by implanting a mixed thrombus prepared in vitro into the coronary artery by percutaneous coronary intervention (PCI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study included 14 healthy Beagle dogs aged 10–13 months. First, 5 ml of canine venous blood was drawn to prepare the coronary artery thrombus in vitro. The thrombus was then implanted into the canine coronary artery by PCI to establish an animal model of acute coronary artery occlusion. Dogs were randomly divided into two experimental groups: group A, in which dogs were assessed for 2 h after coronary occlusion, and group B, in which dogs were assessed for 4 h after surgery. Baseline and postoperative assessment included cardiac troponin T (cTnT) levels, electrocardiography (ECG), plain and contrast echocardiography, and large-scale digital subtraction angiography (DSA).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Canine venous blood was successfully used to prepare a mixed thrombus with reticular fibrin structure and activated platelets in vitro. After the mixed thrombus was implanted into the coronary artery, large-scale DSA showed no contrast medium perfusion, confirming complete occlusion of the coronary artery. After the coronary artery occlusion, dogs in both groups showed ST segment elevation &gt;0.5 MV, a 0.9 μg/L increase in CTnT (<i>p</i> &lt; 0.001), and increased EDV and ESV. Dogs also showed decreased left ventricular EF and FS and decreased MBF in the infarcted area (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>An experimental model of acute coronary artery occlusion in dogs was successfully established by implanting a mixed thrombus developed in vitro into the coronary artery using minimally invasive PCI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 4","pages":"294-302"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.38","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135728576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of fetal renal artery hemodynamics in normohydramnios, idiopathic oligohydramnios and polyhydramnios in third trimester pregnancy","authors":"Deepak Jain,&nbsp;Rajesh Kumar Singh,&nbsp;Jyoti Jaiswal,&nbsp;Pranjali Mittal,&nbsp;Satyabhuwan Singh Netam","doi":"10.1002/ird3.37","DOIUrl":"10.1002/ird3.37","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the renal artery (RA) flow indices (RI and PI) among normohydramnios, idiopathic oligohydramnios, and polyhydramnios and determine applicability of fetal RA Doppler indices in predicting the pregnancy outcome.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Total 106 3rd trimester pregnant patients were divided into cases and controls based on amniotic fluid index. Routine antenatal and color Doppler (including kidneys) ultrasound was performed for all patients in this study. The postnatal follow-up was done, and the pregnancies having poor outcomes in terms of NICU admissions were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Statistically significant differences were noted when comparing RI and PI values of normohydramnios (0.91 ± 0.04 and 2.38 ± 0.21, respectively) with oligohydramnios (1.02 ± 0.07 and 2.99 ± 0.38, respectively) and polyhydramnios (0.90 ± 0.12 and 2.7 ± 0.84, respectively) independently (<i>p</i> value &lt; 0.05). Our study demonstrated an increase in NICU admissions in the fetus having raised values of RI and PI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Fetal RA RI and PI can be used as an antenatal predictor for the pregnancy outcome associated with idiopathic oligohydramnios; however, fetal RA PI was found to be a better predictor for the pregnancy outcome than fetal RA RI value in our study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 4","pages":"285-293"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.37","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marchiafava–Bignami disease after the white matter lesions: A case report","authors":"Zhiwei Zhou,&nbsp;Qiongxian Chu,&nbsp;Xingyu Du,&nbsp;Chunhua Pan,&nbsp;Hongyan Zhou,&nbsp;Zhongxiang Xu,&nbsp;Zucai Xu,&nbsp;Ping Xu","doi":"10.1002/ird3.36","DOIUrl":"10.1002/ird3.36","url":null,"abstract":"<p>Marchiafava–Bignami disease (MBD) is an uncommon alcoholism-related neuropsychiatric disorder, featured with symmetrical demyelination of part or whole corpus callosum (CC). Previous studies reported follow-up neuroimaging changes with necrosis, cystic degeneration, and atrophy of the CC after the diagnosis of MBD, but it is unclear whether the white matter is damaged before MBD. We report a case of alcoholic MBD whose magnetic resonance imaging revealed structural lesions in the white matter before the typical demyelination of CC during MBD, which support the prior hypothesis that chronic hazardous drinking may initially lead to microstructure abnormalities of the white matter and CC through some possible mechanisms, then microstructure lesions in the CC, and white matter deterioration into extensive demyelination, that is MBD. In future clinical practice, when patients with chronic alcoholism seek treatment for neuropsychiatric disorders, they may need to undergo repeated MRI scans to reveal progressive neuroimaging features before and after MBD.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 4","pages":"385-389"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.36","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136358516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiolabeled imaging agents for Alzheimer's disease","authors":"Jiajun Wu,&nbsp;Kexin Li,&nbsp;Jie Yang,&nbsp;Meiting Mao,&nbsp;Yan Cheng","doi":"10.1002/ird3.35","DOIUrl":"10.1002/ird3.35","url":null,"abstract":"<p>Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder with long preclinical and prodromal phases in older people. Molecular imaging is a promising approach for noninvasive in vivo identification and tracking pathophysiological changes. In particular, nuclear neuroimaging in AD has extended beyond traditional evaluation of brain perfusion and glucose metabolism, and has achieved substantial progress over the past 2 decades. To gain a comprehensive understanding of nuclear neuroimaging with different targets in the brain, this review provides an overview of the literature on the current status and recent progress of the development of radioligands for definitive and differential diagnosis of AD.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"2 1","pages":"80-95"},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.35","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136308052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and progress of X-ray, computed tomography, and magnetic resonance imaging radiomics in osteosarcoma","authors":"Teng Peihong,&nbsp;Ren Lingling,&nbsp;Hao Haifeng,&nbsp;Liu Chang,&nbsp;Liu Guifeng","doi":"10.1002/ird3.34","DOIUrl":"https://doi.org/10.1002/ird3.34","url":null,"abstract":"<p>Looking back on the development of radiomics in osteosarcoma over recent years, in addition to distinguishing osteosarcoma from other malignant bone tumors (mainly Ewing's sarcoma), more research directions are using radiomics to evaluate and predict the efficacy and survival of patients undergoing neoadjuvant chemotherapy. Among the three commonly used examination methods of X-ray, CT, and magnetic resonance imaging (MRI), more and more studies have been conducted on MRI-based radiomics, which fully reflects the advantages of MRI's high soft tissue contrast, multi-sequence imaging, and most of the studies used a combination of imaging features and clinical features to make predictions. Some articles also considered relevant laboratory examination results and more and more studies are performing external verification. The field is now gradually developing toward multidimensional data and multicenter cooperation and data sharing.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 3","pages":"262-268"},"PeriodicalIF":0.0,"publicationDate":"2023-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.34","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50150560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo visualization of immunosuppressive cells in the tumor microenvironment","authors":"Guangfa Bao,&nbsp;Jianyuan Zhou,&nbsp;Siyuan Cheng,&nbsp;Jun Zhao,&nbsp;Xiaohua Zhu","doi":"10.1002/ird3.33","DOIUrl":"https://doi.org/10.1002/ird3.33","url":null,"abstract":"<p>Immunosuppressive cells are pivotal players in tumor progression by affecting the efficacy of conventional therapies and the prognosis of cancer patients. Visualization and real-time evaluation of these cells are very important to achieve patient-oriented precision oncological medicine. Noninvasive imaging techniques are excellent tools for this purpose, and various molecular imaging probes have been developed to monitor these protumoral immunosuppressive cells in the tumor microenvironment. In this review, we provide a brief update on the biology of immunosuppressive cells and outline recent progress in their visualization.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 3","pages":"269-280"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.33","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50129514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in situ self-assembled peptide derivative for inhibition of glutathione synthesis and selective enhancement of tumor radiotherapy","authors":"Xinyan Gong,&nbsp;Benhang Cui,&nbsp;Paiyun Li,&nbsp;Jie Gao,&nbsp;Yang Gao,&nbsp;Xiaoyao Cai,&nbsp;Hang Wang,&nbsp;Wenxue Zhang,&nbsp;Cuihong Yang","doi":"10.1002/ird3.31","DOIUrl":"https://doi.org/10.1002/ird3.31","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Inhibition of glutathione (GSH) synthesis in cancer cells considerably improves the efficacy of reactive oxygen species (ROS)-related tumor therapy. Self-assembled peptide derivatives can facilitate the efficient delivery and accumulation of small molecular drugs in cancer cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Self-assembling modules were covalently linked to the GSH-biosynthesis inhibitor <span>l</span>-buthionine sulfoximine (BSO) by solid-phase synthesis to form the self-assembling peptide derivative Nap-^DF^DFpY-GG-BSO (Nano-BSO^{@ in situ}). Subsequently, its enzyme-instructed self-assembly in vitro and on cell surfaces were confirmed, and its intracellular GSH depletion and radiotherapy-sensitizing effects were determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nano-BSO^{@ in situ} successfully self-assembles into a hydrogel with a nanofibrous microstructure upon incubation with alkaline phosphatase (ALP) at a critical concentration of 9.84 μM. Furthermore, it selectively self-assembles in situ on HeLa cells with high ALP expression. At a concentration of 50 μM, Nano-BSO^{@ in situ} decreases intracellular GSH levels by 80%, ∼2.3 times more than free BSO. Meanwhile, pretreatment of HeLa cells with 50 μM Nano-BSO^{@ in situ} for 24 h results in a radiotherapy sensitization enhancement ratio to γ-rays of 2.09.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>A novel in situ self-assembling peptide derivative for GSH depletion and selective enhancement of tumor radiotherapy was constructed. The excellent GSH-depletion ability and remarkable radiotherapy-enhancement performance indicate that Nano-BSO^{@ in situ} is a promising selective sensitizer for ROS-related treatment of tumor cells with high ALP expression.</p>\u0000 </section>\u0000 </div>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 3","pages":"199-208"},"PeriodicalIF":0.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.31","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50129886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics in colorectal cancer","authors":"Long Wu,&nbsp;Huan Wu,&nbsp;Chen Li,&nbsp;Baofang Zhang,&nbsp;Xiaoyun Li,&nbsp;Yunhuan Zhen,&nbsp;Haiyang Li","doi":"10.1002/ird3.29","DOIUrl":"https://doi.org/10.1002/ird3.29","url":null,"abstract":"<p>Colorectal cancer (CRC) is a global health challenge with high morbidity and mortality. Radiomics, an emerging field, utilizes quantitative imaging features extracted from medical images for CRC diagnosis, staging, treatment response assessment, and prognostication. This review highlights the potential of radiomics for personalized CRC management. Radiomics enables noninvasive tumor characterization, aiding in early detection and accurate diagnosis, and it can be used to predict tumor stage, lymph node involvement, and prognosis. Furthermore, radiomics guides personalized therapies by assessing the treatment response and identifying patients who could benefit. Challenges include standardizing imaging protocols and analysis techniques. Robust validation frameworks and user-friendly software are needed for the integration of radiomics into clinical practice. Despite challenges, radiomics offers valuable insights into tumor biology, treatment response, and prognosis in CRC. Overcoming technical and clinical hurdles will unlock its full potential in CRC management.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 3","pages":"236-244"},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.29","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50124622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound diagnosis of round ligament varices in pregnancy","authors":"Dragan Vasin,&nbsp;Danijela Sekulić","doi":"10.1002/ird3.32","DOIUrl":"https://doi.org/10.1002/ird3.32","url":null,"abstract":"<p>Varicose veins of the round ligaments during pregnancy are rare with only 16 reported cases in literature in the last 65 years [<span>1</span>]. It can easily be mistaken for an inguinal hernia. Anatomically, the round ligament extends from the lateral uterus to the labium majorus containing veins, arteries, lymphatic channels, and nerves. Round ligament varices are prominent veins within the round ligament and are more common in pregnancy because pregnancy promotes increased venous flow and decreased venous tone [<span>2</span>]. During physical examination, it is difficult to differentiate between round ligament varicosity and inguinal hernia.</p><p>A 29-year-old woman, in the 30th week of pregnancy, presented to the emergency department with a complaint of a small, painless palpable left groin mass. The surgeon's clinical diagnosis was inguinal hernia and she was referred to the radiology department for diagnostic ultrasound. Doppler sonography showed an asymmetric left inguinal mass composed of multiple anechoic tubular ducts (Figure 1) with a venous flow pattern (Figure 2), consistent with round ligament varices. The patient was treated conservatively without any complication in pregnancy.</p><p>The diagnosis of varicosities of the round ligaments can be made on grayscale and color Doppler sonography [<span>2</span>]. Rapid identification and diagnosis of round ligament varices are important to avoid unnecessary surgical treatment. Ultrasound is the gold standard for the diagnosis with a classic gray-scale ultrasound image of a “bag of worms” appearance associated with varicose veins and a venous flow pattern on Doppler imaging [<span>3</span>].</p><p><b>Dragan Vasin:</b> Conceptualization (lead); investigation (equal); visualization (equal). <b>Danijela Sekulić:</b> Conceptualization (equal); investigation (equal); software (equal).</p><p>There are no conflicts of interest to declare.</p><p>Not applicable.</p><p>Authors obtained inform patient consent.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 3","pages":"283-284"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.32","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50148754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alpha-emitters and targeted alpha therapy in cancer treatment","authors":"Jiajia Zhang,&nbsp;Shanshan Qin,&nbsp;Mengdie Yang,&nbsp;Xiaoyi Zhang,&nbsp;Shenghong Zhang,&nbsp;Fei Yu","doi":"10.1002/ird3.30","DOIUrl":"https://doi.org/10.1002/ird3.30","url":null,"abstract":"<p>Alpha emitters are radionuclides with good pharmacological characteristics for the treatment of cancer because they decay by emitting high linear energy transfer particles. Recent advancements in isotope production and purification and the generation of novel techniques for optimum targeting have led to the development of targeted alpha therapy (TAT). The great cytotoxic potential of α-particle emissions combined with monoclonal antibodies, peptides, small compounds, or nanoparticles has led to investigations of TAT in the pre-clinical context and more recently, in oncology clinical trials. Numerous studies have shown that TAT is effective both in vitro and in vivo. The first α-emitter to obtain FDA approval for the treatment of prostate cancer with metastatic bone lesions was radium-223 dichloride. Many clinical trials are being conducted to evaluate the efficiency and safety of several radionuclides in cancer treatment, including radium-223, astatine-211, actinium-225, bismuth-213, lead-212, and thorium-227. This review provides an overview of the therapeutic use of these radionuclides and a summary of the studies that lay the groundwork for future clinical advancement.</p>","PeriodicalId":73508,"journal":{"name":"iRadiology","volume":"1 3","pages":"245-261"},"PeriodicalIF":0.0,"publicationDate":"2023-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ird3.30","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50140788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}