Advances in Nutrition最新文献

{"title":"Impact of Plant-Based Drinks on Cardiometabolic Outcomes: A Systematic Review and Network Meta-analysis","authors":"Sabina Wallerer ,&nbsp;Julia Stadelmaier ,&nbsp;Maria Petropoulou ,&nbsp;Eva Kiesswetter ,&nbsp;Jaqueline Beck ,&nbsp;Elida Sina ,&nbsp;Toni Meier ,&nbsp;Kathrin Sedlmaier ,&nbsp;Martin Kussmann ,&nbsp;Hans Hauner ,&nbsp;Lukas Schwingshackl","doi":"10.1016/j.advnut.2026.100595","DOIUrl":"10.1016/j.advnut.2026.100595","url":null,"abstract":"<div><div>The global demand for plant-based milk alternatives is rising, but their health effects compared with cow milk remain uncertain. Therefore, we conducted a systematic review and network meta-analysis (NMA) to compare different plant-based drinks with each other and with cow’s milk on cardiometabolic outcomes. A systematic search was conducted in 3 electronic databases (MEDLINE, Cochrane CENTRAL, and Web of Science) and 2 trial registries. Randomized controlled trials (RCTs) with a minimum duration of 3 wk comparing different plant-based drinks (e.g., soy, rice, and oat) with another or with cow milk were included. We rated risk of bias using RoB 2.0 tool. Anthropometric outcomes, blood lipids, fasting glucose, and blood pressure were pooled using mean differences (MDs). NMAs were performed using a random-effects model. The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation approach. Fourteen RCTs involving 543 participants were included, comparing soy-, rice-, oat drinks, and cow milk. Overall, few differences were observed comparing plant-based drinks with another or with cow milk on cardiometabolic outcomes. Replacing 500 mL/d of cow’s milk with soy drink may reduce low-density lipoprotein (LDL) cholesterol [MD: –0.47 mmol/L (–0.85; –0.10); low certainty], but showed no effect for high-density lipoprotein (HDL) cholesterol [MD: 0.01 mmol/L (–0.03; 0.05); moderate certainty]. Oat drink may slightly reduce total cholesterol compared with cow milk and rice drink [MD: –0.12 mmol/L (–0.24; –0.01); MD: –0.23 mmol/L (–0.40; –0.05)], but the evidence is very uncertain. Replacing 500 mL/d of cow milk with soy drink may reduce systolic and diastolic blood pressure [MD: –8.23 mmHg (–10.90; –5.55); MD: –7.82 mmHg (–13.61; –2.02); low certainty]. Our findings suggest that evidence for cardiometabolic differences between plant-based drinks and cow milk is limited. However, soy drink may lower blood pressure and LDL cholesterol compared with cow milk. The certainty of evidence was mainly low, highlighting the need for high-quality RCTs.</div><div>This study was registered at PROSPERO as CRD42025638028.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 3","pages":"Article 100595"},"PeriodicalIF":9.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146133631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Limited Evidence of Benefits from Clinical Trials of Human-Identical Milk Oligosaccharides for Infants","authors":"Rupak Shivakoti ,&nbsp;Barbara Laughton ,&nbsp;Jenna Mandell ,&nbsp;Ana Barrios-Tascon ,&nbsp;Reshma Rajendran ,&nbsp;Richard Glashoff ,&nbsp;Lars Bode ,&nbsp;Grace Aldrovandi ,&nbsp;Louise Kuhn","doi":"10.1016/j.advnut.2026.100593","DOIUrl":"10.1016/j.advnut.2026.100593","url":null,"abstract":"<div><div>Human milk oligosaccharides (HMOs) are complex carbohydrates unique to human milk, and a wealth of observational and mechanistic studies indicate that HMOs are key to infant health by supporting gut microbiota and immune development. This review synthesizes evidence from randomized clinical trials evaluating whether supplementation with human-identical milk oligosaccharides (HiMOs), i.e., synthetic HMOs, in infants and young children improves health outcomes. We identified 12 randomized clinical trials: 8 in healthy infants, 3 in special populations of infants, and 1 in young children. We selected only trials with a randomized, parallel group design; most of the included trials also had an observational human milk-fed control group. The most widely evaluated HiMO was 2′-fucosyllactose used alone or in combination with other HiMOs. In some trials, other bioactive components were included in the control and/or intervention formula groups, complicating interpretation. All trials in healthy infants confirmed the noninferiority of HiMO-supplemented formula on growth and tolerability relative to control formula. Results were mixed with respect to reductions in morbidity, and all studies were underpowered for more severe morbidity outcomes. Stool microbiota and biomarkers of inflammation and gut function generally shifted in a direction closer to human milk-fed infants with HiMO intervention. Some growth improvements were noted in association with HiMO intervention in preterm infants and in infants with severe acute malnutrition. HiMO supplementation may be a promising intervention to improve child health, but due to the heterogeneity and limitations of the clinical trials that have been undertaken, many questions remain about the nature of the benefits and the specific populations who might benefit.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 3","pages":"Article 100593"},"PeriodicalIF":9.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Overweight and Obesity and Its Associated Factors among Preschool Children in Sub-Saharan Africa: a Systematic Review and Meta-analysis","authors":"Abdu Hailu Shibeshi ,&nbsp;Zeytu Gashaw Asfaw ,&nbsp;Aragaw Asfaw Hasen ,&nbsp;Kassaye Getaneh Arge ,&nbsp;Nuru Mohammed Hussen ,&nbsp;Abubeker Alebachew Seid ,&nbsp;Abdulkerim Hassen Moloro ,&nbsp;Hiwot Altaye Asebe ,&nbsp;Etsay Woldu Anbesu ,&nbsp;Dejen Kahsay Asgedom ,&nbsp;Molla Getie Mehari ,&nbsp;Bizunesh Fantahun Kase","doi":"10.1016/j.advnut.2026.100594","DOIUrl":"10.1016/j.advnut.2026.100594","url":null,"abstract":"<div><div>Overweight and obesity among preschool children have become significant public health concerns in sub-Saharan Africa (SSA), driven by rapid urbanization, economic growth, and dietary shifts. This systematic review and meta-analysis assessed the prevalence of overweight and obesity and its associated factors among preschool children in SSA. A comprehensive search of peer-reviewed and gray literature was conducted up to 29 January, 2025, using databases such as MEDLINE, ScienceDirect, Research4Life, and <em>African Journals of Online</em>. The study followed Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines. Due to significant heterogeneity (<em>I</em>² = 99.4%, <em>P</em> &lt; 0.001) identified through Cochran’s Q statistic, a random-effects model was used to estimate the pooled prevalence. Publication bias was assessed with funnel plots and Egger’s test. A total of 27 studies (<em>n</em> = 30,805) were included; 77.78% of studies showed a low risk of bias per the Joanna Briggs Institute appraisal tool. The pooled prevalence of overweight/obesity was 14.77% [95% confidence interval (CI): 11.94%, 17.60%]. Key factors associated with overweight/obesity included being aged 2–3 y [odds ratio (OR) = 2.65; 95% CI: 1.73, 4.05] and 48–60 mo (OR = 1.99; 95% CI: 1.33, 2.98), spending over 2 h on screen activities (OR = 3.33; 95% CI: 1.89, 5.84), consuming sweet foods (OR = 2.55; 95% CI: 1.86, 3.48), and having an overweight mother (OR = 3.72; 95% CI: 1.30, 10.65). Given the high prevalence, interventions should focus on promoting healthy diets, reducing screen time, encouraging physical activity, and supporting maternal health and nutrition. The review was registered in PROSPERO as CRD42024560996.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 3","pages":"Article 100594"},"PeriodicalIF":9.2,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145991919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Scoping Review of Sensor-Based Capture of Eating and Drinking Occasions That Could Be Used for Enhancing Personalized Nutrition Interventions in Real Time","authors":"Leanne Wang ,&nbsp;Margaret Allman-Farinelli ,&nbsp;Eric Hekler ,&nbsp;Anna Rangan","doi":"10.1016/j.advnut.2025.100575","DOIUrl":"10.1016/j.advnut.2025.100575","url":null,"abstract":"<div><h3>Background</h3><div>Traditional dietary assessment methods used in nutrition research and practice are self-reported, burdensome, and prone to error, limiting utility. In recent years, sensor-based devices and machine learning approaches have emerged as promising tools for automating eating behavior detection and initiating different approaches to assessing intake. These technologies have potential to enhance dietary assessment and its accuracy, support personalized dietary interventions through real time, context-aware feedback, and reduce burden on respondents and practitioners. A prior 2021 review by the authors concluded that existing devices are not yet feasible for dietetic practice.</div></div><div><h3>Objectives</h3><div>This study aims to conduct a scoping review of sensor-based devices capable of detecting eating and drinking and to evaluate whether recent advancements have improved their feasibility for use in real-world nutrition applications.</div></div><div><h3>Methods</h3><div>A scoping review was conducted using the Preferred Reporting Items for Systematic reviews and Meta-Analyses for Scoping Reviews framework. Studies published between January 2022 and September 2025 that evaluated the performance of sensor-based devices in identifying food and/or beverage intake were included. Devices were evaluated against 6 feasibility criteria to assess real-world applicability: ≥80% accuracy, freedom in food and beverage selection; social acceptability and comfort; long battery life; real-time detection; and ability to detect both eating and drinking.</div></div><div><h3>Results</h3><div>Fifty studies (52 devices) were included: 19 wrist-worn, 8 neck-worn, 7 ear-worn, 7 glasses-type, 6 in the “other” category, and 5 multiposition devices. None met all 6 feasibility criteria. The most common unmet criterion was adequate battery life (<em>n</em> = 43), followed by real-time processing (<em>n</em> = 37), variety of foods or behaviors in testing (<em>n</em> = 31), detection of both eating and drinking (<em>n</em> = 31), social acceptability and comfort (<em>n</em> = 15), and accuracy (<em>n</em> = 10).</div></div><div><h3>Conclusions</h3><div>Although no sensor-based devices met all criteria for real-world feasibility, recent advancements suggest meaningful progress in areas of social acceptability and computational efficiency. These improvements signal a shift toward more practical, user-friendly designs that may soon be capable of supporting automated dietary assessment and individualized nutrition care.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100575"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145812346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal (Bio)Markers and Risk of Obesity – A Comprehensive Scoping Review","authors":"Farhad Vahid ,&nbsp;Alejandra Loyola-Leyva ,&nbsp;Josep Tur ,&nbsp;Cristina Bouzas ,&nbsp;Yvan Devaux ,&nbsp;Laurent Malisoux ,&nbsp;Silvia Garcia ,&nbsp;Magali De Carvalho ,&nbsp;Marina Ródenas-Munar ,&nbsp;Jonathan Turner ,&nbsp;Elsa Lamy ,&nbsp;Maria Perez-Jimenez ,&nbsp;Gitte Ravn-Haren ,&nbsp;Rikke Andersen ,&nbsp;Sarah Forberger ,&nbsp;Rajini Nagrani ,&nbsp;Maria Giovanna Onorati ,&nbsp;Gino Gabriel Bonetti ,&nbsp;Daniela Rodrigues ,&nbsp;Torsten Bohn","doi":"10.1016/j.advnut.2025.100579","DOIUrl":"10.1016/j.advnut.2025.100579","url":null,"abstract":"<div><div>Obesity has been associated with several chronic diseases, especially noncommunicable ones and related comorbidities. Despite international efforts to decrease the prevalence of obesity, the number of persons struggling with this ailment is not decreasing. An important aspect is obesity prevention, including the early detection of the risk, i.e. whether an individual is likely to develop obesity, to allow for early risk stratification and countermeasure initiation. However, obesity is a complex and multifactorial complication, and many factors appear to play a role, including age, sex, diet, physical activity (PA), psychological and emotional status, genetic make-up, epigenetics, and gut microbiota. One isolated biomarker, therefore, could not enable optimal risk stratification and prognosis for the individual; rather, a combined set or multimodal approach to tackle risk prediction is demanded. Such a multimodal interpretation would integrate biomarkers from various domains, such as more classical markers (insulin, leptin), multiomics (e.g. genetics, epigenomics, transcriptomics, proteomics, and metabolomics), behavioral attributes (dietary, PA, and sleep patterns, and smoking status), psychological traits (mental health status, depression, and eating disorders), and gut–microbiota (composition and diversity) into a combined interpretation, also employing more advanced interpretation tools, such as machine learning and artificial intelligence. In this scoping review, we aimed to summarize the current state of the art in this area, highlighting the progress and novel approaches in combating obesity, and focusing on the feasibility and effectiveness of such biomarkers and their application within clinical trials. In addition, we outline potential future steps and recommendations for future approaches.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100579"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Fat Reduction Campaigns and Their Impact on Young Children—The Root Cause of the Obesity Epidemic?","authors":"Marie-Françoise Rolland-Cachera","doi":"10.1016/j.advnut.2025.100576","DOIUrl":"10.1016/j.advnut.2025.100576","url":null,"abstract":"<div><div>After decades of rising obesity rates, key questions about the causes of this epidemic remain unanswered. One major puzzle is the discrepancy between increasing obesity prevalence and decreasing energy and fat intake. Campaigns to restrict fat intake to prevent obesity have led to a decrease in fat consumption; however, little attention has been paid to the specific effect of this advice in early life. This review aims to evaluate the impact of such campaigns on the dietary habits and future health of young children, and to investigate the potential contribution of early nutritional changes to the obesity epidemic. Available data reveal that children’s fat intake has fallen drastically in recent decades, often reaching levels well below official recommendations. Reducing fat intake is not appropriate in early life, when fat is essential for brain development and meeting high energy needs. Early energy restriction can alter the hypothalamic axis, leading to a reduction in leptin level and irreversibly imprinting a “thrifty metabolism.” These mechanisms may decrease basal energy expenditure, develop leptin resistance, and promote fat storage. The unexpectedly high number of structural, functional, and metabolic similarities between undernourished individuals and subjects with obesity suggests a role of early energy restriction in programming obesity. A person with obesity can then be considered an undernourished individual covered with high-fat stores that cannot easily be used. By affecting the early period of life, advice to reduce fat intake to combat obesity may instead have contributed to its increase. This shift in thinking, from overnutrition to undernutrition, to explain the origin of obesity, highlights that fat intake should not be restricted in young children. The novel hypothesis that fat reduction campaigns, by affecting early life, could be a cause of the obesity epidemic should open new avenues for research and prevention.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100576"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145806128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Protein Source Shapes Gut Microbial Structure and Predicted Functional Potential: a Systematic Integrative Re-Analysis Using Machine Learning","authors":"Samson Adedeji Adejumo ,&nbsp;Garry Lewis ,&nbsp;Pritha Das ,&nbsp;Casey Kin Yun Lim ,&nbsp;Judy Malas ,&nbsp;Angus Nnamdi Oli ,&nbsp;Jacob M Allen ,&nbsp;Jarrad Hampton-Marcell","doi":"10.1016/j.advnut.2025.100582","DOIUrl":"10.1016/j.advnut.2025.100582","url":null,"abstract":"<div><div>Dietary proteins shape gut microbial ecology, yet the taxonomic and functional consequences of plant- compared with animal-based proteins remain poorly defined. Although digestibility and fermentation profiles differ by protein type, a systematic evaluation of how these differences influence microbial diversity, community structure, and metabolic capacity is lacking. This study represents a systematic integrative re-analysis of raw 16S rRNA sequencing datasets derived from independent controlled animal feeding studies. Following PRISMA guidelines, we analyzed 16S rRNA sequencing data from 10 murine studies (<em>n</em> = 187) comparing plant- and animal-protein diets. Alpha diversity was assessed using Shannon, Inverse Simpson, and Chao1 indices, and beta diversity with Aitchison distances. Differentially abundant taxa were identified using linear discriminant analysis, effect size, and class-weighted Random Forest (RF) models. Functional potential was inferred with phylogenetic investigation of communities by reconstruction of unobserved states, and taxon-pathway relationships were explored using correlation and network analyses. Plant-protein diets increased gut microbial diversity across all alpha diversity metrics and were associated with higher representation of saccharolytic and nitrogen-recycling genera such as <em>Bacteroides</em>, <em>Muribaculaceae</em>, and <em>Allobaculum</em>. Animal-protein diets favored proteolytic taxa, including <em>Clostridium sensu stricto 1</em> and <em>Colidextribacter</em>. Microbial community structure differed significantly between diets (analysis of similarities <em>R</em> = 0.663, <em>P</em> &lt; 0.001). RF models achieved &gt;88% accuracy (area under the curve = 0.995) in predicting dietary groups, and linear discriminant analysis effect size identified consistent discriminating taxa. Functional profiling showed that plant-based diets enriched pathways linked to short-chain fatty acid and aromatic amino acid metabolism, whereas animal-based diets favored sulfur- and branched-chain amino acid-associated pathways. Network analysis identified <em>Muribaculaceae</em> as a plant-associated hub and Lactobacillus as an animal-associated hub. Dietary protein source significantly influences gut microbiota composition and functional potential in mice. Plant- and animal-based proteins generate distinct metabolic signatures with implications for nitrogen cycling, sulfur metabolism, and microbial ecology. Future controlled dietary studies that harmonize protein source with other macronutrient variables are needed to isolate protein-specific effects.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100582"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145901774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Donating Human Milk on the Health of the Donor and Their Infant: Evidence from Two Systematic Reviews","authors":"Kendall E Baier ,&nbsp;Alaina Berg ,&nbsp;Abigail Smith ,&nbsp;James Evans ,&nbsp;Jaimie Rogner ,&nbsp;Mohammed H Murad ,&nbsp;Tarah Colaizy ,&nbsp;Zulfiqar A Bhutta ,&nbsp;Aamer Imdad","doi":"10.1016/j.advnut.2025.100581","DOIUrl":"10.1016/j.advnut.2025.100581","url":null,"abstract":"<div><div>Using human milk has been associated with decreased morbidity and mortality in preterm/low birth weight infants. Donor human milk is recommended when maternal milk is unavailable. The benefits of donor human milk for the recipient are well documented, but the impact of donation on donors and their infants is not clear. We aimed to evaluate the effects of donation human milk on donors and their infants. Literature searches were conducted (April 2024) to identify studies (observational, quasi-experimental, and randomized control trials) assessing the impact of human milk donation on donor health, nutrition, well-being, and lactation and on their infants’ health, growth, and development. Bias was assessed using the Risk of Bias in Non-randomized Studies – of Interventions scale. Meta-analysis was conducted when possible. Certainty of evidence was assessed using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) approach. Nine studies examined donor outcomes, and 6 studies examined donor infant outcomes. No differences were found between donors and nondonors regarding the prevalence of overweight [risk ratio (RR): 1.27; 95% confidence interval (CI): 0.81, 2.01], postpartum depression (RR: 0.60; 95% CI: 0.21, 1.72), postpartum anxiety (RR: 0.84; 95% CI: 0.59, 1.18), need to pump for their infant (RR: 1.09; 95% CI: 0.63, 1.89), mastitis (RR: 1.48; 95% CI: 0.71, 3.05), chapped/cracked nipples (RR: 0.61; 95% CI: 0.34, 1.12), and breast engorgement (RR: 1.88; 95% CI: 0.94, 3.77). Similarly, no differences were found between donor and nondonor infants regarding feeding intolerance (vomiting) (RR: 1.26; 95% CI: 0.53, 3.01), slow weight gain (RR: 0.36; 95% CI: 0.13, 1.02), oral thrush (RR: 0.55; 95% CI: 0.12, 2.37), or need for phototherapy (RR: 2.21; 95% CI: 0.93, 5.23). The certainty of evidence was very low for all outcomes. Limited, very low certainty evidence does not support any short-term harms or benefits of human milk donation for donors or their infants. The protocols for both studies were registered with the International Prospective Register of Systematic Reviews (PROSPERO) on March 26, 2024. Study IDs: CRD42024529222 and CRD42024528803.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100581"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145879335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective: Infant Feeding Policies among Women Living with HIV in Latin America and the Caribbean: Should They Be Updated?","authors":"Rafael Pérez-Escamilla ,&nbsp;Sonia Hernández-Cordero ,&nbsp;Tarini Gupta","doi":"10.1016/j.advnut.2025.100469","DOIUrl":"10.1016/j.advnut.2025.100469","url":null,"abstract":"<div><div>Among women living with HIV (WLHIV), adherence to highly active antiretroviral treatment (HAART) combined with undetectable maternal viral loads and exclusive breastfeeding during the first 6 mo of life dramatically reduces the risk of mother-to-child transmission of HIV. This knowledge has led to updated World Health Organization infant feeding guidelines for WLHIV, calling for governments to support safe breastfeeding practices among WLHIV who want to breastfeed their infants by providing universal access to HAART, viral load tracking, and high-quality breastfeeding counseling and other needed support across settings. These guidelines eventually led several high-income countries, including the United States and Canada, to revise their infant feeding guidelines that previously contraindicated breastfeeding among WLHIV to incorporate safe, evidence-based breastfeeding recommendations for WLHIV. However, in most of the rest of the Americas, breastfeeding contraindication remains in place. We strongly recommend that all countries in Latin America and the Caribbean consider updating their breastfeeding guidance for WLHIV to allow for safe breastfeeding. Implementing the updated evidence-based recommendations poses major implementation challenges as there is no room for error. Systems-driven implementation science research will be needed to understand how best to codesign, implement, scale up, and sustain intersectoral and equitable person and family-centered policies and programs to empower WLHIV to breastfeed safely if they have the choice to do so.</div></div>","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100469"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to Reference Values for Minerals in Human MIlk: the Mothers, Infants and Lactation Quality (MILQ) Study [Advances in Nutrition Volume 16, Supplement 1 (Oct 2025) 1-15/100431]","authors":"Lindsay H Allen ,&nbsp;M Munirul Islam ,&nbsp;Gilberto Kac ,&nbsp;Kim F Michaelsen ,&nbsp;Sophie E Moore ,&nbsp;Maria Andersson ,&nbsp;Janet M Peerson ,&nbsp;Andrew M Doel ,&nbsp;Daphna K Dror ,&nbsp;Setareh Shahab-Ferdows ,&nbsp;Daniela de Barros Mucci ,&nbsp;Gabriela Torres Silva ,&nbsp;Daniela Hampel ,&nbsp;The MILQ Study Consortium","doi":"10.1016/j.advnut.2025.100578","DOIUrl":"10.1016/j.advnut.2025.100578","url":null,"abstract":"","PeriodicalId":7349,"journal":{"name":"Advances in Nutrition","volume":"17 2","pages":"Article 100578"},"PeriodicalIF":9.2,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145859604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}