Infectious diseases (London, England)最新文献

{"title":"Self-reported executive functioning in adults with congenital cytomegalovirus infection.","authors":"Karolina Falkenius Schmidt, Anastasia Nyström, Johannes Ehinger, Eva Karltorp, Måns Magnusson, Ulrika Löfkvist","doi":"10.1080/23744235.2025.2486714","DOIUrl":"10.1080/23744235.2025.2486714","url":null,"abstract":"<p><strong>Background: </strong>Congenital Cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is yet not well understood, and follow-up studies on adults screened for CMV at birth are few. The aim of this study was to investigate self-reported executive functioning (EF) in adults with cCMV infection in relation to uninfected controls.</p><p><strong>Method: </strong>All individuals from a universal newborn CMV screening study conducted in Southern Sweden and sampled 1977-85, was invited to participate in a follow-up study. 45/71 individuals (63%) with cCMV infection and 25/46 controls (54%) were enrolled. Participants were aged 34-43 years. Neurological symptoms and neuropsychiatric disabilities were documented through written reports from the original study and a semi-structured study protocol. Executive functioning was evaluated with BRIEF-A (questionnaire).</p><p><strong>Results: </strong>No statistically significant differences were found between groups in self-reported executive functioning, although greater variability in outcomes was observed in the cCMV group.</p><p><strong>Conclusion: </strong>Everyday executive functioning might not be affected at the group level in adults with cCMV infection or may not be adequately captured through self-reports alone. The variability in executive functioning results suggests that individuals with cCMV infection represent a more heterogeneous group compared to the controls.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"819-825"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting whole killed virus vaccines for pandemic preparedness: is the NIH's H5N1 strategy a step back or a necessary bet?","authors":"Kehinde Oreoluwa Adebiyi, Ademola Aiyenuro, Sarah Oladejo, Adewunmi Akingbola","doi":"10.1080/23744235.2025.2531160","DOIUrl":"10.1080/23744235.2025.2531160","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"907-912"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of acute undifferentiated febrile illness and acute encephalitis syndrome cases in Northern India: a prospective observational study.","authors":"Pooja Bhardwaj, Ritesh Kumar, Sthita Pragnya Behera, Nalini Mishra, Rajeev Singh, Imbesat Fatma, Ashutosh Tiwari, Moni Kumari, Aishwarya Shukla, Sonal Rajput, Nirbhay Singh, Krishna Kumar Pandey, Rajni Kant, Manoj Murhekar, Hari Shanker Joshi, Gaurav Raj Dwivedi","doi":"10.1080/23744235.2025.2498426","DOIUrl":"10.1080/23744235.2025.2498426","url":null,"abstract":"<p><strong>Purpose: </strong>Acute undifferentiated febrile illness (AUFI) and acute encephalitis syndrome (AES) continue to be major public health concerns, particularly in rural areas with limited healthcare facility. We investigated the aetiological agents responsible for seasonal sporadic AUFI and AES cases in Northern India.</p><p><strong>Method: </strong>The study included 4200 patient samples (April 2022 to March 2024), fulfilling the AUFI or AES case definition. Clinical samples were tested for IgM antibodies against dengue, chikungunya, Japanese encephalitis, scrub typhus, and leptospirosis. Further, <i>Leptospira</i> IgM ELISA positives (<i>n</i> = 79) were also tested by microscopic agglutination test (MAT) assay.</p><p><strong>Results: </strong>In AUFI cases, scrub typhus was the predominant bacterial aetiology (24.6%, 593/2407) followed by leptospirosis (12.4%, 266/2151). Dengue (23.0%, 321/1398) was the leading cause among viral aetiologies. Similarly, among AES cases, scrub typhus (36% in cerebrospinal fluid and 34.3% in serum) remained the most common bacterial aetiology followed by leptospirosis (5.42%, 11/203). Whereas, chikungunya was the predominant viral cause (5.4%, 17/314) behind AES cases. Further, using MAT assay, 7.6% (6/79) of the AUFI samples tested positive for leptospirosis. The prevalent serogroups identified included <i>L. interrogans</i> serovars Australis, Pomona, Hebdomadis, Pyrogenes and Djasiman, and <i>L. borgpetersnii</i> serovar Tarassovi. Housewives constituted the primary risk group for leptospirosis infection, followed by individuals engaged in various farming practices.</p><p><strong>Conclusion: </strong>This study identifies scrub typhus as the predominant and leptospirosis as the second most common infection in sporadic cases of AUFI and AES. Therefore, continuous monitoring of changing aetiologies is crucial for the effective implementation of targeted control and preventive measures for neglected tropical diseases.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"861-872"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailoring ATS/IDSA community-acquired pneumonia guidelines to high-resistance settings: an antibiotic stewardship framework from Lebanon.","authors":"Rana Attieh, Joe Nahal, Rola Husni, Jacques E Mokhbat, Jamil Barhoun, Joumana Kmeid, Mona Youssef, Zahi Helou, Wael Zorkot, Dania Abdallah, Rima Moghnieh","doi":"10.1080/23744235.2025.2527691","DOIUrl":"10.1080/23744235.2025.2527691","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"896-906"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144565494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of septic arthritis diagnosis and disease characteristics in West Sweden.","authors":"Hanna Alexandersson, Mats Dehlin, Tao Jin","doi":"10.1080/23744235.2025.2492606","DOIUrl":"10.1080/23744235.2025.2492606","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to validate the septic arthritis diagnosis using International Classification of Diseases (ICD)-10 codes against the Newman criteria. Additionally, the study presents disease characteristics and compares subgroups.</p><p><strong>Methods: </strong>475 patients with an ICD-10 code for septic arthritis were identified at a university (<i>n</i> = 265) and a county (<i>n</i> = 167) hospital in West Sweden between 2016 and 2019. Medical records were analysed for adherence to the Newman criteria. Clinical data and culture results were compared between the university hospital and the county hospital, as well as between subgroups categorised by the pathogenetic route of infection, including direct inoculation and haematogenous spread infection.</p><p><strong>Results: </strong>91% of the patients fulfilled the Newman criteria (52% positive for synovial culture or PCR, 24% positive culture from blood or elsewhere, and 24% with radiological evidence or turbid synovial fluid). The patient population was predominantly male (62%), with a median age of 69 years, and the knee was the most commonly affected joint (39%). <i>Staphylococcus aureus</i> emerged as the predominant pathogen across all patient groups. 80% had a haematogenous spread septic arthritis, while 20% resulted from direct inoculation. In the haematogenous spread groups, patients were older, with fewer males, but higher CRP levels compared to those in the direct inoculation group.</p><p><strong>Conclusion: </strong>ICD-10 codes for septic arthritis have a positive predictive value of 91% in relation to the Newman criteria in Swedish hospital care, making the utilisation of ICD-10 codes a reliable data source for future epidemiological studies.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"850-860"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144054212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of viral load on severity and mortality in COVID-19.","authors":"Johan Ringlander, Anna Martner, Li Huiqi, Magnus Gisslén, Magnus Lindh, Johan Westin, Fredrik Nyberg, Martin Lagging, Staffan Nilsson, Kristoffer Hellstrand","doi":"10.1080/23744235.2025.2485274","DOIUrl":"10.1080/23744235.2025.2485274","url":null,"abstract":"<p><strong>Background: </strong>The relationship between the initial viral load in respiratory specimens and the severity of COVID-19 is not fully elucidated. Studies on the impact of patient age on the SARS-CoV-2 load have yielded divergent results.</p><p><strong>Objective: </strong>We aimed to investigate the impact of viral load in COVID-19.</p><p><strong>Methods: </strong>We mined a dataset of 259,511 SARS-CoV-2-infected individuals 0-105 years old in which virus RNA was quantified in nasopharyngeal swabs (viral load) using PCR at first healthcare contact. Subjects were stratified by vaccination and pandemic variant wave. Severity was assessed by hospital admission or death. Multivariable models analysed the influence of age on viral load, and viral load on severity.</p><p><strong>Results: </strong>Among non-vaccinated (<i>n</i> = 140,905), viral loads of SARS-CoV-2 were lowest in children 1-9 years old and highest in infants (<1 year old) and in subjects 70-105 years, with similar results across pandemic waves and in vaccinated individuals. High viral load (≥9log₁₀viral RNA copies/swab) associated with elevated risk of hospital admission across age groups. In adults (20-69 years old), mortality was largely confined to those with high viral load (odds ratio [OR] 5.3, 95%CI 3.6-7.3). Among subjects ≥ 70 years old, deaths occurred across viral loads but were more frequent at high viral loads (OR 2.2, 95% CI 1.9-2.6). High viral load associated with hospitalisation and mortality also in vaccinated individuals (<i>n</i> = 118,606).</p><p><strong>Conclusions: </strong>This study identified high viral load at first sampling as a predictor of severe infection and/or death across age groups of SARS-CoV-2-infected patients.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"811-818"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143796552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of HLA-Ib (HLA-G, HLA-E and HLA-F) with spontaneous HBV clearance.","authors":"Ahmed Baligh Laaribi, Asma Mehri, Houda Chaouch, Wafa Babay, Ichraf Jbir, Hadda-Imene Ouzari, Jalel Boukadida","doi":"10.1080/23744235.2025.2487254","DOIUrl":"10.1080/23744235.2025.2487254","url":null,"abstract":"<p><strong>Background: </strong>The natural history of HBV infection is highly heterogeneous. Failure to clear the virus during the acute phase of infection allows for viral persistence and progression to chronicity. Investigating the immune mechanisms involved in this process is crucial for effectively managing infection outcome. HLA-Ib molecules (HLA-G, HLA-E and HLA-F) play a critical role in regulating the immune response.</p><p><strong>Objectives: primary objective: </strong>we investigate the potential impact of functional polymorphisms in HLA-F*01:03 (rs1736924), HLA-E*01:01/01:03 (rs1264457), and two selected HLA-G polymorphisms in Exon 2 (+292 A > T (rs41551813) and +372 G > A (rs1130355)) on HBV infection outcome. <b>Secondary objective</b>: we evaluate the expression of soluble HLA-E in our cohort.</p><p><strong>Methods: </strong>We evaluated these polymorphisms in a cohort of 200 patients with chronic HBV infection and 100 individuals who spontaneously resolved the infection, using SSP-PCR and Sanger sequencing. Additionally, we measured soluble HLA-E (sHLA-E) levels using ELISA.</p><p><strong>Results: </strong>Our results showed a significant association of HLA-G (rs41551813) and HLA-E (rs1264457) polymorphisms with HBV infection outcome, where carriers of the A allele in both HLA-G (rs41551813) and HLA-E (rs1264457) had a significantly higher likelihood of spontaneous HBV clearance (all <i>p</i> < 0.01). Furthermore, we demonstrate that elevated sHLA-E expression favours HBV persistence. Additionally, our findings has revealed that the HLA-<i>G</i> + 292 A > T polymorphism (rs41551813) is associated with regulation of sHLA-G expression. Haplotype analysis further identified the 'TAAA' haplotype as linked to spontaneous HBV clearance.</p><p><strong>Conclusion: </strong>this study demonstrates, for the first time, the critical role of HLA-Ib on HBV infection outcome, providing insights for potential therapeutic interventions.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"839-849"},"PeriodicalIF":2.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating factors influencing tuberculosis treatment outcomes and the impact of COVID-19 on TB incidence in Bengaluru, India (2017-2023).","authors":"Sanjai Srinivasan, Harshitha D, Shobha Rani R H, Dharani V","doi":"10.1080/23744235.2025.2546488","DOIUrl":"https://doi.org/10.1080/23744235.2025.2546488","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) remains a major public health issue in Bengaluru, India. This study analyzes TB trends, treatment outcomes, and the impact of COVID-19 on TB incidence from 2017 to 2023.</p><p><strong>Methods: </strong>Logistic regression analysis was used to identify factors influencing TB treatment outcomes. An Interrupted Time Series (ITS) analysis using an ARIMA (AutoRegressive Integrated Moving Average) model was used to assess the impact of COVID-19 on TB incidence.</p><p><strong>Results: </strong>Among 71,883 TB cases, age ≥65 years had increased the risk of unsuccessful outcomes for pulmonary TB (PTB) (adjusted odds ratio [aOR] 2.54; 95% confidence interval [CI], 2.24-2.89) and extrapulmonary TB (EPTB) (aOR 3.72; CI, 3.06-4.52). Females had lower odds than males in PTB (aOR 0.72; CI, 0.67-0.78) and EPTB (aOR 0.77; CI, 0.68-0.86). Diabetics had lowered risk for PTB (aOR 0.62; CI, 0.57-0.68) but increased risk for EPTB (aOR 1.44; CI, 1.24-1.67). HIV cases had increased risk in PTB (aOR 1.96; CI, 1.67-2.31) and EPTB (aOR 2.88; CI, 2.32-3.57). Interaction analysis in PTB showed diabetics with ages 35-44 and 45-54 was associated with lower risk (aOR 0.66; CI, 0.44-0.99; aOR 0.67; CI, 0.46-0.99). ITS analysis showed a 24.3% average decline in TB notifications in 2020, reaching a maximum decline of 40.5% in April.</p><p><strong>Conclusion: </strong>This study highlights factors affecting TB treatment outcomes and the significant impact of COVID-19 on TB trends in Bengaluru, providing insights to improve TB control and mitigate future pandemic impacts.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cryptococcus is a common and highly morbid cause of meningoencephalitis in hospitalised patients with cirrhosis.","authors":"Deepa Daryani, Noah Lybik, Saad Saffo","doi":"10.1080/23744235.2025.2549386","DOIUrl":"https://doi.org/10.1080/23744235.2025.2549386","url":null,"abstract":"<p><strong>Background: </strong>Sepsis frequently occurs in hospitalised patients with cirrhosis. Among this cohort, meningoencephalitis is likely underdiagnosed, and <i>Cryptococcus neoformans</i> may be a common pathogen.</p><p><strong>Objectives: </strong>Our study aims to (1) understand the epidemiology and mortality of meningoencephalitis in patients with cirrhosis, (2) identify those at risk for cryptococcal meningitis, and (3) assess the safety of lumbar puncture (LP).</p><p><strong>Methods: </strong>The National Inpatient Sample was screened from 2016 to 2019 to identify hospital stays during which patients with cirrhosis underwent LP. We characterised the demographics, clinical data, and outcomes of those with and without meningoencephalitis. We then used logistic regression models to identify clinical factors associated with cryptococcal meningitis and described the incidence of LP-related complications.</p><p><strong>Results: </strong>Among 3,435 hospitalisations, meningoencephalitis occurred in 274 (8%). Of all pathogens, <i>Cryptococcus neoformans</i> was the most common (19%) and most deadly (33% mortality; adjusted odds ratio [aOR] 2.31, 95% confidence interval [CI] 1.12-4.74; <i>p</i> = 0.02). Ascites was the only risk factor associated with cryptococcal meningitis (aOR 2.86, 95% CI 1.68-4.87; <i>p</i> < 0.001). LP-related complications were rare (<1%).</p><p><strong>Conclusions: </strong>Cryptococcal meningitis is a common and morbid cause of meningoencephalitis among hospitalised patients with cirrhosis. LP is safe and should be considered in those with clinical features of infection without a clear source who fail to improve after standard therapy. However, the role of broader screening strategies among patients with cirrhosis remains uncertain, and further research is needed to refine diagnostic approaches for invasive fungal infections, including cryptococcal meningitis.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of risk factors and mortality of candidemia by <i>Candida auris</i> versus <i>Candida</i> non<i>-auris</i> in intensive care units.","authors":"Eyüp Arslan, Deniz Turan, Ömer Karaşahin, Özge Çaydaşı, Yıldız Olçar, Melike Dilmen Tekin, Esra Adıyeke, Fatma Yılmaz Karadağ, Derya Öztürk Engin","doi":"10.1080/23744235.2025.2546482","DOIUrl":"10.1080/23744235.2025.2546482","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to compare risk factors and mortality of candidemia by <i>Candida auris</i> versus <i>Candida</i> non<i>-auris</i> in intensive care units (ICU).</p><p><strong>Methods: </strong>A total of 437 ICU patients who developed candidemia (90 <i>C. auris</i>, 143 <i>C. albicans</i>, 204 other <i>Candida</i> spp.) in 2021-2023 were included. The risk factors in candidemia caused by <i>C. auris</i>, <i>C. albicans</i> and other <i>Candida</i> spp. were compared. Factors associated with 30-day mortality in <i>C. auris</i> candidemia were explored.</p><p><strong>Results: </strong>Compared to the <i>C. albicans</i> group, the <i>C. auris</i> group had more frequent ceftazidime avibactam use (OR:6.72, 95%CI: 1.29-34.98, <i>p</i> = 0.024) and tracheostomy (OR:4.13, 95%CI: 1.70-10.02, <i>p</i> = 0.002), longer colistin (OR:1.07, 95%CI: 1.01-1.13, <i>p</i> = 0.021) and urinary catheter use (OR:1.02, 95%CI: 1.01-1.03, <i>p</i> = 0.023). Compared to the other <i>Candida</i> spp. group, colistin use (OR:2.79, 95%CI: 1.61-4.87, <i>p</i> < 0.001), chronic obstructive pulmonary disease (OR:2.02, 95%CI: 1.05-3.90, <i>p</i> = 0.036) and concurrent bacteraemia (OR:1.92, 95%CI: 1.06-3.48, <i>p</i> = 0.030) were more frequent in the <i>C. auris</i> group. Rate of 30-day mortality was lower in <i>C. auris</i> patients (63.3%) compared to the <i>C. albicans</i> (82.5%) and other <i>Candida</i> spp. (75.5%) groups. While the 30-day mortality rate was higher in <i>C. auris</i> patients who received vasopressor therapy (OR:3.12, 95%CI: 1.78-5.47, <i>p</i> < 0.001) and had high lactate levels (OR:1.41, 95%CI: 1.00-1.99, <i>p</i> = 0.047) and low platelet counts (OR:1.00, 95%CI: 0.99-1.00, <i>p</i> = 0.003) on the first day of candidemia, it was lower in patients with microbiologic response (OR:0.03, 95%CI: 0.01-0.09, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The necessity of broad-spectrum antibiotics and indwelling catheters should be routinely reassessed to reduce <i>C. auris</i> candidemia. Lower mortality was linked to microbiologic response; thus, fungal eradication should be prioritised in clinical practice.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-15"},"PeriodicalIF":2.3,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144884438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}