Infectious diseases (London, England)最新文献

{"title":"Catheter-related bloodstream infection with coagulase-negative staphylococci in hematological malignancy.","authors":"Megan Biggs, Brian Lahr, Nischal Ranganath, Ryan W Stevens, Aaron Tande","doi":"10.1080/23744235.2026.2749422","DOIUrl":"https://doi.org/10.1080/23744235.2026.2749422","url":null,"abstract":"<p><strong>Background: </strong>Central venous catheters (CVC) are vital in the management of hematological malignancy and complications lead to delayed care and increased costs. Coagulase-negative staphylococci (CoNS) catheter-related bloodstream infection (CRBSI) are common, and the safety of line retention in these infections is unclear.</p><p><strong>Methods: </strong>This single-center retrospective review of individuals with CoNS CRBSI and hematological malignancy between January 1, 2012, and January 1, 2024 compared 90-day all-cause mortality and microbiological relapse in patients managed with CVC retention versus removal. Propensity-weighted analysis was performed to control for baseline differences between groups.</p><p><strong>Results: </strong>A total of 140 individual cases were included, with 68% (<i>n</i> = 95) having a history of haematopoietic cell transplantation (HCT). 80.4% (<i>n</i> = 111) were neutropenic at the time of CRBSI diagnosis. The predominant CoNS isolated was <i>Staphylococcus epidermidis</i> (<i>n</i> = 124, 88.6%). Bacteraemia with an oxacillin-resistant organism represented 126 (90.0%) of the cases. CVC retention was more common in those with HCT (<i>p</i> = 0.007), while removal was more frequent with peripherally inserted central catheters (PICC)(<i>p</i> < 0.001) and in those hospitalised for CRBSI management (<i>p</i> = 0.022). Clearance of bacteraemia occurred after a median of two days for both retention and removal groups. Propensity weighted analysis demonstrated a significantly higher rate of relapse with CVC retention compared to CVC removal (hazard ratio [HR] = 6.1; <i>p</i> = 0.043), whereas the difference in mortality was not statistically significant (HR = 1.8; <i>p</i> = 0.128).</p><p><strong>Conclusions: </strong>Clinicians should be vigilant for risks associated with CoNS CRBSI. Future prospective studies evaluating the implications of clinical decision-making in these infections are needed.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"West Nile virus in Brazil in 2026: interpreting a surveillance signal amid diagnostic decentralisation.","authors":"Paulo Ricardo Martins-Filho, André Luiz de Jesus Morais, Marcela Prado Medonça, Thialla Andrade Carvalho, Rafaela Gois de Mendonça, Janiele de Sá Ferreira, José Ronald Alves Barbosa, Késia Vitória Santos de Jesus, Kátia Santana Santos","doi":"10.1080/23744235.2026.2750187","DOIUrl":"https://doi.org/10.1080/23744235.2026.2750187","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-3"},"PeriodicalIF":2.3,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High proportion of pregnant women and migrants among adults hospitalised with varicella in Belgium 2012-2022: a case series study.","authors":"Emma Buttice, Sara Cherkaoui, Philippe Clevenbergh, Kaoutar Abdellaoui, Quentin Lamelyn, Sandrine Roisin, Sigi Van den Wijngaert, Anne Tilmanne, Charlotte Martin, Nicolas Dauby","doi":"10.1080/23744235.2026.2748904","DOIUrl":"https://doi.org/10.1080/23744235.2026.2748904","url":null,"abstract":"<p><strong>Objectives: </strong>To describe the characteristics and outcomes of adults hospitalised with varicella in Belgium, where universal varicella vaccination is not offered in children and to identify implications for targeted vaccination strategies.</p><p><strong>Methods: </strong>A retrospective study was conducted in three Belgian hospitals during a 10-year period (2012-2022), including adults hospitalised >24 h with varicella or varicella pneumonia, identified through microbiological results and minimal clinical datasets. Demographic, clinical, and outcome data were analysed.</p><p><strong>Results: </strong>Among 74 hospitalised adults, 13 (17.6%) had varicella pneumonia. Most patients were male migrants living in precarious conditions, and a substantial proportion were undocumented. Pregnant women accounted for a quarter of admissions, and many reported recent contacts with a child with varicella. Most patients received antiviral therapy and had favourable outcomes; one death occurred in an immunocompromised patient. A notable fraction of cases would have been missed by routine surveillance relying on minimal clinical data alone.</p><p><strong>Conclusions: </strong>In the three studied hospitals, adult hospitalisations caused by varicella cluster in socially vulnerable groups and pregnant women. Varicella vaccination for newly arrived refugees and systematic identification and vaccination of seronegative women of childbearing age could reduce the burden of varicella hospitalisations.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining neonatal tetanus elimination in Indonesia: why surveillance still matters.","authors":"Kristian Kalvin Sigalingging","doi":"10.1080/23744235.2026.2748326","DOIUrl":"https://doi.org/10.1080/23744235.2026.2748326","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-3"},"PeriodicalIF":2.3,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From efficacy to equity: ensuring global access to twice-yearly lenacapavir for HIV prevention.","authors":"Mohamed Abdirahim Omar, Ilyas Abdullahi Khalif, Xaawo Muxumed Maxamed","doi":"10.1080/23744235.2026.2746337","DOIUrl":"https://doi.org/10.1080/23744235.2026.2746337","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-2"},"PeriodicalIF":2.3,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal dynamics of the cerebrospinal fluid proteome in tick-borne encephalitis and enteroviral meningitis.","authors":"Jakob Morén, Peng Li, Aniko Bartfai, Göran Günther, Åke Lundkvist, Jonas Bergquist, Gabriel Westman","doi":"10.1080/23744235.2026.2743169","DOIUrl":"https://doi.org/10.1080/23744235.2026.2743169","url":null,"abstract":"<p><strong>Background: </strong>Tick-borne encephalitis (TBE) is a severe viral infection of the central nervous system (CNS), causing acute meningoencephalitis and often long-term neurocognitive sequelae. The lack of specific treatment for TBE highlights the need to improve understanding of disease mechanisms and identify novel biomarkers. Enteroviral meningitis is typically a milder infection of the CNS and rarely causes encephalitis.</p><p><strong>Objectives: </strong>In this hypothesis-generating study, we aimed to characterise temporal changes in the cerebrospinal fluid (CSF) proteome in TBE and identify candidate biomarkers associated with pathophysiological mechanisms, disease severity, and neurocognitive outcome.</p><p><strong>Methods: </strong>Patients with TBE, enteroviral meningitis, or aseptic meningoencephalitis of unknown origin were retrospectively included from a previously established cohort. CSF proteomes were analysed by label-free mass spectrometry, followed by differential protein expression analysis and functional annotation. Temporal proteome dynamics and protein associations with disease severity and neurocognitive outcome were assessed. Data are available <i>via</i> ProteomeXchange with identifier PXD077931.</p><p><strong>Results: </strong>Proteomic analyses revealed alterations in proteins related to synaptic function, inflammatory pathways, the complement system, and the 14-3-3 protein family. Adrenomedullin was markedly increased in the late phase of TBE compared with enteroviral meningitis.</p><p><strong>Conclusion: </strong>Temporal changes in the CSF proteome in TBE indicate a strong inflammatory response occurring in concert with lower levels of proteins related to synaptic function during the acute phase. These findings provide insights into the host response and pathogenesis of TBE and identify proteins of potential interest for future validation.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-21"},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bundibugyo Ebola virus disease re-emergence: lessons from earlier outbreaks.","authors":"P Kanta, K Chhikara, K Goyal, A Ghosh, M P Singh","doi":"10.1080/23744235.2026.2736028","DOIUrl":"https://doi.org/10.1080/23744235.2026.2736028","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-4"},"PeriodicalIF":2.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149170952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Chile's rabies milestone: advancing equitable global elimination through One Health.","authors":"Mohamed Abdirahim Omar, Ilyas Abdullahi Khalif","doi":"10.1080/23744235.2026.2744329","DOIUrl":"https://doi.org/10.1080/23744235.2026.2744329","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-2"},"PeriodicalIF":2.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Wolbachia</i> releases for dengue control: why the evidence supports a pause and independent re-evaluation.","authors":"Osvaldo Marinotti, Nitzan Paldi, David Gorla","doi":"10.1080/23744235.2026.2668001","DOIUrl":"10.1080/23744235.2026.2668001","url":null,"abstract":"<p><strong>Background: </strong><i>Aedes aegypti</i> is the primary vector of dengue and other arboviruses whose global incidence continues to rise. In response, releases of <i>Aedes aegypti</i> infected with the <i>w</i>Mel strain of <i>Wolbachia pipientis</i> have been promoted as a sustainable, transmission-blocking strategy to curb arboviral disease.</p><p><strong>Objectives: </strong>This study was undertaken to reassess the real-world performance of <i>w</i>Mel-<i>Wolbachia</i> interventions, evaluate their epidemiological impact and durability under diverse field conditions.</p><p><strong>Methods: </strong>Evidence from peer-reviewed publications, program documentation, and routine surveillance systems in countries with large-scale <i>Wolbachia</i> deployments, including Brazil, Colombia, Vietnam, and Indonesia, was synthesised. Temporal patterns of dengue incidence, <i>Wolbachia</i> infection frequencies in mosquito populations, and contextual environmental and operational factors were examined using national and municipal datasets and official reports.</p><p><strong>Results: </strong>Across settings, <i>w</i>Mel-<i>Wolbachia</i> releases have been associated with highly variable epidemiological outcomes, including areas where substantial dengue transmission has persisted or re-emerged after deployment. Field data have documented loss or marked decline of <i>Wolbachia</i> infection in local <i>Aedes aegypti</i> populations and dengue outbreaks within release zones. Limited access to underlying data is available for independent analyses. Theoretical and empirical evidence from vector-pathogen systems indicates that partial transmission blocking potentially imposes selection favouring more transmissible or virulent viral variants.</p><p><strong>Conclusion: </strong>Available evidence does not support unqualified scale-up of <i>w</i>Mel-<i>Wolbachia</i> releases as a robust, long-term dengue control strategy across diverse ecological and operational contexts. A global pause on ongoing and planned deployments, alongside an independent, transparent, science-based re-evaluation of effectiveness, safety, and sustainability, is therefore warranted before further expansion.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"991-1001"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147847018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of ABO and Rh blood groups with hepatitis C virus infection: a systematic review and meta-analysis.","authors":"Wanatsanan Chulrik, Chayanit Phaenui, Haris Duemalee, Natthida Chuaichunu, Pimchanok Srijan, Punyawee Sopaphol, Putawan Worratrairat, Rungruedee Kimseng, Thitinat Duangchan","doi":"10.1080/23744235.2026.2660921","DOIUrl":"10.1080/23744235.2026.2660921","url":null,"abstract":"<p><strong>Background: </strong>The association between ABO and Rhesus (Rh) blood groups and susceptibility to hepatitis C virus (HCV) infection remains uncertain. This systematic review and meta-analysis aimed to clarify these associations.</p><p><strong>Methods: </strong>PubMed, Scopus, Embase, and MEDLINE were searched from inception to 23 January 2025. Studies reporting HCV infection by ABO and/or Rh blood group were eligible. Risk of bias was assessed using the NIH tools. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model. Heterogeneity was assessed with the <i>I</i>² statistic. Subgroup, sensitivity, and publication bias analyses were also performed. The protocol was registered in PROSPERO (CRD420250635714).</p><p><strong>Results: </strong>Thirty-eight studies comprising 3,404,016 participants were included. No significant associations were observed for blood groups A (OR = 1.03, 95% CI: 0.97-1.10), AB (OR = 0.99, 95% CI: 0.85-1.17), O (OR = 0.94, 95% CI: 0.85-1.06), or Rh factor (OR = 0.99, 95% CI: 0.87-1.12). In contrast, blood group B was associated with an 11% higher odds of HCV infection (OR = 1.11, 95% CI: 1.02-1.22, <i>p</i> = 0.02). This association remained robust in sensitivity analyses. Heterogeneity was generally low to moderate, and Egger's test indicated no evidence of publication bias.</p><p><strong>Conclusions: </strong>ABO and Rh blood groups were not strongly associated with HCV infection, except for a consistent positive association with blood group B. Interpretation remains limited by study design and methodological variability. Therefore, large, prospective, multi-regional studies with standardized protocols are needed to validate these findings and explore potential biological mechanisms.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"977-990"},"PeriodicalIF":2.3,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}