Infectious diseases (London, England)最新文献

{"title":"Area-related sociodemographic factors and the risk of severe COVID-19: a longitudinal study of the total adult population in Sweden.","authors":"Henrik Mellström Dahlgren, Huiqi Li, Leif Dotevall, Fredrik Nyberg","doi":"10.1080/23744235.2025.2503466","DOIUrl":"10.1080/23744235.2025.2503466","url":null,"abstract":"<p><strong>Introduction: </strong>For public health purposes, it is essential to understand which population groups and their areas of residence are affected by a disease as COVID-19 and to what extent these groups are reached by preventive measures.</p><p><strong>Aim: </strong>We investigated how individual-level and area-level characteristics are associated with COVID-19 morbidity and vaccine uptake.</p><p><strong>Methods: </strong>A population-based observational study including the total adult population age 18 and older in Sweden from 1 January 2020 to 1 April 2022, except individuals living in nursing homes. Associations between both individual and area-level characteristics and COVID-19 morbidity (hospitalisation, admission to intensive care unit and death) and vaccine uptake were analysed using Cox proportional hazards regression and adjusted for age, sex, comorbidity and socioeconomic and demographic factors.</p><p><strong>Results: </strong>In the fully adjusted model, the hazard ratio (HR) for COVID-19 hospitalisation was 34% lower for individuals living in the most affluent neighbourhoods (HR 0.66, 95%CI 0.63-0.68) compared to individuals in the most deprived neighbourhoods. For intensive care unit (ICU)-admission and COVID-19 death, the risks were 53% (HR 0.47, 95%CI 0.42-0.53) and 47% (HR 0.53, 95%CI 0.48-0.59) lower, respectively. When stratified by cross-classified sociodemographics, this pattern was consistent within all strata. A composite area-level measurement had a better predictive value compared to single measures.</p><p><strong>Conclusions: </strong>Living in deprived neighbourhoods is associated with substantially higher risk of COVID-19 hospitalisation, ICU-admission, mortality and lower vaccine uptake. This risk factor remained strong even when taking individual level characteristics into account and within strata of individual-level factors.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"933-947"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics and outcomes of patients with infective native aortic aneurysm or vascular graft and endograft infection.","authors":"Lucas Lalevée, Malikov Sergueï, Elodie Jeanbert, Maïa Simon, Amandine Luc, Nicla Settembre, Sandrine Hénard, Emmanuel Novy, Philippe Guerci, Benjamin Lefèvre","doi":"10.1080/23744235.2025.2502826","DOIUrl":"10.1080/23744235.2025.2502826","url":null,"abstract":"<p><strong>Background: </strong>Infections of the aorta and its branches can occur either in native tissue, known as infective native aortic aneurysms (INAAs), or following vascular surgery involving native or prosthetic grafts, referred to as vascular graft or endograft infections (VGEIs).</p><p><strong>Objectives: </strong>First, this study aimed to assess the all-cause on-year mortality of patients with INAAs and VGEIs. Second, this study described patients' characteristics and prognostic factors.</p><p><strong>Methods: </strong>This observational study included patients hospitalised for INAA or VGEI, between 2014 and 2022, at Nancy University Hospital (France). Data were retrospectively collected from patients' medical record (ClinicalTrials.gov ID NCT05660733).</p><p><strong>Results: </strong>Forty-seven patients were included in the INAAs group versus 40 in the VGEIs group. A history of immunosuppression or autoimmune disease were more frequent in INAAs patients. VGEIs patients had more chronic organ failure or cardiovascular pathology. The most commonly affected site was the infrarenal aorta, with thoracic involvement being more frequent in the INAAs group. <i>Staphylococcus aureus</i> was the most frequent identified pathogen (38.3% vs. 27.5%). There was no significant difference between groups in terms of all-cause 1-year mortality (40.4% in the INAAs group vs. 32.5% in the VGEIs group, log-rank test, <i>p</i> = .4803). The absence of surgery worsened the prognosis in the overall population (HR 2.8, 95% CI [1.2-6.3], <i>p</i> = .0125); this was also observed in the INAA group.</p><p><strong>Conclusions: </strong>Despite different comorbidities and clinical presentations between groups, there was no significant difference in 1-year mortality. Surgical management appeared to be associated with improved outcomes.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"920-932"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re-emergence of arboviruses in South China: a new frontier for chikungunya?","authors":"Ahmad Khan, Laiba Maryam, Shadab Khan","doi":"10.1080/23744235.2025.2542510","DOIUrl":"10.1080/23744235.2025.2542510","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"977-978"},"PeriodicalIF":2.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144796218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between osteoarticular tuberculosis and nontuberculous mycobacterial infection: a retrospective observational cohort study.","authors":"Moonsuk Bae, Yeji Yu, Seul-Ki Kim, A-Reum Kim, Seungjin Lim","doi":"10.1080/23744235.2025.2563642","DOIUrl":"https://doi.org/10.1080/23744235.2025.2563642","url":null,"abstract":"<p><strong>Background: </strong>Osteoarticular mycobacterial infections significantly impact patient health by causing severe joint and bone diseases. However, clinical experience in diagnosis and treatment remains limited.</p><p><strong>Objectives: </strong>We investigated the clinical characteristics and prognosis of patients with osteoarticular mycobacterial infection.</p><p><strong>Methods: </strong>We retrospectively enrolled 74 adult patients diagnosed with osteoarticular mycobacterial infection, including 57 (77%) with tuberculosis (TB) and 17 (23%) with non-tuberculous mycobacteria (NTM) infection, between January 2009 and January 2023 from a tertiary hospital in Korea. Osteoarticular mycobacterial infection was defined as the presence of osteoarticular infection, including prosthetic joint infection, diagnosed using clinical and radiological findings, and aspirate or tissue culture positive or polymerase chain reaction positive for <i>Mycobacterium tuberculosis</i> complex or NTM.</p><p><strong>Results: </strong>Several differences were observed in the predisposing factors, affected sites and multifocal infections between the osteoarticular TB and NTM infection groups. The proportion of disseminated infection in patients with TB was higher than that in those with NTM infection (40% vs. 6%, <i>p</i> = .008). The positivity rate of acid-fast bacilli stain, mycobacterial culture, molecular testing and histological examination in all patients was 34%, 89%, 79% and 51%, respectively. Culture-positive or PCR-positive specimens from another site (respiratory specimens, pleural fluid, urine or blood) were collected from 22 patients (30%). Anti-mycobacterial therapy combined with surgical treatment was performed in 77% of all follow-up patients, and clinical failure occurred in 19%.</p><p><strong>Conclusions: </strong>These findings suggest that, given the differences in optimal treatments, using multiple diagnostic modalities to detect microbiological evidence for discriminating NTM infection from TB is essential.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-10"},"PeriodicalIF":2.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Initiation of dolutegravir vs. efavirenz on 12- and 24-month retention and viral suppression: a target trial emulation.","authors":"Amy Zheng, Alana T Brennan, Ross Greener, Emma M Kileel, Jacob Bor, Willem D F Venter, Eleanor J Murray, Pedro T Pisa, Bridgette Goeieman, Matthew P Fox, Mhairi Maskew","doi":"10.1080/23744235.2025.2557628","DOIUrl":"https://doi.org/10.1080/23744235.2025.2557628","url":null,"abstract":"<p><strong>Background: </strong>South Africa's antiretroviral therapy (ART) treatment guidelines in 2019 were revised to use dolutegravir as part of first-line ART instead of efavirenz due to recommendations from the World Health Organization and findings from clinical trials indicating noninferior efficacy and reduced side effects. Utilizing the target trial framework, we estimated the effect of initiating a dolutegravir-based regimen compared to an efavirenz-based regimen among treatment-naïve people living with HIV initiating treatment in Johannesburg, South Africa from 2019 to 2022 on retention and viral suppression.</p><p><strong>Methods: </strong>We used linear regression to estimate causal risk differences on 12- and 24-month retention and viral suppression. Characteristics of those who initiated dolutegravir vs. efavirenz were balanced through inverse probability of treatment weighting. The covariates included: natal sex, age, year of initiation, education level, employment status, tuberculosis, WHO stage, smoking and alcohol use.</p><p><strong>Results: </strong>Of the 2930 individuals initiating ART, 1847 initiated a dolutegravir-based regimen and 1083 initiated an efavirenz-based regimen. The median age was 45.1 years (IQR: 37.1, 53.0). Initiation of dolutegravir was associated with a 5-percentage point increase (95% confidence interval (CI): -0.02, 0.11) in retention and 4-percentage point increase (95% CI: -0.06, 0.16) in viral suppression at 12 months. At 24 months, dolutegravir was associated with a 10-percentage point (95% CI: 0.03, 0.16) increase in retention and a 14-percentage point (95% CI: -0.02, 0.30) increase in viral suppression.</p><p><strong>Conclusions: </strong>Initiation of dolutegravir led to an appreciable increase in retention and viral suppression over 24 months when compared to efavirenz. Dolutegravir may lead to increases in long-term retention.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-11"},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Vibrio vulnificus</i> epidemiology and risk factors for mortality in the United States, 2000-2022.","authors":"Marisa Hast, Craig Baker-Austin, Iain R Lake, Pritiza Paromita, Zhaohui Cui, Natalia R Jones, Paulette Posen, Michael J Hughes","doi":"10.1080/23744235.2025.2559883","DOIUrl":"10.1080/23744235.2025.2559883","url":null,"abstract":"<p><strong>Background: </strong><i>Vibrio vulnificus</i> is a foodborne and waterborne pathogen causing substantial morbidity and mortality; however, its epidemiology remains poorly understood. To inform prevention and control efforts, we characterized U.S. <i>V. vulnificus</i> epidemiology and identified risk factors for mortality.</p><p><strong>Methods: </strong>For all culture-confirmed <i>V. vulnificus</i> cases reported to the Cholera and Other <i>Vibrio</i> Illness Surveillance (COVIS) system from 2000 to 2022, patient characteristics and medical outcomes were described by foodborne vs. non-foodborne transmission routes. Risk factors for mortality were identified using multivariate logistic regression.</p><p><strong>Results: </strong>Two thousand nine hundred and eighty-nine <i>V. vulnificus</i> cases were reported from 2000 to 2022, including 656 (22%) foodborne and 1,619 (54%) non-foodborne cases. Five-year case total increased 70% from 2000-2004 (<i>n</i> = 487) to 2018-2022 (<i>n</i> = 827). Most patients were male, older and White, with reported underlying health conditions; 2,493 (83%) patients were hospitalized and 692 (23%) died. Number of deaths (260 vs. 200) and fatality rate (40% vs. 12%) were higher among foodborne vs. non-foodborne cases. Mortality was associated with history of liver disease/alcoholism (odds ratio (OR) = 6.5, <i>p</i> < 0.001), age 45-59 (OR = 11.3, <i>p</i> = 0.001), foodborne transmission (OR = 1.3, <i>p</i> = 0.006), and Black (OR = 1.8, <i>p</i> = 0.03) or Asian (OR = 2.5, <i>p</i> = 0.009) race. Antibiotic use was protective (OR = 0.33, <i>p</i> = 0.001). Liver disease associated with diabetes had lower mortality than other forms of liver disease (interaction OR = 0.5, <i>p</i> = 0.04).</p><p><strong>Conclusions: </strong><i>V. vulnificus</i> infections confer a substantial and increasing public health burden in the United States. Non-foodborne transmission caused 2.5 times more cases, and foodborne transmission caused 30% more deaths and had >3 times higher fatality rate. Identifying risk factors for mortality can inform public health and medical interventions.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-12"},"PeriodicalIF":2.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12505355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age differences in factors associated with pulmonary tuberculosis: a cross-sectional study of Indonesian Basic Health Research (RISKESDAS) 2018.","authors":"Erni W Susanti, Bayu S Wiratama, Fang-I Hsieh","doi":"10.1080/23744235.2025.2562230","DOIUrl":"https://doi.org/10.1080/23744235.2025.2562230","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the prevalence across age groups and age disparities in factors associated with pulmonary tuberculosis (PTB) in Indonesia through a large-scale sample study.</p><p><strong>Methods: </strong>The data source was the National Basic Health Survey 2018. We recruited 715,394 individuals aged 16 years and older in this study. Rao-Scott Chi-square analyses and binary logistic regressions were employed to investigate the association of PTB with a significance threshold of 5%. Age-group disparities in factors significantly associated with PTB in all age groups were identified by interaction term analysis.</p><p><strong>Results: </strong>In youth, middle-aged, and elderly groups, the prevalence of PTB was 3.5‰, 6.8‰, and 9.6‰, respectively. Logistic regressions with interaction term analysis found age differences in the association between PTB and former smokers (<i>p</i> for interaction = 0.022), diabetes (<i>p</i> for interaction = 0.0001), and heart disease (<i>p</i> for interaction = 0.005). Moreover, our findings showed age-related differences in the effect of sex, family size, and unemployment status on PTB. Males exhibited a greater PTB risk than females only among the middle-aged group (OR: 2.06; 95% CI: 1.48-2.86) and older adults (OR: 1.89; 95% CI: 1.38-2.62). Larger families (OR: 1.33; 95% CI: 1.12-1.59) and unemployed individuals (OR: 1.49; 95% CI: 1.21-1.83) were significantly associated with PTB only among middle-aged adults.</p><p><strong>Conclusion: </strong>Comprehending age-specific factors for PTB is crucial for developing effective public health strategies. Early detection and advanced health education for PTB should be targeted at elderly men and middle-aged men who are jobless or have a large family.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-12"},"PeriodicalIF":2.3,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can behavioural studies in vector control programme & Kala-azar Mukt Panchayat initiative contribute towards ending visceral leishmaniasis in India?","authors":"Gaurav Raj Dwivedi, Brij Ranjan Misra, Pradeep Kumar Srivastava, Nalini Mishra","doi":"10.1080/23744235.2025.2558169","DOIUrl":"https://doi.org/10.1080/23744235.2025.2558169","url":null,"abstract":"","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and antimicrobial resistance of <i>Salmonella enterica</i> serotype Infantis in the United States: infections and emergence of a multidrug-resistant strain during 1979-2022.","authors":"Felicita Medalla, Hazel J Shah, Preethi Sundararaman, Jessica Chen, Zachary Ellison, Sarah Verlander, Sean Buuck, Samir Hanna, Rebecca Hoelzl, Tamara Rissman, Rosalie Trevejo, Carey Devine, Meseret G Birhane, Jared L Reynolds, Hayat Caidi, Jason Folster, Beth Tolar, Daniel C Payne, Robert M Hoekstra, Louise Francois Watkins","doi":"10.1080/23744235.2025.2553665","DOIUrl":"https://doi.org/10.1080/23744235.2025.2553665","url":null,"abstract":"<p><strong>Background: </strong><i>Salmonella</i> infections are a major cause of human illness in the United States. <i>Salmonella enterica</i> serotype Infantis has re-emerged as a leading serotype with the emergence of a multidrug-resistant <i>S.</i> Infantis strain, designated as REPJFX01 by the Centers for Disease Control and Prevention (CDC). REPJFX01, which typically contains a megaplasmid of emerging <i>Salmonella</i> Infantis (pESI) harbouring multiple resistance genes and a chromosomal <i>gyrA87</i> mutation conferring decreased susceptibility to ciprofloxacin, has caused human infections linked to chicken consumption.</p><p><strong>Objective: </strong>The study aimed to describe the epidemiology and antimicrobial resistance of human <i>S.</i> Infantis infections, including the emergence of REPJFX01, in the United States.</p><p><strong>Methods: </strong>The study used data from five CDC surveillance systems, with combined years from 1979 through 2022. Negative binomial and logistic regression models were used in the multivariable analyses of surveillance data.</p><p><strong>Results: </strong>In 10 active surveillance sites, the mean annual incidence of human <i>S.</i> Infantis infections was twice as high during 2013-2022 vs. 2003-2012 (adjusted rate ratio = 1.96, 95% CI 1.75-2.20). REPJFX01 infections accounted for nearly one-third of <i>S.</i> Infantis infections during 2018-2022 (vs. 2013-2017, adjusted odds ratio = 2.09, 95% CI 1.56-2.79). <i>Salmonella</i> Infantis infections were more likely among persons who were ≥45 years old, female, from racial and ethnic minority groups, and had <i>Salmonella</i> isolated from urine, than infections with other common serotypes.</p><p><strong>Conclusion: </strong>The increase in <i>S.</i> Infantis infections during 2013-2022 was likely driven by an increase in REPJFX01 infections. Public health strategies to reduce <i>Salmonella</i> contamination of chicken could help prevent human infections.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-18"},"PeriodicalIF":2.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Staphylococcus lugdunensis</i> infective endocarditis: a multicentre international observational study.","authors":"Benjamin Lefevre, Gilbert Habib, Bruno Hoen, Christine Selton-Suty, Mary Philip, Nahema Issa, Pierre Danneels, Marine De La Chapelle, Colin Deschanvres, Marie-Line Erpelding, Pierre Tattevin, Audrey Le Bot, Miguel Villamarín, Nuria Fernández-Hidalgo, Christophe Tribouilloy, Emilie Pluquet, Vincent Dubee, Margaret Hannan, Gabriela Dornikova, Emanuele Durante-Mangoni, Lorenzo Bertolino, Rinaldo Focaccia Siciliano, Anna Maria Amaral de Oliveira, Marcelo Goulart Correia, Frédérique Gouriet, Cristiane Lamas","doi":"10.1080/23744235.2025.2556921","DOIUrl":"https://doi.org/10.1080/23744235.2025.2556921","url":null,"abstract":"<p><strong>Background: </strong><i>Staphylococcus lugdunensis</i> (SL) can cause infective endocarditis (IE), with unusually high complication and mortality rates. According to the 2023 Duke-ISCVID criteria, blood cultures positive for SL now count as a major microbiological criterion.</p><p><strong>Objectives: </strong>Our aim was to determine the contemporary characteristics of SLIE, and to identify the factors associated with all-cause in-hospital mortality.</p><p><strong>Methods: </strong>Patients with definite SLIE between 2010 and 2024 were included in a collaborative study involving 17 centres in France, Spain, Brazil, Italy, and Ireland.</p><p><strong>Results: </strong>We collected data on 112 patients with definite SLIE. Mean age was 67 ± 18 years, and 76 (67.9%) were males. Nosocomial and healthcare-related non-nosocomial SLIE accounted for 15.2% and 16.1% of cases, respectively. Prosthetic valves and cardiac implantable electronic devices (CIED) were involved in 36.6% and 10.7% of cases, respectively. Emboli occurred in 50%, heart failure in 32%, acute kidney injury in 39.4%, and perivalvular abscesses in 20.5% of cases. All strains were methicillin susceptible. Valve surgery was performed in 47 (42%) and CIED removal in 10 (8.9%) patients. All-cause in-hospital mortality was 29.5%. Variables associated with mortality were age (OR 1.10 per one-year increment, 95%CI [1.08-1.31], <i>p</i> < 0.001), malignancy (OR 26.22, [3.78-181.72], <i>p</i> < 0.001), a new severe mitral regurgitation (OR 17.10, [2.81-104.09], <i>p</i> = 0.002), paravalvular abscess (OR 63.40, [6.24-644.03], <i>p</i> < 0.001), and new high-degree atrioventricular block (OR 27.76, [2.49-309.82], <i>p</i> = 0.007).</p><p><strong>Conclusion: </strong>This international multicentre study confirms that SLIE mimics <i>Staphylococcus aureus</i> IE, particularly with regard to aggressiveness, healthcare-related acquisition, complications, and mortality. Of note, all SL isolates were methicillin-susceptible.</p>","PeriodicalId":73372,"journal":{"name":"Infectious diseases (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145066519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}