A group with emerging potential in the clinical and public health realms: the genus Providencia.

Abstract

Background: The genus Providencia is increasingly being recognized as an important human pathogen. Previously a member of the family Enterobacteriaceae but now reclassified into the family Morganellaceae along with Morganella and Proteus, the phylogenetic depth of this clade has expanded from 3 species in its inception to 12 as of 2025. Recent clinical and epidemiologic data provide convincing evidence that P. alcalifaciens causes gastroenteritis and there is also increasing recognition of carbapenem-resistant strains of P. stuartii and P. rettgeri causing serious infections in hospital settings.

Objective and methods: Since 2000, no comprehensive review of this genus has been published detailing taxonomic changes, ecological associations, emerging disease trends, pathogenicity and diagnostic modalities useful in detecting and typing providenciae. The objective of this article is to provide a current review and update of recent publications (PubMed, ScienceDirect, Google Scholar, Scopus^®) post-2000 and to summarize results and conclusions to date on this increasingly important genus.

Results: Many reports have now been published describing human cases of enteritis and major outbreaks of gastroenteritis attributed to P. alcalifaciens and supported by multiple epidemiologic lines of evidence including typing methods (serology, molecular), in vivo immune responses, and case-controlled investigations. Similar disease syndromes have also been reported in dogs and pigs with one national canine outbreak of haemorrhagic diarrhoea reported from Norway in 2021. In addition, increasing drug resistance has been noted in both P. stuartii and P. rettgeri leading to the worldwide discovery of multi-, extensive-, and pan-resistant isolates causing disease which presents diagnostic issues in the laboratory and therapeutic challenges.

Conclusion: The analysis reveals that providenciae are increasingly being implicated as important causes of intestinal and systemic disease. This is supported by a ten-fold increase in the number of Providencia studies listed in PubMed between 2000 and 2024. Methods need to be developed in the microbiology laboratory to recognize "pathogenic" strains of P. alcalifaciens that produce enteritis from commensal isolates. Emerging antimicrobial resistance needs to be detected early, monitored, and controlled to avoid further dissemination. New infection control prevention procedures need to be advanced and assessed for usefulness in medical care facilities.