先天性巨细胞病毒感染成人自我报告的执行功能。

Karolina Falkenius Schmidt, Anastasia Nyström, Johannes Ehinger, Eva Karltorp, Måns Magnusson, Ulrika Löfkvist
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引用次数: 0

摘要

背景:先天性巨细胞病毒(cCMV)是发达国家最常见的产前感染,也是神经发育异常的主要感染原因。cCMV感染的长期神经心理结果尚不清楚,对出生时进行CMV筛查的成人的随访研究很少。本研究的目的是调查cCMV感染成人自我报告的执行功能(EF)与未感染对照的关系。方法:从1977- 1985年在瑞典南部进行的新生儿巨细胞病毒筛查研究中,所有个体都被邀请参加一项随访研究。纳入45/71例cCMV感染者(63%)和25/46例对照组(54%)。参与者年龄在34-43岁之间。通过原始研究的书面报告和半结构化研究方案记录了神经症状和神经精神障碍。用BRIEF-A(问卷)评估执行功能。结果:在自我报告的执行功能方面,各组之间没有统计学上的显著差异,尽管在cCMV组中观察到更大的结果差异。结论:cCMV感染成人的日常执行功能在群体水平上可能不会受到影响,或者仅通过自我报告可能无法充分捕获。执行功能结果的可变性表明,与对照组相比,感染cCMV的个体代表了一个更异质性的群体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Self-reported executive functioning in adults with congenital cytomegalovirus infection.

Background: Congenital Cytomegalovirus (cCMV) is the most common prenatal infection and the main infectious cause of neurodevelopmental abnormalities in developed countries. Long-term neuropsychological outcome of cCMV infection is yet not well understood, and follow-up studies on adults screened for CMV at birth are few. The aim of this study was to investigate self-reported executive functioning (EF) in adults with cCMV infection in relation to uninfected controls.

Method: All individuals from a universal newborn CMV screening study conducted in Southern Sweden and sampled 1977-85, was invited to participate in a follow-up study. 45/71 individuals (63%) with cCMV infection and 25/46 controls (54%) were enrolled. Participants were aged 34-43 years. Neurological symptoms and neuropsychiatric disabilities were documented through written reports from the original study and a semi-structured study protocol. Executive functioning was evaluated with BRIEF-A (questionnaire).

Results: No statistically significant differences were found between groups in self-reported executive functioning, although greater variability in outcomes was observed in the cCMV group.

Conclusion: Everyday executive functioning might not be affected at the group level in adults with cCMV infection or may not be adequately captured through self-reports alone. The variability in executive functioning results suggests that individuals with cCMV infection represent a more heterogeneous group compared to the controls.

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