IJID regions最新文献

{"title":"Understanding the cascade of care and predictors of treatment success among patients with hepatitis C - A prospective study at a tertiary care center in India","authors":"Sunvir Kaur Rai ,&nbsp;Simmi Oberoi ,&nbsp;Amandev Singh ,&nbsp;Harpreet Singh","doi":"10.1016/j.ijregi.2025.100783","DOIUrl":"10.1016/j.ijregi.2025.100783","url":null,"abstract":"<div><div><em>Objectives:</em> In India, 6-12 million people experience chronic hepatitis C infection, which can lead to complications such as liver cirrhosis and hepatocellular carcinoma. Despite free diagnostic and treatment services under the national program, treatment initiation is frequently delayed, and patient retention is sub-optimal. The study aims to identify the factors influencing the cascade of care and assess the predictors of treatment success.</div><div><em>Methods:</em> A hospital-based prospective longitudinal study was conducted among adult patients with hepatitis C. All patients with a detectable viral load who chose to initiate treatment in our center were enrolled and prescribed direct-acting antiviral drugs. They were observed throughout the treatment, and sustained viral response was measured at 12 weeks post-treatment. Data were analyzed using suitable statistical tests and a multivariable logistic regression to find the predictors of treatment success.</div><div><em>Results:</em> Of 761 patients who screened positive for viral hepatitis, 600 had detectable hepatitis C virus RNA. Among the 600 patients, only 64.27% (385) initiated the treatment. Of 385 patients, 77.4% underwent a viral load assay within 1 week of the screening test, whereas 78.4% started treatment within 1 month of hepatitis C virus RNA detection. Although 78.9% of patients completed the treatment, only 52.9% of patients underwent Sustained Viral Response testing. Among those tested, 92.6% achieved Sustained Viral Response. Age (adjusted odds ratio [AOR]: 0.95; 95% confidence interval [CI]: 0.92-0.98), intravenous drug use (AOR: 0.18; 95% CI: 0.06-0.52), cirrhosis (AOR: 0.28; 95% CI: 0.10-0.77), and Serum albumin levels (AOR: 2.05; 95% CI: 1.02-4.12) emerged as significant predictors of treatment success.</div><div><em>Conclusions:</em> Significant attrition of patients from screening to Sustained Viral Response testing highlights the gaps in the care continuum. Delayed diagnosis and treatment initiation further exacerbate the situation. Despite these challenges, direct-acting antivirals offer hope for successful treatment. Age, intravenous drug use, cirrhosis, and S. albumin levels emerged as significant predictors of treatment success.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100783"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fifteen years of tuberculosis and HIV diagnostic services in Brazil: disruption, regional disparities, and recovery before, during, and after the COVID-19 pandemic","authors":"Luanne Karolyne Leal dos Santos ,&nbsp;Yan Mathias Alves ,&nbsp;Reginaldo Bazon Vaz Tavares ,&nbsp;Marcela Antunes Paschoal Popolin ,&nbsp;Nathalia Zini ,&nbsp;Ione Carvalho Pinto ,&nbsp;Pedro Fredemir Palha ,&nbsp;Aline Aparecida Monroe ,&nbsp;Erica Chimara ,&nbsp;Ricardo Alexandre Arcêncio","doi":"10.1016/j.ijregi.2025.100796","DOIUrl":"10.1016/j.ijregi.2025.100796","url":null,"abstract":"<div><h3>Objectives</h3><div>This study analyzes fifteen years of nationwide trends and regional disparities in tuberculosis (TB) and HIV diagnostics in Brazil, examining the impacts of the COVID-19 pandemic and the uneven recovery of diagnostic services across different regions.</div></div><div><h3>Methods</h3><div>This nationwide ecological study analyzed monthly data on TB and HIV diagnostic tests performed in Brazil from 2010 to 2024, utilizing real-world data. Temporal trends and interrupted time-series analyses evaluated the immediate and progressive effects of the COVID-19 pandemic. Spatial patterns and autocorrelation were explored using bivariate Moran’s I and Kernel density estimation.</div></div><div><h3>Results</h3><div>Results showed significant abrupt declines during the COVID-19 pandemic for smear microscopy (–16.4%), culture (–21.4%), and HIV (–16.2%). Post-pandemic, Xpert MTB/RIF showed the highest monthly increase (+3.8%; 95% confidence interval: 2.9-4.7), while smear microscopy declined (–1.2%; 95% confidence interval: –2.0 to –0.5). Spatial analysis revealed pronounced regional heterogeneity, with Northern and Northeastern municipalities facing the greatest disruptions. The Xpert MTB/RIF test demonstrated greater resilience, with evident growth in its distribution and implementation over time. However, this increase resulted in a decrease in the conduction of smear microscopy tests and highlighted territorial disparities, since only 167 municipalities (3%) have Xpert MTB/RIF assays, mainly in the Southeast.</div></div><div><h3>Conclusions</h3><div>COVID-19 significantly disrupted traditional TB and HIV diagnostics in Brazil, while there was an evident increase and resilience of Xpert MTB/RIF, reducing the use of smear microscopy tests. Policy efforts should prioritize the equitable expansion of molecular diagnostic technologies across all regions. This approach will improve early TB detection and drug resistance testing, thereby reducing diagnostic disparities and strengthening health system resilience toward achieving the End TB Strategy.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100796"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Viral hepatitis as a differential diagnosis of yellow fever suspected cases in Cameroon: Prevalence and molecular characterization","authors":"Abdou Fatawou Modiyinji ,&nbsp;Huguette Tchetgna Simo ,&nbsp;Aristide Mounchili-Njifon ,&nbsp;Moise Henri Moumbeket-Yifomnjou ,&nbsp;Lionel Franklin Djomo ,&nbsp;Damaris Ngo Yabi ,&nbsp;Justine Gwendolyne Odi ,&nbsp;Gisèle Liliane Machuetum ,&nbsp;Abanda Njei Ngu ,&nbsp;Richard Njouom","doi":"10.1016/j.ijregi.2025.100732","DOIUrl":"10.1016/j.ijregi.2025.100732","url":null,"abstract":"<div><h3>Objectives</h3><div>The aim of this study was to determine the prevalence and genetic diversity of viral hepatitis among clinical cases of acute febrile jaundice initially suspected to be yellow fever (YF).</div></div><div><h3>Methods</h3><div>We conducted a prospective cross-sectional study on YF-negative suspected samples collected between September 2024 and January 2025. The pentaplex polymerase chain reaction assay was used to detect five hepatotropic viruses. All detected viruses were genotyped, sequenced, and phylogenetically analyzed.</div></div><div><h3>Results</h3><div>Among the 404 participants tested, viral hepatitis was diagnosed in 107 (26.5%; 95% confidence interval [CI]: 22.4–31.0%). The proportions were: hepatitis A virus (HAV) 70.1% (75/107), hepatitis B virus (HBV) 23.4% (25/107), hepatitis C virus (HCV) 3.7% (4/107), and hepatitis E virus (HEV) 2.8% (3/107). No sample was positive for hepatitis D virus, and no dual viral infections were detected. HAV was most common in patients under 15 years of age, while HBV was most common in patients aged over 15. The genotypes identified were HAV-IB and HAV-IIA, HBV-A and E, HCV-1 and HCV-4, and HEV-4.</div></div><div><h3>Conclusions</h3><div>Our study shows that viral hepatitis plays a key role in acute febrile jaundice cases, which are often attributed to the YF virus in Cameroon.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100732"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145027759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The urgent need for Middle East respiratory syndrome coronavirus surveillance in Somalia","authors":"Kassim Abdi Jimale,&nbsp;Shafie Abdulkadir Hassan,&nbsp;Abdifetah Ibrahim Omar","doi":"10.1016/j.ijregi.2025.100806","DOIUrl":"10.1016/j.ijregi.2025.100806","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100806"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145684414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of SARS-CoV-2 Antibody Response across Diverse Clinical Settings in Oman: Insights from a Prospective ELISA-based Study","authors":"Asma Al Balushi ,&nbsp;Zainab Abdul Hameed ,&nbsp;Hasina Al Bahri ,&nbsp;Zaina Al Maskari ,&nbsp;Ahlam Al Balushi ,&nbsp;Iman Al Balushi ,&nbsp;Sachin Jose ,&nbsp;Adil Al Wahaibi ,&nbsp;Amina Al-Jardani ,&nbsp;Samira Al-Mahruqi ,&nbsp;Mohammed Hamed Nasr ,&nbsp;Emily Adams ,&nbsp;Tom E. Fletcher ,&nbsp;Iman Nasr","doi":"10.1016/j.ijregi.2025.100736","DOIUrl":"10.1016/j.ijregi.2025.100736","url":null,"abstract":"<div><h3>Objectives</h3><div>The durability of SARS-CoV-2 antibody response varies with disease severity [<span><span>1</span></span>]. Comparative data across diverse clinical settings in the Gulf region are limited. This study assessed the persistence of SARS-CoV-2 immunoglobulin G (IgG) antibodies over 6 months among hospitalized patients, outpatients, and healthcare workers (HCWs).</div></div><div><h3>Methods</h3><div>In this prospective cohort study, 356 confirmed COVID-19 cases (123 inpatients, 113 outpatients, and 120 HCWs) were enrolled. Serum IgG titers were measured using enzyme-linked immunosorbent assay (ELISA) at baseline (≤14 days post-symptom onset), 4-6 weeks, 3 months, and 6 months post-infection. Longitudinal antibody dynamics were analyzed using a linear mixed-effect model adjusting for patient group, age, comorbidities, and symptoms.</div></div><div><h3>Results</h3><div>Inpatients were older, male, and had more comorbidities, including obesity 54.5% (67 of 123), diabetes mellitus 39% (48 of 123), and hypertension 39.8% (49 of 123), compared with outpatients and HCWs. Peak antibody titers were reached at 4-6 weeks, with gradual decline over the 6-month period after initial infection across all groups (<em>P</em> &lt;0.001). Inpatients demonstrated significantly higher IgG titers at all time points (<em>P</em> &lt;0.001).</div></div><div><h3>Conclusions</h3><div>Severe COVID-19 infection, older age, and comorbidities were linked to stronger, more durable IgG responses. These findings provide essential baseline data on post–COVID-19 immunity in the Gulf region during early pandemic.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100736"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and practices of anti-malarial treatment for children under five years among village health teams in Kasese District, Uganda: A cross-sectional study","authors":"Nakitto Irene Kisakye ,&nbsp;Helena C. Maltezou ,&nbsp;Robert Mugarura ,&nbsp;Arthur Nek Jonathan ,&nbsp;Charles Etyang","doi":"10.1016/j.ijregi.2025.100749","DOIUrl":"10.1016/j.ijregi.2025.100749","url":null,"abstract":"<div><h3>Objectives</h3><div>Malaria remains a leading cause of morbidity and mortality among children under 5 in Uganda, particularly in rural and hard-to-reach areas. Village health teams (VHTs) play a pivotal role in community-based malaria diagnosis and treatment, yet their knowledge and practices remain understudied. To assess the knowledge and practice of antimalarial drug use among VHTs for children under 5 years in Kasese District, Uganda.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study was conducted among 102 VHTs using a structured, interviewer-administered questionnaire. Descriptive statistics were used to summarize VHT characteristics, knowledge, and practice scores. Chi-square tests were performed to assess associations between socio-demographic characteristics and key dispensing practices. Data were analyzed using SPSS, version 26.</div></div><div><h3>Results</h3><div>The majority of VHTs demonstrated basic knowledge in antimalarial treatment, with 70.6% routinely checking expiration dates and 76.5% instructing caregivers on when to administer medications. However, fewer VHTs informed caregivers about side effects (21.6%), drug interactions (29.4%), or the effects of herbal medicines (19.6%). Significant associations were found between educational level and multiple dispensing practices (<em>p</em> &lt;0.05), including giving drugs based on rapid diagnostic test results and appropriately addressing caregiver requests.</div></div><div><h3>Conclusions</h3><div>While VHTs in Kasese District generally adhere to key elements of antimalarial drug administration, gaps persist in their pharmacological knowledge and patient education practices. Strengthening ongoing training and supervision may improve rational antimalarial drug use and treatment outcomes in children under 5 years old.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100749"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case-based surveillance of bacterial meningitis following MenAfrivac™ introduction at Sourô Sanou University Hospital, Bobo-Dioulasso, Burkina Faso, 2011-2021","authors":"Zoungrana Jacques ,&nbsp;Kabore D. Odilon ,&nbsp;Tonde Issa ,&nbsp;Ouattara Cheick Ahmed ,&nbsp;Kiodima M.S. Odette ,&nbsp;Muhigwa Merci ,&nbsp;Diallo Ismael ,&nbsp;Sawadogo Yacouba ,&nbsp;Poda Armel ,&nbsp;Ouedraogo Abdoul-Salam","doi":"10.1016/j.ijregi.2025.100764","DOIUrl":"10.1016/j.ijregi.2025.100764","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe the distribution of <em>Neisseria meningitidis</em> serogroups in bacterial meningitis cases diagnosed by polymerase chain reaction at the Sourô Sanou University Hospital, Bobo-Dioulasso, from 2011 to 2021.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study was conducted using retrospective data from cerebrospinal fluid samples collected in Bobo-Dioulasso and surrounding districts and analyzed at the National Reference Laboratory for bacterial meningitis.</div></div><div><h3>Results</h3><div>Among 3823 suspected cases, 3341 samples underwent polymerase chain reaction, confirming 1186 cases (35.5%). The highest number of samples was recorded in 2012 (32.9%), mainly from Dafra district (20.2%). <em>Streptococcus pneumoniae</em> was the leading pathogen (51.9%), followed by <em>N. meningitidis</em> (46.1%) and <em>Haemophilus influenzae</em> type b (1.9%). Most <em>N. meningitidis</em> cases (69.5%) occurred in 2012, declining thereafter, with no cases by 2021. Serogroup W predominated (69.7%), while serogroups A and B were absent.</div></div><div><h3>Conclusions</h3><div>The results emphasize the need to strengthen epidemiological surveillance and adapt vaccination strategies to achieve meningitis elimination in Africa.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100764"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten-year trend and geographic analysis of the incidence of dengue in Taiwan","authors":"Ching-En Jason Chou ,&nbsp;Yi-Hsuan Lee ,&nbsp;Wen-Ching Lin ,&nbsp;Shao-Yi Cheng ,&nbsp;Kuo-Chin Huang ,&nbsp;Chia-Wen Lu","doi":"10.1016/j.ijregi.2025.100754","DOIUrl":"10.1016/j.ijregi.2025.100754","url":null,"abstract":"<div><h3>Objectives</h3><div>To examine a decade of dengue data in Taiwan, focusing on high-risk groups, the influence of imported cases on local outbreaks, and the role of the climate in disease spread.</div></div><div><h3>Methods</h3><div>A descriptive study was carried out utilizing the statistical databases of the Taiwan Centers for Disease Control. The incidence of dengue was analyzed by age, sex, and administrative area. Chi-square tests and <em>t</em>-tests were employed to test differences across subgroups. Geographic information system was used to compare the spatial distribution of dengue incidence.</div></div><div><h3>Results</h3><div>The highest incidence was observed in individuals aged ≥70 years. Comparison of the 2015 and 2023 outbreaks showed a significant surge in dengue incidence in Yunlin County, the first county north of the Tropic of Cancer. Furthermore, no indigenous cases were observed in 2021, the year marked with the longest period of COVID-19 border control in Taiwan.</div></div><div><h3>Conclusions</h3><div>Taiwan should target older age groups and enhance the border control to mitigate dengue outbreaks. Subtropical areas should learn from experienced regions and implement strict preventive strategies against climate change.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100754"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting 7-day mortality in COVID-19 pneumonia: performance of NEWS2, qSOFA, and CRB-65 and development of the CCP-7 prediction scores","authors":"Panika Praputpittaya ,&nbsp;Areeya Phunsupruk ,&nbsp;Piyapat Rattanasuwan ,&nbsp;Borwon Wittayachamnankul ,&nbsp;Wachira Wongtanasarasin","doi":"10.1016/j.ijregi.2025.100792","DOIUrl":"10.1016/j.ijregi.2025.100792","url":null,"abstract":"<div><h3>Objectives</h3><div>Effective early risk stratification of COVID-19 pneumonia patients in emergency departments (EDs) is crucial, especially in resource-limited settings. Common clinical scores (National Early Warning Score version 2 [NEWS2], quick Sequential Organ Failure Assessment [qSOFA], and CRB-65) were not developed for COVID-19 and may inadequately predict short-term mortality. This study aimed to evaluate the prognostic performance of these scores and to develop and internally validate a novel score—the Chiang Mai COVID-19 Pneumonia 7-Day Mortality Prediction Score (CCP-7).</div></div><div><h3>Methods</h3><div>We conducted a retrospective cohort study of patients aged ≥16 years presenting to a tertiary ED in Northern Thailand with confirmed COVID-19 pneumonia between January 2020 and December 2023. Demographic, clinical, and laboratory data were extracted from electronic records. The predictive accuracy of NEWS2, qSOFA, CRB-65, and the newly developed CCP-7 score for 7-day mortality was assessed using a regression framework, the area under the receiver operating characteristic curve (AUROC), calibration, and DeLong tests for AUROC comparisons.</div></div><div><h3>Results</h3><div>Among 735 patients included, the 7-day mortality rate was 5.2%. Four variables—respiratory rate greater than 30/min, altered mental status, abnormal white blood cell count, and thrombocytopenia—were independently associated with mortality and incorporated into the CCP-7. The CCP-7 score demonstrated superior discrimination (AUROC, 0.83; 95% confidence interval [CI]: 0.76-0.90) compared to CRB-65 (0.80, 95% CI: 0.74-0.86), NEWS2 (0.77, 95% CI: 0.68-0.85), and qSOFA (0.64, 95% CI: 0.52-0.75). DeLong tests showed no statistically significant differences between CCP-7 and CRB-65 or NEWS2. At a cutoff of ≥3 points, CCP-7 achieved 57.1% sensitivity and 89.4% specificity.</div></div><div><h3>Conclusions</h3><div>CCP-7 is a simple and context-appropriate tool for predicting 7-day mortality in patients with COVID-19 pneumonia. Although it showed numerically higher discrimination than other scores, the differences were not statistically significant. Its reliance on routine ED parameters makes it particularly suited for rapid risk stratification in low-resource settings, but external validation is essential.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100792"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145466169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human parvovirus B19 infection in dengue patients and potential association with disease progression and clinical outcomes","authors":"Nguyen Minh Nam ,&nbsp;Nguyen Thi Lan Dung ,&nbsp;Nguy Thi Diep ,&nbsp;Le Van Khanh ,&nbsp;Nguyen Thi Thuy Diu ,&nbsp;Ha Van Quang ,&nbsp;Ngo Thu Hang ,&nbsp;Le Van Nam ,&nbsp;Nguyen Linh Toan ,&nbsp;Hoang Van Tong","doi":"10.1016/j.ijregi.2025.100775","DOIUrl":"10.1016/j.ijregi.2025.100775","url":null,"abstract":"<div><h3>Objectives</h3><div>Many viruses can present with clinical symptoms resembling dengue fever (DF), including human parvovirus B19 (B19V). Therefore, patients with DF are not often tested for secondary pathogens. The current study aimed to investigate B19V infection and its association with clinical features in dengue patients.</div></div><div><h3>Methods</h3><div>A total of 230 subjects were recruited for this study, including patients with DF (n = 86), DF with warning signs (DWS, n = 53), and healthy controls (n = 91). Plasma samples were analyzed for B19V using enzyme-linked immunosorbent assay, nested polymerase chain reaction, sequencing, and phylogenetic analysis. The potential association between B19V infection and dengue progression was investigated.</div></div><div><h3>Results</h3><div>Anti-B19V immunoglobulin M antibodies were detected across all groups: 17.4% in the DF group, 7.5% in the DWS group, and 13.2% in healthy controls. Anti-B19V immunoglobulin G positivity was most prevalent in DF patients (26.7%), followed by healthy controls (22.0%) and DWS patients (20.8%). B19V DNA was identified in 10 of 139 dengue patients (7.2%), but not in healthy controls. The rate of B19V infection was significantly higher in DWS patients than in those with DF, suggesting that B19V infection during dengue may be associated with an increased risk of a more severe form of disease (odds ratio = 4.4, <em>P</em> = 0.043). B19V-positive dengue patients had lower platelet counts compared with B19V-negative patients (<em>P</em> = 0.046), although multivariate analysis revealed no significant difference. In addition, only genotype 1, specifically subgenotype 1A, was detected.</div></div><div><h3>Conclusions</h3><div>This study reports the prevalence of B19V infection in Vietnamese dengue patients and reveals a potential association with dengue progression and clinical features.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"17 ","pages":"Article 100775"},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145321258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}