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Association of ambient temperature with tuberculosis incidence in Japan: An ecological study 日本环境温度与肺结核发病率的关系:一项生态研究
IF 1.5
IJID regions Pub Date : 2024-06-04 DOI: 10.1016/j.ijregi.2024.100384
Keita Wagatsuma
{"title":"Association of ambient temperature with tuberculosis incidence in Japan: An ecological study","authors":"Keita Wagatsuma","doi":"10.1016/j.ijregi.2024.100384","DOIUrl":"10.1016/j.ijregi.2024.100384","url":null,"abstract":"<div><h3>Objectives</h3><p>Although several studies have investigated the effects of temperature on the incidence of tuberculosis (TB) in a single city or region, few studies have investigated the variations in this association using nationwide data. This study aimed to quantify the association between temporal variations in TB incidence and temperature across Japan.</p></div><div><h3>Methods</h3><p>The data on the weekly number of newly confirmed TB cases and meteorological variables in 47 Japanese prefectures from 2007 to 2019 were collected. The exposure-response relationships between TB incidence and temperature were quantified using a distributed lag nonlinear model for each prefecture, and estimates from all prefectures were then pooled using a meta-regression model to derive nationwide average associations.</p></div><div><h3>Results</h3><p>This study included 335,060 patients with TB. Compared to those with minimum risk temperature on TB incidence (10<sup>th</sup> percentile at 4.45°C), people who were exposed to the highest temperature concentrations had a 52.0% (relative risk 1.52, 95% confidence interval 1.04-2.23) higher risk for TB incidence at the 99<sup>th</sup> percentile (30.1°C). Our results also emphasized the heterogeneity of these associations in different prefectures. <em>Conclusions:</em> Strengthening monitoring and public health strategies aimed at controlling temperature-related TB may be more effective when tailored to region-specific meteorological conditions.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000559/pdfft?md5=0599dda5eb223537201b9461dafa7948&pid=1-s2.0-S2772707624000559-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating Pakistan's immunization landscape: Progress and pitfalls 驾驭巴基斯坦的免疫格局:进展与陷阱
IF 1.5
IJID regions Pub Date : 2024-06-03 DOI: 10.1016/j.ijregi.2024.100382
Muhammad Fawad Ashraf , Safi Ur Rehman Daim , Hafsa Fayyaz , Muhammad Aizaz Ashraf , Maham Ashraf
{"title":"Navigating Pakistan's immunization landscape: Progress and pitfalls","authors":"Muhammad Fawad Ashraf ,&nbsp;Safi Ur Rehman Daim ,&nbsp;Hafsa Fayyaz ,&nbsp;Muhammad Aizaz Ashraf ,&nbsp;Maham Ashraf","doi":"10.1016/j.ijregi.2024.100382","DOIUrl":"10.1016/j.ijregi.2024.100382","url":null,"abstract":"<div><h3>Objectives</h3><p>This study aims to assess the impact of the 2022 floods in Pakistan on the incidence of vaccine-preventable diseases (VPDs) in flood-affected regions, specifically focusing on areas with traditionally low vaccination coverage.</p></div><div><h3>Design</h3><p>Weekly incidence data of VPDs from September to November 2021 and 2022 were collected and analyzed for the provinces of Sindh, Khyber Pakhtunkhwa, and Baluchistan. The study compared year-on-year changes in disease incidence to evaluate the effect of the floods on disease burden.</p></div><div><h3>Results</h3><p>The analysis revealed significant increases in the incidence of various VPDs in the flood-affected regions compared to the previous year. Diseases such as pertussis showed a 171% increase, while mumps exhibited nearly a 1000% increase in reported cases. Other diseases including polio, diphtheria, neonatal tetanus, measles, chickenpox, and rubella also experienced substantial rises in case numbers. Concurrently, cases of lower respiratory tract illnesses and diarrheal diseases in children under five years old surged notably.</p></div><div><h3>Conclusions</h3><p>The findings underscored the failure of relief and healthcare efforts in managing vaccine-preventable diseases in flood-affected areas of Pakistan. The study highlights an urgent need for targeted intervention strategies, including enhanced immunization drives and healthcare infrastructure improvements in vulnerable regions. The post-flood scenario presents a critical opportunity to address existing challenges in vaccination coverage and to mitigate future disease outbreaks through comprehensive public health initiatives.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000535/pdfft?md5=ce76e227726234ac5a3282449e293ccb&pid=1-s2.0-S2772707624000535-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141279488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mycobacterium wolinskyi infection after breast augmentation: A case report and comprehensive review 隆胸术后的沃林斯基分枝杆菌感染:病例报告与综合评述
IJID regions Pub Date : 2024-06-01 DOI: 10.1016/j.ijregi.2024.100378
Oscar A. Rommens , Wilfred F.A. Kolkman , Peter van Wijngaarden
{"title":"Mycobacterium wolinskyi infection after breast augmentation: A case report and comprehensive review","authors":"Oscar A. Rommens ,&nbsp;Wilfred F.A. Kolkman ,&nbsp;Peter van Wijngaarden","doi":"10.1016/j.ijregi.2024.100378","DOIUrl":"10.1016/j.ijregi.2024.100378","url":null,"abstract":"<div><p>We present a case report about a 26-year-old female with a <em>Mycobacterium wolinskyi</em> surgical site infection after bilateral breast augmentation. In a unique approach compared with previously reported cases, the patient was successfully treated in an outpatient setting using only orally administered cotrimoxazole (trimethoprim-sulfamethoxazole) and ciprofloxacin with one-sided preservation of the breast prothesis. We also provide a comprehensive overview of all report cases of <em>M. wolinskyi</em> infections available in the PubMed database until December 2023 and compare the different diagnostic and therapeutic approaches.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000493/pdfft?md5=f42e2e4af45da9d97ef08e519a0ae6cb&pid=1-s2.0-S2772707624000493-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141033973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The hidden burden of melioidosis in Nepal: a paradigm for the urgent need to implement a simple laboratory algorithm to detect Burkholderia pseudomallei in low-resource endemic areas 尼泊尔的类鼻疽隐性负担:迫切需要在资源匮乏的地方病流行地区采用简单的实验室算法检测类鼻疽的范例
IJID regions Pub Date : 2024-06-01 DOI: 10.1016/j.ijregi.2024.100377
Suraj Bhattarai , Isabel Klugherz , Chiranjay Mukhopadhyay , Ivo Steinmetz
{"title":"The hidden burden of melioidosis in Nepal: a paradigm for the urgent need to implement a simple laboratory algorithm to detect Burkholderia pseudomallei in low-resource endemic areas","authors":"Suraj Bhattarai ,&nbsp;Isabel Klugherz ,&nbsp;Chiranjay Mukhopadhyay ,&nbsp;Ivo Steinmetz","doi":"10.1016/j.ijregi.2024.100377","DOIUrl":"10.1016/j.ijregi.2024.100377","url":null,"abstract":"<div><p>Melioidosis, an emerging infectious disease caused by the Gram-negative bacillus <em>Burkholderia pseudomallei</em>, is massively underdiagnosed in many low- and middle-income countries. The disease is clinically extremely variable, has a high case fatality rate, and is assumed to be highly endemic in South Asian countries, including Nepal. The reasons for underdiagnosis include the lack of awareness among clinicians and laboratory staff and limited microbiological capacities. Because costly laboratory equipment and consumables are likely to remain a significant challenge in many melioidosis-endemic countries in the near future, it will be necessary to make optimum use of available tools and promote their stringent implementation. Therefore, we suggest that health facilities in resource-poor countries, such as Nepal, introduce a simple and low-cost diagnostic laboratory algorithm for the identification of <em>B. pseudomallei</em> cultures. This screening algorithm should be applied specifically to samples from patients with fever of unknown origin and risk factors for melioidosis, such as diabetes. In addition, there could also be a role of low-cost, novel, promising serological point-of-care tests, which are currently under research and development.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000481/pdfft?md5=3a2087c1b2cea0eb101f3e3a4744ce12&pid=1-s2.0-S2772707624000481-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141024665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing article numbering to IJID Regions 将文章编号引入 IJID 区域
IJID regions Pub Date : 2024-06-01 DOI: 10.1016/S2772-7076(24)00064-X
{"title":"Introducing article numbering to IJID Regions","authors":"","doi":"10.1016/S2772-7076(24)00064-X","DOIUrl":"https://doi.org/10.1016/S2772-7076(24)00064-X","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277270762400064X/pdfft?md5=5984037cc83ffc3248ff95f4c30efd73&pid=1-s2.0-S277270762400064X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141429005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Avian ‘Bird’ Flu – undue media panic or genuine concern for pandemic potential requiring global preparedness action? 禽'鸟'流感--媒体的过度恐慌还是对需要采取全球备灾行动的大流行可能性的真正担忧?
IJID regions Pub Date : 2024-06-01 DOI: 10.1016/j.ijregi.2024.100367
Eskild Petersen , Ziad A Memish , David S Hui , Alessandra Scagliarini , Lone Simonsen , Edgar Simulundu , Jennifer Bloodgood , Lucille Blumberg , Shui-Shan Lee , Alimuddin Zumla
{"title":"Avian ‘Bird’ Flu – undue media panic or genuine concern for pandemic potential requiring global preparedness action?","authors":"Eskild Petersen ,&nbsp;Ziad A Memish ,&nbsp;David S Hui ,&nbsp;Alessandra Scagliarini ,&nbsp;Lone Simonsen ,&nbsp;Edgar Simulundu ,&nbsp;Jennifer Bloodgood ,&nbsp;Lucille Blumberg ,&nbsp;Shui-Shan Lee ,&nbsp;Alimuddin Zumla","doi":"10.1016/j.ijregi.2024.100367","DOIUrl":"https://doi.org/10.1016/j.ijregi.2024.100367","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000389/pdfft?md5=ca485471e1203101375fdf729ec59b96&pid=1-s2.0-S2772707624000389-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141286289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing the performance of commercial serological tests for SARS-CoV-2 diagnosis 评估用于诊断 SARS-CoV-2 的商业血清学测试的性能
IJID regions Pub Date : 2024-06-01 DOI: 10.1016/j.ijregi.2024.100383
Leonardo Maia Leony , Larissa Carvalho Medrado Vasconcelos , Ricardo Sampaio Hein da Silva , Aquiles Assunção Camelier , Antônio Carlos Bandeira , Deivide Luis Souza Costa , Isadora Cristina de Siqueira , Fred Luciano Neves Santos
{"title":"Assessing the performance of commercial serological tests for SARS-CoV-2 diagnosis","authors":"Leonardo Maia Leony ,&nbsp;Larissa Carvalho Medrado Vasconcelos ,&nbsp;Ricardo Sampaio Hein da Silva ,&nbsp;Aquiles Assunção Camelier ,&nbsp;Antônio Carlos Bandeira ,&nbsp;Deivide Luis Souza Costa ,&nbsp;Isadora Cristina de Siqueira ,&nbsp;Fred Luciano Neves Santos","doi":"10.1016/j.ijregi.2024.100383","DOIUrl":"10.1016/j.ijregi.2024.100383","url":null,"abstract":"<div><h3>Objectives</h3><p>The emergence of SARS-CoV-2 has triggered a global pandemic with profound implications for public health. Rapid changes in the pandemic landscape and limitations in <em>in vitro</em> diagnostics led to the introduction of numerous diagnostic devices with variable performance. In this study, we evaluated three commercial serological assays in Brazil for detecting anti-SARS-CoV-2 antibodies.</p></div><div><h3>Methods</h3><p>We collected 90 serum samples from SARS-CoV-2-negative blood donors and 352 from SARS-CoV-2-positive, unvaccinated patients, categorized by symptom onset. Subsequently, we assessed the diagnostic performance of three commercial enzyme immunoassays: GOLD ELISA (enzyme-linked immunosorbent assay) COVID-19 Ig (immunoglobulin) G + IgM, Anti-SARS-CoV-2 NCP IgM ELISA, and Anti-SARS-CoV-2 NCP IgG ELISA.</p></div><div><h3>Results</h3><p>Our findings revealed that the GOLD ELISA COVID-19 IgG + IgM exhibited the highest sensitivity (57.7%) and diagnostic odds ratio, surpassing the manufacturer's reported sensitivity in most analyzed time frames while maintaining exceptional specificity (98.9%). Conversely, the Anti-SARS-CoV-2 NCP IgG ELISA demonstrated lower sensitivity but aligned with independent evaluations, boasting a specificity of 100%. However, the Anti-SARS-CoV-2 NCP IgM ELISA exhibited lower sensitivity than claimed, particularly in samples collected shortly after positive reverse transcription polymerase chain reaction results. Performance improved 15-21 days after symptom onset and beyond 22 days, but in the first week, both Anti-SARS-CoV-2 NCP IgM ELISA and Anti-SARS-CoV-2 NCP IgG ELISA struggled to differentiate positive and negative samples.</p></div><div><h3>Conclusions</h3><p>Our study emphasizes the need for standardized validation protocols to address discrepancies between manufacturer-claimed and actual performance. These insights provide essential information for health care practitioners and policymakers regarding the diagnostic capabilities of these assays in various clinical scenarios.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000547/pdfft?md5=72f324bf4f26887807919956171f78ae&pid=1-s2.0-S2772707624000547-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141229840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotic usage patterns in COVID-19 patients in five tertiary hospitals from Bangladesh: A countrywide picture 孟加拉国五家三级医院 COVID-19 患者的抗生素使用模式:全国情况
IJID regions Pub Date : 2024-05-31 DOI: 10.1016/j.ijregi.2024.100381
Tabiha Binte Hannan , Shrebash Paul , Md. Mohiuddin Khan , Binayak Bhattacharjee , Md. Zainal Abedin , Pritish Tarafder , T.M. Al-Amin , Muhammad Abdullah Al Amin , Md. Sayedur Rahman , Fazle Rabbi Chowdhury
{"title":"Antibiotic usage patterns in COVID-19 patients in five tertiary hospitals from Bangladesh: A countrywide picture","authors":"Tabiha Binte Hannan ,&nbsp;Shrebash Paul ,&nbsp;Md. Mohiuddin Khan ,&nbsp;Binayak Bhattacharjee ,&nbsp;Md. Zainal Abedin ,&nbsp;Pritish Tarafder ,&nbsp;T.M. Al-Amin ,&nbsp;Muhammad Abdullah Al Amin ,&nbsp;Md. Sayedur Rahman ,&nbsp;Fazle Rabbi Chowdhury","doi":"10.1016/j.ijregi.2024.100381","DOIUrl":"https://doi.org/10.1016/j.ijregi.2024.100381","url":null,"abstract":"<div><h3>Objectives</h3><p>Irrational and injudicious use of antibiotics in COVID-19 patients could be detrimental in a tropical country with a weak antibiotic stewardship policy such as Bangladesh. This study aimed to focus on the antibiotic usage patterns in COVID-19 patients in Bangladesh.</p></div><div><h3>Methods</h3><p>This prospective observational study was performed from July 2020 to June 2021 in five tertiary hospitals in Bangladesh. Data on demographic profile, disease severity, and antibiotic usage were collected directly from the patients’ hospital documents.</p></div><div><h3>Results</h3><p>A total of 3486 (94.4%) patients were treated with at least one antibiotic; 3261 (93.6%) patients received a single antibiotic, and 225 (6.5%) received multiple antibiotics. The most used antibiotics were ceftriaxone (37.3%), co-amoxiclav (26.3%), azithromycin (10.6%), and meropenem (10.3%). According to the World Health Organization AWaRe categorization, most (2260; 69.6%) of the antibiotics prescribed in this study belonged to the “Watch” group. Culture and sensitivity reports were available in 111 cases from one center. Only 18.9% of the patients were found to be co-infected with multi-drug-resistant bacteria (52.4% yield from sputum, 28.6% from urine, and 14.3% from blood).</p></div><div><h3>Conclusions</h3><p>Strict antibiotic prescribing policy and antibiotic stewardship should be implemented immediately to limit the future threat of antimicrobial resistance in countries such as Bangladesh.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000523/pdfft?md5=abb7ce1b058f0b55c27fcb8c6bb0e4cc&pid=1-s2.0-S2772707624000523-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141329109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Automated local lockdowns for SARS-CoV-2 epidemic control—assessment of effect by controlled interrupted time series analysis 为控制 SARS-CoV-2 疫情而自动实施地方封锁--通过受控中断时间序列分析评估效果
IJID regions Pub Date : 2024-05-25 DOI: 10.1016/j.ijregi.2024.100380
Laura Espenhain , Steen Ethelberg , Laust Hvas Mortensen , Lasse Engbo Christiansen
{"title":"Automated local lockdowns for SARS-CoV-2 epidemic control—assessment of effect by controlled interrupted time series analysis","authors":"Laura Espenhain ,&nbsp;Steen Ethelberg ,&nbsp;Laust Hvas Mortensen ,&nbsp;Lasse Engbo Christiansen","doi":"10.1016/j.ijregi.2024.100380","DOIUrl":"https://doi.org/10.1016/j.ijregi.2024.100380","url":null,"abstract":"<div><h3>Objectives</h3><p>During the COVID-19 pandemic, broad non-pharmaceutical interventions such as national lockdowns were effective but had significant drawbacks, prompting targeted approaches, such as Denmark's localized lockdowns, based on specific epidemiological criteria. This study evaluates the effect of Denmark's automated local lockdown strategy on epidemic control to inform future response.</p></div><div><h3>Methods</h3><p>This was a register-based controlled interrupted time series analysis, examining SARS-CoV-2 infection rates in Danish parishes from March to September 2021. The matching of control parishes was based on location, time, and pre-lockdown infection trends, with the lockdown's start defined as the day after a parish exceeded the lockdown criteria. Follow-up included 3-week pre-lockdown and 2-week post-lockdown.</p></div><div><h3>Results</h3><p>A total of 30 parishes were mandated to lockdown, approximately 3.5% of the population of Denmark. A total of 94 control parishes were used as 109 controls. The decrease in the incidence during the 2-week follow-up period after the initiation of the lockdown was 13% points higher in case parishes: in case parishes, the incidence was reduced by 78% compared with 65% in control parishes.</p></div><div><h3>Conclusions</h3><p>Our findings demonstrate that local lockdowns did have a positive effect in mitigating the spread of the SARS-CoV-2 virus, making them valuable in the fight against the COVID-19 pandemic and an important alternative to national lockdowns.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772707624000511/pdfft?md5=1f0278ad45bb259cd3453a608a04662b&pid=1-s2.0-S2772707624000511-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141302787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia BA.5 与 COVID-19 感染严重程度相关的亚系:印度尼西亚的一项横断面研究
IJID regions Pub Date : 2024-05-09 DOI: 10.1016/j.ijregi.2024.100379
Yovita Hartantri , Basti Andriyoko , Josephine Debora , Febi Ramdhani Rachman , Evan Susandi , Ferdy Ferdian , Ahmad Rizal Ganiem , Bachti Alisjahbana , Arto Yuwono Soeroto , Dewi Kartika Turbawaty
{"title":"BA.5 sub-lineages associated with higher severity of COVID-19 infection: A cross-sectional study in Indonesia","authors":"Yovita Hartantri ,&nbsp;Basti Andriyoko ,&nbsp;Josephine Debora ,&nbsp;Febi Ramdhani Rachman ,&nbsp;Evan Susandi ,&nbsp;Ferdy Ferdian ,&nbsp;Ahmad Rizal Ganiem ,&nbsp;Bachti Alisjahbana ,&nbsp;Arto Yuwono Soeroto ,&nbsp;Dewi Kartika Turbawaty","doi":"10.1016/j.ijregi.2024.100379","DOIUrl":"10.1016/j.ijregi.2024.100379","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to compare the clinical severity and outcome among laboratory-confirmed Omicron variant cases admitted between January and December 2022.</p></div><div><h3>Methods</h3><p>This is a cross-sectional study conducted in Hasan Sadikin General Hospital between January and December 2022. We enrolled patients aged ≥18 years with laboratory-confirmed Omicron infection. Data were collected from clinical records and a whole genome sequencing database. We compared the risk of severe symptoms and mortality using a logistic regression analysis adjusted for sex, age, comorbidities, and vaccination status.</p></div><div><h3>Results</h3><p>We enrolled 255 patients and the main sub-lineages were BA.1 (16.1%), BA.2 (11.4%), BA.5 (35.7%), XBB (22.7%), and BQ.1 (14.1%). Compared with BA.1/BA.2, BA.5 sub-lineages were associated with severe symptoms (adjusted odds ratio of 2.9, 95% confidence interval 1.1-8.2, <em>P</em> &lt;0.05). The highest risk of severe symptoms and mortality was linked with a high number of comorbidities (adjusted odds ratio of 7.8, 95% confidence interval 1.7-22.4, <em>P</em> &lt;0.05). Booster vaccination was protective of severity and mortality.</p></div><div><h3>Conclusions</h3><p>Disease severity was associated with BA.5 sub-lineages and multiple comorbidities. Good management is particularly important for people with comorbidities. Furthermore, booster vaccination is also required to reduce severity and mortality.</p></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S277270762400050X/pdfft?md5=5044a1da1d0c3b2fcc36d9b202933128&pid=1-s2.0-S277270762400050X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141044988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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