IJID regions最新文献

{"title":"Chronic viral hepatitis B: evaluation of the care of patients monitored at the SMIT in Tivaouane, Sénégal","authors":"Agbogbenkou Tevi Dela Dem Lawson,&nbsp;Maimouna Sidibé,&nbsp;Daouda Thioub,&nbsp;Khadim Mbaye,&nbsp;Sylvie Audrey Diop","doi":"10.1016/j.ijregi.2025.100701","DOIUrl":"10.1016/j.ijregi.2025.100701","url":null,"abstract":"<div><h3>Objectives</h3><div>Chronic hepatitis B is a liver-tropic disease caused by hepatitis B virus (HBV) with hepatitis B surface antigen persisting beyond 6 months. According to a 2024 report by the Pasteur Institute, the prevalence of chronic HBV infection in Senegal is alarming, ranking among the highest in the world, between 10 and 17%. Senegal currently does not have a standardized algorithm for the management of chronic hepatitis B. Since 2017, the European Association for the Study of the Liver (EASL) has proposed a new classification of chronic hepatitis B and a surveillance scheme. The objective was to evaluate the management of patients with viral hepatitis B in rural areas according to the EASL criteria.</div></div><div><h3>Methods</h3><div>Retrospective and prospective, descriptive study with analytical aim from March 15, 2022 to December 7, 2024, at the SMIT Mame Abdou Aziz Sy Dabakh hospital in Tivaouane. Included were patients with chronic hepatitis B who had benefited from an initial management assessment according to the criteria of the EASL. Data were captured using Kobocollect software, encoded, and analyzed using R software, V.4.4.0. Ethical considerations were respected.</div></div><div><h3>Results</h3><div>We collected 72 patients. The median age was 34 years (28-41), with a female predominance (56.9%). Housewives (34.7%) and teachers (16.7%) were the most represented. The notion of familial liver cancer (16.67%) was reported with 41.67% in the first degree as well as in the second degree. The discovery of HBV carriage was made during an assessment initiated by the practitioner (63.9%), prenatal assessment (19%), and during a blood donation (9.7%). Nine patients (12.51%) were symptomatic. The hepatitis B e-antigen dosage was negative in 69 patients (95.53%). The median alanine aminotransferase levels were 23.10 IU/l (16-32.25) and viral load 379.5 IU/ml (37-1562). Two hepatitis D virus/HBV co-infections were observed. Fibrosis (F0-F1) was found in 82.5% of cases, F2-F3 in 14.3%, and cirrhosis in 3.2%. Tenofovir disoproxil fumarate treatment was initiated in 10 patients (13.9%), according to the 2017 EASL guidelines. Ineligible patients (86.1%) were placed on surveillance, the rate and frequency of which depended on the initial phase. Among the patients lost to follow-up, 42 were under surveillance (67.64%) and four were under treatment (40%). Lack of treatment and high cost of care were the main reasons for exclusion from follow-up. In multivariate analysis, no factor was significantly associated with loss to follow-up.</div></div><div><h3>Conclusions</h3><div>Our study highlights the challenges of managing chronic viral hepatitis B in rural areas. The high cost of monitoring and the lack of treatment for the majority of patients contribute to loss of follow-up.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100701"},"PeriodicalIF":1.7,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144723625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of hepatitis B virus infection in Zakho City, Kurdistan Region, Iraq; a population-based study","authors":"Nawfal R. Hussein ,&nbsp;Ibrahim A. Naqid ,&nbsp;Halder J. Abozait ,&nbsp;Nashwan MR Ibrahim ,&nbsp;Shakir A. Jamal ,&nbsp;Brisik H. Rashad ,&nbsp;Rijwan Azad Waisi ,&nbsp;Dalia Ayhan Naji ,&nbsp;Nadia Sulaiman Salih ,&nbsp;Iman Salah Hassan ,&nbsp;Parween Fadhil Ahmed ,&nbsp;Nidar Loqman Khwasty ,&nbsp;Marwa Faris Haji ,&nbsp;Alina Abo Issa ,&nbsp;Marwa Talib Abdulrazaq ,&nbsp;Merdeen Muhammed Rasheed Morad ,&nbsp;Zana Sidiq Mohammed Saleem ,&nbsp;Dildar H. Musa","doi":"10.1016/j.ijregi.2025.100703","DOIUrl":"10.1016/j.ijregi.2025.100703","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Hepatitis B virus (HBV) infection remains a significant global health challenge, particularly in developing countries. Despite the availability of an effective vaccine, chronic HBV infection continues to cause substantial morbidity and mortality. This study aimed to determine the prevalence and associated risk factors of HBV infection in Zakho City, Kurdistan Region of Iraq.</div></div><div><h3>Methods</h3><div>A population-based cross-sectional study was conducted on 26 February 2025 in Zakho City, Kurdistan Region, Iraq, using a multistage random sampling method. Data were collected from 386 participants through structured face-to-face interviews and serological testing for hepatitis B surface antigen (HBsAg) and anti-hepatitis B core immunoglobulin G antibody (HBcAb) using enzyme-linked immunosorbent assay.</div></div><div><h3>Results</h3><div>The overall HBV positivity rate (HBcAb-positive) was 8%, with 7% indicating past infection (HBcAb-positive, HBsAg-negative) and 1% indicating chronic infection (HBcAb-positive and HBsAg-positive). In the multivariate analysis, HBV positivity was significantly associated with older age (<em>P</em> = 0.001) and male gender (<em>P</em> = 0.026). The highest prevalence (32.1%) was observed among participants aged ≥ 60 years.</div></div><div><h3>Conclusions</h3><div>The findings demonstrate a moderate prevalence of past HBV infection and a relatively low rate of chronic carriers in Zakho city. Older age and male gender were significant predictors of HBV positivity. These results underscore the importance of continued public health efforts in HBV screening, early detection, and vaccination, particularly targeting older and at-risk populations.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100703"},"PeriodicalIF":1.5,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring methicillin-resistant Staphylococcus aureus prevalence in Taiwan: a hospital-based surveillance study from 2022 to 2024","authors":"Ying-Ju Chen ,&nbsp;Tze-Kiong Er","doi":"10.1016/j.ijregi.2025.100702","DOIUrl":"10.1016/j.ijregi.2025.100702","url":null,"abstract":"<div><h3>Objectives</h3><div>Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) remains a significant public health concern, associated with high morbidity, increased healthcare costs, and limited treatment options due to antimicrobial resistance. Monitoring MRSA trends is essential to support effective infection prevention and control strategies in healthcare settings.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed clinical specimens tested for <em>Staphylococcus aureus</em> between January 2022 and December 2024 at a regional hospital in central Taiwan. Monthly and annual MRSA prevalence rates were calculated as the proportion of MRSA-positive isolates. A chi-square test of independence was used to assess the statistical significance of prevalence differences across years.</div></div><div><h3>Results</h3><div>A total of 1,824 <em>Staphylococcus aureus</em> isolates were identified during the study period, including 287 MRSA cases in 2022 (48.9%), 281 in 2023 (42.3%), and 278 in 2024 (48.5%). The chi-square test revealed a statistically significant difference in annual MRSA prevalence (χ² = 6.94, <em>P</em> = 0.031), indicating a meaningful variation in resistance patterns across years.</div></div><div><h3>Conclusion</h3><div>MRSA prevalence fluctuated over the 3-year period, with a temporary decline in 2023 followed by a rebound in 2024. These findings underscore the importance of continuous surveillance and adaptable infection control strategies to address evolving antimicrobial resistance in hospital environments.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100702"},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seventy-year retained calcified Schistosoma japonicum ova incidentally found in a rectal cancer resection specimen","authors":"Emiri Muranaka ,&nbsp;Koya Yokoyama ,&nbsp;Makio Kawakami ,&nbsp;Ryota Hase","doi":"10.1016/j.ijregi.2025.100704","DOIUrl":"10.1016/j.ijregi.2025.100704","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100704"},"PeriodicalIF":1.5,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resurgence of cholera in Kosti City, Sudan: impact of armed conflict and water supply disruption","authors":"Ayman Azhary ,&nbsp;Nooh Mohamed Hajhamed ,&nbsp;Ahmed Noralla Altyip ,&nbsp;Elham Elamin ,&nbsp;Eman Taha Osman Ali ,&nbsp;Ayman Ahmed ,&nbsp;Emmanuel Edwar Siddig","doi":"10.1016/j.ijregi.2025.100700","DOIUrl":"10.1016/j.ijregi.2025.100700","url":null,"abstract":"<div><h3>Objectives</h3><div>This study assesses the magnitude and epidemiological characteristics of the recent cholera resurgence in Kosti City, Sudan, amid ongoing armed conflict and water supply disruptions.</div></div><div><h3>Methods</h3><div>This was a retrospective cross-sectional study based on hospital records that analyzed cholera surveillance data from Kosti Teaching Hospital from February 20, 2025, to February 24, 2025 (peak period). Epidemiological measures included case fatality rate (CFR) based on the following factors: age, sex, and displacement status. We analyzed the data using R software version 4.2.2.</div></div><div><h3>Results</h3><div>During the peak period, 1714 cholera cases and 69 fatalities were reported (CFR: 4.02%). 136 individuals were internally displaced, and age groups 1-4 and ≥65 years demonstrated the highest CFRs of 9.7% and 9.9%, respectively. By March 5, 2025, 1004 new cases had overwhelmed Kosti Teaching Hospital, with a lower fatality rate (2.3%) compared to the peak period’s CFR.</div></div><div><h3>Conclusions</h3><div>The resurgence of cholera in Kosti underscores the critical need for strengthened water, sanitation, and hygiene interventions and coordinated outbreak response strategies. Addressing underlying vulnerabilities is essential to prevent future outbreaks, especially in conflict-affected settings.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100700"},"PeriodicalIF":1.5,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine and human African trypanosomiasis in Angola: Local insights into challenges and opportunities for remote health delivery","authors":"Fernanda Gonçalves Ferreira Salvador ,&nbsp;Liliane de Fátima A. Oliveira ,&nbsp;Constantina Pereira Furtado Machado ,&nbsp;Pedro Mbueno Nzila ,&nbsp;Henrique Silveira ,&nbsp;Cláudia Maria Valete","doi":"10.1016/j.ijregi.2025.100696","DOIUrl":"10.1016/j.ijregi.2025.100696","url":null,"abstract":"<div><h3>Objectives</h3><div>Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease (NTD) endemic in rural Angola. Although telemedicine can improve healthcare access and coordination, its absence from HAT care highlights gaps in achieving World Health Organization goals for digital health equity and NTD control by 2030. To identify the challenges and opportunities for the local implementation of telemedicine in HAT care.</div></div><div><h3>Methods</h3><div>A mixed-methods study was conducted at the Instituto de Combate e Controlo das Tripanossomiases, a specialized unit of the Angolan Ministry of Health. One interview was conducted with the national HAT manager, and questionnaires were distributed to healthcare professionals, with a response rate of 61.5 %. This study was approved by the Ethics Committee of the Ministry of Health of Angola.</div></div><div><h3>Results</h3><div>Analysis revealed strong local interest in piloting telemedicine for HAT to improve healthcare access, particularly for remote case discussions among healthcare professionals in underserved areas. However, key barriers included unstable Internet connectivity, low digital literacy, insufficient human resources, and limited informatics support.</div></div><div><h3>Conclusions</h3><div>These challenges underscore the need for a multi-sectoral strategy to enable the integration of telemedicine into HAT care and advance digital health equity in Angola.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100696"},"PeriodicalIF":1.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, mortality rate, and factors associated with mortality in patients with sepsis in Vietnam","authors":"Luu Thi Thanh Duyen ,&nbsp;Nguyen Thanh Viet ,&nbsp;Ngo Thu Hang ,&nbsp;Nguyen Anh Tuan ,&nbsp;Le Van Khanh ,&nbsp;Tran Viet Tien ,&nbsp;Hoang Van Tong","doi":"10.1016/j.ijregi.2025.100695","DOIUrl":"10.1016/j.ijregi.2025.100695","url":null,"abstract":"<div><h3>Objectives</h3><div>The burden of sepsis in Vietnam remains largely undocumented. This study aims to estimate the prevalence and mortality rate of sepsis and to identify mortality-associated factors among patients with sepsis in a Vietnamese hospital.</div></div><div><h3>Methods</h3><div>A prospective observational study was conducted to describe the clinical features, laboratory characteristics, and mortality rate of patients with sepsis. All patients admitted to intensive care units with culture-confirmed sepsis from October 2018 to December 2020 were included. Logistic regression and receiver operating characteristic analyses were conducted to identify mortality predictors.</div></div><div><h3>Results</h3><div>Of the 3890 enrolled patients, 2.7% (105 patients) had culture-confirmed sepsis, with 64% (67/105) classified as sepsis and 36% (38/105) as septic shock. The overall mortality rate was 52% (55 out of 105), with mortality rates of 42% (28 out of 67) for sepsis and 71% (27 out of 38) for septic shock. <em>Escherichia coli</em> (38%) was the most frequently isolated pathogen. Although resistance to carbapenems and third-generation cephalosporins was high, it was not associated with an increased risk of mortality. Logistic regression analysis identified neurologic dysfunction, comorbidities, blood lactate levels, and the number of acute organ dysfunctions as independent predictors of mortality in the overall cohort (area under the curve = 0.77). Among patients infected with <em>E. coli</em> or <em>Klebsiella pneumoniae</em>, hypertension, mechanical ventilation, and renal dysfunction were independently associated with mortality (area under the curve = 0.8).</div></div><div><h3>Conclusions</h3><div>Patients with sepsis in Vietnam exhibited a high mortality rate, with <em>E. coli</em> identified as the most common pathogen. Neurologic dysfunction was an independent predictor of mortality, whereas antibiotic resistance was not associated with higher mortality. The identified risk factors may help guide early clinical interventions to improve patient outcomes.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100695"},"PeriodicalIF":1.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on other respiratory viruses in the Haut-Ogooué Province of Gabon","authors":"Christ-Emery Kombe Moulengui ,&nbsp;Jean-Bernard Lekana-Douki ,&nbsp;Sonia Etenna Lekana-Douki","doi":"10.1016/j.ijregi.2025.100699","DOIUrl":"10.1016/j.ijregi.2025.100699","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the impact of the COVID-19 pandemic on the circulation, prevalence, and diversity of respiratory viruses other than SARS-CoV-2.</div></div><div><h3>Methods</h3><div>Between May 2020 and December 2021, 640 nasopharyngeal swabs were collected from individuals with or without respiratory symptoms, all of whom tested negative for SARS-CoV-2. Samples were analyzed for other respiratory viruses using real-time reverse transcription-polymerase chain reaction.</div></div><div><h3>Results</h3><div>The overall positivity rate for respiratory viruses was 4.37% (95% confidence interval: 2.79-5.96). Rhinovirus was the most common virus detected (1.25%), followed by PIV4 (0.78%), Human Coronavirus 229E (HCoV-229E) (0.62%), and influenza B (0.46%). Influenza A (H1N1pdm09) and Human Coronavirus OC43 (HCoV-OC43) each had a prevalence of 1%. Other viruses, including H3N2, Human Coronavirus NL63 (HCoV-NL63), and Human Coronavirus HKU1 (HCoV-HKU1), were less frequent (0.15%).</div></div><div><h3>Conclusions</h3><div>The study reveals a low circulation of respiratory viruses other than SARS-CoV-2 during the period from May 2020 to December 2021. This observation is directly linked to the preponderant circulation of SARS-CoV-2 and the strict measures put in place to limit its transmission.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100699"},"PeriodicalIF":1.5,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144714119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis: The insidious threat that compromises health in post-Assad Syria","authors":"Emir Muvaffak ,&nbsp;Salah Safadi ,&nbsp;Mohammad Al-Abbas ,&nbsp;Mazen Kherallah ,&nbsp;Abdulselam Daif ,&nbsp;Alfonso J. Rodriguez-Morales ,&nbsp;Josette Najjar ,&nbsp;Hazem Bakleh ,&nbsp;Mahmoud Karim ,&nbsp;Zaher Sahloul ,&nbsp;Aula Abbara","doi":"10.1016/j.ijregi.2025.100697","DOIUrl":"10.1016/j.ijregi.2025.100697","url":null,"abstract":"<div><div>This perspective explores the state of tuberculosis (TB) after the prolonged conflict in Syria and fall of the regime in December 2024; we discuss key considerations in light of multiple competing health priorities within Syria’s borders and the recovering health system. During the conflict, the health system fragmentation under differing geopolitical control led to unequal access to TB prevention, diagnostics and management social determinants such as poverty, malnutrition, inadequate water and sanitation, and lack of proper shelter, along with risks associated with disadvantaged groups, including internally displaced people, detainees, former detainees, and rural communities, not only increase the risk of TB transmission and the activation of latent infections but also hinder active case finding. Tackling these risks requires re-establishing the National TB Program (NTP) across the country, which acts equitably across all geographical areas to identify new cases, support robust surveillance activities, ensure drug resistance is identified promptly, and monitor treatment. Leadership from the Ministry of Health and the World Health Organization, with support from other stakeholders e.g., humanitarian, civil society or private sector can support the NTP and optimize health worker education and referral pathways. Beyond this, addressing the social determinants, which contribute to TB in Syria, is an essential component of TB control in post-conflict Syria.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100697"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors associated with infections linked to carbapenemase-producing Acinetobacter species circulating in the city of Yaoundé, Cameroon","authors":"Cedric Fossi Tchinda ,&nbsp;Karyom Djim-Adjim-Ngana ,&nbsp;Therence Annie Mbogning ,&nbsp;Brice Fredy Nemg Simo ,&nbsp;Sosthene Boido Baira ,&nbsp;Gaizirene Egoume Feudjieu ,&nbsp;Sonia Gayap Matchuenkam ,&nbsp;Gael Njini Nfor ,&nbsp;Guy Roussel Nguemto Takuissu ,&nbsp;Kikie Josiane Essola ,&nbsp;Connie Constance Georgina Walyaro ,&nbsp;Armelle Deutou Tchamgoue","doi":"10.1016/j.ijregi.2025.100698","DOIUrl":"10.1016/j.ijregi.2025.100698","url":null,"abstract":"<div><h3>Objectives</h3><div>Carbapenems are critical antibiotics used against multidrug-resistant infections, yet resistance is increasing, especially among Gram-negative bacteria like <em>Acinetobacter</em> species. In Cameroon, while <em>Acinetobacter baumannii</em> is well studied, little is known about other species such as <em>Acinetobacter pittii, Acinetobacter nosocomialis</em>, and <em>Acinetobacter calcoaceticus</em>. This study assessed the prevalence of carbapenemase-producing <em>Acinetobacter</em> and associated risk factors in Yaoundé hospitals.</div></div><div><h3>Methods</h3><div>A 6-month prospective cross-sectional study (April-September 2024) was conducted using 531 clinical samples from four health facilities. Strains were identified via morphologic, biochemical, and API 20 NE® tests. Antibiotic susceptibility was assessed using disc diffusion, and carbapenemases were characterized phenotypically.</div></div><div><h3>Results</h3><div>Of the samples, 4.9% yielded <em>Acinetobacter</em>, with <em>A. baumannii</em> being most common (80.8%), followed by <em>A. calcoaceticus</em> (11.5%) and <em>Acinetobacter anitratus</em> (7.7%). <em>A. baumannii</em> showed high antibiotic resistance, especially to beta-lactams, with 85.71% producing carbapenemases (83.33% class B and 16.67% class A). Significant risk factors included hospitalization, current antibiotic therapy, recent antibiotic use, and age group 38-47 years.</div></div><div><h3>Conclusions</h3><div>These findings highlight an urgent need for better surveillance, stricter antibiotic stewardship, and enhanced infection control strategies to limit the spread of resistant <em>Acinetobacter</em> infections in Yaoundé’s health care settings.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"16 ","pages":"Article 100698"},"PeriodicalIF":1.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}