IJID regions最新文献

Outbreak of severe acute respiratory infections caused by recombinant human adenovirus type B 7/3 in hospitalized infants from a nursery in Dakar, April 2024 2024 年 4 月，达喀尔一家托儿所的住院婴儿爆发重组人腺病毒 B 型 7/3 引起的严重急性呼吸道感染

IF 1.5

IJID regions Pub Date : 2024-10-16 DOI: 10.1016/j.ijregi.2024.100473

{"title":"Outbreak of severe acute respiratory infections caused by recombinant human adenovirus type B 7/3 in hospitalized infants from a nursery in Dakar, April 2024","authors":"","doi":"10.1016/j.ijregi.2024.100473","DOIUrl":"10.1016/j.ijregi.2024.100473","url":null,"abstract":"<div><h3>Objectives</h3><div>Acute respiratory infections are among the leading cause of mortality in children under 5 years of age worldwide, with most of these deaths due to bronchiolitis and pneumonia. We investigated and analyzed a pediatric outbreak of acute respiratory infections that resulted in the hospitalization of four infants in a nursery in Dakar in late April 2024.</div></div><div><h3>Methods</h3><div>Nasopharyngeal specimens were collected from infants and tested for a panel of respiratory pathogens by multiplex real-time reverse transcription–polymerase chain reaction. Subsequently, the positive samples underwent next-generation sequencing for molecular analysis.</div></div><div><h3>Results</h3><div>Human adenovirus (HAdV) was the principal etiologic agent detected in hospitalized infants with pneumonia and nearly half (46.7%; seven of 15) of the suspected cases identified during the investigation at the nursery. All the HAdV isolates were classified as being of subgroup B1. Molecular characterization revealed that infants attending the nursery were infected with a recombinant HAdV strain containing an adenovirus serotype 7 penton and serotype 3 hexon and fiber proteins.</div></div><div><h3>Conclusions</h3><div>Our findings reinforce previous evidence that recombination leads to the emergence of new adenovirus strains with epidemic and lethal potential. These results emphasize the need to strengthen surveillance in inpatient settings across the country.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The incidence, clinical features and outcome of urinary tract infections in geriatric patients: A prospective longitudinal study 老年患者尿路感染的发病率、临床特征和结果：前瞻性纵向研究

IF 1.5

IJID regions Pub Date : 2024-10-11 DOI: 10.1016/j.ijregi.2024.100469

{"title":"The incidence, clinical features and outcome of urinary tract infections in geriatric patients: A prospective longitudinal study","authors":"","doi":"10.1016/j.ijregi.2024.100469","DOIUrl":"10.1016/j.ijregi.2024.100469","url":null,"abstract":"<div><h3>Objectives</h3><div>This study compares the incidence, clinical features, microbial profiles, and outcomes of urinary tract infections (UTIs) in patients aged 65 years and older versus those younger than 65 years.</div></div><div><h3>Methods</h3><div>A longitudinal cohort of 1,123 patients was divided into Group A (≥65 years, n = 560) and Group B (<65 years, n = 563) and followed for 2 years. The study analyzed UTI incidence, clinical features, microbial profiles, and outcomes, including recurrence and antibiotic resistance.</div></div><div><h3>Results</h3><div>Over 2 years, Group A had a significantly higher UTI incidence (38.0%) compared with Group B (12.8%) (<em>P</em> <0.0001). Complete recovery was less common in Group A (44.6%) than in Group B (70.83%), whereas recurrent UTIs and antibiotic resistance were more frequent in Group A (43.5% vs 22.2%, <em>P</em> <0.0001 and 11.7% vs 2.78%, <em>P</em> = 0.0017, respectively). <em>Escherichia coli</em> was the most prevalent pathogen in both groups, with <em>Klebsiella</em> and <em>Pseudomonas</em> species more common in recurrent UTIs, particularly in older patients<u>.</u> Risk factors for recurrent UTIs included advanced age, female sex, diabetes, immunosuppression, and renal stones.</div></div><div><h3>Conclusions</h3><div>These findings highlight the need for age-specific UTI prevention and management strategies that account for microbial resistance patterns and higher recurrence rates in older patients, addressing clinical and microbial challenges.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outpatient parenteral antimicrobial therapy (OPAT) for the management of periprosthetic joint infections in the Republic of Ireland (ROI) from 2013 to 2021 2013年至2021年爱尔兰共和国用于治疗假体周围关节感染的门诊病人肠外抗菌疗法（OPAT

IF 1.5

IJID regions Pub Date : 2024-10-11 DOI: 10.1016/j.ijregi.2024.100466

{"title":"Outpatient parenteral antimicrobial therapy (OPAT) for the management of periprosthetic joint infections in the Republic of Ireland (ROI) from 2013 to 2021","authors":"","doi":"10.1016/j.ijregi.2024.100466","DOIUrl":"10.1016/j.ijregi.2024.100466","url":null,"abstract":"<div><h3>Objectives</h3><div>Periprosthetic joint infection (PJI) is a complication of joint arthroplasty and is seen in 1-2% of cases. Since its initiation in 2013, the national outpatient parenteral antimicrobial therapy (OPAT) program has facilitated the outpatient management of intravenous antimicrobials for PJI. This study aims to describe the clinical epidemiology of patients on OPAT with PJI between 2013 and 2021.</div></div><div><h3>Methods</h3><div>A retrospective analysis of patients discharged on OPAT between January 1, 2013 to August 31, 2021 was performed using data available from the national OPAT program. This study focused on those with a PJI. Data were analyzed using STATA/SE version 17.0.</div></div><div><h3>Results</h3><div>From January 1, 2013 until August 31, 2021, there were 14,749 patients managed through the national OPAT program, 8.35% (1232 of 14,749) of which were PJI. Of these, 53% (653 of 1232) were hip arthroplasty, 22.7% (280 of 1232) were knee arthroplasty, and 24.3% (299 of 1232) were “other.” The mean age was 64.5 years (SD 14.15 years). Of those on OPAT, 66.15% (815 of 1232) were health care–administered OPAT, whereas 33.85% (417 of 1232) were self-administered (S) OPAT (S-OPAT). Patients on S-OPAT were statistically younger (61 vs 66 years old, <em>P</em> <0.001, 95% confidence interval 14.1-63.6). The most common antimicrobial prescribed was daptomycin (35.8%; 441 of 1232), followed by ceftriaxone (21.2%; 262 of 1232). The median duration on the OPAT program was 27 days (interquartile range 14.5-35 days).</div></div><div><h3>Conclusion</h3><div>OPAT use in PJI is growing. Cumulatively, it has saved 26,992 hospital bed-days. Although S-OPAT is the preferred strategy and should be considered for all patients, our data demonstrate that health care–administered OPAT is required more frequently in older patients.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142537528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mal'aria in the Republic of Ireland; A retrospective review of the clinical epidemiology of mal'aria between 2016 and 2020 爱尔兰共和国的疟原虫；2016 年至 2020 年间疟原虫临床流行病学的回顾性研究

IF 1.5

IJID regions Pub Date : 2024-10-11 DOI: 10.1016/j.ijregi.2024.100467

{"title":"Mal'aria in the Republic of Ireland; A retrospective review of the clinical epidemiology of mal'aria between 2016 and 2020","authors":"","doi":"10.1016/j.ijregi.2024.100467","DOIUrl":"10.1016/j.ijregi.2024.100467","url":null,"abstract":"<div><h3>Objectives</h3><div>Mal'aria is a parasitic infection that continues to present significant morbidity and mortality figures throughout the world. In the Republic of Ireland (Ireland), mal'aria is an imported infection linked most frequently to travel routes from West Africa. There is a paucity of data on the clinical epidemiology and hospital service utilization of mal'aria in non-endemic setting to inform physician practice. This study aims to fill that gap, providing a clinical context to the national picture of both adult and pediatric cases.</div></div><div><h3>Methods</h3><div>A retrospective review of data from all public Irish hospitals was performed from 2016 to 2020, inclusive. Ethical approval was granted following review by the Social Research Ethics Committee (SREC) of University College Cork.</div></div><div><h3>Results and Conclusions</h3><div>During the study period, there were 337 cases of mal'aria presenting to Irish hospitals, 15.1% (51/337) in the pediatric age category. Presentations occurred nationwide with a predictable seasonality. The majority (77.45%; 261/337) were <em>Plasmodium falciparum</em> and 6% (20/337) required critical care admission. Interestingly, females had a higher likelihood of admission to critical care (odds ratio 2.75, 95% confidence interval 1.1-6.86). The COVID-19 pandemic saw a 78% reduction in mal'aria presentations in 2020. A total of 1,166 bed days were utilized by cases of mal'aria.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High incidence of multidrug-resistant tuberculosis in Bhutan: A cohort study based on national TB surveillance data 不丹耐多药结核病发病率高：基于国家结核病监测数据的队列研究

IF 1.5

IJID regions Pub Date : 2024-10-10 DOI: 10.1016/j.ijregi.2024.100471

{"title":"High incidence of multidrug-resistant tuberculosis in Bhutan: A cohort study based on national TB surveillance data","authors":"","doi":"10.1016/j.ijregi.2024.100471","DOIUrl":"10.1016/j.ijregi.2024.100471","url":null,"abstract":"<div><h3>Objectives</h3><div>The emergence of multidrug-resistant tuberculosis (MDR-TB) has made the elimination of TB difficult. Currently, there are limited data on MDR-TB and other drug-resistant TB in Bhutan. We aimed to estimate the incidence and explore the potential risk factors associated with MDR/pre-extensively drug-resistant (pre-XDR)-TB using comprehensive national TB data.</div></div><div><h3>Methods</h3><div>We used the data from the Tuberculosis Information Surveillance System of the National Tuberculosis Reference Laboratory to analyze the resistance pattern and epidemiologic data for all TB cases tested for resistance for the year 2018-2021. Multiple logistic regression was performed to identify risk factors associated with MDR/pre-XDR-TB.</div></div><div><h3>Results</h3><div>Of the 2,290 samples tested for drug resistance, 10.6% (n = 243) was MDR-TB, 3.5% (n = 81) was isoniazid-resistant TB, and 0.61% (n = 14) was pre-XDR-TB. A high incidence of MDR/RR-TB/pre-XDR-TB was documented among patients in Thimphu, Samtse, and Sarpang districts. MDR/pre-XDR-TB was more likely documented among patients aged 18-39 years (adjusted odds ratio [aOR] 2.79; 95% confidence interval [CI] 1.46-6.07), female sex (aOR 1.37; 95% CI 1.01-1.86), and patients previously treated for TB (aOR 2.98; 95% CI 1.99-4.42).</div></div><div><h3>Conclusions</h3><div>Given the high burden of MDR-TB in some districts, decentralization of diagnostic facilities for more rapid characterization could improve early recognition of drug-resistant cases and assist in management. Comprehensive follow-up and monitoring of high-risk groups should be performed.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Candida auris cluster in a large third level Italian hospital: a case series 意大利一家大型三级甲等医院的念珠菌簇：系列病例

IF 1.5

IJID regions Pub Date : 2024-10-09 DOI: 10.1016/j.ijregi.2024.100468

{"title":"Candida auris cluster in a large third level Italian hospital: a case series","authors":"","doi":"10.1016/j.ijregi.2024.100468","DOIUrl":"10.1016/j.ijregi.2024.100468","url":null,"abstract":"<div><h3>Objectives</h3><div><em>Candida auris</em> has been circulating since 2019 in Northern and Middle-Italy regions.</div></div><div><h3>Design</h3><div>This report details the first three cases of <em>C. auris</em> isolation in Puglia (Southern Italy), which occurred as a nosocomial outbreak.</div></div><div><h3>Results</h3><div>The first <em>C. auris</em> specimen was isolated on April 19, 2024 from a blood culture obtained from a 55-year-old male (GM) in an intensive care unit (ICU) of Bari Policlinico General Hospital. The patient had been admitted on April 06, 2024 due to subarachnoid hemorrhage. On April 12, 2024, a blood sample tested positive for multidrug-resistant <em>Klebsiella pneumoniae</em>, requiring isolation and wide-spectrum antibiotic therapy. Exitus occurred on April 17, 2024, but 2 days later, a pre-mortem blood sample tested positive for <em>C. auris</em>, leading to epidemiologic investigation in the whole ICU.</div><div>A second case was therefore identified (SD), a 36-year-old male admitted on March 21, 2024, shortly after undergoing a dental procedure in Tirana (Albania). Due to the timing of admission, he was identified as the index case.</div><div>A third case was later found on April 29, 2024 (CM), a 52-year-old woman with a history of acute myeloid leukemia located in the same ICU but on a different floor.</div><div>A link of transmission was identified via environmental sampling, as the medics’ common telephone tested positive for <em>C. auris</em> contamination.</div></div><div><h3>Conclusion</h3><div>The pathogen's circulation has shown to be inapparent and difficult to track, making it a potential threat even for facilities outside of known high-risk geographical areas. ICUs should be monitored routinely.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemsex and rising substance use linked to sexually transmitted infections among men who have sex with men living with HIV in Bangkok, Thailand 泰国曼谷感染艾滋病毒的男男性行为者中，化学性性行为和药物使用增加与性传播感染有关

IF 1.5

IJID regions Pub Date : 2024-09-28 DOI: 10.1016/j.ijregi.2024.100465

{"title":"Chemsex and rising substance use linked to sexually transmitted infections among men who have sex with men living with HIV in Bangkok, Thailand","authors":"","doi":"10.1016/j.ijregi.2024.100465","DOIUrl":"10.1016/j.ijregi.2024.100465","url":null,"abstract":"<div><h3>Objectives</h3><div>We report longitudinal trends in alcohol and recreational drug use, and their associations with sexual behaviors and clinical outcomes in a Thai cohort of predominantly men who have sex with men (MSM) living with HIV.</div></div><div><h3>Methods</h3><div>From 2017 to 2019, participants in the RV254/SEARCH010 acute HIV cohort answered questions every 24 weeks about drug use and sexual behaviors. Longitudinal trends were assessed using the χ2 test for trend. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for factors potentially associated with recreational drug and alcohol use.</div></div><div><h3>Results</h3><div>Among 604 participants, the median age was 26 (interquartile range 23-31) years, and 93.5% were MSM. Alcohol consumption was reported in 83.3% and recreational drug use in 46.9% during the study period, with rising trends in both over the years. Participants who reported recreational drug use were more likely to have hepatitis C (OR 3.42, 95% CI 1.88-6.21), syphilis (OR 2.69, 1.75-4.13), gonorrhea (OR 7.74, 5.04-11.89), and chlamydia (OR 1.61, 1.12-2.31), and to engage in group sex (OR 7.74, 5.04-11.89). Participants who used any recreational drugs had more frequent viral blips (23.1% vs 14.2%, <em>P</em> = 0.007) and reported missed doses of antiretroviral drugs more often (52.4% vs 36.9%, <em>P</em> <0.001), but had no significant difference in viral suppression (94.1% vs 97.4%, <em>P</em> = 0.06).</div></div><div><h3>Conclusions</h3><div>Among MSM living with HIV in Bangkok, recreational drug use has increased in recent years and was associated with hepatitis C and sexually transmitted infections, especially among men who participate in group sex. Prevention strategies and other interventions may improve treatment adherence and other HIV outcomes.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global landmark: 2023 marks the worst year for dengue cases with millions infected and thousands of deaths reported 全球里程碑：2023 年是登革热病例最严重的一年，数百万人感染，数千人死亡

IF 1.5

IJID regions Pub Date : 2024-09-26 DOI: 10.1016/j.ijregi.2024.100459

{"title":"Global landmark: 2023 marks the worst year for dengue cases with millions infected and thousands of deaths reported","authors":"","doi":"10.1016/j.ijregi.2024.100459","DOIUrl":"10.1016/j.ijregi.2024.100459","url":null,"abstract":"<div><h3>Objectives</h3><div>In 2023, the world experienced the worst dengue virus (DENV) outbreak on record. The study aimed to identify global regions and continents with high burden of dengue in 2023.</div></div><div><h3>Design</h3><div>We collected data on the number of DENV cases and deaths reported by various countries to the World Health Organization and World Health Organization regional offices. We estimated DENV cases per million population and case fatality ratio (CFR) among the confirmed cases reported by each country.</div></div><div><h3>Results</h3><div>Overall, in 2023 more than 6.5 million cases and over 6,800 deaths attributed to DENV were recorded globally, marking a historic milestone. Two distinct hotspots of DENV circulation emerged: South America and South and Southeast Asian regions. South America reported the highest number of cases (3,924,992), and 1,946 deaths, with a CFR of 0.05. In Asia, 1,622,405 cases and 3,637 deaths were reported, with a CFR of 0.22. We observed a statistically significant difference in the number of cases and deaths per million across different continents (<em>P</em>-value <0.001). However, the CFR did not differ significantly across continents (<em>P</em>-value = 0.123).</div></div><div><h3>Conclusions</h3><div>The increased cases and mortality highlight the urgent need for a comprehensive global approach aimed at DENV infection control, including vaccine development, vector control, public health initiatives, and improved clinical management.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Undiagnosed West Nile virus lineage 2d infection in a febrile patient from South-west Uganda, 2018 2018 年乌干达西南部一名发热患者未确诊的西尼罗河病毒 2d 系感染

IF 1.5

IJID regions Pub Date : 2024-09-26 DOI: 10.1016/j.ijregi.2024.100462

引用次数: 0

Oropouche virus: A re-emerging arbovirus of clinical significance 奥罗普切病毒重新出现的具有临床意义的虫媒病毒

IF 1.5

IJID regions Pub Date : 2024-09-25 DOI: 10.1016/j.ijregi.2024.100456

引用次数: 0