IJID regions最新文献

{"title":"Tuberculosis treatment outcomes and their related factors in patients with tuberculosis treated at the Antituberculosis Center of Brazzaville, Republic of Congo","authors":"Breli Bonheur Ngouama ,&nbsp;Freisnel Hermeland Mouzinga ,&nbsp;Mita Naomie Merveille Dello ,&nbsp;Jean Claude Djontu ,&nbsp;Darrel Ornelle Elion Assiana ,&nbsp;Franck Hardain Okemba Okombi ,&nbsp;Salomon Bonsi Tchuandom ,&nbsp;Michel Illoye Ayet ,&nbsp;Lemercier Khunell Siele ,&nbsp;Jeannhey Christevy Vouvoungui ,&nbsp;Martin Peter Grobusch ,&nbsp;Alain Maxime Mouanga ,&nbsp;Alain Brice Vouidibio Mbozo ,&nbsp;Francine Ntoumi","doi":"10.1016/j.ijregi.2025.100647","DOIUrl":"10.1016/j.ijregi.2025.100647","url":null,"abstract":"<div><h3>Objectives</h3><div>Tuberculosis (TB) treatment outcome is one of the key indicators to evaluate the performance of TB control programs. This study aims to assess TB treatment outcomes and their related associated factors in patients treated at the Antituberculosis Center of Brazzaville, Republic of Congo.</div></div><div><h3>Methods</h3><div>A prospective cohort study was conducted at the Antituberculosis Center of Brazzaville from July 2022 to August 2023, involving 305 patients with pulmonary TB diagnosed with the GenXpert MTB/RIF assay. These patients were closely monitored using acid-fast bacillus microscopy while receiving treatment based on whether they were drug-sensitive (DS) or drug-resistant. Sputum samples from patients who were DS were analyzed at 2, 5, and 6 months, whereas patients who were multi-drug–resistant (MDR) underwent a monthly sputum analysis for 9 months.</div></div><div><h3>Results</h3><div>The overall successful treatment rate was 80.3%, with 70.8% of patients cured and 9.5% completing treatment. Conversely, 19.7% experienced unsuccessful outcomes, including 13.4% loss to follow-up, 3.6% deaths, and 1.6% treatment failures. The treatment success in individuals co-infected with HIV was 46.7% (seven of 15), whereas it was 42% (eight in 19) in patients who were MDR. HIV-negative status (adjusted odds ratio = 5.11; 95% confidence interval: 1.73-13.44) and DS-TB (adjusted odds ratio = 8.29; 95% confidence interval: 3.17-21.04) were associated with increased success of treatment outcome.</div></div><div><h3>Conclusions</h3><div>The overall TB treatment success rate was below the World Health Organization End TB Strategy threshold, with a high proportion of patients lost to follow-up and a low treatment success in patients with TB/HIV and those who were MDR. The findings highlight the need to enhance supervision, improve directly observed treatment short course monitoring, and develop strategies to minimize patients lost to follow-up.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100647"},"PeriodicalIF":1.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment on the prevalence of malaria and its associated risk factors in individuals visiting the health centers in the wetlands of Bahir Dar Zuria District, Northwestern Ethiopia","authors":"Ayalew Sisay Beyene ,&nbsp;Felegush Abebe ,&nbsp;Adem Nega Yimer","doi":"10.1016/j.ijregi.2025.100651","DOIUrl":"10.1016/j.ijregi.2025.100651","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to assess the prevalence and risk factors of malaria in individuals visiting health centers in the wetlands of Bahir Dar Zuria District, Northwest Ethiopia.</div></div><div><h3>Methods</h3><div>A cross-sectional study design was used on 422 study participants from three selected health centers from February to March 2020. Plasmodium parasite detection was examined using thick and thin blood smears, with a rapid diagnostic test. The chi-square (χ²) test was used to analyze the association between the prevalence of malaria and categorical variables, whereas binary logistic regression was used to identify potential risk factors using SPSS Version 25. For all types of tests, <em>P</em>-values below 0.05 were considered significant.</div></div><div><h3>Results</h3><div>The overall prevalence of malaria observed at the selected health centers around the wetlands of Bahir Dar Zuria District was 23.90% (95% confidence interval: 20.30-27.70%). There was a higher prevalence of malaria in males (39.78%) than in females (11.44%). The younger age group (16-30 years) was the most affected (47.76%), compared with the remaining 0-2 (19.23%), 3-15 (8.64%), 36-45 (37.25%), and above 45 years age groups (13.01%). Individuals with bed net–using habit decreased the risk of malaria infection by 99.70% compared with their counterparts (adjusted odds ratio: 0.003, 95% confidence interval: 0.001-0.011).</div></div><div><h3>Conclusions</h3><div>In this study, the wetlands of Bahir Dar Zuria District were found conducive to the survival and reproduction of mosquitoes, and the occurrence of malaria prevalence was very high. Therefore, wetland management practices and community mobilizations that might decrease vector abundance and malaria transmission should be strengthened in the study area.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100651"},"PeriodicalIF":1.5,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144090429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of native mitral valve infective endocarditis by Lactobacillus jensenii in a healthy young patient","authors":"Thanaboon Yinadsawaphan ,&nbsp;Narathorn Kulthamrongsri ,&nbsp;Reed McCardell Malone ,&nbsp;Salinda Surapongpairat ,&nbsp;Chanokporn Puchongmart ,&nbsp;Ben Thiravetyan ,&nbsp;Korakrit Imwattana ,&nbsp;Jutatip Na Witayanan","doi":"10.1016/j.ijregi.2025.100648","DOIUrl":"10.1016/j.ijregi.2025.100648","url":null,"abstract":"<div><div><em>Lactobacillus jensenii</em>, a Gram-positive facultative anaerobic bacterium, is part of the normal vaginal microbiome and is occasionally found in fermented foods and probiotics. It is a rare cause of infections, with infective endocarditis (IE) being exceedingly uncommon. We report a case of IE caused by <em>Lactobacillus jensenii</em> in a previously healthy 15-year-old female who presented with progressive dyspnea, fever, and severe mitral regurgitation. Echocardiography revealed a vegetative mass on the anterior mitral leaflet. Blood cultures identified <em>L. jensenii</em> using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry. Surgical repair confirmed myxomatous degeneration and chronic inflammation of the mitral valve. The patient fully recovered after surgery and a 6-week antibiotic course. A review of 12 reported cases of <em>L. jensenii</em> IE, including our case, shows a predominance in immunocompetent females, possibly due to its role as a vaginal commensal. Most cases involved native valves with underlying pathology facilitating bacterial colonization. An empirical regimen with ampicillin and gentamicin is effective against <em>L. jensenii</em>. A treatment duration of 4-6 weeks is sufficient, with favorable outcomes.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100648"},"PeriodicalIF":1.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute gastroenteritis outbreak linked to Escherichia coli contamination in a swimming pool during a state-level school sports championship","authors":"Mohd Faiz Ibrahim ,&nbsp;Md Faizul Abd Razak ,&nbsp;Noor Adillah Dawad ,&nbsp;Meruwan Amin Shoib ,&nbsp;Yong Xiang Cheah ,&nbsp;Haidar Rizal Toha","doi":"10.1016/j.ijregi.2025.100643","DOIUrl":"10.1016/j.ijregi.2025.100643","url":null,"abstract":"<div><div>Acute gastroenteritis (AGE) outbreaks caused by <em>Escherichia coli</em> are typically foodborne, and linked to contaminated food or water sources. This article describes an outbreak associated with a public aquatic facility during a state-level championship in Johor Bahru, Malaysia, in July 2024. The outbreak was linked to a malfunctioning pool filtration system and inadequate maintenance, creating an unusual environmental source of <em>E. coli</em> transmission. Epidemiological investigations were conducted, along with environmental assessments and laboratory analyses of clinical (rectal swabs and stool cultures) and environmental (water and surface swabs) samples. A total of 92 AGE cases were identified among 917 exposed individuals, yielding an attack rate of 10.03%. Symptoms included diarrhea, abdominal pain, nausea, vomiting, and fever. Laboratory investigations revealed <em>E. coli</em> contamination in five water samples, with levels exceeding permissible limits. Low residual chlorine levels (&lt;0.2 mg/l) were observed. <em>Leptospira</em> species were detected in two water samples, but no confirmed leptospirosis cases were reported. Environmental assessment revealed poor pool hygiene, malfunctioning filtration systems, and incomplete renovations. This outbreak underscores the critical need for stringent hygiene standards in public swimming pools and consistent maintenance of water quality to prevent waterborne disease outbreaks in aquatic facilities.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100643"},"PeriodicalIF":1.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143876609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From sixty-four percent hyperparasitemia to recovery: Managing severe falciparum malaria and delayed hemolytic anemia","authors":"Fiona Murphy ,&nbsp;Tanna Tan ,&nbsp;Josephine Hebert ,&nbsp;Cora Mc Nally","doi":"10.1016/j.ijregi.2025.100644","DOIUrl":"10.1016/j.ijregi.2025.100644","url":null,"abstract":"<div><h3>Objectives</h3><div>Severe <em>Plasmodium falciparum</em> malaria with hyperparasitemia is a life-threatening condition requiring urgent intervention, particularly in non-immune individuals. Artesunate has revolutionized its management, though complications such as post-artesunate delayed hemolysis (PADH) necessitate ongoing vigilance.</div></div><div><h3>Methods</h3><div>We report a case of a 26-year-old sailor with a history of recent travel to Nigeria who presented to an Irish hospital with severe falciparum malaria and hyperparasitemia of 64.35%. Initial management included intravenous artesunate, continuous renal replacement therapy, and hemodynamic support, leading to rapid parasite clearance and recovery from multi-organ dysfunction. However, 1 week post-discharge, the patient developed PADH, manifesting as severe anemia requiring blood transfusion.</div></div><div><h3>Results</h3><div>This case underscores the importance of prompt diagnosis, rapid parasite clearance with artesunate, and multidisciplinary supportive care in severe malaria. Furthermore, the occurrence of PADH highlights the need for structured post-treatment follow-up, particularly in non-endemic regions where clinicians may be unfamiliar with such complications.</div></div><div><h3>Conclusions</h3><div>Severe falciparum malaria requires urgent and aggressive management. While artesunate is life-saving, its delayed complications necessitate systematic monitoring. This case highlights the importance of integrating acute care with vigilant follow-up to optimize outcomes in severe malaria, especially in non-immune individuals with hyperparasitemia.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100644"},"PeriodicalIF":1.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular characteristics of antimicrobial resistance and biofilm formation of bloodstream infection pathogens isolated from pediatric patients in Ukraine","authors":"Arkadii Vodianyk,&nbsp;Vadym Poniatovskiy,&nbsp;Voldymyr Shyrobokov","doi":"10.1016/j.ijregi.2025.100646","DOIUrl":"10.1016/j.ijregi.2025.100646","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine antimicrobial resistance and biofilm-associated genes among clinical isolates of bloodstream infection pathogens in Ukraine.</div></div><div><h3>Methods</h3><div>A total of 35 clinical strains of <em>Klebsiella pneumonia</em> and 50 clinical strains of <em>Staphylococcus</em> spp. were isolated from patients from Ukrainian tertiary-level children`s hospitals during 2023 with bloodstream infections including central venous catheter-associated infections. Antimicrobial susceptibility testing was conducted following the European Committee on Antimicrobial Susceptibility Testing methodology. Capacity to form biofilms was assessed using a microtiter plate assay. Amplification of the variable resistance genes (<em>blaNDM-1, blaKPC, OXA-48, blaCTX-M-1, blaTEM, qnrB, gyrA, mecA</em>) and biofilm-associated genes (<em>clfA, fnbpA, icaA, fimH, mrkA, matBecp)</em> was performed by polymerase chain reaction.</div></div><div><h3>Results</h3><div>|Overall, 96% (n = 46/50) of all Staphylococcus spp. strains expressed icaA, 94% (n = 47/50) of strains expressed fnbpA and 92% (n = 45/50) expressed clfA genes. In total, 32% (n = 16/50) of strains were resistant to methicillin, and all of the strains expressed mecA. All <em>K. pneumoniae</em> strains expressed <em>matBecp</em>, and 97% (n = 34/35) expressed <em>fimH</em> and <em>mrkA</em> genes. All of <em>K. pneumonia</em> were resistant to third-generation cephalosporins, 74.3% (n = 25/35) of isolates expressed <em>CTX</em> and 80% (n = 28/35) expressed <em>blaTEM</em> gene, 71.4% (n = 25/35) strains expressed both genes. In total, 80% (n = 28/35) of <em>K. pneumoniae</em> were resistant to carbapenems, 60.7% (n = 17/28) expressed <em>blaNDM-1</em>, 64.3% (n = 18/28) expressed <em>OXA-48</em> and all 28 strains expressed <em>blaKPC</em>. A total of 90% (n = 18/20) of <em>K. pneumoniae</em> were resistant to fluoroquinolones, 88.9% (n = 16/18) expressed <em>qnrB</em> and none of the isolates expressed <em>gyrA</em> gene.</div></div><div><h3>Conclusions</h3><div>Very high prevalence of genes associated with biofilm formation was observed in clinical isolates of <em>Staphylococcus</em> spp. and <em>K. pneumoniae</em>. High-level resistance to all antimicrobials was observed in <em>K. pneumoniae</em> strains.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100646"},"PeriodicalIF":1.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience of a Nationwide implementation of single-tablet second-generation integrase inhibitors-based treatment in Mexico","authors":"Alicia Piñeirúa-Menéndez ,&nbsp;Yanink Caro-Vega ,&nbsp;Juan Luis Mosqueda-Gómez ,&nbsp;Santiago Ávila Ríos ,&nbsp;Florentino Badial-Hernández ,&nbsp;Alethse De la Torre-Rosas ,&nbsp;Juan Sierra-Madero","doi":"10.1016/j.ijregi.2025.100645","DOIUrl":"10.1016/j.ijregi.2025.100645","url":null,"abstract":"<div><h3>Objectives</h3><div>In Mexico, until 2018, antiretroviral therapy (ART) primarily relied on efavirenz-containing regimens or other options suitable for optimization, with ART costs among the highest in the region. This study evaluated the impact of a national strategy using single-tablet, second-generation integrase inhibitors (STSGII)—either bictegravir, emtricitabine, and tenofovir alafenamide or abacavir/lamivudine/dolutegravir—for ART initiation or switch.</div></div><div><h3>Methods</h3><div>Adults initiating or switching to STSGII between June 1, 2019, and June 30, 2021, at clinics for individuals without social security, were categorized into three groups: G1 (initiated with STSGII), G2 (initiated with non-STSGII), and G3 (switched to STSGII). The switch was defined as individuals changing ART in the presence of virological suppression. Viral suppression (VS) at 6 months post-initiation or switch was reported. A Cox model evaluated VS and regimen durability, defined as maintaining VS without ART change, loss to follow-up, or death.</div></div><div><h3>Results</h3><div>A total of 70,732 individuals were included; 24,133 (34.1%) on G1, 4605 (6.5%) on G2, and 41,994 (59.4%) on G3. VS was achieved in 85.7%, 52.7%, and 82.7% of individuals in G1, G2, and G3, respectively. Durability was met in 85.1%, 41.3%, and 90.8% of individuals in G1, G2, and G3.</div></div><div><h3>Conclusions</h3><div>Second-generation INSTIs are effective and durable in this 2-year follow-up analysis, both for ART initiation and optimization in Mexico's population, offering a valuable strategy for improving ART outcomes.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100645"},"PeriodicalIF":1.5,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the evidence for antibiotic management of laboratory-confirmed Streptococcus A skin infections to prevent acute rheumatic fever and rheumatic heart disease: a systematic review","authors":"Trudy D Leong ,&nbsp;Ameer SJ Hohlfeld ,&nbsp;Funeka Bango ,&nbsp;Denny Mabetha ,&nbsp;Ntombifuthi Blose ,&nbsp;Joy Oliver ,&nbsp;Mark E Engel ,&nbsp;Tamara Kredo","doi":"10.1016/j.ijregi.2025.100642","DOIUrl":"10.1016/j.ijregi.2025.100642","url":null,"abstract":"<div><h3>Objectives</h3><div>Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) are potential sequelae of untreated group A streptococcal (<em>Strep A</em>) infections. Guidelines focus on treating <em>Strep A</em> pharyngitis but seldom on skin infections. This systematic review explored whether directed antibiotic therapy for superficial <em>Strep A</em> skin infections prevents ARF/RHD.</div></div><div><h3>Methods</h3><div>We searched PubMed, Scopus, Cochrane Library, and clinical trial registries for published and ongoing trials measuring the eradication of <em>Strep A</em> and clinical resolution of polymicrobial infections with antibiotics through December 13, 2024. We calculated risk ratios and absolute risk differences, using the grading of recommendations, assessment, development, and evaluation (GRADE) to assess the certainty of evidence.</div></div><div><h3>Results</h3><div>No trials were reported on ARF/RHD outcomes. However, we identified 12 trials and pooled data comparing penicillin, cotrimoxazole, macrolides, and cephalosporins. There was probably no difference between interventions for eradicating <em>Strep A</em> (very low certainty evidence). For clinical resolution, cotrimoxazole was comparable to intramuscular benzathine benzylpenicillin and macrolides to penicillin (moderate certainty evidence). First- and second-generation cephalosporins showed no difference (low certainty evidence), whereas third-generation cephalosporins demonstrated improved clinical response (moderate certainty evidence)<em>.</em> Benzathine benzylpenicillin-associated injection-site pain and oral antibiotic-associated gastrointestinal disorders were commonly reported.</div></div><div><h3>Conclusions</h3><div>The available evidence for directed treatment of <em>Strep A</em> skin infections to prevent ARF/RHD is uncertain, requiring further research, with consideration of antimicrobial resistance and the limited antibiotic pipeline.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100642"},"PeriodicalIF":1.5,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholera resurges in Zambia: Challenges and future directions","authors":"Clyde Moono Hakayuwa ,&nbsp;Olivier Sibomana ,&nbsp;Chapline Shike Kalasa","doi":"10.1016/j.ijregi.2025.100640","DOIUrl":"10.1016/j.ijregi.2025.100640","url":null,"abstract":"<div><div>Cholera remains a major global health challenge, disproportionately affecting low-income countries with inadequate water, sanitation, and hygiene (WASH) infrastructure. Zambia, historically prone to outbreaks, experienced a severe resurgence in 2023-2024, with over 10,887 cases and 432 deaths. The contributing factors include poor WASH access, systemic health care weaknesses, stigma, and logistical barriers. Only 32% of households have basic water services, and health care worker shortages persist, especially in densely populated areas. Misinformation and cultural practices hinder public health efforts, whereas fiscal constraints limit prevention strategies. Strengthening epidemic preparedness through WASH investments, systems thinking, predictive modeling, artificial intelligence–driven surveillance, and multi-sectoral approach integrating community engagement and health system resilience is essential to mitigate the outbreak. This commentary explores Zambia's cholera control challenges and outlines strategic directions for a resilient, sustainable response to this enduring public health threat.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100640"},"PeriodicalIF":1.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143844916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term dynamics of SARS-CoV-2 immunity in a university hospital in Colombia: A cohort study","authors":"Nohemi Caballero ,&nbsp;Diana M. Monsalve ,&nbsp;Yeny Acosta-Ampudia ,&nbsp;Natalia Fajardo ,&nbsp;Sergio Moreno ,&nbsp;Oscar Martínez ,&nbsp;Catalina González-Uribe ,&nbsp;Carolina Ramírez-Santana ,&nbsp;Juliana Quintero","doi":"10.1016/j.ijregi.2025.100641","DOIUrl":"10.1016/j.ijregi.2025.100641","url":null,"abstract":"<div><h3>Objectives</h3><div>This prospective cohort study aimed to estimate the natural, vaccine-induced, and hybrid immunity to SARS-CoV-2, alongside the immunogenicity of the messenger RNA (mRNA)‐1273 booster after the BNT162b2 primary series in health care workers in Colombia.</div></div><div><h3>Methods</h3><div>Immunoglobulin (Ig) G, IgA, and neutralizing antibodies were measured in 110 individuals with SARS-CoV-2 infection or a BNT162b2 primary series. Humoral responses and related factors were explored in a subgroup (n = 36) that received a BNT162b2 primary series, followed by a mRNA-1273 booster (2BNT162b2 + 1mRNA-1273), and T-cell responses were evaluated in a subgroup of them (n = 16).</div></div><div><h3>Results</h3><div>For natural immunity, IgG and IgA peaked within 3 months, declining gradually but remaining detectable up to 283 days post-infection. Neutralizing antibody inhibition post-infection was below positive range (≥35%) but exceeded 97% in vaccine-induced and hybrid immunity groups. After 2BNT162b2 + 1mRNA-1273, IgG peaked 3-4 months post-booster, gradually declining but remaining positive over 10 months, with IgA and neutralizing antibodies stable. Age and blood group were related to IgG response, whereas obesity and blood type were related to IgA response post-booster. Autoimmunity and blood type B were associated with lower neutralizing antibody inhibition. There were no differences in T-cell responses according to previous infection.</div></div><div><h3>Conclusions</h3><div>These findings provide long-term insights into the immunity against SARS-CoV-2 and the immunogenicity of mRNA vaccines.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"15 ","pages":"Article 100641"},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}