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Lessons and updates from India's National Tuberculosis Elimination Program – bold decisions and innovative ways of fast-tracking progress toward ending tuberculosis
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100599
Urvashi B. Singh , Kirankumar Rade , Raghuram Rao , Nishant Kumar , Sanjay Kumar Mattoo , Sreenivas Nair , Alimuddin Zumla , Suvanand Sahu
{"title":"Lessons and updates from India's National Tuberculosis Elimination Program – bold decisions and innovative ways of fast-tracking progress toward ending tuberculosis","authors":"Urvashi B. Singh ,&nbsp;Kirankumar Rade ,&nbsp;Raghuram Rao ,&nbsp;Nishant Kumar ,&nbsp;Sanjay Kumar Mattoo ,&nbsp;Sreenivas Nair ,&nbsp;Alimuddin Zumla ,&nbsp;Suvanand Sahu","doi":"10.1016/j.ijregi.2025.100599","DOIUrl":"10.1016/j.ijregi.2025.100599","url":null,"abstract":"<div><div>India has the highest burden of tuberculosis (TB) globally. Strong political commitment, bold targets, and innovations have been the hallmark of the TB response. Lessons learned in India, such as understanding the diversity of TB epidemiology, approaches beyond conventional response strategies, bold decisions, and innovations, are invaluable for the global TB response. The India TB response is supported by strong political commitment cascading from the Prime Minister to local stakeholders. An initial key step was the sub-national assessment of the diverse TB burden and recognition of the public and private health care landscape. India effectively demonstrated innovative models to meaningfully engage all stakeholders, leveraging technology to bridge gaps. Community participation and social engineering movements were used to reduce stigma and address the nutritional needs of TB patients. Patient-support systems through an innovative adoption program, crowdsourced solutions, and direct benefit cash transfers were implemented to mitigate the socio-economic impact of TB. Decentralized initiatives such as the TB-Free Panchayat, district, and city schemes empowered local stakeholders and encouraged healthy sub-national competition. Advances in research and development of screening tools, rapid molecular diagnostics, real-time integrated digital surveillance systems such as Ni-kshay, and innovations such as telemedicine, call centers, direct benefit transfers, and artificial intelligence (AI)-based tools are accelerating the TB response in India.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100599"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of risky sexual behavior: Evidence from Zimbabwe Population-Based HIV Impact Assessment 2020
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100607
Solomon Mukwenha , Munyaradzi Mapingure , Tafadzwa Dzinamarira , Enos Moyo , Elliot Mbunge , Rutendo Birri Makota , Tapiwa Dhiwayo , Innocent Chingombe , Amon Mpofu , Owen Mugurungi , Godfrey Musuka
{"title":"Comparison of risky sexual behavior: Evidence from Zimbabwe Population-Based HIV Impact Assessment 2020","authors":"Solomon Mukwenha ,&nbsp;Munyaradzi Mapingure ,&nbsp;Tafadzwa Dzinamarira ,&nbsp;Enos Moyo ,&nbsp;Elliot Mbunge ,&nbsp;Rutendo Birri Makota ,&nbsp;Tapiwa Dhiwayo ,&nbsp;Innocent Chingombe ,&nbsp;Amon Mpofu ,&nbsp;Owen Mugurungi ,&nbsp;Godfrey Musuka","doi":"10.1016/j.ijregi.2025.100607","DOIUrl":"10.1016/j.ijregi.2025.100607","url":null,"abstract":"<div><h3>Objectives</h3><div>Risky sexual behaviors are associated with the acquisition of sexually transmitted infections, including HIV/AIDS. Understanding the intricate dynamics of sexual behavior is pivotal in the relentless pursuit of curtailing the HIV epidemic. To compare risky sexual behaviors based on knowledge of HIV status and viral suppression.</div></div><div><h3>Methods</h3><div>Data from 2958 people living with HIV who participated in a Zimbabwe Population-Based HIV Impact Assessment were used to determine the association between risky sexual behaviors, awareness of HIV status, and viral load suppression.</div></div><div><h3>Results</h3><div>The number of partners in the last 12 months was associated with the first 90 of the 90-90-90, with those who were unaware of their HIV status having more partners than those who were aware, adjusted odds ratio (aOR) = 1.18, 95% (confidence interval [CI]: 1.03-1.35). Those who did not use a condom during the last sexual encounter with a non-regular partner in the last 12 months were more likely to be unaware of their status, aOR = 2.11, (95% CI: 1.28-3.50). Those who did not use a condom at their last sexual encounter were more likely to be virally unsuppressed (aOR 2.25, 95% CI: 1.78-2.85). Women were less likely to be virally unsuppressed than men.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that gaps in HIV knowledge and viral suppression are critical factors in ongoing HIV transmission. To effectively curb HIV transmission, preventive interventions should prioritize individuals who are unaware of their HIV status or those who are virally unsuppressed, addressing these gaps to reduce risky sexual behaviour and the potential for further transmission.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100607"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143562010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baseline knowledge on chronic pulmonary aspergillosis and tuberculosis among health care workers involved in tuberculosis care in Uganda
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100603
Felix Bongomin , Ritah Nantale , Joseph Baruch Baluku , Tobius Odongo , Shamim Katusabe , Nixson Oyoo , Martin Muddu , Norman van Rhijn , David W Denning
{"title":"Baseline knowledge on chronic pulmonary aspergillosis and tuberculosis among health care workers involved in tuberculosis care in Uganda","authors":"Felix Bongomin ,&nbsp;Ritah Nantale ,&nbsp;Joseph Baruch Baluku ,&nbsp;Tobius Odongo ,&nbsp;Shamim Katusabe ,&nbsp;Nixson Oyoo ,&nbsp;Martin Muddu ,&nbsp;Norman van Rhijn ,&nbsp;David W Denning","doi":"10.1016/j.ijregi.2025.100603","DOIUrl":"10.1016/j.ijregi.2025.100603","url":null,"abstract":"<div><h3>Objectives</h3><div>Chronic pulmonary aspergillosis (CPA) often mimics pulmonary tuberculosis (PTB), leading to misdiagnosis and inappropriate management. We aimed to determine the baseline knowledge, practices, and self-rated confidence of health care workers (HCWs) regarding CPA in Uganda.</div></div><div><h3>Methods</h3><div>Between January and April 2024, we conducted a cross-sectional survey involving HCWs at four public health facilities in Uganda currently enrolling patients with current or previously treated for PTB into a cohort study aimed at establishing the incidence of CPA. Data on sociodemographic characteristics, awareness, knowledge, practices regarding CPA, PTB, and finger-prick tests for point of care testing were collected using semi-structured questionnaires. Adequate knowledge was defined as a score of ≥80%.</div></div><div><h3>Results</h3><div>A total of 110 HCWs participated, predominantly males (61, 57.5%), with a mean age of 38.8 years. Although most HCWs had heard of aspergillosis (78, 82.1%), only 23 (21.7%) demonstrated adequate knowledge about CPA. In addition, 25 (28.7%) reported encountering a patient with CPA in the past year, with 41 (47.1%) never routinely screening for CPA. Confidence in managing CPA was low among HCWs, with 29 (29.8%) expressing no confidence. Furthermore, only 22 (20.8%) had adequate knowledge about PTB. Referral hospital practice was significantly associated with higher odds of adequate CPA knowledge (adjusted odds ratio: 6.69, 95% confidence interval: 1.67-26.82, <em>P</em> = 0.007).</div></div><div><h3>Conclusions</h3><div>There are significant gaps in awareness, knowledge, and practices of HCWs in Uganda related to CPA and PTB. Strategies to enhance training, guideline dissemination, and diagnostic capacity are essential to improve the management of these respiratory conditions and reduce misdiagnosis.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100603"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blood culture time to positivity in pediatric patients with bloodstream infection in rural Gambia
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100606
Isaac Osei , Baleng Mahama Wutor , Alieu Kuyateh , Ousman Barjo , Golam Sarwar , Mayowa Omotosho , Williams Oluwatosin Adefila , Yusuf Abdulsalam Olawale , Keita Modou Lamin , Ilias Hossain , Babila G. Lobga , Muhammed Wally , Morr Cham , Minteh Molfa , Rasheed Salaudeen , Grant A. Mackenzie
{"title":"Blood culture time to positivity in pediatric patients with bloodstream infection in rural Gambia","authors":"Isaac Osei ,&nbsp;Baleng Mahama Wutor ,&nbsp;Alieu Kuyateh ,&nbsp;Ousman Barjo ,&nbsp;Golam Sarwar ,&nbsp;Mayowa Omotosho ,&nbsp;Williams Oluwatosin Adefila ,&nbsp;Yusuf Abdulsalam Olawale ,&nbsp;Keita Modou Lamin ,&nbsp;Ilias Hossain ,&nbsp;Babila G. Lobga ,&nbsp;Muhammed Wally ,&nbsp;Morr Cham ,&nbsp;Minteh Molfa ,&nbsp;Rasheed Salaudeen ,&nbsp;Grant A. Mackenzie","doi":"10.1016/j.ijregi.2025.100606","DOIUrl":"10.1016/j.ijregi.2025.100606","url":null,"abstract":"<div><h3>Objectives</h3><div>There is a lack of data on the time to blood culture positivity (TTP) in pediatric populations in low-income countries. We aimed to assess the host and pathogen factors associated with TTP in children aged under 5 years in rural Gambia.</div></div><div><h3>Methods</h3><div>Between September 2019 and December 2023, we collected blood cultures from children under 5 years with suspected bloodstream infections. We determined the TTP from the time of culture incubation to when bacterial growth was first detected.</div></div><div><h3>Results</h3><div>Overall, 547 invasive bacteria pathogens were evaluated. The median TTP was 19.2 hours and 70%, 76%, 89%, and 96% of cases had TTP at 24, 36, 48, and 72 hours, respectively. <em>Streptococcus pneumoniae</em> had the shortest median TTP (17.4 hours), whereas <em>Neisseria</em> species had the longest (45 hours). TTP was dependent on the pathogen and independent of age, sex, temperature, clinical outcome, nutritional status, and length of hospital stay. Gram-positive bacteria had shorter TTP than gram-negative bacteria (18.6 vs 19.6 hours, <em>P</em> &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>In rural Gambia, most blood cultures from pediatric patients would turn positive within 48 hours of incubation. A maximum of 48 hours of observation after the commencement of antibiotic therapy in hospitalized children may be sufficient for clinicians to receive feedback on blood culture results.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100606"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and laboratory profiles of dengue infection in the hospitals in North Jakarta, Indonesia
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100612
Soegianto Ali , Maria Mardalena Martini Kaisar , Anastasia Hengestu , Angeline Imelda Teguh , Angelica Michelle Janova , Febie Chriestya , Luse Loe , Jullyany Waty Wijaya
{"title":"Clinical and laboratory profiles of dengue infection in the hospitals in North Jakarta, Indonesia","authors":"Soegianto Ali ,&nbsp;Maria Mardalena Martini Kaisar ,&nbsp;Anastasia Hengestu ,&nbsp;Angeline Imelda Teguh ,&nbsp;Angelica Michelle Janova ,&nbsp;Febie Chriestya ,&nbsp;Luse Loe ,&nbsp;Jullyany Waty Wijaya","doi":"10.1016/j.ijregi.2025.100612","DOIUrl":"10.1016/j.ijregi.2025.100612","url":null,"abstract":"<div><h3>Objectives</h3><div>Indonesia is one of the dengue endemic countries. The criteria for diagnosing dengue infection are based on World Health Organization (WHO) guidelines. Chikungunya and Zika virus infections have also been reported sporadically in Indonesia. This study aimed to evaluate the clinical features of patients with dengue in a hospital setting and investigate the potential for other arboviral infections in patients with fever.</div></div><div><h3>Methods</h3><div>This case-control study was conducted at two hospitals in North Jakarta between August 2023 and May 2024. Patients admitted with 3 or more days of fever without any proven cause of bacterial infection or autoimmune disease were recruited. The cases were those who tested positive for Dengue, Chikunguya, Zika, and West Nile viruses by multiplex reverse transcription-quantitative polymerase chain reaction, whereas the controls were those who tested negative. Questionnaires were used to collect the signs and symptoms. Blood tests were conducted using autoanalyzers. Chi-square and Student's <em>t</em>-tests were used for statistical analyses.</div></div><div><h3>Results</h3><div>Of the 135 respondents, 70 tested positive for dengue and two tested positive for chikungunya using multiplex reverse transcription-quantitative polymerase chain reaction. Having fever with two additional two signs and symptoms, as per the WHO guidelines, is predictive of dengue infection. Leukopenia and thrombocytopenia were significantly more common in dengue cases. An increase in hematocrit was inconclusive. Serum aspartate transaminase levels are also increased in patients with dengue. The dengue virus nonstructural protein-1 antigen test is the preferred point-of-care test for the diagnosis of dengue virus infections.</div></div><div><h3>Conclusions</h3><div>Our investigation confirmed that the WHO guidelines for diagnosing dengue are still applicable. The Chikungunya virus also circulates in Jakarta, and physicians should be aware of this.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100612"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143601821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genomic surveillance reveals COVID-19 outbreak clusters in a tertiary center in Malaysia: A cross-sectional study
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100604
Norazimah Tajudin , Seok Mui Wang , Mariam Mohamad , Siti Farah Alwani Mohd Nawi , Mohd Nur Fakhruzzaman Noorizhab
{"title":"Genomic surveillance reveals COVID-19 outbreak clusters in a tertiary center in Malaysia: A cross-sectional study","authors":"Norazimah Tajudin ,&nbsp;Seok Mui Wang ,&nbsp;Mariam Mohamad ,&nbsp;Siti Farah Alwani Mohd Nawi ,&nbsp;Mohd Nur Fakhruzzaman Noorizhab","doi":"10.1016/j.ijregi.2025.100604","DOIUrl":"10.1016/j.ijregi.2025.100604","url":null,"abstract":"<div><h3>Background</h3><div>Genomic surveillance activity is a useful tool in epidemiologic investigations and monitoring of virus evolution. This study aimed to describe the COVID-19 outbreaks through SARS-CoV-2 virus genomic surveillance by whole genome sequencing.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted using archived clinical samples of confirmed laboratory-positive COVID-19 from June 2021 to June 2022 from a tertiary center in Malaysia. The samples were subjected to whole genome sequencing. A phylogenetic tree was constructed using the maximum likelihood method in MEGA 11 software. The clinical data were obtained through paper, electronic, and hospital information systems.</div></div><div><h3>Results</h3><div>A total of 86 clinical samples were successfully sequenced. The phylogenetic tree revealed seven clusters, consisting of 24 cases. Three clusters were associated with health care workers and health care–associated individuals. The SARS-CoV-2 Delta variants were observed in the first three clusters and subsequently replaced with the Omicron variants.</div></div><div><h3>Conclusions</h3><div>Whole genome sequencing is robust and reliable, enhancing epidemiologic investigations, leading to the identification of clusters and preventing the spreading of COVID-19 among health care workers. Monitoring of the SARS-CoV-2 variants is necessary to study the viral dynamics and maintain the effectiveness of public health interventions.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100604"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Undiagnosed burden of latent tuberculosis, active tuberculosis and tuberculosis-HIV co-infections in Africa—status quo, needs, priorities, and opportunities
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100585
Nathan Kapata , John Tembo , Peter Mwaba , Juliet Nabyonga-Orem , Francine Ntoumi , Timothy D. McHugh , Alimuddin Zumla
{"title":"Undiagnosed burden of latent tuberculosis, active tuberculosis and tuberculosis-HIV co-infections in Africa—status quo, needs, priorities, and opportunities","authors":"Nathan Kapata ,&nbsp;John Tembo ,&nbsp;Peter Mwaba ,&nbsp;Juliet Nabyonga-Orem ,&nbsp;Francine Ntoumi ,&nbsp;Timothy D. McHugh ,&nbsp;Alimuddin Zumla","doi":"10.1016/j.ijregi.2025.100585","DOIUrl":"10.1016/j.ijregi.2025.100585","url":null,"abstract":"<div><div>Tuberculosis (TB) remains a leading cause of morbidity and mortality in Africa, with latent TB infection (LTBI) and TB co-infections posing significant public health challenges. This viewpoint examines the undiagnosed burden of LTBI and TB co-infections across the continent, emphasizing findings from autopsy studies. Data from the World Health Organization's Global Tuberculosis Report 2024 and recent autopsy research highlight the prevalence of undetected TB cases, particularly among individuals with HIV. Autopsy studies reveal a substantial proportion of TB cases that were undiagnosed <em>ante mortem</em>, underscoring the limitations of current diagnostic approaches. The co-infection of TB with HIV exacerbates disease progression and complicates diagnosis and treatment. Addressing the hidden burden of LTBI and TB co-infections necessitates enhanced diagnostic strategies, increased autopsy surveillance, and integrated healthcare services to reduce transmission and improve patient outcomes in Africa.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100585"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global perspectives on tuberculosis in prisons and incarceration centers - Risk factors, priority needs, challenges for control and the way forward
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100621
Peter S. Nyasulu , David S. Hui , Peter Mwaba , Jacques L. Tamuzi , Doris Y. Sakala , Francine Ntoumi , Markus Maeurer , Delia Goletti , Eskild Petersen , Alimuddin Zumla
{"title":"Global perspectives on tuberculosis in prisons and incarceration centers - Risk factors, priority needs, challenges for control and the way forward","authors":"Peter S. Nyasulu ,&nbsp;David S. Hui ,&nbsp;Peter Mwaba ,&nbsp;Jacques L. Tamuzi ,&nbsp;Doris Y. Sakala ,&nbsp;Francine Ntoumi ,&nbsp;Markus Maeurer ,&nbsp;Delia Goletti ,&nbsp;Eskild Petersen ,&nbsp;Alimuddin Zumla","doi":"10.1016/j.ijregi.2025.100621","DOIUrl":"10.1016/j.ijregi.2025.100621","url":null,"abstract":"<div><div>Tuberculosis (TB) remains a prominent cause of illness and mortality worldwide. Prisons are hotspots for TB transmission worldwide. We reviewed the literature on TB in prisons worldwide, including TB risk factors, delays in diagnosis including drug resistance, the treatment accorded, and operational and logistical issues of TB care in prison. The quantity and quality of data on TB in prisons varies worldwide. The TB incidence rate in prisons varies by World Health Organization region, with African countries having the highest rates of TB and TB/HIV co-infection. Its incidence rate among inmates is about 10 times higher than that of the general population. The growing prevalence of multidrug-resistant TB is particularly concerning, as it may affect high-risk settings and disproportionately affects vulnerable populations, such as prisoners and incarcerated individuals who go undiagnosed for extended periods of time. Factors that drive the high TB rates in prisons include limited access to health services such as TB care, overcrowding, poor ventilation, malnutrition, HIV, alcohol use disorders, illegal drug use, smoking, and other comorbidities, compounded by limited access to healthcare. Addressing TB in prisons requires a multifaceted approach, that includes improving living conditions, enhancing healthcare services, and developing innovative detection methods. The ongoing conflicts in Europe, the Middle East, Asia, and Africa further complicated TB prevention and control efforts in prisons, emphasizing the need for targeted interventions to address TB in these high-risk settings. Structured interventions tailored to the specific risk factors present in each environment should be investigated to effectively focus measures aimed at diminishing the overall burden of TB in prisons. Electronic record-keeping worldwide will allow for accurate data to be collected and shared.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100621"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A step forward in tuberculosis elimination: implementing migrant latent tuberculosis screening and treatment in Oman
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100614
Fatma M Alyaquobi , Fatma Alhakamani , Mohammed Alsabari , Khalsa Althuhli , Moza Al AlMahroqi , Amina Al-Jardani , Mohammed Al-Yazidi , Bader Al Rawahi , Amal Al Maani
{"title":"A step forward in tuberculosis elimination: implementing migrant latent tuberculosis screening and treatment in Oman","authors":"Fatma M Alyaquobi ,&nbsp;Fatma Alhakamani ,&nbsp;Mohammed Alsabari ,&nbsp;Khalsa Althuhli ,&nbsp;Moza Al AlMahroqi ,&nbsp;Amina Al-Jardani ,&nbsp;Mohammed Al-Yazidi ,&nbsp;Bader Al Rawahi ,&nbsp;Amal Al Maani","doi":"10.1016/j.ijregi.2025.100614","DOIUrl":"10.1016/j.ijregi.2025.100614","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to outline the process of implementation of latent tuberculosis (TB) infection (LTBI) screening among migrants using interferon-γ release assay (IGRA), describe the LTBI treatment protocol and cascade of care, and highlight success factors and challenges.</div></div><div><h3>Design</h3><div>This is a description of the process of implementation of screening of TB infection through a medical fitness program for residency, using primary care treatment module and short regimen.</div></div><div><h3>Results</h3><div>Before 2018, expatriates seeking residency employment in Oman undergo two-step medical fitness examination process that mainly rely on chest X-ray (CXR) before arrival and physical examination after arrival, with 15% random sample repeated. In 2018, Oman implemented CXR screening for all alongside symptom checks. With further surge of TB cases after COVID-19, screening using IGRA was introduced through a medical fitness program in 2024. Those who are IGRA-positive or indeterminate will proceed to CXR with subsequent referral to primary care for short regimen treatment (3 months of daily rifampicin plus isoniazid and pyridoxine) if eligible.</div></div><div><h3>Conclusions</h3><div>Oman aims to achieve sustainability through establishing an integrated LTBI screening for migrants within the residency medical fitness program using integrated electronic system, highly sensitive test, public private model (under government regulation), and high throughput testing methods. Treatment using a short regimen (3 months of daily rifampicin plus isoniazid) through primary care will improve treatment adherence, improve outcome, and reduce TB incidence.</div></div>","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100614"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inequities underlie the alarming resurgence of Tuberculosis as the world's top cause of death from an Infectious Disease - Breaking the silence and addressing the underlying root causes
IF 1.5
IJID regions Pub Date : 2025-03-01 DOI: 10.1016/j.ijregi.2025.100587
Alimuddin Zumla , Suvanand Sahu , Lucica Ditiu , Urvasha Singh , Young-Joon Park , Dorothy Yeboah-Manu , Stephen Osei-Wusu , Danny Asogun , Peter Nyasulu , John Tembo , Nathan Kapata , Fatma Alyaqoubi , Amal Al Maani , Lucille Blumberg , Adam Zumla , Rizwan Ahmed , Unyeong Go , David S Hui , Delia Goletti , Eskild Petersen
{"title":"Inequities underlie the alarming resurgence of Tuberculosis as the world's top cause of death from an Infectious Disease - Breaking the silence and addressing the underlying root causes","authors":"Alimuddin Zumla ,&nbsp;Suvanand Sahu ,&nbsp;Lucica Ditiu ,&nbsp;Urvasha Singh ,&nbsp;Young-Joon Park ,&nbsp;Dorothy Yeboah-Manu ,&nbsp;Stephen Osei-Wusu ,&nbsp;Danny Asogun ,&nbsp;Peter Nyasulu ,&nbsp;John Tembo ,&nbsp;Nathan Kapata ,&nbsp;Fatma Alyaqoubi ,&nbsp;Amal Al Maani ,&nbsp;Lucille Blumberg ,&nbsp;Adam Zumla ,&nbsp;Rizwan Ahmed ,&nbsp;Unyeong Go ,&nbsp;David S Hui ,&nbsp;Delia Goletti ,&nbsp;Eskild Petersen","doi":"10.1016/j.ijregi.2025.100587","DOIUrl":"10.1016/j.ijregi.2025.100587","url":null,"abstract":"","PeriodicalId":73335,"journal":{"name":"IJID regions","volume":"14 ","pages":"Article 100587"},"PeriodicalIF":1.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143644871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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