Igiene e sanita pubblica最新文献

{"title":"Probable airborne transmission in a nosocomial Sars-CoV-2 outbreak with an high attack rate.","authors":"Paola Anello, Riccardo Boscolo Cegion, Andrea Basso, Chiara Cabbia, Francesca Azzolini, Luciano Crimi, Myriam Ruggiero, Mara Carraro, Stefano Mazzon, Milvia Marchiori","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Throughout the current COVID-19 pandemic, preventing nosocomial COVID-19 outbreaks has been a significant challenge for hospitals. It is essential to understand the ways in which SARS-CoV-2 spreads in healthcare settings to apply proper infection prevention and control (IPC) measures. The objectives of this study are to report on the hospital's response to a COVID-19 cluster and the transmission dynamics in a hospital ward of Geriatrics, Rehabilitation and Long term care. The study will focus specifically on how insufficient air replacement and directional airflow in indoor settings may have contributed to the transmission of the virus.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 5","pages":"110-117"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The ERM experience of the Lombardy Region as a tool for improving the safety of the regional health care system.","authors":"Enrico Burato, Liviana Scotti, Enrico Trombetta, Giacomo Taddei, Alessandro Audino, Enrico Malinverno, Davide Molteni, Giorgia Saporetti, Alessandra Rossodivita, Silvana Castaldi, Rossella Barni, Simona Amato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The Regional Center for Healthcare Risk Management and Patient Safety of the Lombardy Region, with the technical partnership of Aon, designed an innovative Healthcare Enterprise Risk Management Model (hereafter HERM) to meet the following objectives: 1) Improve the safety of the Regional Healthcare System through the implementation of methods and tools aimed to identify, analyze and mange in an integrated way all the risks to which are exposed the healthcare companies. 2) Preserve the creation of social value in the medium-long term and the sustainable achievement of strategic and operational objectives. 3) Optimize risk management costs. 4) Reduce/mitigate adverse events in all business processes. 5) Enable the ability to anticipate and react to changes. 6) Establish sound long-term and risk-based strategies. This paper describes the structuring of the overall HERM Model Framework, and the related information flows, the tools supporting the Healthcare Enterprise Risk Management Methodology (such as the Risk Model and the Assessment Metrics) and presents the preliminary result of first experience of Healthcare ERM in Italy.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 5","pages":"101-109"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138814663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Safety and Surgery: the Experience of the Lombardy Region. A Project on External Evaluation of Best Practices Implementation.","authors":"Luciana Bevilacqua,&nbsp;Giulia Domeniconi,&nbsp;Chiara Picchetti,&nbsp;Davide Mozzanica,&nbsp;Elisabetta Brivio,&nbsp;Luca Merlino Luca Merlino,&nbsp;Liviana Scotti,&nbsp;Romina Colciago,&nbsp;Enrico Comberti,&nbsp;Anna D'Andrea,&nbsp;Paola Garancini,&nbsp;Maristella Moscheni,&nbsp;Chiara Oggioni,&nbsp;Cristina Oppezzo,&nbsp;Paolo Trucco,&nbsp;Antonio Vitello,&nbsp;Simona Amato,&nbsp;Enrico Burato","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Meta-analysis studies published over the past 20 years document that approximately 10 -14 % of hospitalised patients have an adverse event in Surgery and at least half of these adverse events are considered preventable using the current standards of care. In order to improve the safety of surgical patients and increasing adherence to current standard of care in surgery, including communication within the team and teamwork, in 2007 the WHO launched the campaign &quot;Safe Surgery Saves Lives&quot;. The WHO has also built a checklist for safety in the operating room containing 19 item in support of the operating team. The Ministry of Health in 2009 has taken the instruments produced by WHO in the \"Guide to Safety in the operating room: Recommendations and Checklist\". Studies conducted in industrialized countries report a strong heterogeneity in compliance to the check list for the surgical safety, with a range of between 38% and 96%. The aim of this project was to adopt the methodology of the external &quot;peer review&quot; to improve quality and patient safety applied to the surgical process and assess the degree of implementation of good practice in the operating room, both in public and private structures. Between 2015 and 2018 we have carried out 16 external evaluation visits. These visits included a first plenary session followed by the inspection of the operating theaters identified and a second plenary session. Several factors emerged during the visits; these factors represent both the strengths and criticalities of the organizations. The creation of a team of experts, coordinated by the Lombardy Region with the role of leadership, using the \"peer review\" methodology, is the leverage to promote among operators the growth of awareness of the usefulness of the tools.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 4","pages":"81-93"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41142092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training and career opportunities for residencies in Hygiene and Preventive Medicine: results of a survey on 39 Italian schools.","authors":"F Pennisi, T Lo Presti, G E Ricciardi, Z Dalla Valle, M Minerva, G Privitera, C Signorelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The Italian National Health Service (SSN) is currently grappling. with a complex situation, characterized by a persistent shortage of medical personnel and the divergent aspirations of young medical graduates. Additionally, recent regulatory developments concerning specialist training further contribute to the intricacies of the landscape, calling for a comprehensive analysis of the challenges and opportunities within the sector. This study aims to provide an updated overview of the current placement of medical graduates, residents and specialists in the specific hygiene and preventive medicine (Public Health) field.</p><p><strong>Methods: </strong>Data on admissions, withdrawals and resignations were obtained from the Ministries of Universities and Health and from the archives of the \"Associazione Liberi Specializzandi\" (ALS). Information regarding the professional prospects for specialists and residents in the field of Public Health was gathered through a tailored survey conducted by the \"Consulta dei Medici in Formazione Specialistica\" (Council of Medical Residents) of the Italian Society of Hygiene (SItI).</p><p><strong>Results: </strong>In 2022, a total of 483 specialization contracts were granted, indicating a decrease of 37% compared to the previous year. Notably, 85 positions (17.6%) remained unallocated or resulted in dropouts. Six months after completing their residency, 1.5% of hygiene residents were still actively seeking employment. On a positive note, 75.4% of fourth-year residents secured contracts under the \"Decreto Calabria\". Career opportunities within the Italian SSN have witnessed growth, with a significant proportion of placements in territorial services and hospital medical directorates.</p><p><strong>Discussion and conclusions: </strong>The updating of training programs provided by residency schools and the exploration of innovative approaches are of paramount importance to address the urgent need for high-quality training and to cater to the requirements of the national health system.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 4","pages":"94-100"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitudes, and practices of violence in hospitals: the case of users of the reception and emergency service of the Ebolowa Regional Hospital.","authors":"André Izacar Gaël Bita,&nbsp;Eddy Thomas Biwole Omgba,&nbsp;Hermine Ngo Mey Essi,&nbsp;Raquel Perdy Mbom,&nbsp;Agbor Agbornkwai Nyenty","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The phenomena of incivility and violence are increasingly recurrent within health facilities in Cameroon. This study examines the knowledge, attitudes, and practices of violence by users in the reception and emergency departments of the Ebolowa Regional Hospital (ERH).</p><p><strong>Methods: </strong>This was a qualitative study of a non-random sample of users encountered in the reception and emergency department at the ERH in southern Cameroon. The principle of saturation was used to determine the sample size. An interview guide was used to collect the data. Demographic data were analyzed by EPI Info 7 and qualitative data by thematic analysis.</p><p><strong>Results: </strong>Acts of violence in hospitals are perceived as the use of intense and brutal force that affects the physical and/or moral integrity of others. The forms of violence cited include physical, moral, verbal, and psychological violence. The most frequently cited reasons for the violence were: negligence, the insolence of the nurse, abandonment of the patient without care or information, care not explained and not mentioned in the care booklet, lack of speed in care, insufficient communication about the illness of a relative and ineffective care despite the patient's fatigue. According to the participants, the circumstances that could lead individuals to do violence to nursing staff on duty include theft of medicines, contempt, rudeness, negligence in care, late care, abandonment of patients and poor hospital hygiene, refusal to answer questions, deception or professional incompetence, lack of welcome, attempts to extort or overcharge for prescriptions, and swindling and adultery. The consequences of violence mentioned in the responses mainly included: fighting, injuries, as well as staff reluctance, low hospital attendance, self-medication, and loss of life. Most respondents did not know or had no idea about legal sanctions after an act of violence, but one response mentioned the existence of sanctions such as police custody and blame.</p><p><strong>Conclusion: </strong>Violence in hospitals is a major problem that can have serious consequences for patients, health care staff, and the health care system. The reasons given for the violence highlight the importance of clear and effective communication between patients and healthcare staff, as well as prompt and quality medical care.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 3","pages":"60-72"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renovation and creation of a Biocontainment Unit: the experience of Azienda Ospedaliero-Universitaria Pisana (Pisa, Italy).","authors":"Angelo Baggiani,&nbsp;Francesca Di Serafino,&nbsp;Michele Totaro,&nbsp;Sara Civitelli,&nbsp;Giulia Geminale,&nbsp;Alessandro Daole,&nbsp;Federico Vannini,&nbsp;David Rocchi,&nbsp;Nunzio Zotti,&nbsp;Alessia Civitelli,&nbsp;Monica Scateni,&nbsp;Stefano Gaffi,&nbsp;Stefano Colombini,&nbsp;Michele Cristofano,&nbsp;Grazia Luchini,&nbsp;Silvia Briani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Infectious diseases are a major public health concern. In recent decades, there has been a succession of bacterial and viral diseases, which when added to the endemic diseases found in certain areas of the world, can become a global health problem. In emergency medicine we talk a lot about Mass Casualty Incident (MCI) preparedness, but the main focus today is bio-preparedness. Therefore, especially after the Ebola experience, much investment has been made in the development of Biocontainment Units (BCUs). At present, in Italy there are no national realities that have experimented the construction of a completely new biocontainment units detached from the Emergency Department (ED) RNPP-funded. Given this, the project of the Azienda Ospedaliero-Universitaria Pisana (AOUP) is to make renovations on existing ED structure and build an entire new facility for biocontainment.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 3","pages":"73-80"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Networks as a way to hospital and primary/community care integration: findings from a narrative review of the main international models.","authors":"Marcello Di Pumpo, Lorenzo Sommella, Gianfranco Damiani","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Background Healthcare systems are complex systems. Achieving financial, social, and environmental sustainability of these systems requires a high degree of integration and coordination at all levels, especially between acute-care settings and primary/community care services. Some authors have, therefore, suggest redirecting integrated healthcare research towards the network theory and network concepts as a useful lens. Objective The current paper proposes to investigate the existence, the institutional level of formalization and the degree of development of hospital/primary-community care Networks currently present in the main types of healthcare systems worldwide by studying an appropriate selection of representative countries for each system typology. Materials and Methods A narrative review of the scientific and gray literature following the methodology by Green et al. was, therefore, conducted to describe hospital and primary/community care networks and their integration/coordination in the main international models. To select these models, one country with the current highest life expectancy at birth for each of the B öhm's five healthcare system categories was chosen. The grade of integration of the Networks retrieved for each State was therefore qualitatively appraised (high, medium or low degree), following Valentijn's framework. Results The networks retrieved show: in Norway, Australia and Japan both at the government/ national and at the regional/lower level/other a high degree of systemic, organizational, normative and functional integration; in Switzerland both at the government/national and at the regional/lower level/other a medium degree of systemic, organizational, normative and functional integration; in the USA at the governmental/institution level a low degree of systemic, organizational and normative integration, with a medium degree of functional integration and at the regional/lower level/other integration a low degree of systemic and normative integration with medium degree of organization integration and high degree of functional integration. Discussion The high levels and degree of hospital/primary - community care integration of Norway, Australia and Japan are in line with what could be expected from the universalistic healthcare system in place. The medium levels of integration of Switzerland are also in line with what the Social health insurance system and, especially, the cantonal system. The low levels of integration of the USA are in line with the privatistic healthcare systems. However, a medium degree was found for functional integration probably due to its unparalleled technological advancement. Conclusions The study shows how the levels of hospital/primary-community care integration are connected to the specific healthcare system in place in each country. COVID-19 showed how complex systems like healthcare systems had to reconfigure themselves to reach high levels of integration in small time to be able to","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 2","pages":"27-48"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9443646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monkeypox resurgence and its implications for Dentistry - A scoping review.","authors":"Syed Sarosh Mahdi, Rabeea Yaqoob, Raheel Allana, Gopi Batteneni, Syeda Sakina, Daniyal Agha, Niekla Survia Andiesta, Muneer Gohar Babar, Zohaib Ahmed, Umer Daood","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Monkeypox caused by the Monkeypox virus, a member of the Orthopoxvirus genus, is currently considered a major concern among healthcare authorities due to its high transmissibility rate. Currently, no specific treatment is available for this disease, due to which healthcare professionals, specifically Dentists, are required to look out for symptoms at early stages to prevent its spread.</p><p><strong>Objective: </strong>To analyze the role of dentists in identifying Monkeypox cases and limiting its spread.</p><p><strong>Methods: </strong>We conducted a scoping review on monkeypox and its oral manifestation. PRISMA protocols were observed in data collection. The relevant literature search was conducted in relevant databases like PubMed, Scopus, Web of Science, Embase, CINAHL, and Google Scholar. Relevant articles related to Monkeypox, and Dentistry were included in the final review. Articles published from March 2022- September 2022 were included in the review. Keywords and Mesh words related to monkeypox, and dentistry were used as part of the search strategy.</p><p><strong>Results: </strong>A total of 1881 articles were reviewed, among which 7 articles were included. Dentists were strongly advised to be on high alert for Monkeypox symptoms due to their close contact with patients. Around 70% of Monkeypox cases reported oral lesions at early stages, which requires a differential diagnosis from other oral lesions. Considering this, dentists should be well-versed in this new and emerging threat.</p><p><strong>Conclusion: </strong>Although dentists have been shown to play an important role in the treatment of monkeypox, there is insufficient data available. More research on dentistry and monkeypox will be needed in the near future.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 2","pages":"49-59"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9454171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of environmental sanitization in health clinics: evaluation of potassium peroxymonosulfate (KMPS) efficacy at two different concentrations.","authors":"Michele Totaro,&nbsp;Francesco Castellani,&nbsp;Francesca Di Serafino,&nbsp;Nunzio Zotti,&nbsp;Federica Badalucco,&nbsp;David Rocchi,&nbsp;Sara Civitelli,&nbsp;Giulia Geminale,&nbsp;Davide Masetti,&nbsp;Angelo Baggiani","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Healthcare-associated infections (HAI) are closely related to several factors, such as prolonged hospital stay in high-risk areas and intensive care units, potentially predisposing underlying conditions. It has also been demonstrated that HAI incidence may be related to non-respected standards of assistance, such as not adequately cleaned structures or medical devices contaminated by environmental bacteria and multidrug resistant enterobacteria.</p><p><strong>Objective: </strong>In this case it has been carried on an efficacy evaluation of a microionization system using potassium peroxymonosulfate (KMPS) for outpatient clinics indoor air disinfection.</p><p><strong>Material and methods: </strong>Two outpatient clinics (AMB-1 and AMB-2) were treated with KMPS (1% and 2% concentration), at the end of routinary clinic activities. Microbial sampling of air (settle plates) and surfaces (contact plates) were submitted before and after sanitizing, checking total microbial load at 37°C, possible opportunistic pathogens and moulds.</p><p><strong>Results: </strong>Sanitizing system at 1% concentration was efficient in mesophilic bacteria reduction (max 83%). Moreover, total abatement of Klebsiella pneumoniae in AMB1 and Acinetobacter lwoffi in AMB2 has been seen, both on surfaces. Regarding air samplings, 89% moulds reduction has been seen, as observed on surfaces. Scaling up concentration to 2%, mesophilic bacteria reduction was ≥ 94%, both in air and on surfaces of the outpatient clinics. Same results have also been seen on moulds, whose maximum reduction was 97%.</p><p><strong>Discussion: </strong>Comparing results at different concentrations it has been observed that 2% KMPS induces an higher average reduction of mesophilic bacteria and moulds than 1%.</p><p><strong>Background: </strong>In this regard, microbial reduction percentage, either on surfaces or in the air, can be considered positive for outpatient clinics and healthcare settings indoor decontamination.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10671686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antibody response anti SARS-Cov-2: A retrospective observational study (Marche-Italy).","authors":"Isabella Baglioni,&nbsp;Alessia Galli,&nbsp;Chiara Gatti,&nbsp;Simona Tufoni,&nbsp;Renato Rocchi,&nbsp;Federico Lattanzi,&nbsp;Fabio Toia,&nbsp;Adoriano Santarelli,&nbsp;Stefano Marcelli","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 has hit every country in the world. Almost a quarter of a billion cases and nearly 5 million deaths reported globally as of late September 2021. Compared to over 6 billion doses of COVID-19 vaccine administered, the pandemic does not seem to disappear. The duration of protective immunity is currently not defined. Primary immune responses are inevitably declining and the continuous transmission of increasingly worrying viral variants.</p><p><strong>Objective: </strong>The primary objective of the study is to evaluate the antibody response at 120 and 180 days in employees of an hospital of Marche (Italy) who have completed the vaccination cycle with Pzifer-Biontech vaccine and to highlight the correlation with quantitative and qualitative variables. The secondary objective is to study the nature and frequency of adverse events in relation to variables such as comorbidity, age, gender, working areas and developed antibody titer.</p><p><strong>Materials and methods: </strong>An observational retrospective study was carried out to evaluate the antibody response at 120 and 180 days. Subjects receiving a double dose of vaccine at least 21 days apart and those receiving the second dose of the same vaccine between 18 January 2021 and 31 March 2021 shall be considered. The study included non-probability sampling of convenience. All parties have provided informed written consent to access personal and clinical data.</p><p><strong>Results: </strong>The sample is composed by 1.115 subjects. The results of the study reveal an important immune response detected by IgG dosage, both at 120 and 180 days after the second dose of Sars-Cov-2 vaccine mRNA BNT162b2 vaccine (Pzifer-Biontech), other than very rare exceptions. Antibody values are higher among hospital workers compared to those working in other areas, both 120 and 180 days. These values are even higher in the health professionals who provide assistance in wards with positive Covid patients, both at 120 days (p=0.06) and at 180 days; the mean values of IgG are statistically higher in direct assistance of Covid patients at 180 days(p=0.029). The most frequent adverse drug events after the second dose of vaccine were pain at the site of inoculation of the vaccine (70.7%), fatigue (35%) and arthralgia (19%). It was finally shown that people with diabetes or smokers had an average antibody response statistically lower than 120 days and 180 days from the second dose.</p><p><strong>Discussion and conclusion: </strong>This study leads to the conclusion that the second dose of vaccine Sars-Cov-2 vaccine mRNA BNT162b2 vaccine allows a consistent antibody response. Further multicentric studies are needed to investigate the antibody response to vaccination Sars-Cov-2 mRNA BNT162b2.</p>","PeriodicalId":73329,"journal":{"name":"Igiene e sanita pubblica","volume":"80 1","pages":"13-26"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10680762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}