David B. Olawade , Ojima Z. Wada , Abimbola O. Ige , Bamise I. Egbewole , Adedayo Olojo , Bankole I. Oladapo
{"title":"Artificial intelligence in environmental monitoring: Advancements, challenges, and future directions","authors":"David B. Olawade , Ojima Z. Wada , Abimbola O. Ige , Bamise I. Egbewole , Adedayo Olojo , Bankole I. Oladapo","doi":"10.1016/j.heha.2024.100114","DOIUrl":"10.1016/j.heha.2024.100114","url":null,"abstract":"<div><div>The application of Artificial Intelligence (AI) in environmental monitoring offers accurate disaster forecasts, pollution source detection, and comprehensive air and water quality monitoring. This article provides an overview of the value of environmental monitoring, the challenges of conventional methods, and potential AI-based solutions. Several significant AI applications in environmental monitoring are highlighted, showcasing their contributions to effective environmental management. AI technologies enhance environmental monitoring by enabling better understanding, prediction, and mitigation of environmental risks. However, realizing the full potential of AI faces hurdles such as a shortage of specialized AI experts in the environmental sector and challenges related to data access, control, and privacy. These issues are more pronounced in regions with developing technological infrastructure. The paper advocates for proactive data governance measures by governments to protect sensitive information. Despite these challenges, the future of AI in environmental monitoring remains promising, with advancements in AI algorithms, data collection techniques, and computing power expected to further improve accuracy and efficiency in pollution monitoring and management.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100114"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142553590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yudan Zheng , Lei Zhao , Yuming Zheng , Wenya Bai , Xuefeng Lai , Liangle Yang , Xiaomin Zhang , Miao Liu
{"title":"A longitudinal panel study exploring associations of urinary phthalate metabolites mixture with renal function in Chinese children","authors":"Yudan Zheng , Lei Zhao , Yuming Zheng , Wenya Bai , Xuefeng Lai , Liangle Yang , Xiaomin Zhang , Miao Liu","doi":"10.1016/j.heha.2024.100116","DOIUrl":"10.1016/j.heha.2024.100116","url":null,"abstract":"<div><div>Evidence from longitudinal studies examining the associations between urinary phthalate metabolites (mPAEs) and early kidney damage in children has been limited, and the underlying mechanisms still remain unclear. We carried out a longitudinal panel study involving up to 3 repeated visits, and each visit across 4 consecutive days, with 142 children aged 4-12 years from Guangzhou. mPAEs were determined in morning urine of each day and early kidney damage indicators were detected on the 4<sup>th</sup> day. We employed linear mixed-effect models (LMEs), and Bayesian kernel machine regression (BKMR) models to evaluate associations of mPAEs as individual and mixture with early kidney damage, and the interaction of thyroid hormones with mPAEs in such associations. We found that each 1-fold increment of mono-n-butyl phthalate (MBP) at health examination day (Lag0) was significantly associated with 4.734% (95% confidence interval: 1.313%, 8.155%) reduction of Cystatin-C (CysC)-based estimated glomerular filtration rate (eGFR<sub>CysC</sub>) (FDR< 0.05) and such relationships were in dose-response manner. Meanwhile, BKMR models showed the relations of mPAEs mixture with increased CysC and Beta-2-microglobulin (β2MG), and reduced eGFR<sub>CysC</sub> were dominated by MBP. Moreover, thyroid hormones were linked to early kidney damage, and free thyroxin (FT4) modified the associations of MBP and β2MG, which was more obvious in children with low level of FT4. Interactions of age group and gender with MBP were significant, the effect of MBP on early kidney damage was stronger in primary school children and boys. In summary, our findings indicated that urinary mPAEs as individual and mixture were associated with early kidney damage indicators, which contributed to MBP were modified by FT4.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100116"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142698392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Avishek Talukdar , Sayan Bhattacharya , Saptarshi Pal , Pracheta Pal , Soumyajit Chowdhury
{"title":"Positive and negative impacts of COVID-19 on the environment: A critical review with sustainability approaches","authors":"Avishek Talukdar , Sayan Bhattacharya , Saptarshi Pal , Pracheta Pal , Soumyajit Chowdhury","doi":"10.1016/j.heha.2024.100107","DOIUrl":"10.1016/j.heha.2024.100107","url":null,"abstract":"<div><div>Coronavirus, which practically brought the world to a standstill, is a member of the Coronaviridae family of the order Nidovirales, and was termed as the \"severe acute respiratory syndrome coronavirus 2″ (SARS-CoV-2) by the International Committee on Taxonomy of Viruses. The COVID-19 pandemic was probably the most critical healthcare and scientific challenge of this century. Apart from health concerns, the pandemic has also resulted in certain long-lasting social, economic, and environmental issues. The article, for the first time, executes a multidisciplinary assessment of the effects of COVID-19 on the environment, highlighting future research approaches and the possible ways to achieve sustainability in the post-COVID era. Both positive and negative impacts of COVID-19 pandemic are discussed in this context. While there are certain positive impacts of COVID-19 on the environment (including reduced air, water and noise pollution with cleaner landscapes), the negative impacts (increased production and consumption of plastics, increase in waste generation because of online consumption, decrease in waste recycling, energy consumption in vaccine manufacturing) pose considerable threats to the environment. We highlight urgent research priorities, and also discuss potential means of tackling any such pandemic in the future without hampering sustainable lifestyle or jeopardizing the environment and ecosystem dynamics. The findings will help to identify the possible areas of concern of pandemic management and can help in formulation of policies which will be helpful to reduce the impact of future pandemics on the environment.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100107"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000205/pdfft?md5=09f664e89679e1f8e4613f3697d38a36&pid=1-s2.0-S2773049224000205-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Xin Meng , Qiaoyi Hua , Ruiwei Xu , Yunxiu Shi , Yi Zhang , Meilin Yan , Wu Chen , Yifan Xu , Yunfei Fan , Yuan Yao , Teng Wang , Yidan Zhang , Haonan Li , Yaqi Yu , Xiaoyu Cui , Qianqian Chai , Ailin Li , Mengshuang Sheng , Rui Tang , Ruohong Qiao , Tong Zhu
{"title":"A prospective study on the cardiorespiratory effects of air pollution among residents of the Tibetan Plateau","authors":"Xin Meng , Qiaoyi Hua , Ruiwei Xu , Yunxiu Shi , Yi Zhang , Meilin Yan , Wu Chen , Yifan Xu , Yunfei Fan , Yuan Yao , Teng Wang , Yidan Zhang , Haonan Li , Yaqi Yu , Xiaoyu Cui , Qianqian Chai , Ailin Li , Mengshuang Sheng , Rui Tang , Ruohong Qiao , Tong Zhu","doi":"10.1016/j.heha.2024.100115","DOIUrl":"10.1016/j.heha.2024.100115","url":null,"abstract":"<div><div>The Tibetan Plateau is characterized by high ozone concentration which poses a significant public health concern. However, the causal evidence linking ozone pollution to adverse cardiopulmonary health impacts, as well as the understanding of its underlying biological mechanisms, remains limited. Additionally, exposure levels to particulate and other gaseous air pollutants along with their associated health effects in this region are largely unknown. To address these gaps, we conducted a prospective follow-up study in Tibet from May 2021 to November 2021. In consideration of the potential synergistic effects of chronic hypobaric hypoxia, two Tibetan cities with different altitudes, Lhasa (3650 m) and Nyingchi (3000 m), were chosen to implement atmospheric monitoring and health measurement. We employed cutting-edge, high-precision instruments at stationary monitoring sites to measure ambient air pollution and collected particle samples. Portable devices were used to monitor personal exposure levels of ozone and black carbon. A total of 212 healthy Tibetan college students participated in up to four clinical visits, yielding 774 visits in total, during which functional endpoints were measured and biological samples were collected. The primary aim of this study is to evaluate the cardiorespiratory effects of ambient ozone under hypoxic conditions, where its impact may be amplified due to the region's unique environmental characteristics. The secondary aim is to provide a comprehensive assessment of other air pollutants, including their exposure levels, sources, and health effects. By addressing these aims, the study offers valuable insights into air quality and its health implications in this unique high-altitude setting. This paper outlines the research motivation, measurement framework, and preliminary findings.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100115"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142536251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boubakari Ibrahimou , Ning Sun , Sophie Dabo-Niang
{"title":"Assessing the multi-dimensional effects of air pollution on maternal complications and birth outcomes: A structural equation modeling approach","authors":"Boubakari Ibrahimou , Ning Sun , Sophie Dabo-Niang","doi":"10.1016/j.heha.2024.100113","DOIUrl":"10.1016/j.heha.2024.100113","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study aims to investigate the direct and indirect relationships between exposure to a metal mixture in air and adverse pregnancy outcomes across gestational stages.</div></div><div><h3>Methods</h3><div>With 46,829 births in 2021 in two Florida counties and Air Quality System data, structural equation modeling was used to construct latent metal mixtures in PM<sub>2.5</sub> and unravel their effects on pregnancy complications (preeclampsia and gestational diabetes) and birth outcomes (low birth weight and preterm birth risks).</div></div><div><h3>Results</h3><div>A latent variable featuring seven metals (Aluminum, Calcium, Iron, Magnesium, Manganese, Silicon, Vanadium) was identified through the measurement model. The latent metal mixture exposure had direct effects on gestational diabetes and preterm birth (1st trimester, 2nd trimester), low birth weight (1st trimester), and preeclampsia (2nd trimester). When considering total effects, the effects on low birth weight in the 1st trimester and on preeclampsia in 2nd trimester were masked, and the latent metal mixture increased the low-birth-weight risk in 2nd trimester by 2 % (OR = 1.02, 95 % CI = [1.00, 1.03]).</div></div><div><h3>Conclusion</h3><div>This study reveals time-dependent associations between a metal mixture in PM<sub>2.5</sub> exposure and adverse pregnancy outcomes, highlights the need to address dust in PM<sub>2.5</sub>, and provides additional evidence for understanding the pathway of the pollution effects on fetal health.</div></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100113"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142420438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"From human cohorts to plant cohorts: The potential of plants in epidemiological studies","authors":"Tianyu Zhao , Joachim Heinrich","doi":"10.1016/j.heha.2024.100105","DOIUrl":"10.1016/j.heha.2024.100105","url":null,"abstract":"<div><p>Cohort studies are traditionally focused on human participants. The emergence of the “Planetary Health” and “One Health” paradigms has expanded the scope of cohort studies to include animal participants. Despite this, plants remain largely overlooked in traditional biomedical research. This gap prompts the introduction of the concept of a “plant cohort,” which involves treating plants as participants in cohort studies. By collecting comprehensive data on plant characteristics and biosamples, plant cohorts may assist in enhancing our understanding of the interactions between plants, ecosystems, and human health. However, establishing plant cohorts presents unique challenges, including interdisciplinary collaboration and data collection methods. Nonetheless, the potential contribution of plant cohorts to environmental health and human well-being may warrant further exploration and research.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100105"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000187/pdfft?md5=a712573f282290ee7a4ca8ec8a17c2e4&pid=1-s2.0-S2773049224000187-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142162254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Removal mechanism of decabromodiphenyl ether in soil by Cu/Fe nanoparticles","authors":"Siyuan Ling , Ying Han , Shuangqing Hu","doi":"10.1016/j.heha.2024.100106","DOIUrl":"10.1016/j.heha.2024.100106","url":null,"abstract":"<div><p>Decabromodiphenyl ether (BDE-209), a widely used and environmentally significant legacy brominated flame retardant, is frequently found in farmland soil near electronic waste disposal sites and manufacturing facilities. Due to their high adsorption and dehalogenation capabilities, nanoparticles have become a prominent solution for soil remediation. Herein, Cu/Fe bimetallic nanoparticles (BNPs) were prepared and the use of these particles was investigated for the removal of BDE-209 from soil. Optimal conditions, including 9.1 wt% Cu loading and acidic environments, were identified to enhance the removal efficiency. The process involves desorption from soil, adsorption onto BNPs, and subsequent degradation. The contributions of adsorption and degradation were investigated by isolating the BNPs after the experiments conducted herein. Initially, adsorption played an important role, accounting for 25 %–38 % of the total removal, but this decreased to 14 % to 20 % as the reaction progressed, reaching at the equilibrium adsorption capacity after ∼3 h. Notably, hydroxylated polybrominated diphenyl ethers (PBDE) congeners were absent in all soil, BNP, and aqueous solution samples, indicating that stepwise debromination primarily drives the degradation process.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"12 ","pages":"Article 100106"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000199/pdfft?md5=34a95efe77d5a8b0d0b57cc93713e90c&pid=1-s2.0-S2773049224000199-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mobile air-decontamination units: Can they be used for immunocompromised patients at high risk for fungal infections?","authors":"Joris Voisin , Jacqueline Shum Cheong Sing , Claire Terreaux-Masson , Carola Pierobon , Anne Thiebaut-Bertrand , Hervé Pelloux , Caroline Landelle , Marie-Pierre Brenier-Pinchart","doi":"10.1016/j.heha.2024.100102","DOIUrl":"10.1016/j.heha.2024.100102","url":null,"abstract":"<div><p>Immunocompromised patients in the hematology department are usually hospitalized in areas protected by the high-efficiency particulate air (HEPA) filtration system. Renovations may require moving these patients at risk for invasive fungal infection to areas without HEPA. Mobile air handling units may be a solution in these cases. For renovation purposes, we evaluated the efficiency of mobile air handling units called Plasmair® as well as their optimization, by comparing two generations of devices.</p><p>Particle counts were performed to determine a particle cleanliness classification according to the ISO 14644–1 standard (high ISO classes correspond to a degraded particulate cleanliness). Mycological air samples were also taken to determine the percentage of positive samples and the median number of filamentous fungi colonies.</p><p>Without air treatment, only 18 % (38/216) of particle counts were classified as ISO 6. With the use of mobile air treatment units, this proportion increased to 71 % (205/288). The positivity rate of mycological samples without air treatment was 86 % (31/36) with a median number of fungal colonies of 3 (1–5)/0.5m<sup>3</sup>. A significant decrease in fungal pressure was observed when using Plasmair®. Percentages of positive air samples and the median number of colonies found between the old generation Plasmair® (T2006) and the new generation Plasmair® (Guardian) were significantly different, respectively 55.6 % (20/36) <em>versus</em> 22.2 % (8/36) and 1(0–1) <em>versus</em> 0 (0–0).</p><p>Finally, we confirm Plasmair® were effective in reducing airborne fungal pressure, the new generation especially. However, they were not effective enough to obtain negative mycological air samples as usually observed with the HEPA system, whatever the generation.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000151/pdfft?md5=88679416b1a922398b45cfc4f2f29bed&pid=1-s2.0-S2773049224000151-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tinh Huu Ho , Chinh Van Dang , Thao Thi Bich Pham , Hien Thi Thu Ngo , Supat Wangwongwatana
{"title":"Assessment of the association between PM2.5 concentration and hospital admissions for pediatric asthma in Ho Chi Minh City, Viet Nam","authors":"Tinh Huu Ho , Chinh Van Dang , Thao Thi Bich Pham , Hien Thi Thu Ngo , Supat Wangwongwatana","doi":"10.1016/j.heha.2024.100097","DOIUrl":"https://doi.org/10.1016/j.heha.2024.100097","url":null,"abstract":"<div><p>Despite the growing concern over the impact of ambient fine particulate matter (PM<sub>2.5</sub>) on respiratory health, studies on the association between PM<sub>2.5</sub> and childhood asthma in Vietnam have remained relatively sparse.</p><p>The study aimed to evaluate the short-term effects of PM<sub>2.5</sub> on asthma hospital admissions in Ho Chi Minh City (HCMC), the most populous city in Vietnam. The PM<sub>2.5</sub> database from 2016 to 2019 was collected at two fixed monitoring stations. The health database was collected from all three children's hospitals. A time-series regression analysis was conducted to examine the associations between the daily PM<sub>2.5</sub> concentration and hospitalizations for asthma.</p><p>A total of 11,223 records of children under five years old hospitalized for asthma were collected, of which 64 % were male and 70 % were aged 2 to under five years old. The daily mean PM<sub>2.5</sub> concentration over the study period was 28.2 μg/m<sup>3</sup>. Each 10 μg/m<sup>3</sup> increase in PM<sub>2.5</sub> at lag<sub>2</sub>, lag<sub>3,</sub> and lag<sub>04</sub>, we found that the excess risk of total asthma hospital admission was 2.71 %, 2.63 %, and 3.9 %, respectively. According to the subgroup analysis, female gender and children aged from two to under five years had more significant effects.</p><p>PM<sub>2.5</sub> poses a risk to children's health; therefore, the local authority should prioritize improving the air quality.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100097"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000102/pdfft?md5=487e0ffd0276fd44abd429d71af22baa&pid=1-s2.0-S2773049224000102-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jiaoyang Chen , Yue Wang , Zhixin Zhao , Ye Deng , Tianyun Wang , Yuting Xiang , Yuting Wang , Jiamei Chen , Miao He
{"title":"Associations of endocrine disrupting chemicals with renal function in older individuals","authors":"Jiaoyang Chen , Yue Wang , Zhixin Zhao , Ye Deng , Tianyun Wang , Yuting Xiang , Yuting Wang , Jiamei Chen , Miao He","doi":"10.1016/j.heha.2024.100098","DOIUrl":"10.1016/j.heha.2024.100098","url":null,"abstract":"<div><h3>Background</h3><p>Since the twentieth century, endocrine-disrupting substances (EDCs) such as phthalates and organophosphates have been utilised in various goods. The long-term usage of these products may have negative effects on people's health. Most EDCs are metabolized through kidneys, but there are few research investigating renal damage from exposure to EDCs in the elderly. This study aims to examine the effects of EDCs exposure on renal function in the elderly population.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, a total of 200 elder from a community in northeast China were enrolled. All subjects were investigated by questionnaire, physical examination, and biological sample collection. Estimated glomerular filtration rate (eGFR) was used to classify renal function group. Lasso regression was used to screen out the EDCs related to renal function. After covariate adjustment, binary logistic regression was used to analyze the relationship between decreased renal function and EDCs. Weighted quantile sum (WQS) regression was used to assess the association of combined-EDCs with decreased renal function, subgroup analyses were performed to identify potentially sensitive populations to the effects of EDCs on decreased renal function.</p></div><div><h3>Results</h3><p>Binary logistic regression showed that 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT-COOH), Mono(3-carboxypropyl) phthalate (MCPP), and Methyl paraben (MeP) were negatively associated with decreased renal function, with odds ratio (OR) and 95% confidence intervals of 0.591 (0.366, 0.954), 0.990 (0.981, 0.999) and 0.997 (0.995, 0.999), respectively. WQS regression found DPP (Weights = 22.5%) to have the greatest effect on decreased renal function in the elderly. Moreover, significant potential interactions were observed among MEHP&MOcP with hypertension on decreased renal function (<em>P</em><sub>interaction</sub> = 0.014), as well as BPS and MEHP&MocP with Overweight/obesity on decreased renal function (<em>P</em><sub>interaction</sub> = 0.032, 0.024).</p></div><div><h3>Conclusions</h3><p>BHT-COOH, MCPP, and MeP were negatively associated with decreased renal function in the elderly. Elders with hypertension and who are overweight /obesity may be more sensitive to EDCs.</p></div>","PeriodicalId":73269,"journal":{"name":"Hygiene and environmental health advances","volume":"11 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2773049224000114/pdfft?md5=081838dccf4e3b0f93d1a1e22127a1ae&pid=1-s2.0-S2773049224000114-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141637343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}