GMS ophthalmology casesPub Date : 2020-08-07eCollection Date: 2020-01-01DOI: 10.3205/oc000162
Dominika Pohlmann, Mirjam Rossel, Daniel J Salchow, Eckart Bertelmann
{"title":"Outcome of a penetrating keratoplasty in a 3-month-old child with sclerocornea.","authors":"Dominika Pohlmann, Mirjam Rossel, Daniel J Salchow, Eckart Bertelmann","doi":"10.3205/oc000162","DOIUrl":"https://doi.org/10.3205/oc000162","url":null,"abstract":"<p><p>Sclerocornea is a rare congenital anomaly with clouding of the peripheral cornea that possibly extends up to the center of the cornea. Characteristically, a clear distinction (limbus) between sclera and cornea is lacking. Early surgical treatment is essential for preventing amblyopia, but penetrating keratoplasty in children carries a relatively high risk of complications. Especially for sclerocornea, penetrating keratoplasty has generally been reported to have a poor surgical outcome and a high risk of complications, including corneoscleral adhesions. Here, we report the 4-year follow-up on a child with sclerocornea, who was successfully operated on at the age of 3 months and had a favorable outcome. Our findings suggest that in some cases, penetrating keratoplasty may be an option to treat sclerocornea in young children.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc35"},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GMS ophthalmology casesPub Date : 2020-08-06eCollection Date: 2020-01-01DOI: 10.3205/oc000157
Laura Tabuenca Del Barrio, Marcos Mozo Cuadrado, Luiz Miguel Nova Camacho, Alicia Zubicoa Enériz, Miren Dolores Aranguren Laflin, Araceli Alcaine Soler
{"title":"Epithelial conjunctival neoplasias - the importance of an early diagnosis and optimal treatment.","authors":"Laura Tabuenca Del Barrio, Marcos Mozo Cuadrado, Luiz Miguel Nova Camacho, Alicia Zubicoa Enériz, Miren Dolores Aranguren Laflin, Araceli Alcaine Soler","doi":"10.3205/oc000157","DOIUrl":"https://doi.org/10.3205/oc000157","url":null,"abstract":"<p><p><b>Objective:</b> To emphasize the importance of an early diagnosis and an adequate treatment in conjunctival tumors. <b>Methods:</b> We present two clinical cases and compare the course of each case: one of conjunctival intraepithelial neoplasia (CIN) which took a positive course, and a fatal case of squamous cell carcinoma (SCC) with intraocular and orbital extension. <b>Results:</b> Epithelial conjunctival malignancies are one of the most prevalent ocular surface tumors. Among these, CIN are the most common. CIN have an excellent prognosis, given adequate treatment. However, when the diagnosis of CIN is late, the epithelial basement membrane will be affected, resulting in SCC. SCC may have poorer results due to its capacity to infiltrate near tissues and create distant metastasis. <b>Conclusion:</b> It is not common today to treat patients with orbital extension of SCC; however, it is crucial to note the importance of an early diagnosis of conjunctival malignancies. An early diagnosis is essential to prevent the transformation to other life-threatening types.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc30"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7453141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Macular hole and submacular hemorrhage secondary to retinal arterial macroaneurysm - successfully treated with a novel surgical technique.","authors":"Ramin Nourinia, Nazanin Behnaz, Hossein Hassanpour, Zahra Karjoo, Kiana Hassanpour","doi":"10.3205/oc000158","DOIUrl":"https://doi.org/10.3205/oc000158","url":null,"abstract":"<p><p><b>Purpose:</b> To present a 65-year-old patient with macular hole (MH) and submacular hemorrhage (SMH) secondary to a ruptured retinal arterial macroaneurysm (RAM) which was successfully treated with a novel surgical technique. <b>Patient:</b> A 65-year-old woman presented with a 1-week history of sudden-onset visual loss in her right eye. Her best-corrected visual acuity (BCVA) was hand motion in the right eye. Her fundus examination revealed intraretinal and massive subretinal hemorrhage with macular involvement. An MH with an approximate diameter of 600 microns was also noted. The patient was treated by a standard pars plana vitrectomy (PPV) and internal limiting membrane (ILM) peeling, followed by 10 µg recombinant tissue plasminogen activator injection into the submacular space via the MH with a 25-gauge vitrectomy probe. BCVA of the patient increased to 20/320 and 20/60, one and four weeks after surgery, respectively. Optical coherence tomography (OCT) images confirmed the complete anatomical closure of the MH and the restoration of the outer retinal layers such as the external limiting membrane and the ellipsoid zone. <b>Conclusion:</b> This case report expands our knowledge about the management of MH in combination with SMH after a ruptured RAM. We suggest the use of a vitrectomy probe and MH for subretinal recombinant tissue plasminogen activator (rtPA) injection.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc31"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GMS ophthalmology casesPub Date : 2020-08-06eCollection Date: 2020-01-01DOI: 10.3205/oc000160
Nils Alexander Steinhorst, Martin Spitzer, Christos Skevas
{"title":"Bevacizumab as a treatment option for choroidal neovascularisation due to large optic nerve drusen in a 14-year-old girl.","authors":"Nils Alexander Steinhorst, Martin Spitzer, Christos Skevas","doi":"10.3205/oc000160","DOIUrl":"https://doi.org/10.3205/oc000160","url":null,"abstract":"<p><p><b>Purpose:</b> To report the effects of a single intravitreous injection of bevacizumab for the treatment of secondary choroideal neovascularisation due to large optic disc drusen. <b>Methods:</b> A 14-year-old female patient with painless loss of vision in one eye presented with unusually large optic disc drusen and juxtapapillary choroidal neovascularisation with subretinal hemorrhage. She was treated with a single intravitreous injection of bevacizumab. <b>Results:</b> Visual acuity increased from 20/100 to 20/25 within 4 weeks after injection and remained at this level during the 12-month follow-up period. <b>Conclusions:</b> Bevacizumab is a possible primary treatment option for secondary choroidal neovascularisation due to large optic disc drusen in children as an alternative to other more invasive or complex procedures.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc33"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Orbito-sinal foreign body with floor fracture: an unusual presentation.","authors":"Narendra Patidar, Saket Agrawal, Rukmendra Pratap Singh, Prerana Phadnis","doi":"10.3205/oc000159","DOIUrl":"https://doi.org/10.3205/oc000159","url":null,"abstract":"<p><p>Wooden foreign bodies penetrating through the orbit into paranasal sinuses are rare. We report a case of a young male who complained of double vision, pain and redness after a fall from a tree. There was no external wound over periocular skin. The clinical and radiological examination was suggestive of an inferior orbito-sinal wooden foreign body with floor fracture, which was managed by surgical removal of the foreign body and orbital floor fracture repair using a silicon sheet in a single sitting.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc32"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GMS ophthalmology casesPub Date : 2020-08-06eCollection Date: 2020-01-01DOI: 10.3205/oc000161
Mona Bischoff-Jung, Elias Flockerzi, Andrea Hasenfus, Arne Viestenz, Pinio Matoula, Ursula Schlötzer-Schrehardt, Berthold Seitz
{"title":"Recurrence of macular corneal dystrophy on the graft 50 years after penetrating keratoplasty.","authors":"Mona Bischoff-Jung, Elias Flockerzi, Andrea Hasenfus, Arne Viestenz, Pinio Matoula, Ursula Schlötzer-Schrehardt, Berthold Seitz","doi":"10.3205/oc000161","DOIUrl":"https://doi.org/10.3205/oc000161","url":null,"abstract":"<p><p><b>Purpose:</b> To report the recurrence of a macular corneal stromal dystrophy 50 years after penetrating keratoplasty (PKP). <b>Methods:</b> Observational case report <b>Case</b> <b>description:</b> A 76-year-old male patient presented with visual impairment in the right eye (OD) 50 years after PKP in 1962 (44 years after PKP also in the left eye (OS) in 1968) following explosion injury. His visual acuity had already been impaired before the trauma because of bilateral corneal opacities. The central corneal thickness of the graft measured 584 µm (OD) and 544 µm (OS), whilst the peripheral host thickness (8 mm zone), however, was 1233 µm (OD, cranial) and 1131 µm (OS, nasal). The original graft diameter measured 6 mm in both eyes and the recipient cornea was cloudy and gray. The endothelial cell count was measured centrally (OD 1162 c/mm<sup>2</sup>, OS 1320 c/mm<sup>2</sup>). The visual acuity was 20/100 (OD) and 20/40 (OS). After excimerlaser-assisted repeated PKP (8.0/8.1 mm, OD), the histological analysis of the former graft revealed deposits of acid mucopolysaccharides (AMP) subepithelially, within the interface, in the donor stroma, and in the endothelium, which proved the peripheral recurrence of a macular corneal stromal dystrophy on the graft. <b>Conclusion:</b> Recurrence of macular corneal stromal dystrophy is seldom, but it may occur many decades after PKP. In this patient, the host's stroma was twice as thick as that of the graft. This may be caused by the active production of acid mucopolysaccharides in the host endothelium with secondary endothelial decompensation. Thus, PKP remains the gold standard in the cure of macular corneal dystrophy for long-term visual rehabilitation.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc34"},"PeriodicalIF":0.0,"publicationDate":"2020-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7452946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38343843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GMS ophthalmology casesPub Date : 2020-06-29eCollection Date: 2020-01-01DOI: 10.3205/oc000155
Virna M Shah, Ratnesh Ranjan, Mrunmayi Jeste, Peter MacIntosh, Duraiswamy Ashwath
{"title":"Bilateral vertical gaze palsy due to midbrain infarct associated with iron deficiency anemia in a young boy.","authors":"Virna M Shah, Ratnesh Ranjan, Mrunmayi Jeste, Peter MacIntosh, Duraiswamy Ashwath","doi":"10.3205/oc000155","DOIUrl":"https://doi.org/10.3205/oc000155","url":null,"abstract":"<p><p>An 8-year-old boy presented with complaints of sudden-onset binocular vertical diplopia of one day duration. Ophthalmic examination showed restricted up- and downgaze movement with rotatory nystagmus. Systemic investigations revealed iron-deficiency anemia and localized acute infarct in the left paramedian rostral and dorsal part of the upper midbrain at the level of the red nucleus on magnetic resonance imaging. The patient was started on oral iron supplement, which resulted in symptomatic as well as clinical improvement after 2 weeks.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc28"},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mirtazapine-induced bilateral secondary angle closure in a female.","authors":"Srishti Raj, Manpreet Kaur, Kandragunta Srinivasarao, Faisal Thattaruthody, Sushmita Kaushik, Surinder Singh Pandav","doi":"10.3205/oc000156","DOIUrl":"https://doi.org/10.3205/oc000156","url":null,"abstract":"<p><p><b>Purpose:</b> To report a case of bilateral secondary angle closure in a female using mirtazapine for 6 months. <b>Patient and method:</b> A 55-year-old female was diagnosed with secondary angle closure in both eyes with raised intraocular pressure, and ultrasound biomicroscopic findings suggestive of ciliary body effusion. It was associated with adjoining cyst presumably because of the use of mirtazapine for depression and sleep disturbances. <b>Results:</b> After the planned discontinuation of mirtazapine, the ocular angle opened, the ciliary body edema decreased, and the cyst regressed in size. The intraocular pressure was controlled with topical timolol (0.5%). <b>Conclusion:</b> Patients with risk factors for angle closure should be prescribed antipsychotic drugs with caution. The peripheral laser iridotomy is not indicated in secondary angle closure due to ciliary body effusion.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc29"},"PeriodicalIF":0.0,"publicationDate":"2020-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Inverted temporal internal limiting membrane flap technique for chronic large traumatic macular hole.","authors":"Archana Kumari, Lalit Agarwal, Nisha Agrawal, Sabin Sahu, Indranath Prasad, Deepti Pradhan","doi":"10.3205/oc000154","DOIUrl":"https://doi.org/10.3205/oc000154","url":null,"abstract":"<p><p>Various modifications of surgical techniques and surgical adjuncts are adopted with standard pars plana vitrectomy (PPV) to improve the outcome of traumatic macular hole (TMH) surgeries. We describe a successful closure of a chronic large TMH of three years duration with inverted temporal internal limiting membrane (ILM) flap technique. A 36-year-old male patient had an optical coherence tomography (OCT) documented chronic macular hole (MH) for three years following blunt trauma. Fundus examination also showed choroidal rupture scar temporal to fovea. The minimum MH diameter was 769 µ and the basal diameter 1431 µ in OCT. Standard PPV with inverted temporal ILM flap and gas tamponade was done. The postoperative period was uneventful. The best corrected visual acuity improved from 6/60 preoperatively to 6/18 six months postoperatively, and OCT showed a closed MH with anatomical type 1 closure. This case highlights that the inverted temporal ILM flap technique is a safe and effective technique for patients with even chronic and large TMH.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc27"},"PeriodicalIF":0.0,"publicationDate":"2020-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332995/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
GMS ophthalmology casesPub Date : 2020-05-04eCollection Date: 2020-01-01DOI: 10.3205/oc000153
Giuseppe Casalino, Stefano Erba, Vasuki Sivagnanavel, Shervin Lari, Antonio Scialdone, Carlos Pavesio
{"title":"Spontaneous resolution of acute syphilitic posterior placoid chorioretinitis: reappraisal of the literature and pathogenetic insights.","authors":"Giuseppe Casalino, Stefano Erba, Vasuki Sivagnanavel, Shervin Lari, Antonio Scialdone, Carlos Pavesio","doi":"10.3205/oc000153","DOIUrl":"https://doi.org/10.3205/oc000153","url":null,"abstract":"<p><p>Acute syphilitic posterior placoid chorioretinitis (ASPPC) is a rare clinical manifestation of ocular syphilis. Spontaneous resolution of this condition has been reported in a few cases. The aim of this manuscript is to report an additional case and to discuss the possible pathogenesis of this condition by reviewing the current evidence on this subject. A 45-year-old man presented to us with decreased vision in the right eye secondary to a placoid macular lesion. Fourteen days after presentation, there was a dramatic improvement of the vision, and multimodal retinal imaging showed almost complete spontaneous resolution of the placoid lesion. Syphilis serology turned out positive and a diagnosis of ASPPC was made. The pathogenesis of ASPPC is unclear, and there is contrasting evidence about the role of the cellular immune system. Since this condition may resolve spontaneously before systemic antimicrobial treatment, the presence of a placoid macular lesion should raise a high suspicion of ASPPC in order to make a timely diagnosis and to avoid progression of untreated syphilis.</p>","PeriodicalId":73178,"journal":{"name":"GMS ophthalmology cases","volume":"10 ","pages":"Doc26"},"PeriodicalIF":0.0,"publicationDate":"2020-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7332998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38161858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}